Thermodynamic Study of Formation of Amorphous ß-Tricalcium Phosphate for Calcium Phosphate Cements

2003 ◽  
Vol 254-256 ◽  
pp. 249-252 ◽  
Author(s):  
Uwe Gbureck ◽  
J.E. Barralet ◽  
R. Thull
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Thermodynamic Study ◽  
Calcium Phosphate Cements

Synthesis of Alpha-Tricalcium Phosphate by Wet Reaction and Evaluation of Mechanical Properties

2012 ◽  
Vol 727-728 ◽  
pp. 1164-1169 ◽  
Author(s):  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Juliana Machado Fernandes ◽  
Wilbur Trajano Guerin Coelho ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Nitrate ◽  
Chemical Precipitation ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calcium Phosphate Cements

Calcium phosphate cements have bioactivity and osteoconductivity and can be molded and replace portions of bone tissue. The aim of this work was to study the obtainment of α-tricalcium phosphate, the main phase of calcium phosphate cement, by wet reaction from calcium nitrate and phosphoric acid. There are no reports about α-tricalcium phosphate obtained by this method. Two routes of chemical precipitation were evaluated and the use of two calcinations temperatures to obtain the phase of cement. The influence of calcination temperature on the mechanical properties of cement was evaluated. Cement samples were characterized by particle size analysis, X-ray diffraction, mechanical strength and scanning electron microscopy. The results demonstrate the strong influence of synthesis route on the crystalline phases of cement and the influence of concentration of reactants on the product of the reaction, as well as, on the mechanical properties of cement.

Processing and in vivo evaluation of multiphasic calcium phosphate cements with dual tricalcium phosphate phases

2012 ◽  
Vol 8 (9) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Matilde Bongio ◽  
Marc Bohner ◽  
Vincent Cuijpers ◽  
Louis A.J.A. Winnubst ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Cements

scholarly journals Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres

2020 ◽  
Vol 21 (11) ◽  
pp. 3745
Author(s):  
Michiyo Honda ◽  
Yusuke Kawanobe ◽  
Kohei Nagata ◽  
Ken Ishii ◽  
Morio Matsumoto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bacterial Adhesion ◽  
Inflammatory Responses ◽  
Spray Pyrolysis Technique ◽  
Biological Properties ◽  
Histological Evaluation ◽  
Bone Apposition ◽  
Calcium Phosphate Cements

Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Silver-containing tricalcium phosphate (Ag-TCP) microspheres consisting of α/β-TCP phases were synthesized by an ultrasonic spray-pyrolysis technique. The powders prepared were mixed with the setting liquid to fabricate the CPCs. The resulting cements consisting of β-TCP and hydroxyapatite had a porous structure and wash-out resistance. Additionally, silver and calcium ions could be released into the culture medium from Ag-TCP cements for a long time accompanied by the dissolution of TCP. These data showed the bioresorbability of the Ag-TCP cement. In vitro antibacterial evaluation demonstrated that both released and immobilized silver suppressed the growth of bacteria and prevented bacterial adhesion to the surface of CPCs. Furthermore, histological evaluation by implantation of Ag-TCP cements into rabbit tibiae exhibited abundant bone apposition on the cement without inflammatory responses. These results showed that Ag-TCP cement has a good antibacterial property and good biocompatibility. The present Ag-TCP cements are promising for bone tissue engineering and may be used as antibacterial biomaterials.

Foamed β-Tricalcium Phosphate Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 323-326 ◽  
Author(s):  
Edgar Benjamin Montufar ◽  
C. Gil ◽  
Tania Traykova ◽  
M.P. Ginebra ◽  
Josep A. Planell
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Initial Material ◽  
Sintering Process ◽  
Bioactive Material ◽  
Bioactive Scaffolds ◽  
Calcium Phosphate Cements ◽  
Beta Tricalcium Phosphate ◽  
Nanometric Range

The design and processing of 3D macroporous bioactive scaffolds is one of the milestones for the progress of bone tissue engineering and bone regeneration. Calcium phosphate based ceramics are among the most suitable materials, due to their similarity to the bone mineral. Specifically, beta-tricalcium phosphate (β-TCP) is known to be a resorbable and bioactive material, with well established applications as bone regeneration material. The aim of this work is to explore a new route to obtain β-TCP macroporous scaffolds starting from calcium phosphate cements. To this end foamed calcium phosphate cement, composed of alpha tricalcium phosphate as starting powder was used as initial material. The set foamed structures, made of calcium deficient hydroxyapatite (CDHA) were sintered to obtain the final β-TCP macroporous architecture. The interconnected macroporosity was maintained, whereas the porosity in the nanometric range was strongly reduced by the sintering process. The sintering produced also an increase in the mechanical properties of the scaffold.

Evaluation of α-Tricalcium Phosphate Cement Obtained at Different Temperatures

2012 ◽  
Vol 727-728 ◽  
pp. 1187-1192 ◽  
Author(s):  
Rafaela Silveira Vieira ◽  
Wilbur Trajano Guerin Coelho ◽  
Mônica Beatriz Thürmer ◽  
Juliana Machado Fernandes ◽  
Luis Alberto Santos
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Calcium Pyrophosphate ◽  
In Vitro Test ◽  
Calcium Phosphate Cements ◽  
Similar Chemical ◽  
Different Temperatures ◽  
Vitro Test

The calcium phosphate cements (CPCs) based on α-tricalcium phosphate (α-TCP) are highly attractive for use in medicine and odontology, since they have similar chemical and phase composition of mineral phase of bones (calcium deficient hydroxyapatite (CDHA)). However, one of the biggest difficulties for use of this type of cement is its low mechanical strength due to the presence of undesirable phases, such as β-tricalcium phosphate. The route for obtaining α-TCP is at high temperature by solid state reaction, mixing calcium carbonate and calcium pyrophosphate. The aim of this work was to obtain calcium phosphate cements with improved strength, by studying the obtaining of α-TCP at temperatures of 1300, 1400 and 1500°C. The samples were analyzed by crystalline phases, pH, setting time, particle size, in vitro test (Simulated Body Fluid), porosity, density and compressive strength. The results show that the synthesis temperatures influence strongly the phases of powders obtained and the mechanical properties of cement, being unnecessary quenching for obtaining pure α-TCP.

Strontium-Substituted Calcium Phosphate Cements Prepared with Strontium-Containing Solutions

2007 ◽  
Vol 330-332 ◽  
pp. 795-798 ◽  
Author(s):  
Emi Fujihara ◽  
Masayuki Kon ◽  
Kenzo Asaoka
Keyword(s):  
Calcium Phosphate ◽  
Chemical Shift ◽  
Pharmacological Activity ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Physiological Saline ◽  
High Solubility ◽  
Calcium Phosphate Cements ◽  
Xrd Patterns ◽  
Cacl2 Solution

The purpose of this study was to determine if a strontium (Sr)-containing mixing liquid could be used as an exchanging agent for calcium phosphate cement crystallized with Sr-replacing hydroxyapatite (Sr-HAP). Alpha-tricalcium phosphate (α-TCP) powder was mixed with Srcontaining and phosphorous (P)-containing solutions, that is, SrCl2 or SrCl2+CaCl2 solution and NaH2PO4 or Na2HPO4 solution. After storage in the incubator for 7 days, the α-TCP crystals in all set cements were confirmed to have been transformed to HAP crystals by the mixing liquids. The XRD patterns of the set cements implied that the Sr-HAP could be precipitated by using Srcontaining solutions as the mixing liquid because of the chemical shift of a peak (002) in XRD of the HAP crystal. The solubility (shaking immersion in physiological saline) of set cements containing Sr was markedly higher than that of set cement not containing Sr. These results revealed that the Sr-containing solutions used as mixing liquids for α-TCP cement acted as precipitating agents for Sr-HAP. Sr-HAP-precipitating cement could be useful because of its pharmacological activity with high solubility.

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