Synthesis of Ionic Liquids [BMIM]BF4 and [BMIM]PF6 under Microwave Irradiation by One-Pot

2012 ◽  
Vol 496 ◽  
pp. 84-87
Author(s):  
Xi Gang Du ◽  
Jin Ping Du ◽  
Jun Zhang ◽  
Xu Ming Guo ◽  
Wei Wei Lu ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Microwave Heating ◽  
Good Method ◽  
Molar Ratio ◽  
Reaction Yield ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Sodium Tetrafluoroborate

Ionic liquids 1-brutyl-3-methylimidazolium Tetrafluoroborate [BMIM]BF4 and 1-brutyl-3-methylimidazolium hexafluorophosphate [BMIM]PF6 were synthesized directly from 1-butylbromide, 1-methylimidazole, sodium tetrafluoroborate or hexafluorophosphate using microwave by one-pot under solvent-free conditions in an unmodified household oven. This method requires only a few minutes of reaction time, in contrast to the several hours needed using conventional methods by two pots that requires a lot of organic solvent. The reaction yield of ionic liquids with intermittent microwave heating is much higher than that of ionic liquids with conventional microwave heating. Thus the intermittent microwave heating is a good method for the reaction. The yield of the two ionic liquids increased slightly with increment of molar ratio of sodium tetrafluoroborate or potassium hexafluorophosphate.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

scholarly journals Tandem Fries Reaction–Conjugate Addition under Microwave Irradiation in Dry Media; One-pot Synthesis of Flavanones

1999 ◽  
Vol 23 (9) ◽  
pp. 574-575
Author(s):  
Firouz Matloubi Moghaddam ◽  
Mohammad Ghaffarzadeh ◽  
Seyed Hossein Abdi-Oskoui
Keyword(s):  
Microwave Irradiation ◽  
Silica Gel ◽  
Conjugate Addition ◽  
Solvent Free ◽  
Naphthalene Derivatives ◽  
One Pot ◽  
Fries Rearrangement ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Fries Reaction

An AICl3–ZnCl2 mixture supported on silica gel is found to be an efficient medium for the Fries rearrangement of acyloxybenzene or naphthalene derivatives in solvent-free conditions under microwave irradiation.

scholarly journals TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

RSC Advances ◽  
2021 ◽  
Vol 11 (45) ◽  
pp. 28061-28071
Author(s):  
Kesatebrhan Haile Asressu ◽  
Chieh-Kai Chan ◽  
Cheng-Chung Wang
Keyword(s):  
Microwave Irradiation ◽  
Nitrogen Source ◽  
Microwave Heating ◽  
Solvent Free ◽  
Solvent Free Conditions

Trisubstituted imidazoles are synthesized efficiently from the readily available 1,2-diketones and aldehydes using hexamethyldisilazane as a new and stable nitrogen source under TMSOTf-catalysis system, microwave heating and solvent-free conditions.

Heterogeneous Microwave Irradiation Biodiesel Processing of Jatropha Oil

2014 ◽  
Vol 554 ◽  
pp. 500-504 ◽  
Author(s):  
Farid Nasir Ani ◽  
Ahmed Bakheit Elhameed
Keyword(s):  
Reaction Time ◽  
Methyl Ester ◽  
Microwave Irradiation ◽  
Calcium Oxide ◽  
Production Cost ◽  
Catalyst Concentration ◽  
Molar Ratio ◽  
Biodiesel Fuel ◽  
Jatropha Oil ◽  
Reaction Parameters

This paper investigated the three critical reaction parameters including catalyst concentration, microwave exit power and reaction time for the transesterification process of jatropha curcas oil using microwave irradiation. The work is an attempt to reduce the production cost of biodiesel. Similar quantities of methanol to oil molar ratio 6:1 and calcium oxide as a heterogeneous catalyst were used. The results showed that the best yield percentage 96% was obtained using 300W microwave exit power, 8 %wt CaO and 7 min. The methyl ester FAME obtained was within the standard of biodiesel fuel.

scholarly journals Synthesis of Medicinally Important Indole Derivatives: A Review

2021 ◽  
Vol 15 (1) ◽  
pp. 1-16
Author(s):  
Deeptanu Sarkar ◽  
Andleeb Amin ◽  
Tanzeela Qadir ◽  
Praveen K. Sharma
Keyword(s):  
Ionic Liquids ◽  
Microwave Irradiation ◽  
Functional Group ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Indole Derivatives ◽  
Site Specific ◽  
Bioactive Natural Products ◽  
Solvent Free Conditions

Indoles constitute a widely occurring functional group in nature and are present in an extensive number of bioactive natural products and medicinally important compounds. As a result, exponential increases in the development of novel methods for the formation of indole core along with site-specific indoles have been established. Conventional methods for the synthesis of indoles are getting replaced with green methods involving ionic liquids, water as a solvent, solid acid catalyst, microwave irradiation and the use of nanoparticles under solvent-free conditions. In addition, there are immense applications of the substituted indoles in diverse fields.

scholarly journals An Efficient and Green Synthesis of Fluorine Containing Benzo[a]xanthen-11(12H)-ones and Evaluation of their Anticancer Activity

2020 ◽  
Vol 32 (4) ◽  
pp. 923-929
Author(s):  
J. Sumalatha ◽  
A. Sreedevi ◽  
C. Radha Rani
Keyword(s):  
Mass Spectrometry ◽  
Reaction Time ◽  
Anticancer Activity ◽  
Low Cost ◽  
The Other ◽  
Significant Activity ◽  
One Pot ◽  
Efficient Procedure ◽  
Solvent Free Conditions ◽  
One Pot Condensation

A facile and an efficient procedure has been developed by one-pot condensation of naphthalene-diols, fluoro substituted benzaldehydes and cyclic 1,3-dicarbonyl compounds for the synthesis of fluorine containing benzo[a]xanthen-11(12H)-ones under the catalyst and solvent-free conditions. All the synthesized compounds were characterized by IR, NMR (1H & 13C) and mass spectrometry. Several advantages offer the present approach, such as, shorter reaction time, low cost, anticipation of toxic solvents and catalyst, higher yield of products and durability of substrate range. On the other hand, anticancer activity was also performed for the title compounds which demonstrated a significant activity on selected cancer cell lines.

A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-d]Pyrimidine-Triones under Microwave Irradiation

2018 ◽  
Vol 42 (12) ◽  
pp. 604-607
Author(s):  
Loghman Firoozpour ◽  
Hoda Yahyavi ◽  
Ramona Ejtemaei ◽  
Setareh Moghimi ◽  
Alireza Foroumadi
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Barbituric Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
Solvent Free Synthesis

A green and efficient method for preparing novel heterocyclic systems is established through the reaction of differently substituted benzaldehydes, barbituric acid and 4-amino-2H-chromene-2-one under solvent-free conditions. This method affords 6H-chromeno[3’,4’:5,6] pyrido[2,3-d]pyrimidine-trione derivatives in high yields and short reaction times.

Lewis Acid Promoted, One-Pot Synthesis of Fluoroquinolone Clubbed 1,3,4-Thiadiazole Motifs under Microwave Irradiation: Their Biological Activities

2020 ◽  
Vol 7 (1) ◽  
pp. 60-66
Author(s):  
Navin B. Patel ◽  
Rahul B. Parmar ◽  
Hetal I. Soni
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Lewis Acid ◽  
Acid Catalyst ◽  
Antitubercular Activity ◽  
Biologically Active ◽  
High Yield ◽  
One Pot ◽  
One Pot Synthesis ◽  
Lewis Acid Catalyst

Background: A Lewis acid promoted efficient and facile procedure for one-pot synthesis of a novel series of fluoroquinolone clubbed with thiadiazoles motifs under microwave irradiation is described here. This technique has more advantages such as high yield, a clean procedure, low reaction time, simple work-up and use of Lewis acid catalyst. Objective: Our aim is to generate a biologically active 1,3,4- thiadiazole ring system by using a onepot synthesis method and microwave-assisted heating. High yield and low reaction time were the main purposes to synthesize bioactive fluoroquinolone clubbed 1,3,4- thiadiazole moiety. Methods: Fluoroquinolone Clubbed 1,3,4-Thiadiazole Motifs was prepared by Lewis acid promoted, one-pot synthesis, under microwave irradiation. All the synthesized molecules were determined by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial activity of synthesized compounds was examined against two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the MIC (Minimal Inhibitory Concentration) method and antitubercular activity H37Rv using L. J. Slope Method. Results: Lewis acid promoted, one-pot synthesis of Fluoroquinolone clubbed 1,3,4-Thiadiazole motifs under microwave irradiation is an extremely beneficial method because of its low reaction time and good yield. Some of these novel derivatives showed moderate to good in vitro antibacterial, antifungal, and antitubercular activity. Conclusion: One-pot synthesis of 1,3,4-Thiadiazole by using Lewis acid catalyst gives a good result for saving time and also getting more production of novel heterocyclic compounds with good antimicrobial properties via microwave heating method.

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