scholarly journals The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease

2020 ◽  
Vol 8 (A) ◽  
pp. 537-542
Author(s):  
Eryati Darwin ◽  
Eka Fithra Elfi ◽  
Eva Decroli ◽  
Dwitya Elvira
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Medical Condition ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Control Group ◽  
Protective Function ◽  
The Mean ◽  
The Relationship

BACKGROUND: Dyslipidemia is a medical condition that refers to an abnormal of blood lipids level, most common is hyperlipidemia. Elevation of blood lipid such as cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, or a low high-density lipoprotein (HDL) cholesterol level induces disturbance of endothelial function. Endothelial dysfunction in dyslipidemia is in large part due to a reduced bioavailability of nitric oxide (NO) which is synthesized by endothelial NO synthase (eNOS) which will trigger the development of atherosclerosis, and increases the risk of coronary heart disease (CHD). AIM: This study aims to determine the relationship of lipid profiles of dyslipidemia with eNOS levels in CHD patients. MATERIALS AND METHODS: This study design was a cross-sectional study. The sample in this study was 26 patients which diagnosed as CHD of outpatients in the department of cardiology of a regional general hospital and fulfilled the inclusion and exclusion criteria. Fifteen healthy individuals who come for the general check-up were included as a control group. Blood samples were collected for measurements of eNOS levels and lipid profiles that carried out according to laboratory standards. Statistical analyses were conducted using analysis of variance and Shapiro–Wilk test. RESULTS: The results of this study showed that eNOS levels in the group of CHD patients (24.174 ± 7.136 ng/ml) were significantly lower (p < 0.05) than those in the control group (72.092 ± 30.065 ng/ml). The mean of triglycerides and HDL levels has a weak correlation with the level of eNOS (p > 0.05). The mean of LDL level has moderately positive correlation with eNOS, while cholesterol has a moderate negative correlation with the level of eNOS (p > 0.05). CONCLUSION: This study concluded that high cholesterol levels and low HDL levels in dyslipidemia condition were correlated with eNOS, which has a protective function in CHD.

scholarly journals Relationship Between Salivary Nitric Oxide Concentration and Dental Caries in Children: A Systematic Review and Meta-Analysis

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nadia Elyassi ◽  
Ali Malekzadeh Shafaroudi ◽  
Pegah Nasiri ◽  
Mahmood Moosazadeh ◽  
Azam Nahvi
Keyword(s):  
Nitric Oxide ◽  
Nitrous Oxide ◽  
Dental Caries ◽  
Meta Analysis ◽  
Control Group ◽  
Analysis Study ◽  
Oxide Concentration ◽  
The Mean ◽  
The Relationship ◽  
Nitrous Oxide Concentration

Context: Conflicting results have been reported in the literature concerning the relationship between salivary nitrous oxide concentration and dental caries in children. Metaanalysis studies aim to combine different studies and reduce the difference between the parameters by increasing the number of studies involved in the analysis process. Objectives: Accordingly, this meta-analysis study aimed at determining the relationship between salivary nitrous oxide concentration and dental caries in children. Methods: Databases were searched using the keywords “nitric oxide”, “salivary”, “Caries”, “DMFT Index”, “children”, “early childhood caries” and OR, AND and NOT operators. Quality assessment was then performed based on the Newcastle-Ottawa scale (NOS) checklist. The standardized mean difference (SMD) of DMFT, dmft, and salivary nitric oxide (NO) concentration was estimated. Results: Seven studies made a comparison between the mean salivary NO concentration in children with dental caries and that in the control group. In four studies, the mean salivary NO concentration in children with dental caries was lower, as compared to that in the control group. This difference was significant in all four studies. Also, the mean standardized difference of the salivary NO index was also estimated to be -0.11 (CI 95%: -1.77, 1.55). Conclusions: This meta-analysis study demonstrated that salivary NO concentration was not significantly related to dental caries. Moreover, since salivary NO concentration is affected by various factors, it is not sufficient to determine the likelihood of the incidence of caries.

scholarly journals Possible Use of Blood Tryptophan Metabolites as Biomarkers for Coronary Heart Disease in Sudden Unexpected Death

Metabolites ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 6 ◽  
Author(s):  
Kobchai Santisukwongchote ◽  
Yutti Amornlertwatana ◽  
Thanapat Sastraruji ◽  
Churdsak Jaikang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Picolinic Acid ◽  
Sudden Unexpected Death ◽  
Control Group ◽  
Xanthurenic Acid ◽  
Unexpected Death ◽  
Tryptophan Metabolites ◽  
Hydroxyindoleacetic Acid ◽  
The Relationship

Coronary heart disease (CHD) is the major cause of death in sudden unexpected death (SUD) cases. Tryptophan (TRP) and its metabolites are correlated with the CHD patient but less studies in the SUD. The aim of this study was to evaluate the relationship of TRP and its metabolites with the CHD in the SUD cases. Blood samples and heart tissues were collected from CHD subjects (n = 31) and the control group (n = 72). Levels of kynurenine (KYN), kynurenic acid (KYA), xanthurenic acid (XAN), 3-hydroxyanthranillic acid (HAA), quinolinic acid (QA), picolinic acid (PA) and 5-hydroxyindoleacetic acid (HIAA) were determined by HPLC-DAD. A severity of heart occlusion was categorized into four groups, and the relationship was measured with the TRP metabolites. The HIAA and The KYN levels significantly differed (p < 0.01) between the CHD group and the control group. Lower levels of QA/XAN, PA/KA, HAA/XAN, KYN/XAN and KYN/TRP were found in the CHD group. However, PA/HAA, PA/HIAA, PA/KYN and XAN/KA values in the CHD group were higher than the control group (p < 0.05). This study revealed that the values of PA/KA and PA/HAA provided better choices for a CHD biomarker in postmortem bodies.

The Relationship of Various Factors in the Pathogenesis of Atherosclerosis

1998 ◽  
Vol 4 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Hüseyin Sönmez ◽  
Selma Süer ◽  
Turgut Ulutin ◽  
Emine Kökoglu ◽  
Nergiz Uçişik
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Plasminogen Activator ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Tissue Type ◽  
Control Group ◽  
Low Density ◽  
Lipid Parameters ◽  
Pai 1

In this study we investigated the levels of lipid parameters, fibronectin, tissue-type plasminogen activator and plasminogen activator inhibitor (t-PA-PAI-1) complex and si alidase in patients with coronary heart disease and a control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol and lipoprotein Lp(a), levels in patients with coronary heart disease were found to be significantly higher than in the control group (p < .001). High-density lipoprotein (HDL) cholesterol levels in patient group were significantly lower than control group (p < .001). Plasma fibronectin and t-PA-PAI-1 complex levels in patients with coronary heart disease were found to be significantly higher than control group (p < .05 and p < .001, respectively). In addition, we found that serum sialidase levels in patients with coronary heart disease were significantly higher than in the control group (p < .001). The electrophoretic mobility of lipoproteins from patients with coronary heart dis ease was found to be greater than those from the control group. As a result Lp(a) may play an important role in the pathogen esis of atherosclerosis by causing foam cell formation because of interacting with LDL or fibronectin and by interfering with the fibrinolytic system because of binding to plasminogen re ceptors. In addition, modifications of Lp(a) (including desi alylation) may effect these events. Key words: Coronary heart disease—tPA-PAI-1 complex-Fibronectin-sialidase-Lipid parameters.

scholarly journals The relationship between daily physical activity and serum lipid profiles in elderly patients with coronary heart disease

2001 ◽  
Vol 28 (12) ◽  
pp. 197-204
Author(s):  
Eriko SEKI ◽  
Yoshiro WATANABE ◽  
Satoshi SUNAYAMA ◽  
Yoshitaka IWAMA ◽  
Kazunori SHIMADA ◽  
...  
Keyword(s):  
Physical Activity ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Daily Physical Activity ◽  
The Relationship

scholarly journals Aspirin Resistance as a Result of Impaired Interaction of Platelets and Neutrophils in Patients with Coronary Heart Disease

2021 ◽  
Vol 17 (1) ◽  
pp. 16-22
Author(s):  
M. D. Goncharov ◽  
A. A. Savchenko ◽  
Yu. I. Grinshtein ◽  
I. I. Gvozdev ◽  
A. A. Kosinova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Superoxide Radical ◽  
Maximum Intensity ◽  
Control Group ◽  
Platelet Activity ◽  
Before And After ◽  
Artery Disease ◽  
The Relationship

Aim. To study the relationship between the levels of synthesis of reactive oxygen species (ROS) by platelets and neutrophils in patients with coronary heart disease (CHD) before and after coronary artery bypass grafting (CABG), depending on sensitivity to acetylsalicylic acid (ASA).Material and methods. The study included 95 patients with coronary artery disease who are indicated for CABG surgery. The control group consisted of 30 healthy donors. The antiplatelet therapy was stopped for at least 5 days before CABG. In the postoperative period, from the first day, all patients were received 100 mg of an enteric form of acetylsalicylic acid (ASA). Resistance to ASA was determined at the level of platelet aggregation with arachidonic acid ≥20% by optical agregometry at least at one observation point: before CABG, on 1-3 day and on 8-10 day after surgery. We evaluated the spontaneous and induced lucigenin-dependent chemiluminescence (CL) of platelets (ADP induction) and neutrophils (zymosan induction) by the exit time to maximum intensity (Tmax), maximum intensity (Imax) and area (S) under the CL curve.Results. 70.5% sensitive (sASA) and 29.5% resistant (rASA) to ASA patients were revealed. Prior to CABG, in sASA patients, the Imax of spontaneous and zymosan-induced neutrophil CL and CL platelet activity was increased relative to control values. Tmax of spontaneous platelet CL, Imax and S under the ADP-induced platelet CL curve were lower in sASA patients, if to compare with rASA patients. On the 1st and 8-10th day after CABG in sASA patients, the CL indicators of neutrophil and platelet activity also remained elevated compared to control values. On the 1st day after CABG decreased levels of S under the spontaneous CL curve of neutrophils in rASA patients was established compared with sASA patients, and increased levels of Imax and S under the curve of induced neutrophil CL were detected in comparison with the control range. In rASA patients, the values of Tmax of spontaneous platelet CL decreased in relation to the values detected in the control group and sASA patients. On the 8–10th day after CABG, most indicators of spontaneous and zymosan-induced CL neutrophils in rASA patients were also increased compared to control values. In rASA patients a positive correlation of Imax-induced CL was found (r=0.83) on the 1st day after CABG and negative correlations of Tmax of spontaneous CL (r=- 0.75) and S under the curve induced CL (r=-0.70) on the 8-10th day were detected between platelets and neutrophils.Conclusion. In sASA patients with coronary heart disease before and after CABG, a high level of synthesis of superoxide radical by neutrophils and platelets was detected. The relationship between the levels of the synthesis of superoxide radical by neutrophils and platelets was found only after CABG in rASA patients. Increased synthesis of superoxide radical due to metabolic and regulatory relationships in neutrophils and platelets stimulates pro-inflammatory processes in coronary artery disease and determines the sensitivity of platelets to ASA.

Restriction fragment length polymorphisms of apolipoprotein B gene in Chinese population with coronary heart disease

1995 ◽  
Vol 41 (3) ◽  
pp. 424-429 ◽  
Author(s):  
J P Pan ◽  
A N Chiang ◽  
J J Tai ◽  
S P Wang ◽  
M S Chang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Restriction Fragment ◽  
Fragment Length ◽  
Chinese Population ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Length Polymorphisms ◽  
Restriction Fragment Length

Abstract Three restriction fragment length polymorphisms (RFLPs), EcoRI (R), Xbal (X), and Mspl (M) of the apolipoprotein (apo)B gene, were studied to determine their distribution frequencies and influence on the lipid profiles in 148 Chinese patients with documented coronary heart disease (CHD) and in 153 healthy subjects. The plasma concentrations of cholesterol and apoB showed no difference between the CHD patients and controls. However, CHD patients had significantly higher concentrations of low-density lipoprotein cholesterol and triglyceride and lower concentrations of high-density lipoprotein cholesterol than the controls. The frequencies of these three apoB RFLPs did not differ between the CHD patients and controls. Compared with South Asians and Caucasians, the Chinese in Taiwan showed a much lower frequency of R-, X+, and M- alleles. There was no evidence of an association between lipid profiles and RFLPs in either CHD patients or controls. The weak association of EcoRI, Xbal, and Mspl polymorphisms of the apoB gene with CHD indicates that the three RFLPs cannot be used as a predictor for the risk of CHD in the Chinese population.

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