A mathematical analysis of an activator-inhibitor Rho GTPase model

<p style='text-indent:20px;'>Recent experimental observations reveal that local cellular contraction pulses emerge via a combination of fast positive and slow negative feedbacks based on a signal network composed of Rho, GEF and Myosin interactions [<xref ref-type="bibr" rid="b22">22</xref>]. As an examplary, we propose to study a plausible, hypothetical temporal model that mirrors general principles of fast positive and slow negative feedback, a hallmark for activator-inhibitor models. The methodology involves (ⅰ) a qualitative analysis to unravel system switching between different states (stable, excitable, oscillatory and bistable) through model parameter variations; (ⅱ) a numerical bifurcation analysis using the positive feedback mediator concentration as a bifurcation parameter, (ⅲ) a sensitivity analysis to quantify the effect of parameter uncertainty on the model output for different dynamic regimes of the model system; and (ⅳ) numerical simulations of the model system for model predictions. Our methodological approach supports the role of mathematical and computational models in unravelling mechanisms for molecular and developmental processes and provides tools for analysis of temporal models of this nature.</p>

Download Full-text

Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin

Gastroenterology ◽

10.1053/gast.2002.34162 ◽

2002 ◽

Vol 123 (1) ◽

pp. 271-280 ◽

Cited By ~ 36

Author(s):

Andrea Varro ◽

Elaine Hemers ◽

Debbie Archer ◽

Adelina Pagliocca ◽

Chris Haigh ◽

...

Keyword(s):

Plasminogen Activator ◽

Rho Gtpase ◽

Plasminogen Activator Inhibitor ◽

Activator Inhibitor

Download Full-text

Lung Computational Models and the Role of the Small Airways in Asthma

PEDIATRICS ◽

10.1542/peds.2020-023861kkk ◽

2020 ◽

Vol 146 (Supplement 4) ◽

pp. S359.2-S360

Author(s):

Jennilee Eppley ◽

Todd Mahr

Keyword(s):

Computational Models ◽

Small Airways

Download Full-text

Beyond the Social Determinants of Health

Diversity of Research in Health Journal ◽

10.28984/drhj.v3i0.302 ◽

2020 ◽

Vol 3 ◽

pp. 1-11

Author(s):

Laura Hall ◽

Urpi Pine ◽

Tanya Shute

Keyword(s):

Labour Force ◽

Methodological Approach ◽

Active Role ◽

Indigenous Women ◽

Economic Activities ◽

The Earth ◽

The Social ◽

Weather Changes ◽

People First

Abstract This paper will reflect on key findings from a Summer 2017 initiative entitled The Role of Culture and Land-Based Healing in Addressing and Ending Violence against Indigenous Women and Two-Spirited People. The Indigenist and decolonizing methodological approach of this work ensured that all research was grounded in experiential and reciprocal ways of learning. Two major findings guide the next phase of this research, complicating the premise that traditional economic activities are healing for Indigenous women and Two-Spirit people. First, the complexities of the mainstream labour force were raised numerous times. Traditional economies are pressured in ongoing ways through exploitative labour practices. Secondly, participants emphasized the importance of attending to the responsibility of nurturing, enriching, and sustaining the wellbeing of soil, water, and original seeds in the process of creating renewal gardens as a healing endeavour. In other words, we have an active role to play in healing the environment and not merely using the environment to heal ourselves. Gardening as research and embodied knowledge was stressed by extreme weather changes including hail in June, 2018, which meant that participants spent as much time talking about the healing of the earth and her systems as the healing of Indigenous women in a context of ongoing colonialism.

Download Full-text

LANDSLIDE RISK MANAGEMENT IN THE COASTAL ZONE OF THE KUIBYSHEV RESERVOIR DUE THE DESIGN OF HIGH-SPEED LINE "MOSCOW-KAZAN"

Proceedings of International Conference "Managinag risks to coastal regions and communities in a changinag world" (EMECS'11 - SeaCoasts XXVI) ◽

10.31519/conferencearticle_5b1b9403c99983.72529271 ◽

2017 ◽

Author(s):

Nikolai Petrov ◽

Inna Nikonorova ◽

Vladimir Mashin ◽

...

Keyword(s):

High Speed ◽

Computational Models ◽

Stable State ◽

Landslide Risk ◽

Kuibyshev Reservoir ◽

Stepped Surface ◽

The Stability ◽

Landslide Slope ◽

The Village

High-speed railway "Moscow-Kazan" by the draft crosses the Volga (Kuibyshev reservoir) in Chuvashia region 500 m below the village of New Kushnikovo. The crossing plot is a right-bank landslide slope with a stepped surface. Its height is 80 m; the slope steepness -15-16o. The authors should assess the risk of landslides and recommend anti-landslide measures to ensure the safety of the future bridge. For this landslide factors have been analyzed, slope stability assessment has been performed and recommendations have been suggested. The role of the following factors have been analyzed: 1) hydrologic - erosion and abrasion reservoir and runoff role; 2) lithologyc (the presence of Urzhum and Northern Dvina horizons of plastically deformable rocks, displacement areas); 3) hydrogeological (the role of perched, ground and interstratal water); 4) geomorphological (presence of the elemental composition of sliding systems and their structure in the relief); 5) exogeodynamic (cycles and stages of landslide systems development, mechanisms and relationship between landslide tiers of different generations and blocks contained in tiers). As a result 6-7 computational models at each of the three engineering-geological sections were made. The stability was evaluated by the method “of the leaning slope”. It is proved that the slope is in a very stable state and requires the following measures: 1) unloading (truncation) of active heads blocks of landslide tiers) and the edge of the plateau, 2) regulation of the surface and groundwater flow, 3) concrete dam, if necessary.

Download Full-text

Computational Models Exploring the Role of Flexibility in Binding Tat Peptide to TAR RNA

10.31979/etd.9vhc-z853 ◽

2018 ◽

Author(s):

Thanh Quoc Le

Keyword(s):

Computational Models ◽

Tat Peptide ◽

Tar Rna

Download Full-text

Functional Assessment of the Role of BORIS in Ovarian Cancer Using a Novel In Vivo Model System

10.21236/ada598204 ◽

2013 ◽

Author(s):

Adam R. Karpf ◽

Michael Higgins

Keyword(s):

Ovarian Cancer ◽

Functional Assessment ◽

Model System ◽

In Vivo Model

Download Full-text

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

Circulation ◽

10.1161/01.cir.96.9.3180 ◽

1997 ◽

Vol 96 (9) ◽

pp. 3180-3191 ◽

Cited By ~ 157

Author(s):

Peter Carmeliet ◽

Lieve Moons ◽

Roger Lijnen ◽

Stefaan Janssens ◽

Florea Lupu ◽

...

Keyword(s):

Wound Healing ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Neointima Formation ◽

Plasminogen Activator Inhibitor 1 ◽

Inhibitory Role ◽

Activator Inhibitor

Download Full-text

Regulation of Rho GTPases by RhoGDIs in Human Cancers

Cells ◽

10.3390/cells8091037 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1037 ◽

Cited By ~ 6

Author(s):

Cho ◽

Kim ◽

Baek ◽

Kim ◽

Lee

Keyword(s):

Cell Migration ◽

Cancer Progression ◽

Anticancer Agents ◽

Rho Gtpases ◽

Rho Gtpase ◽

Regulatory Mechanisms ◽

Malignant Phenotype ◽

Cellular Processes ◽

Human Cancers

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The expression of RhoGDIs has changed in many human cancers and become associated with the malignant phenotype, including migration, invasion, metastasis, and resistance to anticancer agents. Here, we review how RhoGDIs control the function of Rho GTPases by regulating their spatiotemporal activity and describe the regulatory mechanisms of the dissociation of Rho GTPases from RhoGDIs. We also discuss the role of RhoGDIs in cancer progression and their potential uses for therapeutic intervention.

Download Full-text