scholarly journals Prostate cancer tumor markers

2015 ◽  
Vol 10 (3) ◽  
pp. 246-249
Author(s):  
Nicolae BACALBASA ◽  
◽  
Alexandra GIREADA ◽  
Irina BALESCU ◽  
Vladislav BRASOVEANU ◽  
...  

Prostatic cancer represents an important health problem worldwide, being the third most common malignancy in men older than 55 years, after pulmonary and colon cancer. In early stages prostatic cancer remains hard to be diagnosed at clinical or imagistical studies, the most efficient way to detect it being based on the determination of tumor markers. This is a literature review of the largest studies conducted on the theme of prostatic tumor markers.

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 1541-1541
Author(s):  
C. Villarreal-Garza ◽  
A. R. Villa ◽  
M. Perfecto-Arroyo ◽  
L. García-Aceituno ◽  
M. Rojas-Flores ◽  
...  

1541 Background: Cancer is the second cause of death worldwide. In certain types of cancer, screening may detect the disease in its early stages, increasing survival. Therefore, it becomes extremely important that physicians are aware of its precise indications. We sought to explore the level of knowledge about cancer screening among Mexican medical students and residents. Methods: A questionnaire-based survey about screening in breast, cervical, colon, and prostate cancer was completed by medical students attending either public or private medical schools, and internal medicine residents from five training centers in Mexico City. The survey included 16 questions regarding tumor markers, beginning of screening, method of early detection, and frequency of screening. Knowledge scores were expressed as percentages. Statistical analysis was performed using two-tailed Fisher's exact test and Kruskal-Wallis test. Results: The survey was answered by 451 individuals, 49.22% male and 50.78% female, with a mean age of 24.3 ± 2.55 years (range 20–33). Medical students comprised 64.52% and residents 35.48%. Mean knowledge score was 63.97 ± 14.97 (range 18.75–100), increasing directly with level of training: medical students obtained a mean score of 60.46 ± 14.09 compared to residents with score of 70.35 ± 14.44 (p = 0.0001). Statistical differences were noted between third (50.00), fourth (62.62) and fifth year (60.19) (p = 0.0001) medical students; while there was no difference between sixth and seventh year students, neither between distinct years of residency. No difference was encountered between private and public schools. Comparing screening knowledge regarding tumor subgroups, residents scored higher than students in relation to tumor markers 65.24 versus 22.82, breast cancer 77.33 versus 69.19, and prostate cancer 75.00 versus 68.53 (p = 0.0001 for the three comparisons); whereas there was no difference in the education concerning cervical and colon cancer screening, 69.44 versus 70.83 (p = 0.518) and 50.61 versus 45.20 (p = 0.114), respectively. Conclusions: Knowledge of screening guidelines is suboptimal among medical students and residents, especially regarding cervical and colon cancer. Further educational efforts should be targeted to educational and training programs in this country. No significant financial relationships to disclose.


Praxis medica ◽  
2020 ◽  
Vol 49 (3-4) ◽  
pp. 43-49
Author(s):  
Milica Mijović ◽  
Vladica Nedeljković ◽  
Danica Vukićević ◽  
Nebojša Mitić ◽  
Branislav Đerković ◽  
...  

Prostate cancer (CP) is the most common malignancy in men in America, while it is the second most common in Europe. It is responsible for about 10% of cancer deaths in the same population. It is clinically manifested in various forms, from slow-growing to aggressive forms with pronounced metastatic potential. Diagnosis is made by a well-defined algorithm, which begins with the determination of serum prostate specific antigen values and ends with prostate biopsy as the "gold standard". Pathohistological diagnostic criterias are based on architectural, cytoplasmic, nuclear and characteristics of intraluminal structures, as well as periacinar cleftings, which are deffined as helpfull diagnostic criteria of undoubted importance. Prognostic and predictive parameters are classified into three categories. Some of them are an integral part of routine pathohistologicat report, while others are considered as the diagnostic process progresses. Modern knowledge introduces biomarkers into the everyday practice of personalized medicine, especially when is necessary to treat prostate cancer patients.


2007 ◽  
Vol 33 (4) ◽  
pp. 477-485 ◽  
Author(s):  
Alberto A. Antunes ◽  
Miguel Srougi ◽  
Marcos F. Dall'oglio ◽  
Alexandre Crippa ◽  
Adriano J. Nesrallah ◽  
...  

2015 ◽  
Vol 62 (4) ◽  
pp. 403-407
Author(s):  
Alexandra Gireada ◽  
◽  
Irina Balescu ◽  
Nicolae Bacalbasa ◽  
◽  
...  

Gastric cancer remains an aggressive malignancy responsible for a high number of deaths annually. An important method used in order to determine the response to treatment, follow-up and detection of recurrence in association with imagistic examinations remains laboratory determination of tumor markers. The most common used tumor markers in patients diagnosed with gastric cancer are CA 72-4, CEA, CA 19-9.


2012 ◽  
pp. 2748-2762.e6 ◽  
Author(s):  
Robert H. Getzenberg ◽  
Alan W. Partin

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 20108-20108
Author(s):  
B. O. Dernek ◽  
M. H. Akboru ◽  
A. Yoney ◽  
S. Altin ◽  
M. Unsal

20108 Background: Cancer is one of the most important health problems existing 10.1 millions of new patients and 6.2 millions dead in 2000. 15 millions of new patients will be supposed to be seen in 2020. Method: In this study; between 1999–2003, 41,564 new patients diagnosed as cancer admitted to our center were analyzed. International Classification Disease of Oncology (ICD-O) was used to classify the patients. Basal cell carcinoma and epidermoid carcinoma of the skin were not included. Rest of 41116 patients were reviewed according to their age, sex, diagnosis and coming region. Results: 55.6% of the patients were male. Top five location of the disease can be listed as follows: respiratory system (25.6%), gastrointestinal system (19.2%), breast (15.1%), genitourinary system (11.3%) and lymphoma (4.7%). Analysis according to gender is illustrated in Table . Most cases have come from Marmara Region. While peak incidence was detected between 60–69 years of age in males, it was 50–59 years of age in females. Least comings were seen below 20 years of ages in both sexes. Conclusions: Admission to our department increases gradually while it was 7,020 patients in 1999, it reached to 10,035 person in 2003. General population and population insured by Social Insurance Institution are mostly living in Marmara Region (48.16% of the population are insured by this institution and 41.72% of them reside in Marmara Region). Our department was unique active center in Social Insurance Institution’s order at that time. According to SEER (U.S. Surveillance Epidemiology and EndResults) data in United States (US); although prostate cancer is mostly seen cancer (15%) and lung cancer is recorded in just 13% of cases it is the leading data in our study (22.4%) and prostate cancer is only seen 3.8% of cases. This difference can be explained by effective screening programs in US and prostatic cancer patients mostly prefer to apply the Urology Department in our country. Smoking and environmental conditions may be the reason of high incidence in lung cancer. [Table: see text] No significant financial relationships to disclose.


2000 ◽  
Vol 39 (05) ◽  
pp. 121-126 ◽  
Author(s):  
R. Werz ◽  
P. Reuland

Summary Aim of the study was to find out wether there is a common stop of growth of mandibular bone, so that no individual determination of the optimal time for surgery in patients with asymmetric mandibular bone growth is needed. As there are no epiphyseal plates in the mandibular bone, stop of growth cannot be determined on X-ray films. Methods: Bone scans of 731 patients [687 patients (324 male, 363 female) under 39 y for exact determination of end of growth and 44 (21 male, 23 female) patients over 40 y for evaluation of nongrowth dependant differences in tracer uptake] were reviewed for the study. All the patients were examined 3 hours after injection of 99mTc-DPD. Tracer uptake was measured by region of interest technique in different points of the mandibular bone and in several epiphyseal plates of extremities. Results: Tracer uptake in different epiphyseal plates of the extremities shows strong variation with age and good correlation with reported data of bone growth and closure of the epiphyseal plates. The relative maximum of bone activity is smaller in mandibular bone than in epiphyseal plates, which show well defined peaks, ending at 15-18 years in females and at 18-21 years in males. In contrast, mandibular bone shows no well defined end of growing but a gradually reduction of bone activity which remains higher than bone activity in epiphyseal plates over several years. Conclusion: No well defined end of growth of mandibular bone exists. The optimal age for surgery of asymmetric mandibular bone growth is not before the middle of the third decade of life, bone scans performed earlier for determination of bone growth can be omitted. Bone scans performed at the middle of the third decade of life help to optimize the time of surgical intervention.


2019 ◽  
Vol 7 (1) ◽  
pp. 9-20
Author(s):  
Inna Yeung

Choice of profession is a social phenomenon that every person has to face in life. Numerous studies convince us that not only the well-being of a person depends on the chosen work, but also his attitude to himself and life in general, therefore, the right and timely professional choice is very important. Research about factors of career self-determination of students of higher education institutions in Ukraine shows that self-determination is an important factor in the socialization of young person, and the factors that determine students' career choices become an actual problem of nowadays. The present study involved full-time and part-time students of Institute of Philology and Mass Communications of Open International University of Human Development "Ukraine" in order to examine the factors of career self-determination of students of higher education institutions (N=189). Diagnostic factors of career self-determination of students studying in the third and fourth year were carried out using the author's questionnaire. Processing of obtained data was carried out using the Excel 2010 program; factorial and comparative analysis were applied. Results of the study showed that initial stage of career self-determination falls down on the third and fourth studying year at the university, when an image of future career and career orientations begin to form. At the same time, the content of career self-determination in this period is contradictory and uncertain, therefore, the implementation of pedagogical support of this process among students is effective.


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