scholarly journals Inhibitory Activity of Aqueous extracts of Horseradiash Moringa oleifera (Lam) and Nutmeg Myristica fragrans (Houtt) on Oxidative Stress in Alloxan Induced Diabetic Male Wistar Albino Rats

2014 ◽  
Vol 4 (2) ◽  
pp. 64-75 ◽  
Author(s):  
O.A. Oseni ◽  
A.S.K. Idowu
Keyword(s):  
Oxidative Stress ◽  
Inhibitory Activity ◽  
Moringa Oleifera ◽  
Albino Rats ◽  
Aqueous Extracts ◽  
Myristica Fragrans ◽  
Myristica Fragrans Houtt ◽  
Wistar Albino Rats ◽  
Moringa Oleifera Lam

scholarly journals THE PROTECTIVE EFFECTS OF AQUEOUS EXTRACT OF AFRICAN NUTMEG (Myristica fragrans) IN BROMATE-INDUCED SPLEEN AND CARDIAC TISSUE TOXICITIES USING MALE WISTAR ALBINO RATS

2018 ◽  
Vol 8 (5) ◽  
pp. 257-262
Author(s):  
Oatunde Abass Oseni ◽  
Sulaiman Adeoye Olagboye ◽  
Olusegun Timothy Adams ◽  
Bamaiyi Sunday Maikasuwa
Keyword(s):  
Aqueous Extract ◽  
Cardiac Tissue ◽  
Potassium Bromate ◽  
Toxic Effects ◽  
Albino Rats ◽  
Aqueous Extracts ◽  
Protective Effects ◽  
Myristica Fragrans ◽  
Group I ◽  
Wistar Albino Rats

This study was aimed at investigating the toxic effects of potassium bromate on the spleen and heart of Wistar albino rat and to evaluate the protective effects of aqueous extract of African nutmeg (Myristica fragrans) against potassium bromate induced toxicity in the two organs. Twenty-four (24) male wistar albino rats weighing between 180g and 200g were divided into four groups of six animals each. Group I animals were served with rat feed and water as the control group, group II were administered daily with 30mg/kg bw potassium bromate while groups III and IV animals were administered with 0.5mL of 20% and 40% aqueous extracts of nutmeg seed in addition with 30mg/kg body weight potassium bromate respectively for two weeks. The animals were kept at optimum temperature within a 12 hours light/dark cycle while the experiment lasted. Enzyme biomarkers such as Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase; antioxidant enzymes such as, Superoxide dismutase, Catalase; reduced Glutathione; some lipid profiles like Cholesterol, Triglyceride and malondialdehyde were measured in the spleen and heart homogenates of the animals in all the groups. Results of this study showed that potassium bromate exerted significant (P < 0.05) toxic effects on the spleen and heart homogenates while the administration of aqueous extracts of African nutmeg seed caused a marked reversal in the toxicity in a dose dependent manner. However, the results of this study showed that aqueous extract of the seed of African nutmeg is a potential antioxidant against potassium bromate toxicity in the two organs.    Keywords: Toxicity, Potassium bromate, Myristica fragrans, Cardiac tissue, Antioxidant

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

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