Improved Syringe Extruder for Improved Processing of Biological Materials

2018 ◽  
Vol 941 ◽  
pp. 2442-2447
Author(s):  
Andreas Engels ◽  
Volker Schlegel ◽  
Steffen Zinn ◽  
Vincenzo Bonaiuto ◽  
Andreas H. Foitzik
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Wide Spectrum ◽  
The Other ◽  
3 Dimensional ◽  
Air Ventilation ◽  
Applied Forces ◽  
Process Behavior ◽  
Expansive Process ◽  
Immense Potential

3 dimensional (3D) printing evolved during the last decade to a consumer friendly and affordable craft. Furthermore, implementations of this techniques in the field of biotechnological research and development within laboratories is a very expansive process. Bio-printers’ prices cover a wide spectrum and most basic models are available for around 5000€. On the other end, high-end printer machines with a vast variety of features are available for several hundreds of thousands of euros. Thus, due to the immense potential in the field of Biotechnology the availability of this technology for research purpose should be enhanced. A developed ecological syringe extruder prototype for processing of biological based gels has been further improved. The original prototype was capable to processing multiple layers of agar with concentrations of 1% and 2.5%. Based on these results the prototype was revised regarding printing process parameter, which include among others applied forces to the substrate, air-ventilation, and heating of the substrate. The process behavior will be simulated with computational fluid dynamics for the processing of biological based substrate. After a concluding validation these results are intended to be implemented into a new design for improved processing of a variety of bioinks.

Effect of the Red Blood Cells on the Primary Thrombus Formation

2007 ◽  
Author(s):  
Koichiro Yano ◽  
Daisuke Mori ◽  
Ken-ichi Tsubota ◽  
Takuji Ishikawa ◽  
Shigeo Wada ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Blood Flow ◽  
Blood Cell ◽  
Blood Cells ◽  
Thrombus Formation ◽  
The Other ◽  
Biochemical Processes ◽  
Mechanical Factors ◽  
Molecular Bridge

It has been pointed out that some mechanical factors play important roles in a series of physiological or biochemical processes during the thrombus formation. Recently, many studies including the authors’ work qualitatively demonstrated how the thrombus is regulated under the influences of the blood flow and the intercellular molecular bridge using computational fluid dynamics techniques[1–4]. They verified the importance of the balance of them in the process of the thrombus formation. However, few studies have taken into account the existence of the other cell constituents than the platelet such as red blood cell (RBC).

Vehicles Aerodynamics while Crossing each other on Road Based on Computational Fluid Dynamics

2010 ◽  
Vol 29-32 ◽  
pp. 1344-1349 ◽  
Author(s):  
Zhe Zhang ◽  
Ying Chao Zhang ◽  
Jie Li
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Numerical Simulations ◽  
Aerodynamic Force ◽  
The Other ◽  
Moving Mesh ◽  
Aerodynamic Coefficients ◽  
Paper Report ◽  
Vehicle Aerodynamics ◽  
Simulation Results

When vehicles run on road, they will be overtaken, cross by other vehicles or be impacted by crosswind. The other events of overtaking and in crosswind were investigated more deeply. A few of paper report the state of the research on this problem. Until now there are no any wind tunnel and road tests to study on road vehicle aerodynamics while crossing each other. Some numerical simulations were carried out by adopting technology of sliding interface and moving mesh. The method of numerical simulations was narrated in detail. The transient process of vehicles crossing each other was realized. Then the trends of aerodynamic coefficients changing were obtained from the flow field of simulation results. The quantificational changing of vehicles aerodynamic coefficients was obtained when they cross each other. The vehicles are sedan and coach. The simulation results indicated that the all aerodynamic coefficients of two vehicles changed large. The aerodynamic force was important to the vehicles’ handling stability when they cross each other.

scholarly journals Evaluation of Seabed Stability and Scour Control Around Subsea Gravity Protection Structures

2010 ◽  
Author(s):  
Richard J. S. Whitehouse ◽  
Carlos Lam ◽  
Stephen Richardson ◽  
Peter Keel
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
North Sea ◽  
Cfd Analysis ◽  
Cfd Model ◽  
3 Dimensional ◽  
Computational Fluid Dynamics Cfd ◽  
The Uk ◽  
Study Application

Results from an advanced 3-dimensional Computational Fluid Dynamics (CFD) model have proven to form an effective basis on which to design stable and scour resistant subsea structures in areas of seabed which are prone to scouring. A case study application from the UK sector of the southern North Sea is presented to demonstrate the benefits of the CFD analysis.

Computational Study of Single-Sided Ventilation Through a 3-Dimensional Room With Rounded Edges

2013 ◽  
Author(s):  
A. Idris ◽  
B. P. Huynh
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Wind Speed ◽  
Flow Pattern ◽  
Flow Rate ◽  
Software Package ◽  
Computational Study ◽  
Ventilation Rate ◽  
3 Dimensional ◽  
Computational Fluid Dynamics Cfd

A commercial Computational Fluid Dynamics (CFD) software package is used to investigate numerically a 3-dimensional rectangular-box room with rounded edges. The room has all its window openings located on one wall only. The standard K-ε turbulence model is used. Air’s flow rate and flow pattern are considered in terms of wind speed and the openings’ characteristics, such as their number, location, size and shape. Especially, comparison with ventilation rate corresponding to when the room edges are sharp is made; and thereby the effects of the edges being rounded are examined.

Computational fluid dynamics simulations of cerebral aneurysm using Newtonian, power-law and quasi-mechanistic blood viscosity models

2020 ◽  
Vol 234 (7) ◽  
pp. 711-719 ◽  
Author(s):  
Khalid M Saqr
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Power Law ◽  
The Other ◽  
Lower Wall ◽  
Computational Fluid Dynamics Simulations ◽  
Wall Shear ◽  
Dynamics Simulations

Cerebral aneurysm is a fatal neurovascular disorder. Computational fluid dynamics simulation of aneurysm haemodynamics is one of the most important research tools which provide increasing potential for clinical applications. However, computational fluid dynamics modelling of such delicate neurovascular disorder involves physical complexities that cannot be easily simplified. Recently, it was shown that the Newtonian simplification used to close the shear stress tensor of the Navier–Stokes equation is not sufficient to explore aneurysm haemodynamics. This article explores the differences between the latter simplification, non-Newtonian power-law model and a newly proposed quasi-mechanistic model. The modified Krieger model, which treats blood as a suspension of plasma and particles, was implemented in computational fluid dynamics context here for the first time and is made available to the readers in a C# code in the supplementary material of this article. Two middle-cerebral artery and two anterior-communicating artery aneurysms, all ruptured, were utilized here as case studies. It was shown that the modified Krieger model had higher sensitivity for wall shear stress calculations in comparison with the other two models. The modified Krieger model yielded lower wall shear stress values consistently in comparison with the other two models. Moreover, the modified Krieger model has generally predicted higher pressure in the aneurysm models. Based on published aneurysm rupture studies, it is believed that ruptured aneurysms are usually correlated with lower wall shear stress values than unruptured ones. Therefore, this work concludes that the modified Krieger model is a potential candidate for providing better clinical relevance to aneurysm computational fluid dynamics simulations.

scholarly journals 3D Flow Modeling of the First Trifurcation Made in Nepal

1970 ◽  
Vol 5 ◽  
pp. 56-61 ◽  
Author(s):  
R K Malik ◽  
Paras Paudel
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Vortex Formation ◽  
Maximum Flow ◽  
Flow Modeling ◽  
Zone Formation ◽  
Physical Constraints ◽  
3 Dimensional ◽  
Dimensional Flow ◽  
Computational Fluid Dynamics Cfd

The foremost objective of the study was to find out the most efficient profile of trifurcation in given constraints of pressure, velocity and layout of the overall geometry. The study was done for the 3.2 MW Madi Khola Hydropower Project of Gandaki Hydropower Development Co. Pvt. Ltd. The 3 Dimensional Flow modeling of the trifurcation was based on the application of Computational Fluid Dynamics (CFD).The loss in the Trifurcation greatly depends upon its geometrical configuration. The research started with a general profi le and the flow pattern generated inside it was studied with the help of 3 Dimensional Flow modeling. The extent of vortex zone formation inside the trifurcation indicates the loss inside trifurcation. The profile of the trifurcation was hence changed to reduce the vortex formation as far as possible, till we get minimum possible loss. The profile under study should meet maximum flow efficiency under the physical constraints of fabrication. The flow efficient profile was then analyzed to capture the stress amplifi cation near junction. The reinforcing element in the form of steel T-section was added of different sectional values till the stress was within allowable limits under severe conditions.Key words: Symmetrical Trifuraction; Trifurcation; Computational fluid dynamics; Hydropower; NepalDOI: 10.3126/hn.v5i0.2493Hydro Nepal Vol. 5, July 2009 Page:56-61

A Novel Method that uses Light to Test Aerodynamics

2021 ◽  
Author(s):  
Dhyey Patel
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
The Other ◽  
New Method ◽  
Dynamics Simulation ◽  
Wind Tunnels ◽  
Computational Fluid Dynamics Simulation ◽  
New Novel ◽  
Novel Method ◽  
The Cost

Aerodynamics is a very important topic which has uses in a wide array of fields and is involved in things that range from bridges to spacecrafts. Despite this, most aerodynamic tests are performed only one of two ways, using extremely expensive wind tunnels or by using CFD (computational fluid dynamics) simulation. Both of these preexisting methods have flaws however, with wind tunnels costing gargantuan amounts of money and CFD methods consuming large amounts of energy. These flaws have prompted scientist and engineers to actively seek new solutions and methods that will help to address the cost and energy issues associated with the other two methods. This search has been to no avail so far as new novel methods have not been found until now. I have found a new method that concerns the use of light in order to test the aerodynamics of objects. To prove the feasibility, I have experimented using this method and have found it to accurately simulate aerodynamics behavior in all cases tested by me. This discovery is rather significant as it would lead to a substantial shift in the field of testing aerodynamics.

Effects of Negatively Sloped Jet Inclination Angle and Other Parameters on Air Curtain Performance

2009 ◽  
Author(s):  
Samir R. Traboulsi ◽  
Ali H. Hammoud ◽  
M. Farid Khalil
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Shear Layer ◽  
Latent Heat ◽  
Inclination Angle ◽  
Heat Load ◽  
The Other ◽  
Air Curtain ◽  
Air Jet ◽  
Computational Fluid Dynamics Cfd

Tilted air jet planes are used as barriers between two environments of different temperature, humidity and quality. Entrainment of one environment fluid (air) into the curtain by shear layer mixing contributes to both the sensible and the latent heat load on the other environment and the impingement of the air curtain formed. Perturbation of one side affects the shape of the air jet and might endanger its integrity. Protrusion present in the direction of the flow impacts the performance of the air curtain and defeats its purpose of existence. Computational Fluid Dynamics (CFD) – Fluent 6.3.26® method is used to evaluate the performance of the air curtain formed by negatively sloped tilted jet plane and is also validated by comparing the CFD calculations results with experimental results. Qualitative design combination of various parameters and various levels of obstruction in the direction of the flow(s) are proposed to achieve optimal performance of the air curtain.

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