scholarly journals The current state of validated small molecules inhibiting SARS-CoV-2 non-structural proteins

2021 ◽  
Keyword(s):  
Small Molecules ◽  
Structural Proteins ◽  
Current State

scholarly journals Recent Progress on the Versatility of Virus-Like Particles

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 139 ◽  
Author(s):  
Ciying Qian ◽  
Xinlin Liu ◽  
Qin Xu ◽  
Zhiping Wang ◽  
Jie Chen ◽  
...  
Keyword(s):  
Immune Responses ◽  
Small Molecules ◽  
Genetic Material ◽  
Structural Proteins ◽  
Cell Penetration ◽  
Virus Like Particles ◽  
Humoral Immune ◽  
Specific Targeting ◽  
Humoral Immune Responses ◽  
Antigenic Epitopes

Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural proteins of a virus in the absence of genetic material. Having similar morphology to natural viruses but lacking any pathogenicity or infectivity, VLPs have gradually become a safe substitute for inactivated or attenuated vaccines. VLPs can achieve tissue-specific targeting and complete and effective cell penetration. With highly ordered epitope repeats, VLPs have excellent immunogenicity and can induce strong cellular and humoral immune responses. In addition, as a type of nanocarrier, VLPs can be used to display antigenic epitopes or deliver small molecules. VLPs have thus become powerful tools for vaccinology and biomedical research. This review highlights the versatility of VLPs in antigen presentation, drug delivery, and vaccine technology.

scholarly journals Allergy to latex - current state of problem

2012 ◽  
Vol 9 (1) ◽  
pp. 5-11
Author(s):  
T A Evdokimova ◽  
O S Fedorova ◽  
M M Fedotova
Keyword(s):  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Latex Allergy ◽  
Structural Proteins ◽  
Biological Functions ◽  
Current State ◽  
Modern Methods ◽  
Food Workers

During the last 20 years the incidence of sensitization to latex proteins is growing. Allergy to latex is found predominantly in persons, professionally contacting with latex products: medical workers, workers employed in the manufacture of rubber products and food workers. This review describes the main clinical symptoms of latex allergy, characteristics of structural proteins and their basic biological functions. Modern methods of diagnostics and approaches to the application of specific immunotherapy for allergy to latex are presented.

scholarly journals Metabolomics in Central Sensitivity Syndromes

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 164 ◽  
Author(s):  
Joseph S. Miller ◽  
Luis Rodriguez-Saona ◽  
Kevin V. Hackshaw
Keyword(s):  
Small Molecules ◽  
Central Sensitization ◽  
Metabolic Pathways ◽  
Treatment Options ◽  
Case Series ◽  
Opiate Abuse ◽  
Current State ◽  
Increased Risk ◽  
Adults And Children

Central sensitization syndromes are a collection of frequently painful disorders that contribute to decreased quality of life and increased risk of opiate abuse. Although these disorders cause significant morbidity, they frequently lack reliable diagnostic tests. As such, technologies that can identify key moieties in central sensitization disorders may contribute to the identification of novel therapeutic targets and more precise treatment options. The analysis of small molecules in biological samples through metabolomics has improved greatly and may be the technology needed to identify key moieties in difficult to diagnose diseases. In this review, we discuss the current state of metabolomics as it relates to central sensitization disorders. From initial literature review until Feb 2020, PubMed, Embase, and Scopus were searched for applicable studies. We included cohort studies, case series, and interventional studies of both adults and children affected by central sensitivity syndromes. The majority of metabolomic studies addressing a CSS found significantly altered metabolites that allowed for differentiation of CSS patients from healthy controls. Therefore, the published literature overwhelmingly supports the use of metabolomics in CSS. Further research into these altered metabolites and their respective metabolic pathways may provide more reliable and effective therapeutics for these syndromes.

Connectivity Mapping: Methods and Applications

2019 ◽  
Vol 2 (1) ◽  
pp. 69-92 ◽  
Author(s):  
Alexandra B. Keenan ◽  
Megan L. Wojciechowicz ◽  
Zichen Wang ◽  
Kathleen M. Jagodnik ◽  
Sherry L. Jenkins ◽  
...  
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Historical Perspective ◽  
Disease Gene ◽  
Cellular Tissue ◽  
Hypothesis Generation ◽  
Connectivity Mapping ◽  
Current State ◽  
Global View

Connectivity mapping resources consist of signatures representing changes in cellular state following systematic small-molecule, disease, gene, or other form of perturbations. Such resources enable the characterization of signatures from novel perturbations based on similarity; provide a global view of the space of many themed perturbations; and allow the ability to predict cellular, tissue, and organismal phenotypes for perturbagens. A signature search engine enables hypothesis generation by finding connections between query signatures and the database of signatures. This framework has been used to identify connections between small molecules and their targets, to discover cell-specific responses to perturbations and ways to reverse disease expression states with small molecules, and to predict small-molecule mimickers for existing drugs. This review provides a historical perspective and the current state of connectivity mapping resources with a focus on both methodology and community implementations.

scholarly journals Targeting uPAR in diabetic vascular pathologies*

2019 ◽  
Vol 73 ◽  
pp. 803-808
Author(s):  
Martyna Durak-Kozica ◽  
Francisco J. Enguita ◽  
Ewa Stępień
Keyword(s):  
Cell Proliferation ◽  
Small Molecules ◽  
Cell Invasion ◽  
Biological Processes ◽  
Effective Inhibitor ◽  
Current State

The uPAR protein is one of the most important elements in fibrinolysis. uPAR is associated with many biological processes, such as cell invasion, angiogenesis and cell proliferation. Because of its multifunctional character, it is difficult to produce an effective inhibitor of uPA-uPAR interactions. The present paper shows the current state of knowledge about the contribution of uPA-uPAR complex in many biological processes and the application of uPAR inhibitors (antibodies, small-molecules, peptides), which might be potentially useful in the treatment of vascular pathologies.

scholarly journals MALAT1 Long Non-Coding RNA: Functional Implications

2020 ◽  
Vol 6 (2) ◽  
pp. 22 ◽  
Author(s):  
Gayatri Arun ◽  
Disha Aggarwal ◽  
David L. Spector
Keyword(s):  
Small Molecules ◽  
Functional Significance ◽  
Antisense Oligonucleotides ◽  
Normal Development ◽  
Mammalian Genome ◽  
Dependent Manner ◽  
Current State ◽  
Non Coding Rna ◽  
Functional Implications ◽  
Long Non Coding Rna

The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is one of the most well-studied lncRNAs. MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, Malat1 has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that MALAT1 plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to MALAT1 with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting MALAT1 using antisense oligonucleotides and small molecules.

scholarly journals The current state of the art for biological therapies and new small molecules in inflammatory bowel disease

2018 ◽  
Vol 11 (6) ◽  
pp. 1558-1570 ◽  
Author(s):  
Sudarshan Paramsothy ◽  
Adam K. Rosenstein ◽  
Saurabh Mehandru ◽  
Jean-Frederic Colombel
Keyword(s):  
Inflammatory Bowel Disease ◽  
Small Molecules ◽  
Bowel Disease ◽  
State Of The Art ◽  
Biological Therapies ◽  
Current State ◽  
Inflammatory Bowel

scholarly journals Pharmacological Interventions That Target Biological Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 818-818
Author(s):  
Matt Kaeberlein
Keyword(s):  
Small Molecules ◽  
Mtor Inhibitors ◽  
Mechanisms Of Action ◽  
Laboratory Animals ◽  
Biological Aging ◽  
Pharmacological Interventions ◽  
Current State ◽  
Age Related ◽  
Disease Risks ◽  
High Level

Abstract There is a high level of interest in drugs that may delay or even reverse the functional declines and disease risks that accompany biological aging. Several interventions have been shown to improve age-related outcomes and increase lifespan in laboratory animals by targeting the hallmarks of aging. A number of these small molecules are being clinically evaluated for age-related indications, including mTOR inhibitors such as rapamycin, the anti-diabetic drug metformin, and senescent-cell clearing senolytics. Others are being marketed to consumers outside of the federal regulatory process as “anti-aging” natural products with little information about safety or efficacy. Here I will provide an overview of the current state of “anti-aging drugs” with an emphasis on potential mechanisms of action and evaluation of the existing pre-clinical and clinical data.

Sign in / Sign up

Export Citation Format

Share Document