scholarly journals In vitro Antibacterial Activity of Doripenem against Gram-Negative Blood Isolates in a Korean Tertiary Care Center

2015 ◽  
Vol 47 (3) ◽  
pp. 175 ◽  
Author(s):  
Seong-Ho Choi ◽  
Mi Young Ahn ◽  
Jin-Won Chung ◽  
Mi-Kyung Lee
Keyword(s):  
Antibacterial Activity ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Gram Negative ◽  
In Vitro Antibacterial Activity

scholarly journals Chemical Composition and in Vitro Antibacterial Activity of the Essential Oil of Minthostachys Mollis (Kunth) Griseb Vaught from the Venezuelan Andes

2009 ◽  
Vol 4 (7) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Flor D. Mora ◽  
María Araque ◽  
Luis B. Rojas ◽  
Rosslyn Ramírez ◽  
Bladimiro Silva ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Salmonella Typhi ◽  
Inhibitory Effect ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Significant Inhibitory Effect ◽  
In Vitro Antibacterial Activity

Chemical constituents of the essential oil from the leaves of Minthostachys mollis (Kunth) Griseb Vaught var. mollis collected in January 2008 at Tuñame, Trujillo State, Venezuela, were separated and identified by GCMS analysis. The essential oil was obtained by hydrodistillation and thirteen components (98.5% of the sample) were identified by comparison with the Wiley GCMS library data base. The two major components were pulegone (55.2%) and trans-menthone (31.5%). The essential oil showed a significant inhibitory effect against Gram-positive and Gram-negative bacteria, especially Bacillus subtilis and Salmonella typhi (4 μg/mL).

scholarly journals Microwave Mediated Synthesis of Novel 1,3,5-Triazine Derivative and their Biological Evaluation

2021 ◽  
Vol 3 (12) ◽  
pp. 181-185
Author(s):  
Krishn Kumar Barmase ◽  
Deepak Basedia ◽  
Balkrishna Dubey
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Effect ◽  
Bacterial Species ◽  
Biological Evaluation ◽  
Chloride Ions ◽  
Gram Negative ◽  
Triazine Derivative ◽  
Triazine Derivatives ◽  
In Vitro Antibacterial Activity

1,3,5-Triazine derivative are synthesized by replacement of chloride ions of Cyanuric chloride and 1,3,5-Triazine derivative are showing promising biologically activity such as Antibacterial, Antifungal, Antimalarial, Antivirus, Anticancer that’s why interest of researches on synthesis of 1,3,5-Triazine derivatives always in focused. The present study reported the synthesis of 2,4,6-Trisubstituted 1,3,5-Triazine derivatives by Microwave mediated Method which gave the desired result in less time with higher yield. The structure of 1,3,5-Triazine derivatives have been elucidated by Spectral of IR, NMR and MASS. The derivative of 1,3,5-Triazine are evaluated for their In vitro Antibacterial activity against Gram Positive and Gram Negative Bacterial species and shown good Antibacterial effect.

scholarly journals Prevalence of Colistin-resistant Gram-negative Isolates Carrying the mcr-1 Gene among Patients Visiting a Tertiary Care Center

2020 ◽  
Vol 58 (232) ◽  
Author(s):  
Ashmita Paudel ◽  
Surya Prasad Devkota ◽  
Anima Shrestha ◽  
Anil Kumar Shah
Keyword(s):  
Confidence Interval ◽  
Binary Data ◽  
Care Center ◽  
Tertiary Care ◽  
Point Estimate ◽  
Drug Resistant ◽  
Tertiary Care Center ◽  
Colistin Resistance ◽  
Cross Sectional ◽  
Gram Negative

Introduction: Gram-negative isolates harboring mobilized colistin resistance (mcr-1) gene are a great threat to human health. They have been reported worldwide among various bacterial isolates. This work aimed to study the prevalence of colistin resistance among Gram-negative bacteria and the incidence of mcr-1 gene among these isolates. Methods: A descriptive cross-sectional study was done at a tertiary care center from June 2016 to February 2017. An ethical approval was taken from review board of the Nepal Health Research Council (Reg. no: 274/2016). Convenience sampling was used. The data was collected and analyzed using Microsoft Excel 2010 and Statistical Package for Social Sciences (SPSS) Version 16 . Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Among 485 gram-negative isolates, only 13 (2.68%) (1.26-6.62 at 95% Confidence Interval) isolates were colistin-resistant and mcr-1 was present in two isolates. Predominant colistin-resistant isolates were E. coli 6 (4.1%), Enterobacter spp 2 (2.81%), and Acinetobacter spp 2 (2.81%). A high level of colistin-resistance was noted in 4 (30.7%) isolates as indicated by the very high value of colistin MIC (>256 µg/ml). ICU was the major site of isolation of colistin-resistant and mcr-1 positive pathogens. The majority of colistin-resistant isolates were highly drug-resistant and were sensitive only to polymyxin B. Antibiotics like imipenem, amikacin, gentamicin, aztreonam, ciprofloxacin, and piperacillin-tazobactam were effective for few of these isolates. Conclusions: Though the prevalence of mcr-1 gene was low among colistin-resistant gram-negative isolates, the resistant pattern was quite alarming as these isolates were highly drug-resistant.

scholarly journals Awareness of Periodontal Diseases and its associated Adverse Pregnancy Outcomes among Pregnant Women attending a Tertiary Care Center

2021 ◽  
Vol 17 (3) ◽  
pp. 213-219
Author(s):  
Junima Rajkarnikar ◽  
Samriddhi Vaidya ◽  
Jemish Acharya
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Dental Treatment ◽  
Periodontal Diseases ◽  
Care Center ◽  
Tertiary Care ◽  
Adverse Pregnancy Outcomes ◽  
Tertiary Care Center ◽  
Gram Negative ◽  
Adverse Pregnancy

Introduction: Periodontal diseases are associated with high levels of gram-negative periodontal pathogens that apparently increase abundantly in the presence of pregnancy-associated hormones. Endotoxins from gram-negative bacteria enter the circulation at high levels to stimulate the production of inflammatory mediators, such as prostaglandins and other inflammatory mediators which are potent inducers of labor. The present study was conducted to assess oral health awareness and experience among pregnant women attending a tertiary care hospital. Methods: A cross-sectional study was conducted in 167 pregnant women visiting a tertiary care center using self- administered structured questionnaire consisting of questions related to knowledge and awareness regarding periodontal diseases and its possible associated adverse pregnancy outcomes. Results: Of the total participants, 55.7% said that they did not think gum disease can have adverse pregnancy outcomes. Only 35.9% had, at some point, consulted a dentist for bleeding gums and 36.5% of them had gingival enlargement during pregnancy but 46.1% said that they should wait for the delivery before they could do any dental treatment. Also, 40.1% did not know the safe trimester to undergo dental treatment and only 20.4% said the second trimester was the safest to undergo any dental procedure. Conclusions: The study showed that awareness and knowledge of periodontal health among pregnant women was not satisfactory. Keywords: Awareness; adverse pregnancy; periodontal disease; pregnancy outcomes.

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