The Research Progress of Fluorescent Probes for Detection of Selenols

2020 ◽  
Vol 861 ◽  
pp. 315-319
Author(s):  
Yan Gao ◽  
Li Han ◽  
Jing Jing Liu ◽  
Xing Gao ◽  
Wen He
Keyword(s):  
Cancer Research ◽  
Fluorescent Probes ◽  
Biological Imaging ◽  
Research Progress ◽  
Disease Treatment ◽  
Hydrogen Selenide

Selenols (R-SeH) are similar to thiols , both of them are important reducing substance. Selenocysteine (Sec) and hydrogen selenide (H2Se) are two important selenols. They play a key role in cancer research and disease treatment. Recently, fluorescent probes and nanoprobes for detecting selenols have been developed rapidly because that fluorescent methods can be applied for biological imaging of cells or in vivo. Therefore, it is very important to the detect selenols. In this paper, we summarized the fluorescent probes for detecting the selenols in recent years.

scholarly journals Biological nanoscale fluorescent probes: From structure and performance to bioimaging

2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su
Keyword(s):  
Fluorescent Probes ◽  
Organic Dyes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Biological Imaging ◽  
Fluorescent Materials ◽  
And Performance

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

scholarly journals Research Progress of Small Molecule Fluorescent Probes for Detecting Hypochlorite

Sensors ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 6326
Author(s):  
Zhi-Guo Song ◽  
Qing Yuan ◽  
Pengcheng Lv ◽  
Kun Chen
Keyword(s):  
Fluorescent Probes ◽  
High Selectivity ◽  
Hypochlorous Acid ◽  
High Sensitivity ◽  
Chloride Ions ◽  
Research Progress ◽  
Oxygen Species ◽  
Low Toxicity ◽  
Fluorescent Probe Method

Hypochlorous acid (HOCl) generates from the reaction between hydrogen peroxide and chloride ions via myeloperoxidase (MPO)-mediated in vivo. As very important reactive oxygen species (ROS), hypochlorous acid (HOCl)/hypochlorite (OCl−) play a crucial role in a variety of physiological and pathological processes. However, excessive or misplaced production of HOCl/OCl− can cause variety of tissue damage and human diseases. Therefore, rapid, sensitive, and selective detection of OCl− is very important. In recent years, the fluorescent probe method for detecting hypochlorous acid has been developed rapidly due to its simple operation, low toxicity, high sensitivity, and high selectivity. In this review, the progress of recently discovered fluorescent probes for the detection of hypochlorous acid was summarized with the aim to provide useful information for further design of better fluorescent probes.

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

2020 ◽  
Vol 21 (13) ◽  
pp. 996-1008
Author(s):  
Mengli Wang ◽  
Qiuzheng Du ◽  
Lihua Zuo ◽  
Peng Xue ◽  
Chao Lan ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Small Molecule ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Research Progress ◽  
Future Research ◽  
Pharmacokinetic Parameters ◽  
Molecular Characteristics ◽  
Targeted Drugs

Background: As a new tumor therapy, targeted therapy is becoming a hot topic due to its high efficiency and low toxicity. Drug effects of targeted tumor drugs are closely related to pharmacokinetics, so it is important to understand their distribution and metabolism in vivo. Methods: A systematic review of the literature on the metabolism and distribution of targeted drugs over the past 20 years was conducted, and the pharmacokinetic parameters of approved targeted drugs were summarized in combination with the FDA's drug instructions. Targeting drugs are divided into two categories: small molecule inhibitors and monoclonal antibodies. Novel targeting drugs and their mechanisms of action, which have been developed in recent years, are summarized. The distribution and metabolic processes of each drug in the human body are reviewed. Results: In this review, we found that the distribution and metabolism of small molecule kinase inhibitors (TKI) and monoclonal antibodies (mAb) showed different characteristics based on the differences of action mechanism and molecular characteristics. TKI absorbed rapidly (Tmax ≈ 1-4 h) and distributed in large amounts (Vd > 100 L). It was mainly oxidized and reduced by cytochrome P450 CYP3A4. However, due to the large molecular diameter, mAb was distributed to tissues slowly, and the volume of distribution was usually very low (Vd < 10 L). It was mainly hydrolyzed and metabolized into peptides and amino acids by protease hydrolysis. In addition, some of the latest drugs are still in clinical trials, and the in vivo process still needs further study. Conclusion: According to the summary of the research progress of the existing targeting drugs, it is found that they have high specificity, but there are still deficiencies in drug resistance and safety. Therefore, the development of safer and more effective targeted drugs is the future research direction. Meanwhile, this study also provides a theoretical basis for clinical accurate drug delivery.

Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

2021 ◽  
Vol 8 (8) ◽  
pp. 1867-1889
Author(s):  
Zhiming Xing ◽  
Wanhui Wu ◽  
Yongxiang Miao ◽  
Yingqun Tang ◽  
Youkang Zhou ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Imaging ◽  
Luminescence Properties ◽  
Luminescent Materials ◽  
Future Outlook ◽  
Recent Advances

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

scholarly journals Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

2021 ◽  
Author(s):  
Li Li ◽  
Zheng Lv ◽  
Zhongwei Man ◽  
Zhenzhen Xu ◽  
YuLing Wei ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Binding Affinity ◽  
Fluorescent Probes ◽  
Amyloid Fibrils ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

scholarly journals Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity

RSC Advances ◽  
2020 ◽  
Vol 10 (62) ◽  
pp. 37721-37727 ◽  
Author(s):  
Keisuke Yuzu ◽  
Mikael Lindgren ◽  
Sofie Nyström ◽  
Jun Zhang ◽  
Wakako Mori ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Structural Polymorphism

Structural polymorphism of insulin amyloids in vivo can be recognized using novel amyloid specific fluorescent probes, pFTAA and BTD21.

scholarly journals New insights on CRISPR/Cas9-based therapy for breast Cancer

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Hussein Sabit ◽  
Shaimaa Abdel-Ghany ◽  
Huseyin Tombuloglu ◽  
Emre Cevik ◽  
Amany Alqosaibi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Animal Models ◽  
Human Cancer ◽  
Step Process ◽  
Cancer Initiation ◽  
Malignant State ◽  
Treat Breast Cancer

AbstractCRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result in the hallmark of the malignant state. The goal of cancer research is to identify these mutations and correlate them with the underlying tumorigenic process. Using CRISPR/Cas9 tool, specific mutations responsible for cancer initiation and/or progression could be corrected at least in animal models as a first step towards translational applications. In the present article, we review various novel strategies that employed CRISPR/Cas9 to treat breast cancer in both in vitro and in vivo systems.

scholarly journals In vivo visualization of osteoarthritic hypertrophic lesions

2015 ◽  
Vol 6 (11) ◽  
pp. 6256-6261 ◽  
Author(s):  
Hai-Yu Hu ◽  
Ngee-Han Lim ◽  
Hans-Paul Juretschke ◽  
Danping Ding-Pfennigdorff ◽  
Peter Florian ◽  
...  
Keyword(s):  
Animal Models ◽  
Fluorescent Probes

Cartilage-binding bimodal MRI and fluorescent probes were developed to monitor osteoarthritic damage in animal models over extended periods of time.

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