Carbon Nanotubes as Drug Delivery Vehicles

2014 ◽  
Vol 222 ◽  
pp. 145-158 ◽  
Author(s):  
Shweta Arora ◽  
Vanish Kumar ◽  
Shriniwas Yadav ◽  
Sukhbir Singh ◽  
Deepika Bhatnagar ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Building Blocks ◽  
Water Soluble ◽  
Cancer Therapies ◽  
Drug Delivery Vehicles ◽  
Toxicological Profile ◽  
Drug Doses ◽  
Delivery Vehicles ◽  
Novel Drug

Various biomedical applications of nanomaterials have been proposed in the last few years leading to the emergence of a new field in diagnostics and therapeutics. Most of these applications involve the administration of nanoparticles into patients. Carbon Nanotubes are enjoying increasing popularity as building blocks for novel drug delivery systems as well as for bioimaging and biosensing. The recent strategies to functionalize carbon nanotubes have resulted in the generation of biocompatible and water-soluble carbon nanotubes that are well suited for high treatment efficacy and minimum side effects for future cancer therapies with low drug doses. The toxicological profile of such carbon nanotube systems developed as nanomedicines will have to be determined prior to any clinical studies undertaken.

5-Aminolevulinic acid functionalized boron-nitride and carbon nanotubes as drug delivery vehicles for skin anticancer drugs: a theoretical study

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92547-92559 ◽  
Author(s):  
Pabitra Narayan Samanta ◽  
Kalyan Kumar Das
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Boron Nitride ◽  
Theoretical Study ◽  
Aminolevulinic Acid ◽  
Quantum Chemical Study ◽  
Chemical Study ◽  
Drug Molecule ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

A quantum chemical study has been made on the interaction of 5-aminolevulinic acid (ALA) drug molecule with boron-nitride and carbon nanotubes so as to use these nanomaterials as drug-delivery vehicles.

scholarly journals Utilization of Nanomaterials in Target Oriented Drug Delivery Vehicles

2021 ◽  
Vol 13 (1) ◽  
pp. 299-316
Author(s):  
T. K. Mandal ◽  
V. Patait
Keyword(s):  
Drug Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Current Status ◽  
Future Perspectives ◽  
Delivery Vehicle ◽  
Treatment Target ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Novel Drug ◽  
Cancerous Cells

The present investigation deals with the fundamentals of nanorobots, its fabrication, and possible utilization in a different target-oriented drug delivery vehicles. Details of various types of nanorobots and their specific applications are studied in this research. The use of nanorobots in cancer treatment, target-oriented drug delivery, medical imaging, and in new health sensing devices has also been studied. The mechanism of action of nanorobots for the treatment of cancerous cells as well as the formulation and working functions of some recently studied nanorobots are investigated in this work. This paper reviews the research in finding the suitable nanorobotic materials, different fabrication processes of nanorobots, and the current status of application of nanorobots in biomedical, especially in the treatment of cancers. Superparamagnetic iron oxide nanoparticles (SPIONs) have been observed to be used as novel drug delivery vehicle materials. The future perspectives of nanorobots for the utilization in drug delivery are also addressed herewith.

scholarly journals Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

2020 ◽  
Vol 21 (18) ◽  
pp. 6621
Author(s):  
Filippo Pinelli ◽  
Fabio Pizzetti ◽  
Óscar Fullana Ortolà ◽  
Alessandro Marchetti ◽  
Arianna Rossetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
High Volume ◽  
Polymer Chains ◽  
Pluronic F127 ◽  
Synthesis Methods ◽  
Drug Delivery Vehicles ◽  
The Core ◽  
Delivery Vehicles ◽  
Novel Drug

In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics.

A REVIEW ON BASICS AND APPLICATIONS OF MODIFIED CARBOHYDRATES IN DRUG DELIVERY

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (02) ◽  
pp. 7-17
Author(s):  
Smita T. Kumbhar ◽  
◽  
Shitalkumar S. Patil ◽  
Manish S. Bhatia ◽  
Yogesh S. Thorata ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Structural Features ◽  
Water Soluble ◽  
Drug Delivery Vehicles ◽  
Broad Array ◽  
Water Soluble Drugs ◽  
Delivery Vehicles ◽  
Poorly Water Soluble ◽  
Nanoparticulate Systems

Polysaccharides demonstrate a wide diversity in their structural features as well as physicochemical properties owing to a variety of functional groups, chemical structure and a broad array of molecular mass. The most important feature of modified polysaccharides is their amphiphilic character which allows the application of these conjugates as an emulsifier, modifiers of surface in liposomes and micro/ nanoparticles, viscosity modifiers and drug delivery vehicles. Recently, the lipophilic modification of polysaccharides, which serve as a nano-container for water-insoluble or poorly water-soluble drugs, has gained attention in the biomedical applications due to their ability to form self-assembled nanoparticles. The natural polysaccharides are readily available, stable, biodegradable, economical, safe and biocompatible. It is difficult to synthesize compounds with such diversity in characteristics. In recent decades, many researchers have taken interest in polysaccharides and their derivatives for use in nanoparticulate systems. This review focuses on the chemical modification of mono and polysaccharides and the mechanisms involved in the formation of polysaccharide-based nanoparticles

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