scholarly journals Peptidoglycan-Induced IL-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, PGE2/PGE4 Receptors, Protein Kinase A, IκB Kinase, and NF-κB

2006 ◽  
Vol 177 (1) ◽  
pp. 681-693 ◽  
Author(s):  
Bing-Chang Chen ◽  
Chiao-Chun Liao ◽  
Ming-Jen Hsu ◽  
Yi-Ting Liao ◽  
Chia-Chin Lin ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Cyclooxygenase 2 ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Iκb Kinase ◽  
Kinase A

scholarly journals Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB

2007 ◽  
Vol 179 (6) ◽  
pp. 4180-4186 ◽  
Author(s):  
Verena von Bülow ◽  
Svenja Dubben ◽  
Gabriela Engelhardt ◽  
Silke Hebel ◽  
Birgit Plümäkers ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Iκb Kinase ◽  
Tnf Α ◽  
Kinase A

scholarly journals Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling

2012 ◽  
Vol 287 (15) ◽  
pp. 11899-11910 ◽  
Author(s):  
Li Liu ◽  
Zhongying Cao ◽  
Jing Chen ◽  
Rui Li ◽  
Yanhua Cao ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Influenza A Virus ◽  
Influenza A ◽  
Mononuclear Cells ◽  
Cyclooxygenase 2 ◽  
Lung Epithelial Cells ◽  
Prostaglandin E ◽  
Immune Factor ◽  
Kinase A

We previously reported that IL-27, which belongs to the IL-12 family of cytokines, is elevated in the serum of patients infected with influenza A virus (IAV). Here, we show that the expression of IL-27 was significantly up-regulated in A549 human lung epithelial cells and human peripheral blood mononuclear cells infected with IAV. Additionally, IAV triggered IL-27 expression through protein kinase A and cAMP-response element-binding protein signaling, which was mediated by cyclooxygenase-2-derived prostaglandin E2. IL-27 inhibited IAV replication by STAT1/2/3 phosphorylation and activated antiviral factor protein kinase R phosphorylation. Clinical analysis showed that IL-27 levels were significantly elevated in a cohort of patients infected with IAV compared with healthy individuals and that circulating IL-27 levels were tightly and positively correlated with prostaglandin E2 levels. These results indicate that IL-27 expression is one host immune factor produced in response to IAV infection and that elevated IL-27 levels inhibit viral replication.

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