Research of the True Flow with High Polymers as a Critical Process Parameter

2014 ◽  
Vol 490-491 ◽  
pp. 34-37
Author(s):  
Xian Wei Wang ◽  
Guang Liang Cheng

In this article should be noted that the accuracy of determining the viscosity of the flow is particularly low in the highly elastic with state of the polymer. It is therefore very important to identity the viscosity of the flow, which has great practical significance. solidity can be changed as a result of intermolecular interaction which can be observed in the process of polymer swelling, which means improving its chain flexibility and lowering the temperature of vitrifying. It should be noted that the processing of the experiment showed no pronounced dependence of the voltage, so it is under-read as the average results for all levers of the stress at a fixed temperature. Processed a method for determining the viscosity of polymer materials, which allows you to divide segmental strength and toughness of the true flow.

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (10) ◽  
pp. 42-50
Author(s):  
Hemant S. Kandle ◽  
Sangram S. Patil ◽  
Sujata S. Sawant ◽  
Ganesh B. Vambhurkar ◽  
Asha M. Jagtap ◽  
...  

Allopurinol USP batches of same size, method, equipment and validation criterion were taken. The critical process parameter involved were reaction, drying, milling, sifting, milling, and blending stages were validation. Quality cannot be assured by daily quality control testing because of the limitations of statistical samples, and the limited facilities of finished product testing. Validation checks the accuracy and reliability of process. Aim of this work was to study prospective process validation of allopurinol USP designed to meet the current regulatory requirements and prove with assurance that the product meets the predetermined specifications and quality attributes. The critical process parameter was identified with the help of process capability and evaluated by challenging its in house and compendial specification. Three initial process validations batches APL/008, APL/009 and APL/010 were identified and evaluated as per validation master plan. The outcome indicated that this process validation data provides high degree of assurance so that manufacturing process produces a quality product.


Author(s):  
Shouichi Hosaka ◽  
Masaki Yamazawa ◽  
Yoshiteru Takahashi

Objective: Bitter taste-masked drug substance should be needed for the development of orally disintegrating tablets (ODT). We selected a new type of a complex fluidized-bed granulator equipped with a particle-sizing mechanism for treating famotidine (FAM). This study was conducted to demonstrate the critical process parameter, which controls particle size of treated FAM, to determine its acceptable particle size considering uniformity of assay and to perform scale-up study from a laboratory scale to a commercial scale.Methods: Particle size of treated FAM was evaluated by changing spraying air pressure on the operation of a complex fluidized-bed granulator. Uniformity of assay in granules after blending and tablets were compared at different particle size of treated FAM. On the scale-up study, particle size and assay of treated FAM in both scales were evaluated.Results: The particle size of treated FAM decreased as the increase in spraying air pressure in relation to the spraying mist size. Better uniformity of assay was observed when the diameter of treated FAM was 20 µm compared to that of 50 µm. Therefore, target particle size of treated FAM was set at approximately 20 µm. Similar qualities could be obtained between both scales in the points of particle size and assay.Conclusion: On the operation of a complex fluidized-bed granulator, spraying air pressure was the critical process parameter that controlled particle size of treated FAM. On Scale-up study of treated FAM, spraying air pressure in relation to the spraying mist size was important.


2009 ◽  
Vol 102 (1) ◽  
pp. 161-167 ◽  
Author(s):  
Mathieu Streefland ◽  
Bas van de Waterbeemd ◽  
Joeri Kint ◽  
Leo A. van der Pol ◽  
E. Coen Beuvery ◽  
...  

Cytotherapy ◽  
2019 ◽  
Vol 21 (12) ◽  
pp. 1216-1233 ◽  
Author(s):  
Katherine N. MacDonald ◽  
Sabine Ivison ◽  
Keli L. Hippen ◽  
Romy E. Hoeppli ◽  
Michael Hall ◽  
...  

1959 ◽  
Vol 32 (3) ◽  
pp. 915-939
Author(s):  
D. Bulgin ◽  
G. D. Hubbard

Abstract Rubberlike polymeric materials, particularly in the technical form when compounded with carbon black, are imperfectly elastic and the associated energy loss is of considerable practical significance. In some applications a high energy loss is of value to provide high damping, but in many cases and particularly in tires, the temperature rise due to the losses may be a limiting operational factor. The losses cause the tire to exhibit rolling resistance which, in the case of solid tires, can be related accurately to the modulus and resilience of the rubber. An analysis of this system has been carried out by Evans, while Tabor has considered the case of rigid cylinders and spheres rolling on flexible rubber surfaces. In the case of pneumatic tires the composite nature of the construction of fabric and rubber and the complex system of strain distribution make the calculation of rolling resistance from polymer properties extremely complicated. In order to approach this problem it is necessary to know the modulus and resilience of the materials used over a very wide range of temperature and a range of amplitude of deformation and of frequency. The required temperature range may be from −60° C to above 200° C, but the frequency range over which appreciable amplitudes are involved does not extend beyond approximately a thousand cycles per second while the amplitude of deformation does not exceed 50 per cent. In order to investigate adequately the many possible combinations of polymers and compounding systems, the values of resilience and modulus are required over the above range of conditions, and various instruments have been described which measure some or all of these properties. The rebound pendulum was one of the earliest instruments and is widely used for the measurement of resilience because of its inherent simplicity of operation and high accuracy, but as normally operated at a fixed temperature does not provide sufficient information for evaluation of materials for use in tires. This type of instrument also is not well suited for determination of modulus owing to its single cycle method of operation. The vibrator type instruments give more complete information but normally demand a high degree of skill in their operation and in the interpretation of results and are more suited to research than routine work.


2020 ◽  
pp. 3-14
Author(s):  
Igor Smyrnov

The aim of the study. Theoretical substantiation and practical application of the geologistical approach to the development and functioning of cruise tourism in the conditions of COVID-19 coronavirus pandemic crisis. Research methodology. It is based on a comprehensive approach to supply chain optimization in the cruise business, which includes three components - the theory of logistics strategies by A. Bask, the model of supply chain flexibility by M. Naim and the P. Kralich matrix, which determines the structure of the supply chain, which is needed to ensure flexibility and implementation of an effective logistics strategy in the management of cruise tourism in the crisis associated with the pandemic coronary virus COVID-19. Results of the research. A strategy for optimizing supply chains in cruise tourism and its practical application in the context of the crisis associated with the COVID-19 coronary virus pandemic has been developed. Scientific novelty. For the first time in Ukraine, a comprehensive approach to optimizing the logistics of cruise tourism is proposed, which is based on the use of the theory of logistics strategies by A. Bask, the model of supply chain flexibility by M. Naim and the P. Kralich matrix, which defines a certain supply chain structure implementation of an effective logistics strategy in the management of cruise tourism in the crisis associated with the pandemic coronary virus COVID-19. Practical significance. It consists in the development and practical application of the theoretical basis of the logistics strategy for the development of cruise tourism in the crisis associated with the conovanvirus pandemic COVID-19. As a practical result, it can be argued that the logistics strategy of the cruise company should be customized to the needs of the cruise business and the needs of different categories of cruise tourists, and therefore should be quite flexible. Internal and external flexibility of cruise logistics is observed at the level of cruise ship types, transport hub, communication, power, route and communication, as well as mix (complex), volume and availability, respectively. Thus, the flexibility of cruise logistics is greater in the internal dimension than in the external, which explains the concentration of the cruise company, primarily on the maximum satisfaction of the needs of cruise tourists than just a sea (river) jorney. In turn, the Kralich matrix determines the importance of different groups of product positions in the logistics (supply) of a cruise company by dividing them into strategic, basic, critical and non-critical groups based on the ratio of their impact on company profits and the degree of logistics risk. The most important is a group of strategic product positions with a very high impact on profits and the same degree of logistical risk. This includes the services of travel agencies, bus companies, insurance companies and classification societies. Their importance is so great that cruise companies are encouraged to maintain long-term relationships with them for the sake of close cooperation and coordination, which will ensure the minimization of misunderstandings and mistakes and maximization of tourist satisfaction and the company's profits. On the opposite side is a group of non-critical product items (hotel products, food and beverages, fuel and tools). They are characterized by low logistics risk (there are many suppliers, it is not a problem to replace them) and a weak impact on the profits of the cruise company, which does not diminish their importance in the daily service of cruise tourists and meeting their requirements.


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