Properties of Deproteinized Natural Rubber Latex/Gelatinized Starch Blended Films

2015 ◽  
Vol 659 ◽  
pp. 45-49 ◽  
Author(s):  
Rungtiwa Waiprib ◽  
Wiwat Pichayakorn ◽  
Prapaporn Boonme ◽  
Wirach Taweepreda ◽  
Jirapornchai Suksaeree
Keyword(s):  
Natural Rubber ◽  
Transdermal Delivery ◽  
Natural Rubber Latex ◽  
Homogeneous Mixture ◽  
Rubber Latex ◽  
Viscous Liquids ◽  
Transdermal Patches ◽  
Gelatinized Starch ◽  
Homogeneous Film ◽  
Deproteinized Natural Rubber

This research aimed to study the compatibility and properties of deproteinized natural rubber latex (DNRL)/gelatinized starch blended films for use as transdermal patches. Various starches were previously gelatinized by heat treatment. Then, the DNRL/gelatinized starch blended films were prepared by simple mixing of DNRL with gelatinized starch and then drying at 50°C. The various parameters such as types (potato, sago, bean, corn, tapioca, rice and glutinous starches), amounts (5, 10, 15 and 20 part per hundred of rubber (phr)) and concentrations of gelatinized starch pastes (5, 10, 20 and 50%) were evaluated. It was found that all starch types could be blended as a homogeneous mixture with DNRL only in 5 phr. Bean starch also provided the good mixture in 10 and 15 phr. Rice and corn starches in the concentrations up to 20 phr could also be blended. Higher concentration of gelatinized starch pastes obtained the higher viscous liquids that were difficult to blend as a homogeneous mixture with DNRL, and provided inhomogeneous blended films. The dried films of all homogeneous DNRL/gelatinized starch mixtures were slightly yellowish transparent with good physical appearances. The tensile strength, swelling and erosion of these blended films increased when increasing amounts of gelatinized starch, but their elasticities were not different comparing to that of DNRL film itself. However, their strengths should be further improved by adding some plasticizers. Some drugs would be further loaded in these homogeneous film formulations for transdermal delivery.

Deproteinized natural rubber latex/gelatinized starch blended films as drug delivery carrier

2017 ◽  
Vol 148 (7) ◽  
pp. 1223-1228 ◽  
Author(s):  
Rungtiwa Waiprib ◽  
Prapaporn Boonme ◽  
Wirach Taweepreda ◽  
Ekwipoo Kalkornsurapranee ◽  
Jirapornchai Suksaeree ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Drug Delivery Carrier ◽  
Gelatinized Starch ◽  
Deproteinized Natural Rubber

Novel membranes from physico-chemically modified deproteinized natural rubber latex: development, characterisation and drug permeation

2018 ◽  
Vol 42 (17) ◽  
pp. 14179-14187
Author(s):  
Janisha Jayadevan ◽  
G. Unnikrishnan
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Drug Permeation ◽  
Chemically Modified ◽  
Blend Membranes ◽  
Deproteinized Natural Rubber

Novel blend membranes from physico-chemically modified deproteinized natural rubber latex for drug release applications.

Characterization of Lidocaine Transdermal Patches from Natural Rubber Latex

2013 ◽  
Vol 747 ◽  
pp. 103-106 ◽  
Author(s):  
Prapaporn Boonme ◽  
Hasleena Boontawee ◽  
Wirach Taweepreda ◽  
Wiwat Pichayakorn
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Physicochemical Properties ◽  
Rubber Tree ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Transdermal Patches ◽  
The Stability ◽  
Main Component

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

Development of latex foam pillows from deproteinized natural rubber latex

2021 ◽  
Author(s):  
Roslim Ramli ◽  
Ai Bao Chai ◽  
Shamsul Kamaruddin ◽  
Jee Hou Ho ◽  
Fatimah Rubaizah Mohd. Rasdi ◽  
...  
Keyword(s):  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Deproteinized Natural Rubber

Deproteinized Natural Rubber as Chewing Gum Base for Nicotine Delivery

2013 ◽  
Vol 844 ◽  
pp. 470-473
Author(s):  
Wiwat Pichayakorn ◽  
Prapaporn Boonme ◽  
Wirach Taweepreda
Keyword(s):  
Natural Rubber ◽  
Room Temperature ◽  
Natural Rubber Latex ◽  
Sodium Carboxymethylcellulose ◽  
Rubber Latex ◽  
Initial Modulus ◽  
Chewing Gums ◽  
Significant Difference ◽  
Saccharin Sodium ◽  
Deproteinized Natural Rubber

This study aimed to prepare the nicotine chewing gums for smoking cessation using deproteinized natural rubber latex (DNRL) as gum bases due to its highly flexible property. The formulations were produced by the conventional heat melting and kneading methods. The experimental design was used to obtain the optimum 3 gum base formulations. Each formulation composed of olive oil as a plasticizer; sodium carboxymethylcellulose as an adsorbent; xylitol, mannitol and saccharin sodium as sweeteners instead of sugar. Gum base 1 and gum base 2 had the same sweetener amount but gum base 2 had the lower plasticizer amount, while gum base 1 and gum base 3 had the same plasticizer amount but different sweetener amount. Nicotine was added into each 3 gum bases (NCT1-3). The results showed no significant difference of appearance and taste. Their physicochemical properties were as following: pH of 8.45, 8.46, 8.54, hardness of 39.80, 36.28, 33.14 Shore A, initial modulus of 0.090, 1.260, 0.065 MPa, %elongation of 286, 403, 489%, drug content of 63.62, 70.95, 72.70%, and drug release when 500 times for force clamping of 48.72, 45.72, 67.74%, respectively. After storage at room temperature for 1 month, NCT1 and NCT2 showed unchangeable appearance, but NCT3 showed the slightly liquefied film and much sticky due to hygroscopic property of its sweetener. However, all formulations showed the significant reduction of drug amount which should be further improved in their stability properties.

scholarly journals Novel Deproteinized Natural Rubber Latex Adhesive Used in Extraoral Maxillofacial Prostheses

2021 ◽  
Vol 50 (11) ◽  
pp. 3383-3394
Author(s):  
Paweena Kongkon ◽  
Wiwat Pichayakorn ◽  
Sasiwimol Sanohkan
Keyword(s):  
Bond Strength ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Control Group ◽  
Rubber Latex ◽  
Factor Ii ◽  
Biocompatibility Testing ◽  
Silicone Prostheses ◽  
Deproteinized Natural Rubber ◽  
Scanning Electron

This study aimed to develop an adhesive for silicone maxillofacial prostheses and compared the properties with the Daro adhesive hydrobond (Factor II, Inc, Lakeside, AZ, USA). Two adhesives were developed from non-vulcanized natural rubber-based adhesives (Adhesive A) and deproteinized natural rubber latex (DNRL) products (Adhesive B) and stored at 4 °C. The Control group was the commercial Daro adhesive hydrobond (Factor II, Inc, Lakeside, AZ, USA). The physical properties (appearance, viscosity, spreadability, color, and pH) of the adhesives were measured and every week for 12 weeks after storing at 4 °C. The adhesives were characterized under scanning electron microscopy. Mechanical testing done were peel bond strength and biocompatibility testing was done using MTT assay. Physical, surface, and mechanical properties were compared with the commercial adhesive. Data analysis was done using SPSS version 24. Both adhesives were physically and chemically stable at temperature 4 °C and had suitable peel bond strength adhesives as the commercial adhesive. Hence, the adhesives can be used to adhere to the maxillofacial silicone prostheses.

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