Nghiên cứu một số yếu tố nguy cơ của nhiễm khuẩn sơ sinh sớm tại Bệnh viện Trường Đại học Y Dược Huế

2021 ◽  
Author(s):  
Thanh Binh Nguyen Thi
Keyword(s):  
Risk Factors ◽  
Early Onset ◽  
Abdominal Distension ◽  
Neonatal Infection ◽  
Total Sample ◽  
Peripheral Circulation ◽  
Infected Group ◽  
Related Factors ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

TÓM TẮT Đặt vấn đề: Nhiễm khuẩn sơ sinh sớm là một trong những nguyên nhân gây tử vong cao ở giai đoạn sơ sinh nhưng việc chẩn đoán sớm còn gặp nhiều khó khăn. Vì thế, chúng tôi tiến hành nghiên cứu này nhằm mục đích tìm hiểu các yếu tố nguy cơ giúp thiết lập chẩn đoán nhiễm khuẩn sơ sinh sớm. Đối tượng, phương pháp: Nghiên cứu hồi cứu. Lấy mẫu toàn bộ gồm 295 trẻ sơ sinh được chẩn đoán nghi ngờ nhiễm khuẩn sơ sinh sớm trong 72 giờ đầu sau sinh. Sau đó, chia thành hai nhóm: nhóm nhiễm khuẩn (các trường hợp nhiễm khuẩn hay có khả năng nhiễm khuẩn) và nhóm không nhiễm khuẩn để so sánh. Địa điểm nghiên cứu: phòng Nhi sơ sinh, Bệnh viện Trường Đại học Y Dược Huế từ tháng 5/2019 đến tháng 5/2020. Kết quả: Tỷ lệ của nhóm nhiễm khuẩn là 57,3%. Các yếu tố liên quan giúp chẩn đoán nhiễm khuẩn sơ sinh sớm bao gồm: ối vỡ non (OR = 4,7), thời gian ối vỡ trên 18 giờ (OR = 2,5), da tái, nổi vân tím (OR = 14,9), trẻ có chỉ định thở máy (OR = 8,7), suy hô hấp bắt đầu sau 4 giờ tuổi (OR = 6,8), kém linh hoạt (OR = 6,6), bụng chướng (OR = 4,2), thở nhanh (OR = 2,7), nôn (OR = 2,3), số lượng bạch cầu trong máu ngoại vi > 25 x 109/L (OR = 5,7), tỷ lệ bạch cầu đa nhân trung tính > 65% (OR = 2,0) và nồng độ CRP huyết thanh > 10 mg/L (OR = 8,0). Kết luận: Việc phối hợp các yếu tố nguy cơ trong thai kỳ, triệu chứng lâm sàng và cận lâm sàng, giúp xác định chẩn đoán nhiễm khuẩn sơ sinh sớm, nhằm hạn chế tối đa việc sử dụng kháng sinh không cần thiết ở trẻ sơ sinh. Từ khóa: Sơ sinh, nhiễm khuẩn sơ sinh sớm, yếu tố nguy cơ trước sinh ABSTRACT RELATED FACTORS OF EARLY-ONSET NEONATAL INFECTION AT HUE UNIVERSITY OF MEDICINE AND PHARMARCY HOSPITAL Background: Early - onset neonatal infection is an important cause of morbidity and mortality in neonates and it’s diagnosis remains challenging. Therefore, this study aimed to describle the related factors that can help establish the diagnosis of early - onset neonatal infection. Methods: A retrospective study. A total sample of 295 neonates at Hue University of Medicine and Pharmacy Hospital, Hue, Viet Nam from 5/2019 - 5/2020, who were suspected to suffer from infection within the first 72 hours of life. Then, they were classified as infected group (confirmed or possible infected) and non - infected group to compare. Results: The prevalence of infected group is 57,3%. Some related factors of early - onset neonatal infection are: prelabour rupture of membranes (OR=4,7), rupture of membranes for more than 18 hours (OR = 2,5), pale or mottled skin (OR = 14,9), need for mechanical ventilation (OR = 8,7), respiratory distress starting more than 4 hours after birth (OR = 6,8), responsiveness (OR = 6,6), abdominal distension (OR = 4,2), tachypnoea (OR = 2,7),vomiting (OR = 2,3), white blood cell in peripheral circulation > 25 x 109/L (OR = 5,7), neutrophil ratio in peripheral circulation > 65% (OR = 2,0) and CRP concentrations > 10 mg/L (OR = 8,0). Conclusions: Combination of perinatal risk factors, clinical and subclinical characteristcs are highly suggestive for early - onset neonatal infection will help to reduce the numbers of babies given antibiotics unnecessarily. Key words: Neonate, early - onset infection, perinatal risk factors

scholarly journals Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort

2009 ◽  
Vol 26 (12) ◽  
pp. 1193-1197 ◽  
Author(s):  
C. S. Algert ◽  
A. McElduff ◽  
J. M. Morris ◽  
C. L. Roberts
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Birth Cohort ◽  
Early Onset ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

ASSOCIATION OF SERUM PROCALCITONIN LEVEL IN THE UMBILICAL CORD BLOOD OF THE NEONATES BORN WITH PERINATAL RISK FACTORS FOR EARLY-ONSET SEPSIS.

2021 ◽  
pp. 57-59
Author(s):  
Somsubhra Ghosh ◽  
Sibnath Gayen ◽  
Debarshi Jana
Keyword(s):  
Risk Factors ◽  
Cord Blood ◽  
Early Onset ◽  
Cross Sectional Study ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Mortality And Morbidity ◽  
Early Onset Sepsis

Introduction: Sepsis remains one of the most common causes of neonatal mortality and morbidity in India as also globally. Aim:To evaluate the level of procalcitonin (PCT) in the cord blood of the neonates born with perinatal risk factors for early-onset sepsis (EOS) at a tertiary referral hospital of Kolkata. Materials and methods: st An observational cross-sectional study Labour room of R G Kar Medical College & Hospital, Kolkata From February 1 , st 2019 to July 31 , 2020. Conclusion: This practice would represent a reduction of the potential toxicity in the newborns and in the development of bacterial resistances as well. However, maternal prophylactic antibiotherapy decreases the incidences of vertically transmitted neonatal infections

scholarly journals Perinatal Risk Factors for Early Onset Hypocalcemia in Moderate-to-Late Preterm Infants

Perinatology ◽  
2019 ◽  
Vol 30 (4) ◽  
pp. 208
Author(s):  
Jee Min Jeong ◽  
Eun Hee Lee ◽  
Ju Sun Heo ◽  
Eui Kyung Choi ◽  
Kyu Hee Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Early Onset ◽  
Late Preterm ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Late Preterm Infants

scholarly journals Clinical Profile of Neonatal Early Onset Sepsis: A Study on the Current Scenario

2020 ◽  
Vol 8 (2) ◽  
pp. 36-41
Author(s):  
Kiran C Pankaj ◽  
Sristi Ganguly ◽  
Manas R Upadhyay
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Blood Culture ◽  
Early Onset ◽  
Birth Asphyxia ◽  
Clinical Profile ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Early Onset Sepsis ◽  
Sepsis Screen

Background: Neonatal early onset sepsis remains to be a challenge in India, owing to its variable presentation, diagnostic difficulty and high fatality. An attempt needs to be made to study its clinical profile for easy identification of such babies, with new antibiotic guidelines formulated based on current microorganisms isolated. The aim of the study is to study the clinical profile of early onset sepsis in neonates in terms of      the risk factors, clinical factors and etiology, and ascertain factors associated with definite sepsis. Subjects and Methods: This hospital based cross-sectional study enrolled neonates with suspected early onset sepsis. Those with congenital anomalies, surgical conditions, gestation <28 weeks and birth weight <1kg excluded. Subjects were subjected to sepsis screen and blood culture, and their perinatal history recorded. Blood culture positive babies were considered to have definite sepsis. Data was analysed using Chi square with SPSS 18. Results: Among 300 babies enrolled, 70 babies had definite sepsis. The most common organism isolated was Klebsiella (27.1%) and Staphylococcus hemolyticus (21.4%), most showing sensitivity to Ampicillin and Gentamicin. Respiratory distress was the commonest presentation (71.3%). A significant association with definite sepsis was seen with prematurity (p =0.0026) and low birth weight (p =0.0052), perinatal risk factors namely premature rupture  of membranes (p =0.004), foul smelling liquor (p=0.016) and birth asphyxia (p-value=0.02). 28.3% had positive sepsis screen, which was significant (p = 0.001). Conclusion: Early onset sepsis needs prompt identification and treatment initiation, possible with aid of sepsis screen and high index of suspicion with certain perinatal risk factors and gestational age and birth weight.

scholarly journals Prenatal and perinatal risk factors for psychiatric diseases of early onset

BMJ ◽  
1999 ◽  
Vol 318 (7198) ◽  
pp. 1622-1622 ◽  
Author(s):  
P. Rasanen ◽  
H. Hakko ◽  
M.-R. Jarvelin ◽  
C. M Hultman
Keyword(s):  
Risk Factors ◽  
Early Onset ◽  
Psychiatric Diseases ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

scholarly journals Forecasting the possibility of neonatal early onset sepsis based on perinatal risk factors

2020 ◽  
Vol 7 (7) ◽  
pp. 1534
Author(s):  
Kiran C. Pankaj ◽  
Sristi Ganguly ◽  
Manas R. Upadhyay
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Birth Weight ◽  
Blood Culture ◽  
Low Birth Weight ◽  
Early Onset ◽  
Birth Asphyxia ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Early Onset Sepsis

Background: Neonatal sepsis remains a leading cause of neonatal mortality and morbidity, diagnosis of which remains difficult due to variable presentations. With the increasing threat of antimicrobial resistance, it is important to identify perinatal risk factors which are associated with higher incidence of definite sepsis, to initiate empirical antibiotics, while awaiting blood culture reports.Methods: This was hospital based cross-sectional study done in SVPPGIP, Cuttack, Odisha during January 2019 to April 2019, enrolling all neonates  ≥37 weeks gestation and aged less than 72 hours, with suspected early onset sepsis. Neonates with TORCH infections, congenital anomalies, syndromic baby or with surgical conditions were excluded. After obtaining informed consent, blood culture was sent for all and their perinatal risk factors noted. Blood culture positive newborns were considered to have definite sepsis. Data was analysed with Chi-square test and percentages, using SPSS 18.Results: Among the 200 cases, incidence of definite sepsis was 26%. The most common risk factor was low birth weight and birth asphyxia. Majority (67%) had single or lesser risk factor and number of risk factors was significantly associated with definite sepsis. A significant association was seen between blood culture positivity with low birth weight (p=0.003), foul smelling liquor (p= 0.025), birth asphyxia (p 0.018) and premature rupture of membranes (p= 0.016). The combination of maternal fever and unclean vaginal examination was also significantly associated with the same.Conclusions: Protocols for initiating empiric antibiotics need to be formulated, taking into account the significant risk factors, in resource limited settings, to avoid resource and time wastage.

Preterm Birth and Disruptive Cerebellar Development: Assessment of Perinatal Risk Factors

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
A Messerschmidt ◽  
D Prayer ◽  
PC Brugger ◽  
G Zoder ◽  
W Sterniste ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Cerebellar Development ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Development Assessment

scholarly journals Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110317
Author(s):  
Faisal A. Nawaz ◽  
Meshal A. Sultan
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Mental Disorders ◽  
Low Birth Weight ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
High Birth Weight ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
The Impact

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. We reviewed retrospective information from the electronic medical records of 692 patients in Dubai, United Arab Emirates. The prevalence of low birth weight in children with mental disorders was significantly higher as compared to the general population (16% vs 6% respectively). Furthermore, other risk factors, including high birth weight and preterm birth were noted to have a significant association with neurodevelopmental disorders. Future research on the impact of perinatal risk factors will contribute to advancement of early intervention guidelines.

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