Background::
Current study evaluated the protective potential of quercetin against lindane induced toxicity in
mice brain. For investigation, mice were allocated into four groups; First group was control. Second group was administered
with oral dose of lindane (25 mg/kg bw) for 4 consecutive days. Third group was exposed to quercetin (40 mg/kg bw) and in
fourth group, quercetin was administered 1 hour prior to the exposure of lindane.
Objective::
Two major objectives were decided for study. First was to create lesions in the brain by lindane and; second was
to evaluate the neuroprotective potential of quercetin.
Methods::
To study oxidative responses, level of thiobarbituric acid reactive substances (TBARS), protein carbonyl content
(PCC), reduced glutathione (GSH), superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxidase (GPx) were
measured in brain homogenates. Three key step regulating enzymes of tricarboxylic acid (TCA) cycle viz citrate synthase
(CS), pyruvate dehydrogenase (PDH) and fumarase were also assayed.
Results::
Lindane treatment significantly enhanced the levels of TBARS (P<0.001),PCC (P<0.001), GPx (P<0.001), SOD
(P<0.05), PDH (P<0.05) and fumarase (P<0.001) in brains of mice compared to control. Meanwhile, it alleviated GSH, CAT
and CS (P<0.05) activity.
Conclusion::
Pretreatment with quercetin in lindane treated group not only restored, previously altered biochemical parameters
after lindane treatment and also significantly improved them too which suggests that quercetin is not only invulnerable
rather neuroprotective against lindane intoxication.