Evaluation of the Wheat Germ Oil Topical Formulations for Wound Healing Activity in Rats

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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In Vivo Testing of the Wound-healing Activity of a Natural-based Skin Cream for Dogs and Cats

Planta Medica ◽

10.1055/s-2006-950005 ◽

2006 ◽

Vol 72 (11) ◽

Author(s):

S Jia ◽

T Mustoe ◽

JK Ketzis

Keyword(s):

Wound Healing ◽

Skin Cream ◽

In Vivo Testing ◽

Wound Healing Activity

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Wound Healing Activity of Ten Indigenous Plants in Incision and Excision Wound Models in Albino Rats

International Journal of Scientific Research ◽

10.15373/22778179/sep2013/164 ◽

2012 ◽

Vol 2 (9) ◽

pp. 56-58

Author(s):

Vasanthalaxmi K Vasanthalaxmi K ◽

◽

Saraswathi Udupa ◽

Laximinarayana Udupa

Keyword(s):

Wound Healing ◽

Albino Rats ◽

Indigenous Plants ◽

Excision Wound ◽

Wound Healing Activity

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Wound Healing Activity of a Skin Substitute from Residues of Culinary-Medicinal Winter Mushroom Flammulina velutipes (Agaricomycetes) Cultivation

International Journal of Medicinal Mushrooms ◽

10.1615/intjmedmushrooms.2019031175 ◽

2019 ◽

Vol 21 (7) ◽

pp. 683-691 ◽

Cited By ~ 1

Author(s):

Hui Xu ◽

Liangyun Liu ◽

Chongjiang Cao ◽

Weisheng Lu ◽

Zhenhan Zhu ◽

...

Keyword(s):

Wound Healing ◽

Flammulina Velutipes ◽

Skin Substitute ◽

Wound Healing Activity

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Comparison of the ficus for the wound healing activity in various species

International Journal of Research in Phytochemistry and Pharmacology ◽

10.26452/ijrpp.v10i4.1381 ◽

2020 ◽

Vol 10 (4) ◽

pp. 67-70

Author(s):

Mothilal K ◽

Akila CR ◽

Mahender K ◽

Chaitanya Kumar K ◽

Ravi D

Keyword(s):

Wound Healing ◽

Wound Closure ◽

Subcutaneous Tissue ◽

Significant Activity ◽

Herbal Extracts ◽

Standard Drug ◽

Excision Wound ◽

Injuries And Wounds ◽

Skin Conditions ◽

Wound Healing Activity

Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.

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In Vivo Wound Healing Activity of Spirulina platensis

Phytothérapie ◽

10.3166/phyto-2018-0097 ◽

2019 ◽

Vol 18 (1) ◽

pp. 06-16

Author(s):

R. Seghiri ◽

A. Essamri

Keyword(s):

Wound Healing ◽

Spirulina Platensis ◽

Therapeutic Agent ◽

Conventional Medicine ◽

Folk Medicine ◽

Chemical Burns ◽

Amount Of Substance ◽

Test Population ◽

Wound Healing Activity

Spirulina is a microalga used in traditional folk medicine in Morocco for the treatment of various health disorders. The wound healing activity of Moroccan Spirulina is unknown. In the current study, aqueous extracts of Spirulina platensis were investigated for acute toxicity and wound healing activity in Swiss Albino mice and White New Zealand rabbits, respectively. The LD50 (amount of substance required to kill 50% of the test population) of the microalga was greater than 5,000 mg/kg. Healing after application of the same amount of ointment on differently induced (mechanical, chemical, and thermal) wounds was about the same, over five weeks. Aqueous extract had remarkable healing activity on rabbits’ skin, possessing significantly greater healing effect for mechanical and chemical burns than controls. Moreover, the hair growing time was faster in treated groups; Spirulina-treated groups did not show any contamination with microbes compared to others. This study affirms that Spirulina platensis can be considered as a potential therapeutic agent for wound healing not only as a complementary medicine but also in conventional medicine.

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