Pathogen-specific Risk of Reactive Arthritis from Bacterial Causes of Foodborne Illness

Objective.Reactive arthritis (ReA) is a sequelae of common bacterial infections of acute gastroenteritis. We assessed incidence of ReA following Campylobacter, Salmonella, Shigella, or Yersinia infection utilizing a US Department of Defense medical database.Methods.Subjects with acute gastroenteritis attributed to these pathogens were matched with ≥ 4 unexposed subjects. Medical history was analyzed for 6 months postinfection to assess for incident ReA.Results.A total of 1753 cases of gastroenteritis were identified. ReA incidence ranged from 0 to 4 per 100,000 person-years.Conclusion.These data are consistent with prior studies and highlight the need for continued primary prevention efforts.

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HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

Clinical Microbiology Reviews ◽

10.1128/cmr.17.2.348-369.2004 ◽

2004 ◽

Vol 17 (2) ◽

pp. 348-369 ◽

Cited By ~ 97

Author(s):

Inés Colmegna ◽

Raquel Cuchacovich ◽

Luis R. Espinoza

Keyword(s):

Reactive Arthritis ◽

Bacterial Infections ◽

The Body ◽

Current Evidence ◽

Intracellular Bacteria ◽

Molecular Pathways ◽

Hla B27 ◽

Immune Mediated ◽

Clinical Considerations ◽

Active Bacteria

SUMMARY Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, nonculturable bacteria and/or immunogenetic bacterial antigens synthesized by metabolically active bacteria residing in the joint and/or elsewhere in the body. The mechanisms that lead to the development of ReA are complex and basically involve an interaction between an arthritogenic agent and a predisposed host. The way in which a host accommodates to invasive facultative intracellular bacteria is the key to the development of ReA. The details of the molecular pathways that explain the articular and extra-articular manifestations of the disease are still under investigation. Several studies have been done to gain a better understanding of the pathogenesis of ReA; these constitute the basis for a more rational therapeutic approach to this disease.

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P097 Diagnostic dilemma of acquired non-traumatic spinal deformation: Pott's disease; histiocytosis or psoriatic rheumatism? About a case

Rheumatology ◽

10.1093/rheumatology/keab722.089 ◽

2021 ◽

Vol 60 (Supplement_5) ◽

Author(s):

Bendaoud Fadila ◽

Mouffouk Hassen ◽

Ouzani Sara ◽

Brahmi Saida

Keyword(s):

Ct Scan ◽

Medical History ◽

Bacterial Infections ◽

Eosinophilic Granuloma ◽

Spinal Pain ◽

Spinal Deformities ◽

Diagnostic Dilemma ◽

Pott’S Disease ◽

Vertebral Involvement ◽

Lumbar Spinal

Abstract Background Non-traumatic acquired spinal deformities represent a separate entity within the axial pathologies in children. Their causes are variable (neurological, muscular, infectious, especially Pott's disease, inflammatory or tumoral). The etiological diagnosis can be clinically oriented by pain, medical history, especially rheumatic. The contribution of the CT scan is crucial, as it localizes the lesion, specifies its nature, but above all it helps the histological diagnosis by guided biopsies. Our case illustrates the difficulties in diagnosing the aetiology of spinal acquired deformity in a girl with a multi-evocative context. Observation A 14 years-old girl complains for a few months of a dorso-lumbar spinal pain and a vicious attitude. Her medical history includes femoral thrombophlebitis and psoriasis. She had no trauma or fever. Clinically, the general state is preserved, with no local inflammatory signs, a kyphotic attitude with an analgesic lumbar support was noted. The rest of the locomotor exam was normal. CT scan shows cancellous body geodes with a double mirror. Discussion Acquired spinal deformities are always secondary to general disease. The fever may point to bacterial infections, especially tuberculosis (Pott's disease), but also non-infectious causes such as a rheumatic disease. For our patient, psoriasis argues for the latter possibility. However, the rarity of isolated disco-vertebral involvement and the severity of the lytic lesions are against this diagnosis. The histopathological exam showed an eosinophilic granuloma, confirming the histiocytosis X diagnosis. The cortico-response strengthen the diagnosis. The course was marked by the bone remodeling with the posture correction. Conclusion A clinical, radiological, and histological analysis allow the etiological orientation in front of acquired spinal deformity.

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The Department of Defense Medical Mortality Registry

Military Medicine ◽

10.1093/milmed/165.suppl_2.57 ◽

2000 ◽

Vol 165 (suppl_2) ◽

pp. 57-61 ◽

Cited By ~ 8

Author(s):

John W. Gardner ◽

Christine B. Cozzini ◽

Patrick W. Kelley ◽

John A. Kark ◽

Michael R. Peterson ◽

...

Keyword(s):

Department Of Defense ◽

Defense Medical

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Implementation of Biosurety Systems in a Department of Defense Medical Research Laboratory

Biosecurity and Bioterrorism Biodefense Strategy Practice and Science ◽

10.1089/153871304322964291 ◽

2004 ◽

Vol 2 (1) ◽

pp. 7-16 ◽

Cited By ~ 15

Author(s):

Kathleen Carr ◽

Erik A. Henchal ◽

Catherine Wilhelmsen ◽

Bridget Carr

Keyword(s):

Medical Research ◽

Department Of Defense ◽

Research Laboratory ◽

Medical Research Laboratory ◽

Defense Medical

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The incidence of rotavirus infection compared to bacterial infections in different age groups of pediatric patients with gastroenteritis

Sanitarno inženirstvo International Journal of Sanitary Engineering Research ◽

10.2478/ijser-2019-0005 ◽

2019 ◽

Vol 13 (1) ◽

pp. 39-52

Author(s):

Tatjana Babić ◽

Biljana Miljković-Selimović ◽

Dobrila Đorđević-Stanković ◽

Branislava Kocić ◽

Miloš Ranđelović ◽

...

Keyword(s):

Acute Gastroenteritis ◽

Bacterial Infections ◽

Pediatric Patients ◽

Age Groups ◽

Outpatient Setting ◽

Diarrheal Diseases ◽

Rotavirus Infection ◽

Identification Of Bacteria ◽

One Year ◽

The Town

AbstractRotavirus is the important cause of acute gastroenteritis in pediatric patients. The aim of the present research was to determine the incidence of rotavirus infections in infants and children up to seven years of age in the town of Niš. Seasonal prevalence of rotavirus-associated acute gastroenteritis was also evaluated. An enzyme immunoassay (RIDASCREEN® Rotavirus; R-Biopharm AG, Darmstadt, Germany) was used to detect rotavirus in the stool specimens of 1,156 patients (newborns up to 7 years of age) presenting with gastroenteritis. Identification of bacteria and yeasts was performed by classical methods. The overall incidence of rotavirus in examined children was 5.97%. Among 144 hospitalized children, rotavirus infection was diagnosed in 28 (19.44%). In 1,012 children treated in outpatient setting for diarrheal diseases, rotaviruses were found in 41 (4.05%). The highest incidence of rotavirus infection was among the patients of one year of age. Among 1,156 pediatric children tested, bacterial pathogens were found in 6.31% and the most frequently isolated pathogens were Campylobacter spp. and Salmonella enteritidis. The highest prevalence of GE was recorded in the colder season, peaking in April (15.94%). Rotaviruses are an important factor in the etiology of the acute diarrheal diseases, especially in children hospitalized during the winter/spring season.

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