A MODERATELY HIGH PROTEIN DIET IS AS EFFECTIVE  DURING NEOADJUVANT CHEMOTHERAPY AS IT IS 2 YEARS  AFTER BREAST CANCER SURGERY – A PILOT TRIAL

Introduction. Statistically, patients who achieve and maintain their optimal weight during breast cancer treatment have the best prognostic. Breast cancer associated weight gain starts during neoadjuvant chemotherapy when many patients either eat too little because of the decreased appetite or eat too much to emotionally cope with the treatment. Materials and method. To test if we can prevent weight gain during neoadjuvant chemotherapy we assigned 46 patients during neoadjuvant chemotherapy (CH) and of 50 patients 2 years after surgery (S) to follow a moderately high protein diet – based on eating only when hungry foods naturally high in protein, high quality fatty acids and carbohydrates, calcium, pre- and probiotics. We used no dietary supplements. We measured weight (W), subcutaneous fat (%SF) and visceral fat percentages (% VF) with a multi-frequency BIA scale at the beginning of the study and after 12 weeks of intervention (time needed to administrate 4 chemotherapy sessions). To validate BIA measurements, we also measured waist and hips circumferences. Results. Although S patients obtained better results on all measured parameters, CH patients also improved their body composition despite chemotherapy administration during the trial: 1.611±2.89%kg (p=0.005), 1.79±3.32% subcutaneous fat (p=0.006), 0.4±0,81% visceral fat (p=0.012) and had a 0.29±0.4 in the waist to hips ratio (p=0.001). Conclusion. A moderately lower carb diet is as effective for preventing sarcopenic obesity during chemotherapy as it is 2 years after surgery thus sarcopenic obesity prevention can begin from as early as diagnosis.

Download Full-text

The relative biological potencies of retinyl palmitate and β-carotene for the milk-fed lamb

British Journal Of Nutrition ◽

10.1079/bjn19700006 ◽

1970 ◽

Vol 24 (1) ◽

pp. 23-28 ◽

Cited By ~ 3

Author(s):

O. Faruque ◽

D. M. Walker

Keyword(s):

Weight Gain ◽

Live Weight ◽

High Protein Diet ◽

Basal Diet ◽

Retinyl Palmitate ◽

High Protein ◽

Protein Diet ◽

Live Weight Gain ◽

Retinyl Esters ◽

Β Carotene

1. Thirty-four cross-bred newborn lambs were used. A high-protein diet (25% protein calories) was supplemented daily with retinyl palmitate (range, 13.75–440 μg/kg live weight 24 h), or with β-carotene (range, 68.5–2200 μg/kg live weight 24 h) for 21 days.2. Live-weight gain was not increased by supplementing the basal diet with either retinyl palmitate or β-carotene.3. The relative weights of β-carotene and retinyl palmitate (expressed as retinol) that were required to produce equivalent concentrations of retinol in the serum varied from 5:1 to 25:1, and for the liver (retinal + retinyl esters, expressed as retinol) the ratio varied from 3:1 to 9:1.

Download Full-text

Corrigendum to: IGF-I is not a useful marker for nutritional status in the growing pig under commercial conditions

Australian Journal of Agricultural Research ◽

10.1071/ar00096_co ◽

2001 ◽

Vol 52 (7) ◽

pp. 791

Author(s):

L. Ma ◽

F. R. Dunshea ◽

Y. M. Brockwell ◽

R. L. Inglis ◽

D. J. Kingston ◽

...

Keyword(s):

Weight Gain ◽

Nutritional Status ◽

Dietary Protein ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Low Protein ◽

Igf I ◽

Protein Diets

Plasma hormone concentrations were measured in gilts after fasting, long-term protein restriction, or supplementation. In 11-week-old pigs fasted overnight, plasma insulin, glucagon, gastrin, urea, and glucose were increased 30 min after re-feeding (P < 0.05), whereas IGF-I did not change. In 16-week-old gilts fed a standard commercial diet [14.6% crude protein (CP)], or a high-protein diet (16.7% CP) for 4 weeks, the high-protein diet increased weight gain (13%; P < 0.05) and carcass weight (4%; P < 0.05), but did not alter plasma IGF-I, insulin, or glucagon. In 10-week-old gilts fed high-protein diets (19.4% and 18.3% CP), or low-protein diets (15.5% and 13.3% CP) for 12 weeks during the grower and finisher phases, respectively, the low-protein diet decreased weight gain (18%; P < 0.001) and carcass weight (11%; P < 0.01), with a marked increase in plasma glucagon (P < 0.05), no change in insulin, and only a trend towards decreased IGF-I (P = 0.1). The pigs were more sensitive to altered dietary protein at 10 weeks of age than at 16 weeks. Plasma IGF-I was not responsive to the short-term effects of feeding or the long-term effects of dietary protein. Glucagon could provide a useful marker for nutritional status in young pigs, provided that time of feeding is taken into account.

Download Full-text

A High-Protein Diet Reduces Weight Gain, Decreases Food Intake, Decreases Liver Fat Deposition, and Improves Markers of Muscle Metabolism in Obese Zucker Rats

Nutrients ◽

10.3390/nu9060587 ◽

2017 ◽

Vol 9 (6) ◽

pp. 587 ◽

Cited By ~ 9

Author(s):

William French ◽

Sami Dridi ◽

Stephanie Shouse ◽

Hexirui Wu ◽

Aubree Hawley ◽

...

Keyword(s):

Weight Gain ◽

Food Intake ◽

Muscle Metabolism ◽

High Protein Diet ◽

Fat Deposition ◽

High Protein ◽

Protein Diet ◽

Liver Fat ◽

Zucker Rats ◽

Obese Zucker Rats

Download Full-text

The protein requirement of the ruminant calf. II. Further studies on the effect of protein content of the concentrate mixture on the performance of calves weaned at an early age

Animal Science ◽

10.1017/s0003356100038241 ◽

1967 ◽

Vol 9 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

I. J. F. Stobo ◽

J. H. B. Roy ◽

Helen J. Gaston

Keyword(s):

Weight Gain ◽

Crude Protein ◽

Live Weight ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Protein Requirement ◽

Live Weight Gain ◽

Treatment Groups ◽

Low Protein

1. Eighty-four Friesian heifer calves were used in two experiments (Experiments 4 and 5) to study the protein requirement of the ruminant calf to 12 weeks of age. The calves were weaned at 5 weeks of age and given a concentrate containing one of several protein levels, together with hay and water.2. In Experiment 4, the effect of changing the protein content of the concentrates at 8 weeks of age under ad libitum feeding conditions was studied. A concentrate containing 20·6% crude protein (air-dry basis) tended to promote more rapid weight gains in calves to 8 weeks than a similar concentrate with 12·1% crude protein. Following the change in diet at 8 weeks, both groups of calves given the low-protein diet gained weight at similar rates in the period 8–12 weeks, irrespective of the protein level to 8 weeks. During the period 8–12 weeks calves given the high-protein diet, after receiving a low-protein diet to 8 weeks, tended to gain weight at a faster rate than those given the high-protein concentrate throughout. After adjustment for differences between treatment groups in mean concentrate consumption and mean live-weight at 8 weeks, the live-weight gain from 8 to 12 weeks was significantly greater in calves given the high-protein diet after 8 weeks.3. In Experiment 5, a significantly lower growth rate was obtained when concentrate intake was restricted to a maximum of 2 kg./day than when given ad libitum. Calves given the concentrates containing 15·9% or 20·6% crude protein gained weight significantly faster than those given the concentrate containing 12·1% crude protein, at both levels of feeding, after live-weight gain was adjusted for differences between treatment groups in mean food consumption and live-weight at 1 week.4. It is concluded that no advantage is obtained by giving a concentrate containing more than 15·9% protein to Friesian heifer calves weaned at 5 weeks of age. The results indicate clearly the importance of an adequate supply of energy in the diet of the ruminant calf if maximum live-weight gain is to be achieved.

Download Full-text

Protein Recommendation to Increase Muscle (PRIMe): Study protocol for a randomized controlled pilot trial investigating the feasibility of a high protein diet to halt loss of muscle mass in patients with colorectal cancer

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2020.11.016 ◽

2020 ◽

Author(s):

Katherine L. Ford ◽

Michael B. Sawyer ◽

Claire F. Trottier ◽

Sunita Ghosh ◽

Nicolaas E.P. Deutz ◽

...

Keyword(s):

Colorectal Cancer ◽

Muscle Mass ◽

Study Protocol ◽

Pilot Trial ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Randomized Controlled

Download Full-text

LOW WEIGHT GAIN, BETTER GLYCAEMIA AND NO CENTRAL OBESITY ACHIEVED THROUGH A HIGH-PROTEIN DIET

Journal of medical pharmaceutical and allied sciences ◽

10.22270/jmpas.v10i6.1708 ◽

2021 ◽

Vol 10 (6) ◽

pp. 3754-3758

Keyword(s):

Weight Gain ◽

Central Obesity ◽

Metabolic Diseases ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Fat Tissue ◽

High Fat ◽

Low Weight ◽

Mesenteric Fat

A compendium of metabolic diseases associated with unhealthy habits plague the modern world today. Weight gain, hyperglycemia and excess adiposity are some of the metabolic diseases plaguing our modern society. Unhealthy dietary habits coupled with a sedentary lifestyle are recognized as important factors for the development of some metabolic illnesses. Cardiovascular diseases, diabetes mellitus, hypertension, and dyslipidemia were recognized as stemming from metabolic dysregulation due to the consumption of excess calories from certain macronutrients. Our objective in this study is to find out which diet most affects circulating blood glucose levels, body weight, and visceral fat tissue deposition. 35 male Sprague - Dawley rats were separated into five groups and were given five distinct diets for the duration of 8 weeks. The five diets are normal rat feed, high-fat, high-protein, high-sugar, and high-starch. The feeding provided was ad libitum with tap water given as drinking water. Every week, each rat was weighed, and blood were sampled for glucose. Post-sacrifice, mesenteric fat was harvested, fixed, and stained for histological analysis. The results revealed a high-protein diet significantly reduces body weight gain, improved blood sugar with no development of central obesity. At the same time, a high-fat diet was shown to be a promoter of mesenteric fat tissue hypertrophy. It was concluded that the consumption of a high-protein diet was found to achieve low weight gain, better glycaemia with no central obesity.

Download Full-text