Five Years Clinical Follow Up Bone Regeneration with CaP Bioceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1339-1342 ◽  
Author(s):  
Clemencia Rodríguez ◽  
Alain Jean ◽  
Sylvia Mitja ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Ingrowth ◽  
X Ray ◽  
Dental Implantation ◽  
Preventive Method

To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone level after pathological diseases. Biphasic calcium phosphate (BCP), mixture of HA and ß-TCP, have proven its performance in orthopaedic, while few studies have been reported in dentistry. We reported 5 years clinical follow up on bone regeneration after immediate dental root filling. MBCP 60/40 and MBCP 20/80 are biphasic CaP intimate mixture of HA/TCP 60/40 and 20/80; with interconnected macroporosity and microporosity. Forty cases have been distributed in two groups for alveolar pocket filling. Seven cases without filling are used as control. X-Ray at 0, 3, 6, 12 months and 5 years follow up for some patients were performed. In all the 40 cases, radio-opacity of the implantation area decreases on time, indicating resorption and bone ingrowths at the expense of the two bioceramics. No difference in the resorption kinetics appeared on X-Ray. After 1 year, the implantation area looks as physiological bone and is maintained on time. The newly formed bone is preserved after 5 years contrarily to the controls cases (without filling)where we observed decrease of 2 to 5 mm. This study demonstrated that immediate filling of alveolar pocket after tooth extraction is a preventive method of the jaw bone resorption. After long term (other one year) resorption and bone ingrowth were demonstrated for both micro and macroporous biphasic calcium phosphate with two different HA/TCP ratio.

Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules

2013 ◽  
Vol 587 ◽  
pp. 321-324 ◽  
Author(s):  
Kim Chang Seong ◽  
Kim Sung Cho ◽  
Claire Daculsi ◽  
Elodie Seris ◽  
Daculsi Guy
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Orthopedic Procedures ◽  
Height Loss ◽  
Graft Material ◽  
X Rays ◽  
Dental Implantation ◽  
Sinus Grafting

Restoring alveolar bone following tooth extraction or pathological diseases is important, and recent efforts have been made to overcome the use of autografts during dental implantation. Although micro-macroporous biphasic calcium phosphate (MBCPTM) has performed well in orthopedic procedures, few studies have investigated its use in dentistry. Here, we report a greater than eight-year clinical follow-up of bone regeneration using MBCPTM after sinus grafting. MBCPTM technology is a unique mixture of hydroxyapatite and β-tricalcium phosphate, which displays both macroporosity and microporosity. A total of 25 patients (33 implantation sites) were evaluated by X-rays, and their pre-operative and immediate post-operative bone heights were measured. After approximately six months, dental implantation was performed. Subsequently, X rays were performed each year, and bone height was measured. In all cases, radio-opacity of the implantation area decreased with time, indicating resorption and bone ingrowth at the expense of the MBCPTM material. After one year, the implantation area had the appearance of physiological bone and <11% of height loss was observed. Strikingly, the newly formed bone was preserved after 78 years of follow-up, with only <14% of height loss recorded. We demonstrate that sinus grafting followed by dental implantation with a resorbable and bioactive synthetic bone graft material (MBCPTM technology) safely and efficiently supports dental implantation.

scholarly journals Integrated 3D Information for Custom-Made Bone Grafts: Focus on Biphasic Calcium Phosphate Bone Substitute Biomaterials

2020 ◽  
Vol 17 (14) ◽  
pp. 4931
Author(s):  
Alessandra Giuliani ◽  
Maria Laura Gatto ◽  
Luigi Gobbi ◽  
Francesco Guido Mangano ◽  
Carlo Mangano
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Sintering Temperature ◽  
Calcium Phosphates ◽  
Compressive Loading ◽  
Peak Temperature ◽  
X Ray Diffraction ◽  
X Ray ◽  
Custom Made

Purpose: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of β-Ca3(PO4)2 to α-Ca3(PO4)2. This analysis explored, in an innovative way, inferences and correlations between volumetric microstructure, mechanical properties, sintering temperature, and time at peak temperature in order to find the best sintering conditions for biphasic calcium phosphate composites grafted in severe alveolar bone defects. Methods: Sintered biphasic calcium phosphates (30%-hydroxyapatite/70%-tricalcium phosphate) were tested by microCT imaging for the 3D morphometric analysis, by compressive loading to find their mechanical parameters, and by X-ray diffraction to quantify the phases via Rietveld refinement for different sintering temperatures and times at the peak temperature. Data were analysed in terms of statistical inference using Pearson’s correlation coefficients. Results: All the studied scaffolds closely mimicked the alveolar organization of the jawbone, independently on the sintering temperatures and times; however, mechanical testing revealed that the group with peak temperature, which lasted for 2 hours at 1250 °C, showed the highest strength both at the ultimate point and at fracture point. Conclusion: The good mechanical performances of the group with peak temperature, which lasted for 2 hours at 1250 °C, is most likely due to the absence of the α-Ca3(PO4)2 phase, as revealed by X-ray diffraction. However, we detected its presence after sintering at the same peak temperature for longer times, showing the time-dependence, combined with the temperature-dependence, of the β-Ca3(PO4)2 to α-Ca3(PO4)2 transition.

Porous Biphasic Calcium Phosphate for Biomedical Application

2021 ◽  
Vol 49 ◽  
pp. 101-110
Author(s):  
Wafaa A. Hussain ◽  
Entessar H.A. Al-Mosawe ◽  
Mukhlis M. Ismail ◽  
Luay H. Alwan
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Pathogenic Bacteria ◽  
Biomedical Application ◽  
Bone Ingrowth ◽  
Physical And Mechanical Properties ◽  
Apparent Porosity ◽  
X Ray ◽  
Natural Bone ◽  
Fast Bone

Excellent osteoconductivity and resorbability achieved when porous bioceramics have highsurface area that providing fast bone ingrowth. Porous samples were fabricated by using biphasic calcium phosphate BCP (achieved from HA heat treated at 850 oC) with 10 and 20 wt% of ovalbumin binder powder and mixture of carrot fibers and ovalbumin powders (1:1) then dried at 60oC and fired at 1300 oC. Structural, physical and mechanical properties of the prepared porous bioceramic were determined involved X-ray diffraction, Fourier transform infrared spectroscopy FTIR, apparent porosity, water absorption, apparent solid density and compressive strength. The results of X-ray and FTIR showed that the heat treatment of HA was succeeded in forming biphasic calcium phosphate. The apparent porosity values increased with increasing of the binder and carrot fibers content and the growths density of bacteria on bioceramics are less than natural bone. The effect of pathogenic bacteria (Pseudomonas & Staphylococcus) that cause pollution on porous calcium phosphate and natural bone (Albino mice) has been studied.

Macroporous Biphasic Calcium Phosphate Bioceramics Wedges in High Tibial Osteotomy

2007 ◽  
Vol 361-363 ◽  
pp. 1319-1322
Author(s):  
Jean Louis Rouvillain ◽  
F. Lavallé ◽  
Hugues Pascal-Mousselard ◽  
Yves Catonné ◽  
Olivier Delattre ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Tibial Osteotomy ◽  
X Rays ◽  
Histological Data ◽  
Medial Gonarthrosis ◽  
One Year ◽  
Large Bone

In this study, we report human clinical and histological data on the use of micromacroporous biphasic calcium phosphate wedges in combination with osteosynthesis with adjustable screws for open tibial osteotomy. 42 patients were operated for open tibial osteotomy for valgisation due to incipient medial gonarthrosis. The population was composed of 43 knees (25 right knees and 18 left knees) in 13 women and 29 men, with a mean age of 46 years. Radiological follow-up at D+1, D+90 and D+360, and 12 biopsies for histology were processed after the removal of the osteosynthesis. Consolidation was obtained in 100 % of cases (except one, because of failure of the osteosynthesis). Regular bone ingrowth was observed on X-ray, with maintain of the corrections at one year in 98.5 % of cases. Only 8 % of cases showed a radiolucent interface after D+360. Histological examinations demonstrated resorption of the MBCP and large bone ingrowth. Polarised microscopy confirmed the lamellar bone, and the X-rays and microscanner revealed well mineralised and organised newly-formed bone.

scholarly journals Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

2017 ◽  
Vol 131 (3) ◽  
pp. 580-584 ◽  
Author(s):  
Z.A. Guclu ◽  
A.P. Hurt ◽  
L. Ohia ◽  
N.J. Coleman
Keyword(s):  
Bone Regeneration ◽  
Tooth Extraction ◽  
Alveolar Bone

Bone regeneration of multichannel biphasic calcium phosphate granules supplemented with hyaluronic acid

2019 ◽  
Vol 99 ◽  
pp. 1058-1066 ◽  
Author(s):  
Mirana Taz ◽  
Preeti Makkar ◽  
Khan Mohammad Imran ◽  
D.W. Jang ◽  
Yong-Sik Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate

scholarly journals Bone Loss around Dental Implants 5 Years after Implantation of Biphasic Calcium Phosphate (HAp/βTCP) Granules

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Vadims Klimecs ◽  
Alexanders Grishulonoks ◽  
Ilze Salma ◽  
Laura Neimane ◽  
Janis Locs ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Calcium Phosphate ◽  
Bone Loss ◽  
Dental Implants ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Clinical Situation ◽  
Cone Beam ◽  
Calcium Phosphate Ceramic ◽  
Middle Point

Biphasic calcium phosphate ceramic granules (0.5–1.0 mm) with a hydroxyapatite and β-tricalcium phosphate ratio of 90/10 were used. Biphasic calcium phosphate ceramic granules produced in the Riga Technical University, Riga Rudolph Cimdins Biomaterials Innovation and Development Centre, were used for filling the bone loss on 18 patients with peri-implantitis. After 5 years at the minimum, clinical and 3D cone-beam computed tomography control was done. Clinical situation confirmed good stability of implants without any signs of inflammation around. Radiodensity of the previous gap and alveolar bone horizontally from middle point of dental implants showed similar radiodensity as in normal alveolar bone. This trial is registered with ISRCTN13514478.

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