scholarly journals The 3′ Untranslated Region of the Membrane-Bound IL-1R Accessory Protein mRNA Confers Tissue-Specific Destabilization

2004 ◽  
Vol 173 (10) ◽  
pp. 6248-6258 ◽  
Author(s):  
Liselotte E. Jensen ◽  
Alexander S. Whitehead
Keyword(s):  
Untranslated Region ◽  
Accessory Protein ◽  
Tissue Specific ◽  
Membrane Bound

scholarly journals Structural and Enzymatic Characterization ofDrosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression

2002 ◽  
Vol 277 (26) ◽  
pp. 23321-23329 ◽  
Author(s):  
Elena Llano ◽  
Geza Adam ◽  
Alberto M. Pendás ◽  
Vı́ctor Quesada ◽  
Luis M. Sánchez ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Enzymatic Characterization ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Membrane Bound

Tissue-Specific variation in the length of the 5? untranslated region of the ?a-inhibin mRNA in sheep

1995 ◽  
Vol 40 (1) ◽  
pp. 1-8 ◽  
Author(s):  
J. S. Fleming ◽  
S. M. Galloway ◽  
R. J. Crawford ◽  
D. J. Tisdall ◽  
P. J. Greenwood
Keyword(s):  
Untranslated Region ◽  
Tissue Specific ◽  
Specific Variation

scholarly journals Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2162
Author(s):  
Mohammad Taheri ◽  
Hamed Shoorei ◽  
Marcel E. Dinger ◽  
Soudeh Ghafouri-Fard
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Reproductive System ◽  
Estrogen Regulation ◽  
Tissue Specific ◽  
Membrane Bound ◽  
Non Coding Rnas ◽  
And Function ◽  
G Protein Coupled

Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders.

scholarly journals Targeting of c-myc and β-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3′ untranslated region

1994 ◽  
Vol 298 (1) ◽  
pp. 143-148 ◽  
Author(s):  
J Hesketh ◽  
G Campbell ◽  
M Piechaczyk ◽  
J M Blanchard
Keyword(s):  
In Situ Hybridization ◽  
Untranslated Region ◽  
Mrna Localization ◽  
Eukaryotic Cells ◽  
Beta Globin ◽  
Globin Mrna ◽  
Directional Information ◽  
Coding Sequences ◽  
Membrane Bound

The influence of the 3′ untranslated region on mRNA localization was investigated by measuring the distribution of myc, beta-globin and hybrid myc-globin mRNAs between free, cytoskeletal-bound and membrane-bound polysomes in cells transfected with either control or chimeric gene constructs. c-myc sequences and beta-globin-coding sequences linked to the myc 3′ untranslated region were present at greatest enrichment in cytoskeletal-bound polysomes. beta-Globin mRNA and myc-coding sequences linked to the beta-globin 3′ untranslated region were recovered largely in the free polysomes. In situ hybridization confirmed that replacement of the c-myc 3′ untranslated region by that of globin caused a relocalization of the mRNA. The results suggest that mRNA localization in differentiated eukaryotic cells depends on a mechanism that involves directional information in the 3′ untranslated region of mRNAs.

Distinct expression of the soluble and the membrane-bound forms of interleukin-1 receptor accessory protein in the endometrium of women with endometriosis

2011 ◽  
Vol 95 (4) ◽  
pp. 1284-1290 ◽  
Author(s):  
Sophie Guay ◽  
Nadège Michaud ◽  
Nathalie Bourcier ◽  
Mathieu Leboeuf ◽  
Madeleine Lemyre ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Accessory Protein ◽  
Membrane Bound ◽  
Receptor Accessory Protein

The expression and functional activity of membrane-bound human leukocyte antigen-G1 are influenced by the 3′-untranslated region

2013 ◽  
Vol 74 (7) ◽  
pp. 818-827 ◽  
Author(s):  
Signe Goul Svendsen ◽  
Basil M. Hantash ◽  
Longmei Zhao ◽  
Carsten Faber ◽  
Michael Bzorek ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Functional Activity ◽  
Untranslated Region ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Membrane Bound

scholarly journals Structure of the carbonic anhydrase VI (CA6) gene: evidence for two distinct groups within the α-CA gene family

1999 ◽  
Vol 344 (2) ◽  
pp. 385-390 ◽  
Author(s):  
Weiping JIANG ◽  
Dwijendra GUPTA
Keyword(s):  
Carbonic Anhydrase ◽  
Untranslated Region ◽  
Sequence Similarity ◽  
Ca Ix ◽  
Its Gene ◽  
Exon 1 ◽  
Membrane Bound ◽  
Mature Enzyme ◽  
Gene Structures ◽  
Carbonic Anhydrase Vi

The secreted carbonic anhydrase (CA VI) is believed to be one of the oldest mammalian CAs in evolutionary terms. To elucidate its gene structure and compare it with other members of the α-CA family, we cloned genomic fragments encoding the bovine CA6 gene and determined its exon/intron organization. The gene spans approx. 25 kb and consists of eight exons and seven introns. Exon 1 encodes the 5′ untranslated region, the signal peptide and the N-terminus of the mature enzyme. Exon 8 encodes the 3′ untranslated region and the C-terminal extension that is unique to CA VI. Exons 2-7 encode the CA domain, which shows significant sequence similarity to other CAs. Two distinct groups exist in the α-CA family on the basis of a comparison of the known gene structures. One group consists of the cytoplasmic (CA I, II, III and VII) and mitochondrial (CA V) members. The other group consists of the membrane-bound (CA IV and IX) and secreted (CA VI) members. In particular, the seven exon/intron boundaries in the CA domain of the CA6 gene are conserved in the CA9 gene, which encodes the multidomain protein CA IX that is overexpressed in tumours and has transforming potential.

scholarly journals Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Lars-Anders Carlson ◽  
Yun Bai ◽  
Sarah C Keane ◽  
Jennifer A Doudna ◽  
James H Hurley
Keyword(s):  
Self Assembly ◽  
Untranslated Region ◽  
Minimal System ◽  
The Self ◽  
Viral Rna ◽  
Large Excess ◽  
Rna Packaging ◽  
Membrane Bound ◽  
Hiv 1

HIV-1 Gag selects and packages a dimeric, unspliced viral RNA in the context of a large excess of cytosolic human RNAs. As Gag assembles on the plasma membrane, the HIV-1 genome is enriched relative to cellular RNAs by an unknown mechanism. We used a minimal system consisting of purified RNAs, recombinant HIV-1 Gag and giant unilamellar vesicles to recapitulate the selective packaging of the 5’ untranslated region of the HIV-1 genome in the presence of excess competitor RNA. Mutations in the CA-CTD domain of Gag which subtly affect the self-assembly of Gag abrogated RNA selectivity. We further found that tRNA suppresses Gag membrane binding less when Gag has bound viral RNA. The ability of HIV-1 Gag to selectively package its RNA genome and its self-assembly on membranes are thus interdependent on one another.

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