Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules

2013 ◽  
Vol 587 ◽  
pp. 321-324 ◽  
Author(s):  
Kim Chang Seong ◽  
Kim Sung Cho ◽  
Claire Daculsi ◽  
Elodie Seris ◽  
Daculsi Guy
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Orthopedic Procedures ◽  
Height Loss ◽  
Graft Material ◽  
X Rays ◽  
Dental Implantation ◽  
Sinus Grafting

Restoring alveolar bone following tooth extraction or pathological diseases is important, and recent efforts have been made to overcome the use of autografts during dental implantation. Although micro-macroporous biphasic calcium phosphate (MBCPTM) has performed well in orthopedic procedures, few studies have investigated its use in dentistry. Here, we report a greater than eight-year clinical follow-up of bone regeneration using MBCPTM after sinus grafting. MBCPTM technology is a unique mixture of hydroxyapatite and β-tricalcium phosphate, which displays both macroporosity and microporosity. A total of 25 patients (33 implantation sites) were evaluated by X-rays, and their pre-operative and immediate post-operative bone heights were measured. After approximately six months, dental implantation was performed. Subsequently, X rays were performed each year, and bone height was measured. In all cases, radio-opacity of the implantation area decreased with time, indicating resorption and bone ingrowth at the expense of the MBCPTM material. After one year, the implantation area had the appearance of physiological bone and <11% of height loss was observed. Strikingly, the newly formed bone was preserved after 78 years of follow-up, with only <14% of height loss recorded. We demonstrate that sinus grafting followed by dental implantation with a resorbable and bioactive synthetic bone graft material (MBCPTM technology) safely and efficiently supports dental implantation.

Five Years Clinical Follow Up Bone Regeneration with CaP Bioceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1339-1342 ◽  
Author(s):  
Clemencia Rodríguez ◽  
Alain Jean ◽  
Sylvia Mitja ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Ingrowth ◽  
X Ray ◽  
Dental Implantation ◽  
Preventive Method

To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone level after pathological diseases. Biphasic calcium phosphate (BCP), mixture of HA and ß-TCP, have proven its performance in orthopaedic, while few studies have been reported in dentistry. We reported 5 years clinical follow up on bone regeneration after immediate dental root filling. MBCP 60/40 and MBCP 20/80 are biphasic CaP intimate mixture of HA/TCP 60/40 and 20/80; with interconnected macroporosity and microporosity. Forty cases have been distributed in two groups for alveolar pocket filling. Seven cases without filling are used as control. X-Ray at 0, 3, 6, 12 months and 5 years follow up for some patients were performed. In all the 40 cases, radio-opacity of the implantation area decreases on time, indicating resorption and bone ingrowths at the expense of the two bioceramics. No difference in the resorption kinetics appeared on X-Ray. After 1 year, the implantation area looks as physiological bone and is maintained on time. The newly formed bone is preserved after 5 years contrarily to the controls cases (without filling)where we observed decrease of 2 to 5 mm. This study demonstrated that immediate filling of alveolar pocket after tooth extraction is a preventive method of the jaw bone resorption. After long term (other one year) resorption and bone ingrowth were demonstrated for both micro and macroporous biphasic calcium phosphate with two different HA/TCP ratio.

Macroporous Biphasic Calcium Phosphate Bioceramics Wedges in High Tibial Osteotomy

2007 ◽  
Vol 361-363 ◽  
pp. 1319-1322
Author(s):  
Jean Louis Rouvillain ◽  
F. Lavallé ◽  
Hugues Pascal-Mousselard ◽  
Yves Catonné ◽  
Olivier Delattre ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Tibial Osteotomy ◽  
X Rays ◽  
Histological Data ◽  
Medial Gonarthrosis ◽  
One Year ◽  
Large Bone

In this study, we report human clinical and histological data on the use of micromacroporous biphasic calcium phosphate wedges in combination with osteosynthesis with adjustable screws for open tibial osteotomy. 42 patients were operated for open tibial osteotomy for valgisation due to incipient medial gonarthrosis. The population was composed of 43 knees (25 right knees and 18 left knees) in 13 women and 29 men, with a mean age of 46 years. Radiological follow-up at D+1, D+90 and D+360, and 12 biopsies for histology were processed after the removal of the osteosynthesis. Consolidation was obtained in 100 % of cases (except one, because of failure of the osteosynthesis). Regular bone ingrowth was observed on X-ray, with maintain of the corrections at one year in 98.5 % of cases. Only 8 % of cases showed a radiolucent interface after D+360. Histological examinations demonstrated resorption of the MBCP and large bone ingrowth. Polarised microscopy confirmed the lamellar bone, and the X-rays and microscanner revealed well mineralised and organised newly-formed bone.

scholarly journals Bone Loss around Dental Implants 5 Years after Implantation of Biphasic Calcium Phosphate (HAp/βTCP) Granules

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Vadims Klimecs ◽  
Alexanders Grishulonoks ◽  
Ilze Salma ◽  
Laura Neimane ◽  
Janis Locs ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Calcium Phosphate ◽  
Bone Loss ◽  
Dental Implants ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Clinical Situation ◽  
Cone Beam ◽  
Calcium Phosphate Ceramic ◽  
Middle Point

Biphasic calcium phosphate ceramic granules (0.5–1.0 mm) with a hydroxyapatite and β-tricalcium phosphate ratio of 90/10 were used. Biphasic calcium phosphate ceramic granules produced in the Riga Technical University, Riga Rudolph Cimdins Biomaterials Innovation and Development Centre, were used for filling the bone loss on 18 patients with peri-implantitis. After 5 years at the minimum, clinical and 3D cone-beam computed tomography control was done. Clinical situation confirmed good stability of implants without any signs of inflammation around. Radiodensity of the previous gap and alveolar bone horizontally from middle point of dental implants showed similar radiodensity as in normal alveolar bone. This trial is registered with ISRCTN13514478.

Maxillary Sinus Grafting with Biphasic Calcium Phosphate Ceramics: Clinical and Histologic Evaluation in Man

2013 ◽  
Vol 28 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Carlo Mangano ◽  
Vittoria Perrotti ◽  
Jamil A. Shibli ◽  
Francesco Mangano ◽  
Laura Ricci ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Maxillary Sinus ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Histologic Evaluation ◽  
Sinus Grafting

Effect of Nano Biphasic Calcium Phosphate Bioceramics on Periodontal Regeneration in the Treatment of Alveolar Defects

2012 ◽  
Vol 486 ◽  
pp. 422-425 ◽  
Author(s):  
Lan Lei Wang ◽  
Ji Hua Li ◽  
Yong Tao Xie ◽  
Pi Shan Yang ◽  
Yun Mao Liao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Bone Defects ◽  
Beagle Dogs ◽  
Control Groups ◽  
Negative Controls ◽  
Osseous Defects ◽  
Positive Controls

The aim of the present study is to investigate the efficacy of nanobiphasic calcium phosphate (nanoBCP) bioceramic in the treatment of periodontal osseous defects. Alveolar bone defects were surgically created bilaterally at the buccal aspects of four second premolars in two beagle dogs. After root leveling, nanoBCP was randomly filled in one defect and nothing was put into the contralateral defect as negative controls. Bioglass was randomly filled in one of left defect as positive controls and nothing was put into the contralateral defect as negative controls. Dogs were killed at the 12th week. Histological observations were processed through a light microscopy. The results reveal that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups and bioglass groups while no new bone formed in the control groups at all. In this study, nanoBCP has proven to work well as a biocompatible and bioactive material to promote periodontal regeneration effectively.

scholarly journals Integrated 3D Information for Custom-Made Bone Grafts: Focus on Biphasic Calcium Phosphate Bone Substitute Biomaterials

2020 ◽  
Vol 17 (14) ◽  
pp. 4931
Author(s):  
Alessandra Giuliani ◽  
Maria Laura Gatto ◽  
Luigi Gobbi ◽  
Francesco Guido Mangano ◽  
Carlo Mangano
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Sintering Temperature ◽  
Calcium Phosphates ◽  
Compressive Loading ◽  
Peak Temperature ◽  
X Ray Diffraction ◽  
X Ray ◽  
Custom Made

Purpose: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of β-Ca3(PO4)2 to α-Ca3(PO4)2. This analysis explored, in an innovative way, inferences and correlations between volumetric microstructure, mechanical properties, sintering temperature, and time at peak temperature in order to find the best sintering conditions for biphasic calcium phosphate composites grafted in severe alveolar bone defects. Methods: Sintered biphasic calcium phosphates (30%-hydroxyapatite/70%-tricalcium phosphate) were tested by microCT imaging for the 3D morphometric analysis, by compressive loading to find their mechanical parameters, and by X-ray diffraction to quantify the phases via Rietveld refinement for different sintering temperatures and times at the peak temperature. Data were analysed in terms of statistical inference using Pearson’s correlation coefficients. Results: All the studied scaffolds closely mimicked the alveolar organization of the jawbone, independently on the sintering temperatures and times; however, mechanical testing revealed that the group with peak temperature, which lasted for 2 hours at 1250 °C, showed the highest strength both at the ultimate point and at fracture point. Conclusion: The good mechanical performances of the group with peak temperature, which lasted for 2 hours at 1250 °C, is most likely due to the absence of the α-Ca3(PO4)2 phase, as revealed by X-ray diffraction. However, we detected its presence after sintering at the same peak temperature for longer times, showing the time-dependence, combined with the temperature-dependence, of the β-Ca3(PO4)2 to α-Ca3(PO4)2 transition.

scholarly journals Minimally invasive treatment of tibial plateau depression fractures using balloon tibioplasty: Clinical outcome and absorption of bioabsorbable calcium phosphate cement

2020 ◽  
Vol 28 (1) ◽  
pp. 230949902090872 ◽  
Author(s):  
Felix Greimel ◽  
Markus Weber ◽  
Tobias Renkawitz ◽  
Florian Voellner ◽  
Thomas Freude ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Clinical Outcome ◽  
Calcium Phosphate Cement ◽  
Tibial Plateau ◽  
Articular Surface ◽  
Womac Score ◽  
Lateral View ◽  
X Rays ◽  
Invasive Treatment

The exact reconstruction of the tibial plateau and articular surface is the main operative aim in the treatment of tibial plateau depression fractures. For selected cases, a novel technique with the use of balloon tibioplasty in combination of bioabsorbable calcium phosphate cement is available. In this study, the first objective was to answer the question whether the clinical outcome parameters after balloon tibioplasty are comparable to open reduction procedures described in the literature. Secondly, we asked whether the cement absorption is safe in relation to adverse effects like osteolysis and measured the absorption ability during the bone conversion process in the proximal tibia bone. Eight patients (mean age 54 years; 4 males and 4 females) received the abovementioned surgical procedure. Mean follow-up period was 27 months. This study evaluated clinical outcome and radiological measured cement absorption within the postoperative course. Cement absorption was measured on X-rays and calculated based on the greatest extend on anterior–posterior and lateral view radiographs just after the operation on the latest available follow-up. WOMAC score showed a mean of 93. Radiologic absorption was 1/5 at a mean of 18 months. No osteolysis reaction was seen surrounding the cement. This far, promising clinical and radiological results have been shown with WOMAC scores comparable to the results of noninjured knees. The indication for this relatively new technique is restricted to isolated depression fractures. It is a useful tool to facilitate the reduction of select depressed tibial fractures. The radiologic absorption effect seems to be quite fast in bone remodeling and safe without any osteolysis or osseous reaction.

Characterization of Mesoporous Biphasic Calcium Phosphate Synthesized Using Chitosan and Aloe Vera Template

2021 ◽  
Vol 1028 ◽  
pp. 339-345
Author(s):  
Riesma Tasomara ◽  
Nendar Herdianto ◽  
Dwi Gustiono ◽  
Adita Wardani Rahmania ◽  
Hanan Hakim ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Functional Groups ◽  
Biphasic Calcium Phosphate ◽  
Aloe Vera ◽  
Mesoporous Structure ◽  
Precipitation Method ◽  
Size Analysis ◽  
Graft Material ◽  
Pore Size Analysis

Biphasic calcium phosphate (BCP) is a bonegraft material which is a mixture of hydroxyapatite (Ca10(PO4)6(OH)2, HA) and betatricalcium phosphate (Ca3(PO4)2, β-TCP). The combination of HA and β-TCP provides faster osseointegration, compared to HA, into parent bone so it can accelerate the bone recovery process. The mesoporous structure of bone graft material is suitable for drug delivery purpose. In order to study the mesoporous structure of BCP, the BCPs were prepared by precipitation method using chitosan, aloe vera, and chitosan-aloe vera hybrid as templates. A solution containing Ca(NO3)2·4H2O and template and a solution containing (NH4)2HPO4 and NH4HCO3 were used as starting materials. All prepared samples were calcined at 900°C for 1 hour. The identification of phases and functional groups of obtained BCP powders were characterized by X-Ray Diffraction technique and Fourier Transform Infrared (FTIR) spectroscopy, repectively. The XRD patterns show typical peaks of both HA and β-TCP crystal phases. FTIR spectra confirm the presence of phosphate functional groups. Morphological analysis using Scanning Electron Microscope (SEM) observed the presence of regular porous structure, however, the mesoporous structure was not seen. Particle size distribution and pore size analysis were analyzed by Particle Size Analyzer and Brunauer–Emmett–Teller (BET) method, respectively.

Implant Installation With Simultaneous Ridge Augmentation. Report of Three Cases

2011 ◽  
Vol 37 (5) ◽  
pp. 595-603 ◽  
Author(s):  
Jun-Beom Park
Keyword(s):  
Dental Implants ◽  
Alveolar Bone ◽  
Treatment Time ◽  
Clinical Results ◽  
Graft Material ◽  
Ridge Augmentation ◽  
Dental Implantation ◽  
Probing Depth ◽  
Staged Approach ◽  
Adequate Quantity

The anatomic limitations of the residual alveolar bone may cause problems for the insertion of dental implants because implant placement requires an adequate quantity and quality of bone. Ridge augmentation has been performed to reconstruct alveolar ridges as support for the placement of dental implants with a high success rate. However, a staged approach requires multiple surgeries and more treatment time. In this report, the patients were treated with dental implantation with simultaneous ridge augmentation in both submerged and nonsubmerged cases. The prostheses were well in function without any probing depth or gingival inflammation up to final evaluation. It may be suggested that dental implantation with simultaneous bone grafting may be an option when the graft material can be well stabilized around the implants. Further evaluations over long periods of time are needed to monitor the clinical results.

scholarly journals Synthesis and characterization of porous biphasic calcium phosphate scaffold from different porogens for possible bone tissue engineering applications

2011 ◽  
Vol 43 (2) ◽  
pp. 183-192 ◽  
Author(s):  
A. Amera ◽  
A.M.A. Abudalazez ◽  
Rashid Ismail ◽  
Abd Razak ◽  
Malik Masudi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Particle Size ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Room Temperature ◽  
Precipitation Method ◽  
X Rays ◽  
Controlled Porosity ◽  
Oval Shape

By using the wet precipitation method, Biphasic calcium phosphate granules were synthesized with Ca/P ratio1.52 and controlled porosity, pore size distribution, and granule size. Microporosity was then obtained by adjusting sintering temperature while macroporosity was prepared by adding 1:3 wt% ratio of two normally used porogens (naphthalene and sugar) and 2 newly introduced porogens (sago and lentil). Samples from each ratio were pressed into pellets and were fired at 500?C for 2 hours with 0.5?C/minute heating rate (for removal of porogens) and further sintered at 850?C for 2 hours with 5?C/minute before cooling down to room temperature. The granules were prepared by crushing and sieving BCP sintered pellets to get granules of sizes ranging from 250-500?m. X-rays diffraction (XRD), field emission scanning electron microscope (FESEM), particle size and porosity analyses were employed in order to characterize the granules. A round to oval shape pores with 200-400 ?m size were obtained and identical to the prepared porogens? particle size. This approach gives the desirable properties near to normal bone leading to a perfect osteogenesis for the purpose tissue engineering.

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