Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults

2015 ◽  
Vol 6 (3) ◽  
pp. 233-243 ◽  
Author(s):  
P. Hütt ◽  
E. Songisepp ◽  
M. Rätsep ◽  
R. Mahlapuu ◽  
K. Kilk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lactobacillus Plantarum ◽  
Functional Properties ◽  
Dairy Products ◽  
Probiotic Strain ◽  
Healthy Adults ◽  
Food Matrix ◽  
Probiotic Lactobacillus ◽  
Daily Dose ◽  
Baseline Values

The blood pressure-lowering effect of dairy products holds the potential to decrease the risk of cardiovascular disease (CVD). An open question is if the successful expression of functional properties of the probiotic strain depends on host biomarkers and/or food matrix properties. The probiotic Lactobacillus plantarum strain TENSIA® (DSM 21380) is a novel microorganism with antimicrobial and antihypertensive functional properties. The aim of this study was to characterise the functional properties of the probiotic L. plantarum TENSIA and compare its effects on host anthropometric, clinical, and blood biomarkers when consumed with cheese or yoghurt. This study involved two double-blinded randomised placebo-controlled exploratory trials (ISRCTN15061552 and ISRCTN79645828) of healthy adults over a three-week period. The three-week consumption of probiotic L. plantarum TENSIA in a daily dose of 1×1010 cfu in probiotic cheese or a daily dose of 6×109 cfu in yoghurt with different content of carbohydrates, proteins, and lipids did not significantly change the body mass index (BMI), plasma glucose and lipid levels, or inflammatory markers in the blood. Reduced lowered systolic and diastolic blood pressure values were detected, regardless of food matrix or baseline values for blood pressure and BMI. In conclusion, our study showed that three-week consumption of the probiotic L. plantarum TENSIA either in cheese or yoghurt lowered diastolic and systolic blood pressure regardless of food matrix and baseline values of blood pressure and BMI, confirming the impact of the functional properties of the probiotic strain in decreasing CVD risk.

Carteolol Treatment of Essential Hypertension: A Long-Term Study of Safety and Efficacy

1986 ◽  
Vol 14 (4) ◽  
pp. 175-184 ◽  
Author(s):  
Robert R Luther ◽  
Clemeth J Maurath ◽  
Michael J Klepper ◽  
Robert O Peckinpaugh ◽  
Gary L Ringham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multicenter Trial ◽  
Open Label ◽  
Once Daily ◽  
Long Term Study ◽  
Daily Dose ◽  
Baseline Values ◽  
The Mean ◽  
Oral Doses

The long-term safety and antihypertensive efficacy of carteolol were evaluated in an open-label, multicenter trial of 245 hypertensive patients. For those patients maintained on carteolol monotherapy, three months of treatment with once-daily oral doses of carteolol ranging from 2.5 to 60 mg reduced the mean recumbent blood pressure by 12/14 mm Hg from baseline values of 151/100. Blood pressure reductions observed at three months were maintained throughout the study. The final daily dose of carteolol for most patients was 10 mg or less. Carteolol was shown to be safe and well tolerated by most patients.

scholarly journals Preliminary Evaluation of Probiotic Properties ofLactobacillusStrains Isolated from Sardinian Dairy Products

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maria Barbara Pisano ◽  
Silvia Viale ◽  
Stefania Conti ◽  
Maria Elisabetta Fadda ◽  
Maura Deplano ◽  
...  
Keyword(s):  
Functional Properties ◽  
Dairy Products ◽  
Lactobacillus Rhamnosus ◽  
Probiotic Strain ◽  
Microbial Pathogens ◽  
Epithelial Tissue ◽  
Preliminary Evaluation ◽  
Probiotic Properties ◽  
Health Related ◽  
Amoxicillin Clavulanic Acid

Twenty-threeLactobacillusstrains of dairy origin were evaluated for some functional properties relevant to their use as probiotics. A preliminary subtractive screening based on the abilities to inhibit the growth of microbial pathogens and hydrolyze conjugated bile salts was applied, and six strains were selected for further characterization including survival under gastrointestinal environmental conditions, adhesion to gut epithelial tissue, enzymatic activity, and some safety properties. All selected strains maintained elevated cell numbers under conditions simulating passage through the human gastrointestinal tract, well comparable to the values obtained for the probiotic strainLactobacillus rhamnosusGG, and were able to adhere to Caco-2 cells to various extents (from 3 to 20%). All strains exhibited high aminopeptidase, and absent or very low proteolytic and strongβ-galactosidase activities; none was found to be haemolytic or to produce biogenic amines and all were susceptible to tetracycline, chloramphenicol, erythromycin, ampicillin, and amoxicillin/clavulanic acid. Our results indicate that theLactobacillusstrains analyzed could be considered appropriate probiotic candidates, due to resistance to GIT simulated conditions, antimicrobial activity, adhesion to Caco-2 cell-line, and absence of undesirable properties. They could be used as adjunct cultures for contributing to the quality and health related functional properties of dairy products.

scholarly journals Genetic Basis of Tetracycline and Minocycline Resistance in Potentially Probiotic Lactobacillus plantarum Strain CCUG 43738

2006 ◽  
Vol 50 (4) ◽  
pp. 1550-1551 ◽  
Author(s):  
Geert Huys ◽  
Klaas D'Haene ◽  
Jean Swings
Keyword(s):  
Lactobacillus Plantarum ◽  
Genetic Basis ◽  
Probiotic Strain ◽  
Host Strain ◽  
Plasmid Curing ◽  
Phenotypic Resistance ◽  
S Gene ◽  
Probiotic Lactobacillus

ABSTRACT The potentially probiotic strain Lactobacillus plantarum CCUG 43738, which displayed atypical phenotypic resistance to tetracycline (MIC, 512 μg/ml) and minocycline (MIC, 256 μg/ml), was found to contain a tet(S) gene located on a plasmid of approximately 14 kb. Plasmid curing with novobiocin eliminated this plasmid and restored the tetracycline-susceptible phenotype of the host strain.

scholarly journals Viability and in vivo Hypocholesterolemic Effect of Lactobacillus plantarum 29V in Local Honey

2021 ◽  
pp. 24-33
Author(s):  
Ulrich Landry Kamdem Bemmo ◽  
Chancel Hector Momo Kenfack ◽  
Jean Marcel Bindzi ◽  
Raoul Borkeum Barry ◽  
François Zambou Ngoufack
Keyword(s):  
Lactobacillus Plantarum ◽  
Intestinal Tract ◽  
Control Diet ◽  
Hdl Cholesterol ◽  
Probiotic Strain ◽  
In Vivo Studies ◽  
Human Beings ◽  
Food Matrix ◽  
Gastro Intestinal Tract

The conservation of probiotic products requires low temperatures and suitable equipment that are less available in developing countries. The challenge today is to find a local food matrix that can also carry probiotics (microorganisms with benefits for consumers) in the gastro-intestinal tract. The study mainly focus in the current research was to study the use of honey as a food matrix to carry probiotics in treating the cardiovascular disease, hypercholestreolemia. Thus, this study aimed to assess the viability of Lactobacillus plantarum 29V and its in vivo hypocholesterolemic properties when contained in honey. The strain L. plantarum 29V was added in pasteurized honey and was studied its viability in honey and its impact on the physicochemical parameters of honey.¶ For in vivo studies, 0.5 mL of the pasteurized honey containing approximately 108 CFU/mL of L. plantarum 29V were administered to rats fed on a cholesterol-enriched diet (control diet+ pure cholesterol solution (0.04 g/mL) per day per rat) using a feeding syringe; the treatment lasted 4 weeks. Serum lipids were analyzed during the experiment. The results have shown that the probiotic strain L. plantarum 29V can survive in honey for 28 days without affecting the honey’s qualities. Even present in honey, this strain continues to lower serum total cholesterol, (VLDL +LDL)-cholesterol and triglycerides levels of hypercholesterolemic rats. In addition, HDL-cholesterol levels significantly increased, and the atherosclerosis index was significantly lowered. The present study revealed that honey could be used as a food matrix to carry the probiotic Lactobacillus plantarum 29V strain very well into the gastro-intestinal tract. Hence, a probiotic formulation made of pasteurized honey and L. plantarum 29V would be used to treat or prevent hypercholesterolemia if these effects are confirmed in Human beings.

Lactobacillus plantarum A7, a Potential Probiotic Strain from Infant fecal Flora

2017 ◽  
Vol 06 (11) ◽  
Author(s):  
Golnoush Madani ◽  
Maryam Mirlohi ◽  
Sabiheh Soleimanain-Zad ◽  
Parham Hosseini ◽  
Mina Babashahi
Keyword(s):  
Lactobacillus Plantarum ◽  
Probiotic Strain ◽  
Fecal Flora

scholarly journals Probiotic Delivery through Non-Dairy Plant-Based Food Matrices

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 599
Author(s):  
D. M. D. Rasika ◽  
Janak K. Vidanarachchi ◽  
Selma F. Luiz ◽  
Denise Rosane Perdomo Azeredo ◽  
Adriano G. Cruz ◽  
...  
Keyword(s):  
Functional Properties ◽  
Dairy Products ◽  
Microbiological Quality ◽  
Health Benefit ◽  
Food Products ◽  
Quality Characteristics ◽  
Dairy Plant ◽  
Food Matrices ◽  
Probiotic Food ◽  
Probiotic Delivery

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Traditionally, dairy products are the major and most popular probiotic carriers. At present, there is a growing demand for non-dairy probiotic products. Both fermented and non-fermented non-dairy plant-based food products are becoming highly appealing to both dairy and non-dairy consumers worldwide. Non-dairy plant-based food matrices such as fruits, vegetables, plant-based milk, cereals, and legumes have been used successfully in producing probiotic products with the minimum recommended viable probiotic numbers at the time of consumption. However, due to the exclusion of dairy, whether these food matrices can enhance the functional properties of probiotics such as gastrointestinal survival and immune-enhancing effects needs a thorough investigation. Hence, this review focuses on some of the popular non-dairy plant-based probiotic food products and their microbiological quality characteristics in terms of maintaining probiotic viability during product storage. Their gastrointestinal tolerance in these products, other functional properties, and product qualities have also been briefly discussed.

scholarly journals High‐phosphorus diet controlled for sodium elevates blood pressure in healthy adults via volume expansion

2021 ◽  
Author(s):  
Jia‐ying Zhang ◽  
Huai‐zhou You ◽  
Meng‐jing Wang ◽  
Qian Zhang ◽  
Xin‐yu Dong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Volume Expansion ◽  
Healthy Adults ◽  
High Phosphorus ◽  
High Phosphorus Diet
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