Heating Carve Technique for Polymer Microfluidic Microchannel

2012 ◽  
Vol 503 ◽  
pp. 103-107
Author(s):  
Xiao Wei Han ◽  
Wei Wang ◽  
G.H. Ye ◽  
Xiao Wei Liu ◽  
Li Tian ◽  
...  
Keyword(s):  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Mass Production ◽  
Hot Embossing ◽  
Direct Write ◽  
Microfluidic Chips ◽  
Movement Velocity ◽  
Laser Direct Write

A new manufacture mainly for polymethyl methacrylate (PMMA) microfluidic chips is presented in this paper. In this technique, polymer microfluidic microchannels were fabricated by microcutter which temperature is controlled and stabilized by PID methord. There are so many techniques, such as hot embossing, laser direct-write, for mass-production of polymer microfluidic chip. However, we may feel different kinds of shortages when we use these techniques. In this paper, the experiment result shows that microcutter’s movement velocity and temperature have effert on microfluidic microchannel’s roughness.

Design and Fabrication of Micro Hot Embossing Mold for Microfluidic Chip Used in Flow Cytometry

2007 ◽  
Vol 339 ◽  
pp. 246-251
Author(s):  
L.Q. Du ◽  
C. Liu ◽  
H.J. Liu ◽  
J. Qin ◽  
N. Li ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Microfluidic Chip ◽  
Low Cost ◽  
Hot Embossing ◽  
Microfluidic Chips ◽  
Metal Mold ◽  
Nickel Electroforming ◽  
Thick Photoresist ◽  
Nickel Base ◽  
Microfabrication Technology

Micro hot embossing mold of microfluidic chip used in flow cytometry is designed and microfabricated. After some kinds of microfabrication processes are tried, this paper presents a novel microfabrication technology of micro hot embossing metal mold. Micro metal mold is fabricated by low-cost UV-LIGA surface micro fabrication process using negative thick photoresist, SU-8. Different from other micro hot embossing molds, the micro mold with vertical sidewalls is fabricated by micro nickel electroforming directly on Nickel base. Based on the micro Nickel mold and automation fabrication system, high precision and mass-producing microfluidic chips have been fabricated and they have been used in flow cytometry

scholarly journals Prototyping and Production of Polymeric Microfluidic Chip

2021 ◽  
Author(s):  
Honggang Zhang ◽  
Haoyang Zhang ◽  
Tianyu Guan ◽  
Xiangyu Wang ◽  
Nan Zhang
Keyword(s):  
Microfluidic Chip ◽  
Mass Production ◽  
Microfluidic Chips ◽  
Important Research ◽  
Process Chain ◽  
Future Perspectives ◽  
End User ◽  
Research Findings ◽  
Manufacturing Technologies ◽  
Tooling Technology

Microfluidic chips have found many advanced applications in the areas of life science, analytical chemistry, agro-food analysis, and environmental detection. This chapter focuses on investigating the commonly used manufacturing technologies and process chain for the prototyping and mass production of microfluidic chips. The rapid prototyping technologies comprising of PDMS casting, micro machining, and 3D-printing are firstly detailed with some important research findings. Scaling up the production process chain for microfluidic chips are discussed and summarized with the perspectives of tooling technology, replication, and bonding technologies, where the primary working mechanism, technical advantages and limitations of each process method are presented. Finally, conclusions and future perspectives are given. Overall, this chapter demonstrates how to select the processing materials and methods to meet practical requirements for microfluidic chip batch production. It can provide significant guidance for end-user of microfluidic chip applications.

A Microfluidic Chip Microwave Bonding Method Based on the PMMA

2013 ◽  
Vol 562-565 ◽  
pp. 561-565
Author(s):  
Xiao Wei Liu ◽  
Xiao Wei Han ◽  
He Zhang ◽  
Xi Yun Jiang ◽  
Lin Zhao
Keyword(s):  
Microwave Radiation ◽  
Microfluidic Chip ◽  
Mass Production ◽  
Bonding Strength ◽  
Microfluidic Chips ◽  
Ultrasonic Bonding ◽  
Microwave Absorbing ◽  
Bonding Method ◽  
Bonding Technique

A new bonding technique mainly for PMMA microfluidic chips is presented in this paper. In this technique, polymer microfluidic microchannels were bonded by microwave radiation. Its strength and time can be controlled accurately in watt and second level. There are so many techniques for mass-production of polymer microfluidic chip, such as heat bonding, ultrasonic bonding. However, we may find different kinds of shortages when we use these techniques. In this paper, the experiment result shows that microwave radiation’s strength and time have effects on microfluidic chip`s bonding strength. The microwave absorbing coating can also have a certain degree influence on microfluidic chip`s bonding strength.

A NOVEL METHOD FOR RAPID FABRICATION OF PMMA MICROFLUIDIC CHIP BY LASER CUTTING AND SEALING INTEGRATION

2019 ◽  
Vol 26 (08) ◽  
pp. 1950042 ◽  
Author(s):  
XUEYE CHEN ◽  
TIECHUAN LI ◽  
QI GAO
Keyword(s):  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Laser Cutting ◽  
Cost Effective ◽  
Cover Plate ◽  
Microfluidic Chips ◽  
Pmma Substrate ◽  
Rapid Fabrication ◽  
Novel Method ◽  
Liquid Pools

In this paper, we present a new method that is capable of manufacturing microfluidic chips of polymethyl methacrylate (PMMA) rapidly and cheaply. This technique, which we call Tape adhering-Laser Cutting and Sealing Integration (TLCSI), only utilizes a CO2 laser and a piece of double-sided tape to produce a microfluidic chip in several minutes. It only has three main steps. First, the double-sided tape sticks to the surface of a PMMA substrate. Second, the microchannel should be cut on the surface of the double-sided tape. At last, a PMMA cover plate with liquid pools is pressed onto the surface of the double-sided tape and a CO2 laser is used to cut edges of the chip for sealing the chip. We present a qualified microfluidic chip with regular microchannels and sealing strength of 1.2[Formula: see text]Mpa. Compared with most current fabrication methods, TLCSI is a quick and cost-effective way to produce microfluidic chips of PMMA.

Effect of Joule Heat on Hydrophily of Microchannel

2014 ◽  
Vol 609-610 ◽  
pp. 606-610
Author(s):  
Xiao Wei Han ◽  
Xiao Wei Liu ◽  
Li Tian ◽  
He Zhang ◽  
Yao Liu ◽  
...  
Keyword(s):  
Transfer Coefficient ◽  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Room Temperature ◽  
Joule Heat ◽  
Microfluidic Chips ◽  
Interior Surface

We discuss the effect of joule heat which comes from eletroosmosis flow on the microfluidic chip. Our microfluidic chips are fabricated from polymethyl methacrylate (PMMA). As everyone knows, PMMA is a poor conductor of heat, and its transfer coefficient is only 0.19W/m·K in room temperature. So, the heat is generated by eletroosmosis canʼt conduct outside the microchannels of microfluidic chip easily. We research the effect joule heat on walls of microchannels which are made of PMMA. During our study, interior surface of microchannelsʼ hydrophobicity is changed by effect of joule heat.

Redistribution of pads on a singulated IC die using laser direct-write ablation

2006 ◽  
Vol 29 (1) ◽  
pp. 184-189
Author(s):  
Chengping Zhang ◽  
R. Bartholomew ◽  
P.C. Karulkar
Keyword(s):  
Direct Write ◽  
Laser Direct Write

Study on the Manufacture of Microfluidic Chip with Coated Glass

2012 ◽  
Vol 548 ◽  
pp. 254-257 ◽  
Author(s):  
Yan He ◽  
Bai Ling Huang ◽  
Yong Lai Zhang ◽  
Li Gang Niu
Keyword(s):  
Microfluidic Chip ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Critical Factor ◽  
Wet Etching ◽  
Microfluidic Chips ◽  
Etching Technique ◽  
Chip Quality ◽  
Wet Chemical ◽  
Wet Chemical Etching

In this paper, a simple and facile technique for manufacturing glass-based microfluidic chips was developed. Instead of using expensive dry etching technology, the standard UV lithography and wet chemical etching technique was used to fabricate microchannels on a K9 glass substrate. The fabrication process of microfluidic chip including vacuum evaporation, annealing, lithography, and BHF (HF-NH4F-H2O) wet etching were investigated. Through series experiments, we found that anneal was the critical factor for chip quality. As a representative example, a microfluidic channel with 20 m of depth, and 80 m of width was successfully prepared, and the channel surfaces are quite smooth. These results present a simple, low cost, flexible and easy way to fabricate glass-based microfluidic chips.

Picoliter-Scale Protein Microarrays by Laser Direct Write

2002 ◽  
Vol 18 (5) ◽  
pp. 1126-1129 ◽  
Author(s):  
B.R. Ringeisen ◽  
P.K. Wu ◽  
H. Kim ◽  
A. Pique ◽  
R.Y.C. Auyeung ◽  
...  
Keyword(s):  
Protein Microarrays ◽  
Direct Write ◽  
Laser Direct Write
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