scholarly journals Minimally invasive diagnosis of endometriosis

2021 ◽  
Vol 16 (1) ◽  
pp. 25-31
Author(s):  
Cătălina Diana STANICA ◽  
◽  
Adrian NEACSU ◽  
Romina Marina SIMA ◽  
Raluca Gabriela IOAN ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Serum Markers ◽  
Diagnostic Methods ◽  
Reproductive Age ◽  
Routine Practice ◽  
Effective Management ◽  
Women Of Reproductive Age ◽  
Positive Diagnosis ◽  
Non Invasive ◽  
Golden Standard

Endometriosis is a common condition among women of reproductive age that can cause chronic pelvic pain and infertility. Rapid establishment of a positive diagnosis of endometriosis is essential for effective management. The positive diagnosis of endometriosis is difficult to establish and requires invasive methods. The "golden standard" for diagnosis is still laparoscopy. Current research has not yet established specific non-invasive diagnostic methods for endometriosis. Imaging techniques, endometrial or serum markers facilitate diagnosis and are useful in monitoring the patient's progress. A number of noninvasive investigations, such as imaging techniques, or biomarkers are currently being evaluated for use in routine practice. A combination of these noninvasive tests could be the standard for diagnosing endometriosis in the future.

Pathogenesis of adenomyosis

2020 ◽  
Vol 69 (4) ◽  
pp. 73-82
Author(s):  
Ekaterina K. Orekhova
Keyword(s):  
High Sensitivity ◽  
Pathological Process ◽  
Diagnostic Methods ◽  
Reproductive Age ◽  
Resonance Imaging ◽  
Women Of Reproductive Age ◽  
Junctional Zone ◽  
Benign Condition ◽  
Non Invasive ◽  
Transitional Part

Adenomyosis is a common benign condition, often diagnosed in women of reproductive age with dysmenorrhea and polymenorrhea, miscarriage and infertility. Previously, it was believed that the pathological process was associated with intrauterine interventions, parturition or endometriosis diagnosed by histological examination as the gold standard. Currently, adenomyosis is perceived as an independent disease, the etiology and pathogenesis of which are based on complex molecular, genomic and immune processes, also occurring in women without a burdened maternal obstetric and gynecological history. Modern non-invasive diagnostic methods, such as ultrasonography and magnetic resonance imaging, have high sensitivity and specificity and are successfully used for diagnosis of adenomyosis. One of the main initial morphological and functional signs of the disease is a change in the so-called J-zone (junctional zone, JZ), which is the transitional part of the myometrium. Its subendometrial layer has unique structural organization, immunohistochemical structure and functional activity, which remains not fully understood. Data on the effect of adenomyosis on the course and outcome of pregnancy are mixed. This article presents a literature review of world studies on the etiology, pathogenesis and diagnosis of adenomyosis and its effect on fertility.

scholarly journals A CASE REPORT ON EFFECTIVE MANAGEMENT OF PREMENSTRUAL SYNDROME WITH AYURVEDA

2020 ◽  
pp. 57-62
Author(s):  
Khushboo Jha ◽  
K. Bharathi ◽  
Hetal H. Dave ◽  
Sonu
Keyword(s):  
Premenstrual Syndrome ◽  
Well Being ◽  
Reproductive Age ◽  
Behavioral Symptoms ◽  
Thought Process ◽  
Effective Management ◽  
Women Of Reproductive Age ◽  
Presenting Symptoms ◽  
Physical Discomfort ◽  
Patient Reported

Menstruation is a normal physiological process in females starting at the age of twelve years and lasts till the age of fifty years. It is a cyclical phenomenon usually occurring every twenty-one to thirty five days and includes uterine bleeding for about three to seven days. Most well adjusted women experience minor psychological and somatic changes for a few days preceding menstruation. These menstrual molimina give way to a sensation of relief and well being once menstruation is established. Most women of reproductive age have some physical discomfort or dysphoria in the weeks before menstruation. Pre-Menstrual Syndrome is one such commonly reported and highly prevalent disorder characterized by constellation of physical, emotional, cognitive and behavioral symptoms. An 18-year-old female patient reported to OPD with the complaints of pain during menses since six years, extreme mood swings, irritability, sudden tearfulness, anger outbursts, nervousness. These symptoms were also associated with vomiting and loose motions. On physical examination, no abnormalities were detected. Mental Status Examination revealed abnormality in mood and affect, attention, concentration and thought process Based on history, presenting symptoms and diagnostic criteria the case was established as Premenstrual Syndrome. So, the protocol for treatment planned was symptomatic. Internal administration of Gokhura churna plus Yastimadhu with Munnaka kshirapaak was given for 15 days. Rajaswalacharya was advised.

scholarly journals Non-Invasive Assessment of the Liver – Serum Markers and Imaging Techniques

Liver Biopsy ◽  
10.5772/20293 ◽  
2011 ◽  
Author(s):  
Anna Mania ◽  
Pawe Kemnitz ◽  
Katarzyna Mazur-Melewska ◽  
Magdalena Figlerowicz ◽  
Wojciech Suzewski
Keyword(s):  
Imaging Techniques ◽  
Serum Markers ◽  
Non Invasive

scholarly journals Autoimmune markers for non-invasive diagnosis of endometriosis in women

2020 ◽  
Vol 66 (2) ◽  
pp. 162-166
Author(s):  
I.V. Menzhinskaya ◽  
A.G. Melkumyan ◽  
S.V. Pavlovich ◽  
V.D. Chuprynin ◽  
L.V. Vanko ◽  
...  
Keyword(s):  
Immune Response ◽  
Chronic Disease ◽  
Wide Spectrum ◽  
Diagnostic Value ◽  
Reproductive Age ◽  
Igg Antibodies ◽  
Local Inflammation ◽  
Women Of Reproductive Age ◽  
Non Invasive ◽  
Gonadotropic Hormones

Endometriosis is a common estrogen-dependent chronic disease in women of reproductive age; it is associated with dysregulation of the immune response, local inflammation, and increased formation of autoantibodies. The aim of the study was to investigate the profile of autoantibodies in women with endometriosis and to evaluate their diagnostic value using new modifications of enzyme immunoassay. In women with endometriosis of stage III-IV (n=39), a wide spectrum of autoantibodies was detected, mainly of class G, including antibodies to endometrial antigens (tropomyosin 3, tropomodulin 3), the enzyme α-enolase, steroid (estradiol, progesterone) and gonadotropic hormones. At the same time, the frequency of detection of IgG antibodies to tropomyosin 3, α-enolase, estradiol and human chorionic gonadotropin and their levels in patients with endometriosis were higher than in healthy women (n=26) (p

scholarly journals Cardiac amyloidosis: a review of the literature and a practical approach for the clinicians

2019 ◽  
Vol 13 (2) ◽  
pp. 73-90 ◽  
Author(s):  
Annalisa Angelini ◽  
Francesca Zanco ◽  
Chiara Castellani ◽  
Andrea Di Francesco ◽  
Mila Della Barbera ◽  
...  
Keyword(s):  
Cardiac Amyloidosis ◽  
Imaging Techniques ◽  
Systemic Disease ◽  
Treatment Strategies ◽  
Diagnostic Methods ◽  
Review Of The Literature ◽  
Cardiac Tissues ◽  
Non Invasive ◽  
Precursor Proteins ◽  
Recent Treatment

Amyloidosis is a group of progressive and devastating disorders resulting from misfolded proteins extracellular deposition into tissues. When deposition of fibrils occurs in cardiac tissues, this systemic disease can lead to a very poor prognosis. In this review, we focused on the most common types of cardiac amyloidosis and their treatments. Early diagnosis remains critically important, and here we reviewed the diagnostic methods adopted starting from the non-invasive imaging techniques to more invasive approaches, and the typing of precursor proteins. Typing the different misfolding proteins is mandatory since therapy differs accordingly and thus guiding therapy. We highlighted the most updated and recent treatment strategies to cure amyloidosis.

The course of pregnancy and labour in a patient with the remission of Cushing's disease treated with ibandronic acid (Bonviva) for severe steroid-induced osteoporosis. A case report and literature review

2013 ◽  
Vol 59 (5) ◽  
pp. 32-35 ◽  
Author(s):  
N V Dragunova ◽  
Zh E Belaia ◽  
G S Kolesnikova ◽  
L Ia Rozhinskaia
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cushing’S Disease ◽  
Reproductive Age ◽  
Cushing's Disease ◽  
Women Of Reproductive Age ◽  
Ibandronic Acid ◽  
Treatment Of Osteoporosis ◽  
Golden Standard ◽  
Pregnancy And Lactation

Therapy with bisphosphonates (BP) is recognized to be "the golden standard" for the treatment of osteoporosis of different etiology. However, the data on the use of BP by the women during pregnancy and lactation are scarce. This paper reports a case of gestation, labour, and lactation in a patient treated with ibandronic acid (Bonviva) for severe steroid-induced osteoporosis attributable to Cushing's disease. To our knowledge, the application of ibandronic acid during pregnancy has never been described in the literature before. The present study has demonstrated that therapy with ibandronic acid does not necessarily require the interruption of pregnancy or cessation of birth feeding. Nevertheless, the treatment of the women of reproductive age with BP can be prescribed only upon strict indications.

scholarly journals Palm-coein classification of abnormal uterine bleeding and clinicohistopathological correlation

2021 ◽  
Vol 10 (4) ◽  
pp. 1587
Author(s):  
Vimal H. Vasava ◽  
Bhavesh B. Airao ◽  
Milan R. Shingala
Keyword(s):  
Classification System ◽  
Imaging Techniques ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Correct Treatment ◽  
Medical College ◽  
Ovulatory Dysfunction

Background: The aim was to categorize women with AUB as per the PALM-COEIN classification system as this is a step towards cause based diagnosis and focused management of patients. The acronym PALM-COEIN comes from arranging basic categories of the classification system. The PALM group comprises the structural entities, which can be measured visually or by using imaging techniques and histopathology. The COEIN group comprises the non- organic types which cannot be defined by imaging or histopathology.Methods: The study comprised 350 women of reproductive age with AUB for minimum 3 month time span. It describes and observes AUB in amount, interval and frequency for women attending out-patient Gynaecology department of C. U. Shah Medical College and Hospital, Surendranagar (Gujrat) over a period of 1year from November 17 to October 18. They were assessed on the basis of structured history, physical examination, local pelvis examination, investigations, USG findings and endometrial histopathological report. Cause of AUB was determined and treatment was given to the patient as appropriated by categorization done in agreement with the PALM-COEIN classification.Results: The most prevalent cause of AUB was ovulatory dysfunction (n=99, 28.2%). Next common cause was leiomyoma (n=90, 25.7%), followed by endometrial causes (n=52, 14.5%), adenomyosis (n=30, 8.5%) not yet classified (n=32, 9.7%), malignancy and hyperplasia (n=28, 8.1%), polyp (n=9, 2.5%), iatrogenic (n=7, 2.2%) and coagulopathy (n=1, 0.3%).Conclusions: The PALM-COEIN classification helps to practically as certain because of AUB, and there by effectively adopt the correct treatment for AUB patients.

scholarly journals Abnormal uterine bleeding in women of reproductive age

2021 ◽  
Vol 2 (4) ◽  
pp. 416-427
Author(s):  
Radmila Sparić ◽  
Đina Tomašević ◽  
Mladen Anđić ◽  
Svetlana Spremović-Rađenović
Keyword(s):  
Histopathological Examination ◽  
Imaging Techniques ◽  
Public Health Problem ◽  
Abnormal Uterine Bleeding ◽  
Reproductive Organs ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Significant Public Health ◽  
Modern Classification

Introduction: Abnormal uterine bleeding is one of the most common health disorders in women of reproductive age. In addition, it represents a significant public health problem. The aim of this paper is to present the modern classification, as well as the basis for diagnosis and treatment of abnormal uterine bleeding. Methods: This paper presents data from publications selected from the MEDLINE database using a combination of keywords: "menstrual bleeding", "abnormal uterine bleeding", "PALM-COEIN classification", "leiomyoma", "endometrial polyp", "adenomyosis", "gynecological malignancies", "coagulopathy", "diagnostics of abnormal uterine bleeding", and "treatment of abnormal uterine bleeding". The collected data from the selected studies were used and presented in this review paper. Conclusion: In order to achieve a unique classification of abnormal uterine bleeding, a classification was adopted under the name/acronym PALM-COEIN. The causes listed in the first part of the acronym (PALM) have a pathological/ anatomical cause in the reproductive organs that can be diagnosed using imaging techniques and/or histopathological examination. The causes listed in the second part of the acronym (COEIN) represent a group of dysfunctional disorders and they cannot be diagnosed using imaging techniques.

The Utility of Non-invasive Tests for Detection of Previous Proximal-vein Thrombosis

1995 ◽  
Vol 73 (04) ◽  
pp. 592-596 ◽  
Author(s):  
Sabina Villalta ◽  
Paolo Prandoni ◽  
Alberto Cogo ◽  
Paola Bagatella ◽  
Andrea Piccioli ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Femoral Vein ◽  
Clinical Score ◽  
Diagnostic Methods ◽  
Popliteal Vein ◽  
Venous Reflux ◽  
Study Objective ◽  
Vein Thrombosis ◽  
Non Invasive ◽  
The Common

SummaryBackground. Despite the availability of several diagnostic methods for the detection of deep-vein thrombosis (DVT), the identification of previous episodes of DVT remains a diagnostic challenge.Study objective. To assess the reliability of a combination of a standardized clinical score with three non-invasive tests: compression ultrasonography (CUS), Doppler ultrasound (DUS), and photoplethysmography (PPG), in determining the presence or the absence of previous proximal DVT.Methods. One hundred consecutive unselected outpatients were identified, who had undergone contrast venography six to nine years previously because of the clinical suspicion of DVT (confirmed in 43). They were blindly reinvestigated by a panel of trained operators unaware of venography results. They underwent a clinical evaluation of the lower limb, by applying a standardized score to five symptoms and six signs (grading each item from 0 to 3); a PPG test to determine the venous refilling time; a DUS test to determine the venous reflux separately in the common femoral and the popliteal vein; and a CUS test to determine vein compressibility in the same regions.Results. An abnormal CUS test and/or the demonstration of venous reflux in the popliteal region and/or a high clinical score (≥ 8) identified twenty-four of the 43 (56%) DVT + patients with a specificity of 89%. The combination of normal CUS with the absence of venous reflux in both the common femoral and popliteal vein and a low clinical score excluded previous thrombosis in 45 (79%) of the 57 DVT- patients (negative predictive value, 78%). Abnormal venous reflux in the isolated common femoral vein did not reliably predict the presence or absence of previous DVT. However, this occurred in only 13 (13%) patients. The PPG determination of venous refilling time did not improve the results obtained with the other tests.Conclusions. The combination of a standardized clinical evaluation with the results of CUS and DUS can reliably diagnose or exclude previous proximal-vein thrombosis in almost 90% of patients with previous episodes of suspected DVT.

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