scholarly journals Macular Alteration of Topical Diclofenac Sodium after Phacoemulsification Surgery in Diabetic Patients

2021 ◽  
Vol 9 (T3) ◽  
pp. 156-159
Author(s):  
Delfi Delfi ◽  
Vanda Virgayanti ◽  
Julham Alandy
Keyword(s):  
Diclofenac Sodium ◽  
Macular Thickness ◽  
Diabetic Patients ◽  
Eye Drops ◽  
Ocular Coherence Tomography ◽  
Cyclooxygenase 1 ◽  
Before And After ◽  
Quasi Experimental ◽  
Inflammatory Drugs ◽  
Topical Diclofenac

BACKGROUND: Cystoid macular edema (CME) is a serious complication of cataract surgery in a diabetic patient. CME was found 1–19% after phacoemulsification surgery. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase-1, cyclooxygenase-2, and endoperoxides. Inhibition of these enzymes also reduces macular thickening. AIM: The aim of the study was to assess macular thickness alteration after application of 1.00 mg diclofenac sodium eye drops in diabetic patients who receive phacoemulsification surgery. METHODS: This study was a quasi-experimental study. A total of 40 eyes diabetic retinopathy patients having phacoemulsification surgery were randomized to 100 mg diclofenac sodium (n = 20) or placebo eye drops (n = 20), three drops daily on 1 day before surgery until 30 days post-operative. The main outcome measures macular thickness using Ocular Coherence Tomography before and after (14 and 30 days) phacoemulsification. RESULTS: Utilizing an independent t-test, this study had significantly inner macular (p = 0.0001) and central macular (p = 0.008) thickness differences in the diclofenac sodium group during surgery until 14 days postoperatively. However, significant changes in the outer macular thickness were absent. There were no notable alterations in the center, inner, and outer macular thickness in the diclofenac sodium group until 30 days postoperatively. In the placebo group, no significant changes were found in the macular thickness at every point of time. CONCLUSION: Two statistically significant central and inner macular thicknesses in the diclofenac sodium group until 14 days postoperatively were present. There were no significant changes in the center, inner, and outer macular thickness in the diclofenac sodium group until 30 days postoperatively.

scholarly journals EFFECT OF HEMODIALYSIS ON MACULAR THICKENSS IN PATIENTS OF CHRONIC RENAL FAILURE WITH DIABETIC MACULAR EDEMA

2020 ◽  
pp. 1-3
Author(s):  
Kinjal Trivedi ◽  
Charmi Madhani ◽  
Saumil Parikh ◽  
Somesh Aggarwal
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Linear Regression Analysis ◽  
Macular Thickness ◽  
Serum Osmolality ◽  
P Value ◽  
Diabetic Patients ◽  
Before And After

Introduction: End stage renal disease (ESRD) patients undergoing hemodialysis (HD) have higher incidence of diabetic retinopathy (DR) and diabetic macular edema. Optical coherence tomography (OCT) which both diagnoses and quantifies degree of macular edema is gold standard for evaluating macular thickness. Materials and methods: We studied 30 patients, with DR who were treated with hemodialysis for ESRD. All patients underwent OCT examination 30 minutes before and after a hemodialysis session. Blood pressure (BP), weight, serum osmolality, glycemic hemoglobin and albumin levels were measured before and after hemodialysis. Student’s t-test and linear regression analysis test were used to analyze data. SPSS version 21.0 system was used for all statistical analyses and p value <0.05 was accepted as statistically significant. Results: In our study, BCVA failed to change significantly after the HD. Central and average macular thickness decreased by 3.49% and 1.61% respectively, both were statistically significant. Changes in maximum, central and average macular thickness, as well as in total macular volume were found to be significantly affected by changes in serum osmolality (p=0.04, 0.002, 0.02 and 0.03, respectively).We found no significant changes in maximum/average macular thickness with changes in total body weight or in mean arterial pressure after HD. Conclusion: Hemodialysis significantly decreases maximum macular thickness assessed by OCT in chronic renal failure diabetic patients with macular edema with no change in BCVA. Osmolality changes after hemodialysis were significantly associated with macular thickness.

scholarly journals Non-steroidal anti-inflammatory drugs in the post-operative treatment of ophthalmic patients

2015 ◽  
Vol 8 (3) ◽  
pp. 45-48
Author(s):  
Sergey Yurievich Astakhov ◽  
Medeya Vakhtangovna Gobedzhishvili
Keyword(s):  
Cataract Surgery ◽  
Operative Treatment ◽  
Cataract Extraction ◽  
Eye Drops ◽  
Treatment Results ◽  
Before And After ◽  
Inflammatory Processes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Purpose: to analyze the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) after cataract extraction. To determine the NSAID’s role in post-operative inflammatory processes treatment. Results: the rationale of NSAIDs use before and after cataract surgery was validated. The NSAIDs efficacy in terms of post-op inflammation reduction was confirmed. Among NSAIDs benefits, the convenient and easy-to-use instillation regimen of Bromfenac 0.09% eye drops solution was highlighted.

scholarly journals A Comparative Evaluation of Macular Thickness after Phacoemulsification and Manual SICS in Diabetic Patients by Optical Coherence Tomography

2021 ◽  
Vol 8 (7) ◽  
pp. 468-472
Author(s):  
Saswati Biswas ◽  
Santosh Yadawrao Ingle ◽  
Samiran Das
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Macular Edema ◽  
Macular Thickness ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Small Incision Cataract Surgery ◽  
High Rise ◽  
Small Incision ◽  
Before And After

Background: The main aim of the study is to compare the change in macular thickness after uncomplicated phacoemulsification versus uncomplicated manual SICS in known diabetic patients by optical coherence tomography Methods: This study was an observational study involving 50 patients with each group having 25 patients. Group 1 was operated with Phacoemulsification through limbal 2.8 mm incision with Foldable PCIOL implantation. & Manual small incision cataract surgery through 5.5 to 6.5 mm incision with sclerocorneal tunnel with PMMA PCIOL implantation. For all patients, macular OCT was performed during preoperative period & post-op 1st day,7th day, 1st month, 3rd month & 6th month. Statistical software SPSS, version 21.0 was used for statistical analysis. Results: In both PHACO & SICS group MCFT rose steadily during post-operative period and SICS group shows high rise during follow up.The MCFT shows a difference between PHACO & SICS group with the highest MCFT observed in 1st month follow up i.e., 231.6 micrometer (SD ±7.831) in PHACO group & 241.64 (SD ±7.35) micrometer in SICS group. The MCFT returned to near pre-op value by the 6th month. Conclusion: There is no effect of age and sex on macular thickness before and after in both PHACO and SICS groups. In SICS group significant macular thickness was observed as compared to PHACO group, so there should be more cautious to undertake SICS in those patients who are at risk of developing macular edema or who have a higher macular thickness as seen in diabetes patients. Keywords: Phacoemulsification (PHACO), small incision cataract surgery (SICS), Cystoid macular edema.

scholarly journals The Difference Of Visual Acuity And Macular Thickness Post Bevacizumab Therapy In Secondary Macular Edema Retinal Vein Occlusion

2018 ◽  
Vol 4 (2) ◽  
pp. 110
Author(s):  
Citra Rahmadani ◽  
Nur Khoma Fatmawati ◽  
Rahmat Bakhtiar
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Secondary Data ◽  
Macular Thickness ◽  
Vein Occlusion ◽  
Before And After ◽  
Quasi Experimental ◽  
The Mean ◽  
The Difference

Retinal vein occlusion is the second most common cause of blindness in retinal vascular disease after diabetic retinopathy and may lead to complications of macular edema. Bevacizumab is an influential treatment as an anti vascular endothelial growth factor (VEGF). This study aims to determine the difference of visual acuity and macular thickness before and after treatment of Bevacizumab. This is a quasi experimental study in patients with secondary macular edema retinal vein occlusion who meets the inclusion criteria. Visual acuity and macular thickness were evaluated after one month of treatment. This study was conducted for two months since May-June 2017 by collecting secondary data from medical record at SMEC Samarinda from January 2016 – June 2017. Data were analyzed using Wilcoxon. Sixteen eyes from 16 patients were diagnosed with macular edema secondary retinal vein occlusion given bevacizumab treatment. The mean visual acuity before therapy was 1.106 LogMAR ± 0.509 and increased to 0.889 logMAR ± 0.608 (p = 0.116) after treatment while the mean macular thickness before therapy was 504.06 μm ± 301.273 and decreased to 348.81 μm ± 181.17 (p = 0.017) after treatment. There was a significant effect on the decrease in macular thickness but no significant effect on visual acuity improvement in patients with macular edema secondary retinal vein occlusion at SMEC Samarinda.  Keywords: Retinal vein occlusion, macular edema, bevacizumab

scholarly journals Knowledge of diabetic patients about their disease before and after implementing a diabetes education program

2008 ◽  
Vol 16 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Liudmila Miyar Otero ◽  
Maria Lúcia Zanetti ◽  
Michelle Daguano Ogrizio
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Data Collection ◽  
Education Program ◽  
Diabetes Education ◽  
Elderly Subjects ◽  
Diabetic Patients ◽  
Before And After ◽  
Quasi Experimental ◽  
Study Population

The purpose of this quasi-experimental, prospective and comparative study is to evaluate the knowledge that diabetic patients have about their disease before and after implementing a Diabetes Education Program. Fifty-four diabetic patients participated in the study, which occurred from April 2004 to April 2005. Data collection was performed using a questionnaire. The study population was characterized as adult and elderly subjects, with ages between 29 and 78 years; 60 years, on the average; Most participants were female 40/54 (74.1%); white 32/54 (59.3%); married 37/54 (68.5%); retired 23/54 (42.6%); with incomplete primary education 32/54 (59.3%); and an income of one to two minimum wages 16/54 (29.6%). The patients' knowledge regarding their disease increased significantly (p<0.05); especially considering the general topics concerning diabetes mellitus: concept of the disease, physiopathology and treatments; other topics that stood out were physical activity and nutrition.

Impact of Medication with Diclofenac Sodium vs. Etoricoxibum in Patients with Inflammatory Reumatic Pathology, Prosthetic Complications and Algo-dysfunctional Syndrome

2017 ◽  
Vol 68 (5) ◽  
pp. 977-981
Author(s):  
Laura Elisabeta Checherita ◽  
Elena Rezus ◽  
Maria Magdalena Leon ◽  
Ovidiu Stamatin ◽  
Elena Mihaela Carausu
Keyword(s):  
Drug Treatment ◽  
Temporomandibular Joint ◽  
Diclofenac Sodium ◽  
Symptomatic Treatment ◽  
Daily Dose ◽  
Before And After ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Prosthetic Complications ◽  
Important Objective

Affections of temporomandibular joint (TMJ) can lead to imbalances and disfunctions named algodisfunctional syndrome. One of the affections that we will take into consideration in this study is the temporal-mandibular arthrosis, which is, in fact, the frequent pathology at this level, and to which we will measure the pain before and after the administration of the anti-inflammatory therapy: Etoricoxib vs. Dyclofenac.The important objective of this study is to investigate this type of drug treatment over TMJ. The class of drug called non-steroidal anti-inflammatory drugs (NSAIDs)�so called to distinguish this class of drug from steroids, which have similar but additional effects�make NSAIDs one of frequently used drugs for the symptomatic treatment of many common conditions. Etoricoxib is clinically effective in the therapy of TMJ providing a magnitude of effect comparable to that of the maximum recommended daily dose of Diclofenac.

Extractive Spectrophotometric Determination of Some Nonsteroidal Anti-Inflammatory Drugs Using Methylene Blue

2013 ◽  
Vol 96 (4) ◽  
pp. 737-744 ◽  
Author(s):  
Michael E El-Kommos ◽  
Niveen A Mohamed ◽  
Ahmed F Abdel Hakiem
Keyword(s):  
Methylene Blue ◽  
Methylene Chloride ◽  
Diclofenac Sodium ◽  
Pharmaceutical Formulations ◽  
Eye Drops ◽  
Calibration Data ◽  
Pharmaceutical Dosage Forms ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract A simple, rapid, sensitive, and accurate extractive spectrophotometric method has been developed for the determination of seven nonsteroidal anti-inflammatory drugs (NSAIDs)—namely diclofenac sodium, ibuprofen, indomethacin, ketoprofen, ketorolac tromethamine, mefenamic acid, and naproxen—in pure forms as well as their pharmaceutical dosage forms (tablets, capsules, effervescent granules, syrups, oral drops, ampules, eye drops, gels, and suppositories). The method depends on the formation of an intensely colored ion-pair complex between the acidic drug and methylene blue in alkaline medium. The complex is stable and extractable into methylene chloride. All parameters were optimized. Beer-Lambert's law was obeyed in concentrations ranging from 0.04 to 9 μg/mL. Statistical analysis of the calibration data was carried out, and correlation coefficients were in the range from 0.9996 to 0.9998. The developed method was fully validated according to International Conference on Harmonization guidelines, and complied with U.S. Pharmacopeia guidelines. The proposed method was applied to the analysis of the investigated drugs in their pharmaceutical formulations, and good recoveries were obtained. The results obtained were compared with those of reported and official methods, and no significant differences were found with t- and F-tests. Interference effects of some compounds usually present in combination with NSAIDs were studied, and the tolerance limits of these compounds were determined.

scholarly journals COMPARATIVE EVALUATION OF MACULAR THICKNESS AFTER PHACOEMULSIFICATION VERSUS MANUAL SICS IN DIABETIC PATIENTS BY OPTICAL COHERENCE TOMOGRAPHY

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Mamta Singh ◽  
Bibhuti Prassan Sinha
Keyword(s):  
Cataract Surgery ◽  
Macular Thickness ◽  
Diabetic Patients ◽  
Small Incision Cataract Surgery ◽  
Significant Difference ◽  
Before And After ◽  
Spss Software ◽  
Group 2 ◽  
Group 1

Purpose: The main purpose of this study was to compare the macular thickness after uncomplicated Phacoemulsification versus manual SICS in known diabetic patient by OCT. Methods: This study was prospective observational study involving 50 eyes of 50 patients with each arm having 25 patients.  Group 1 was operated with Phacoemulsification with foldable IOL through 2.2 mm incision & group 2 were operated with manual SICS through 5.5 to 6.5 mm incision with PMMA IOL implantation. Macular OCT was performed in all patients during preoperative period & day 7 post op, 1st month, 3rd month & 6th month. The data were analyzed by using SPSS software (version22.0 SPSS Inc). Results: The MCFT rose steadily in both group during post operative period with higher rise noted in SICS group throughout follow up. Significant difference in MCFT between Phaco & SICS group were noted with highest MCFT noted in 1st month follow up in both groups i.e.  231.6 micro m (SD+7.831) in Phaco group & 241.08 (SD+7.35) in SICS group. The MCFT returned to near pre OP value by 6th month. Conclusion: 1 Age & Sex has no effect on macular thickness before and after any type of Cataract surgery be it Phaco or SICS. 2 Significant higher macular thickness was observed in SICS group so       caution should be taken in SICS patients. Keywords: Phacoemulsification, small incision cataract surgery (SICS), Cystoid macular edema

Sign in / Sign up

Export Citation Format

Share Document