KOBIO, the First Web-based Korean Biologics Registry Operated With a Unified Platform Among Distinct Disease Entities

Six human beings were inoculated with dengue and developed typical disease. Two of these were reinoculated and proved immune. The remaining four were later inoculated with Colorado tick fever. Three developed typical disease. The fourth, who remained well, has previously lived in an endemic area (Colorado). One patient was inoculated with Colorado tick fever first and later with dengue. He developed both diseases. Colorado tick fever and dengue do not give a cross-immunity. Hamsters can be infected with Colorado tick fever but not with dengue. Colorado tick fever and dengue appear to be distinct disease entities.

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An Analysis of the Association of Gastroenteric Lesions with Chronic Wasting Syndrome of Marmosets

Veterinary Pathology ◽

10.1177/030098588201907s11 ◽

1982 ◽

Vol 19 (7_suppl) ◽

pp. 141-162 ◽

Cited By ~ 33

Author(s):

L. V. Chalifoux ◽

R. T. Bronson ◽

A. Escajadillo ◽

S. McKenna

Keyword(s):

Lymphoid Hyperplasia ◽

Chronic Colitis ◽

Saguinus Oedipus ◽

Chi Square ◽

Wasting Syndrome ◽

Distinct Disease ◽

Disease Entities ◽

Pathology Data ◽

Increased Susceptibility ◽

Cell Atypia

Retrospective pathology data from necropsies of 162 marmosets, Saguinus oedipus, were studied to determine the nature of chronic wasting syndrome, a poorly defined entity associated with a high mortality rate in many marmoset colonies. Paraffin sections of the gastroenteric organs of 116 of these marmosets were re-examined in detail; lesions were identified, quantitated, and analyzed with a method of multiple chi-square testing for possible associations between findings. Five distinct disease entities were identified: prosthenorchosis, amebiasis, paramyxovirus disease, sepsis, and chronic colitis. Lesions of several of these often occurred in the same monkey, and all but the first were associated with cachexia. Lesions of chronic colitis were crypt abscesses, mononuclear and polymorphonuclear infiltration of the lamina propria, epithelial cell atypia, karyorrhexis, and lymphoid hyperplasia. The cause of chronic colitis was not identified, nor was any explanation found for weight loss and increased susceptibility to disease.

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Health Disparities and the Global Landscape of Lymphoma Care Today

American Society of Clinical Oncology Educational Book ◽

10.1200/edbk_175444 ◽

2017 ◽

pp. 526-534

Author(s):

Adrienne A. Phillips ◽

Dominic A. Smith

Keyword(s):

Health Disparities ◽

Hodgkin Lymphoma ◽

Standard Treatment ◽

Treatment Approach ◽

B Cell Lymphoma ◽

The United States ◽

Non Hodgkin Lymphoma ◽

Large B Cell Lymphoma ◽

Distinct Disease ◽

Disease Entities

Lymphoma encompass a wide variety of distinct disease entities, including, but not limited to, subtypes of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). In the last 3 decades, therapeutic advancements have resulted in substantial improvements in lymphoma outcome. In most high-income regions, HL is a largely curable disease and for patients with two frequent subtypes of NHL, diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), survival has dramatically improved with the incorporation of rituximab as a standard treatment approach. Despite these advances, outcomes vary between and across populations. This review will provide updated information about health disparities in lymphoma in the United States and across the globe.

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The Distinction Between the Affective Psychoses and Schizophrenia

The British Journal of Psychiatry ◽

10.1192/bjp.135.3.243 ◽

1979 ◽

Vol 135 (3) ◽

pp. 243-248 ◽

Cited By ~ 81

Author(s):

I. F. Brockington ◽

R. E. Kendell ◽

S. Wainwright ◽

V. F. Hillier ◽

J. Walker

Keyword(s):

Discriminant Function ◽

Bimodal Distribution ◽

Affective Psychoses ◽

Functional Psychoses ◽

Distinct Disease ◽

Disease Entities ◽

The Universe ◽

Two Populations ◽

Discriminant Function Analyses

SummaryIn an attempt to demonstrate a valid boundary between schizophrenia and the affective psychoses, discriminant function analyses have been carried out with history, mental state and follow-up data in two populations of patients. A bimodal distribution of discriminant scores was obtained in one of them (a general psychotic sample of 128 patients), using a discriminant function derived from the same sample; but when the function was applied to the second population (a schizoaffective sample of 106 patients) the distribution was ambiguous. Functions derived from the schizoaffective sample produced highly skewed distributions of discriminant scores in the general psychotic sample.Kraepelin's hypothesis that the functional psychoses consist of two distinct disease entities receives some support from our findings, but there is still no compelling evidence that the universe of psychotic patients falls naturally into these two groups.

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Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia

Blood ◽

10.1182/blood-2014-03-560227 ◽

2014 ◽

Vol 124 (9) ◽

pp. 1513-1521 ◽

Cited By ~ 158

Author(s):

Luca Malcovati ◽

Elli Papaemmanuil ◽

Ilaria Ambaglio ◽

Chiara Elena ◽

Anna Gallì ◽

...

Keyword(s):

Somatic Mutations ◽

Clinical Decision Making ◽

Myeloproliferative Neoplasms ◽

Clinical Decision ◽

Driver Mutations ◽

Myeloid Neoplasms ◽

Key Points ◽

Distinct Disease ◽

Disease Entities

Key Points Different driver mutations have distinct effects on phenotype of myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). Accounting for driver mutations may allow a classification of these disorders that is considerably relevant for clinical decision-making.

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EPID-15. SURVIVAL TRENDS SUGGEST OLIGOASTROCYTOMA, OLIGODENDROGLIOMA, AND ASTROCYTOMA ARE THREE DISTINCT DISEASE ENTITIES: A SEER-BASED SURVIVAL ANALYSIS

Neuro-Oncology ◽

10.1093/neuonc/now212.241 ◽

2016 ◽

Vol 18 (suppl_6) ◽

pp. vi58-vi58

Author(s):

Tyler Lanman ◽

Jason Compton ◽

Brian Hirshman ◽

Kate Carroll ◽

Mir Ali ◽

...

Keyword(s):

Survival Analysis ◽

Distinct Disease ◽

Disease Entities

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The utility of cardiovascular imaging in heart failure with preserved ejection fraction: diagnosis, biological classification and risk stratification

Heart Failure Reviews ◽

10.1007/s10741-020-10047-9 ◽

2020 ◽

Author(s):

Gavin A. Lewis ◽

Keith Pearce ◽

Simon G. Williams ◽

Erik B. Schelbert ◽

Anita Macnab ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Risk Stratification ◽

Cardiovascular Imaging ◽

Disease Classification ◽

Future Research ◽

Preserved Ejection Fraction ◽

Wide Range ◽

Distinct Disease ◽

Disease Entities

Abstract Heart failure with preserved ejection fraction (HFpEF) does not exist as a singular clinical or pathological entity but as a syndrome encompassing a wide range of clinical and biological phenotypes. There is an urgent need to progress from the unsuccessful ‘one-size-fits-all’ approach to more precise disease classification, in order to develop targeted therapies, personalise risk stratification and guide future research. In this regard, this review discusses the current and emerging roles of cardiovascular imaging for the diagnosis of HFpEF, for distilling HFpEF into distinct disease entities according to underlying pathobiology and for risk stratification.

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Surveying the landscape of MDS/MPN research: overlap among the overlap syndromes?

Hematology ◽

10.1182/asheducation-2015.1.349 ◽

2015 ◽

Vol 2015 (1) ◽

pp. 349-354 ◽

Cited By ~ 5

Author(s):

Eric Padron

Keyword(s):

Bone Marrow ◽

Molecular Biology ◽

Poor Prognosis ◽

Clinical Course ◽

Myeloproliferative Neoplasms ◽

Bone Marrow Failure ◽

Overlap Syndromes ◽

Distinct Disease ◽

Disease Entities ◽

Near Future

Abstract The myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) lie at the interphase of phenotypically opposing bone marrow malignancies. They are characterized by concomitant features of bone marrow failure and myeloproliferation and are generally associated with a poor prognosis. Although much is unknown with respect to the clinical course and molecular biology of MDS/MPNs, emerging research is beginning to uncover the key defining characteristics of this designation. In this review, we will discuss the features of MDS/MPN diseases that unify there clinical and molecular course and those that define distinct disease entities. We will discuss advances in genetics and MDS/MPN modeling, as well as translational discoveries that are anticipated to inform the diagnosis, prognostication, and treatment of MDS/MPNs in the near future.

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Molecular pathobiology of aspirin responsive erythromelalgia in thrombocythemia and incurable inherited erythermalgia in Nav1.7mutated neuropathy

International Journal of Cancer Research & Therapy ◽

10.33140/ijcrt/02/02/00002 ◽

2017 ◽

Vol 2 (2) ◽

Keyword(s):

Sodium Channel ◽

Original Description ◽

Loss Of Function ◽

Gain Of Function ◽

Peripheral Neurons ◽

Burning Pain ◽

Arterial Circulation ◽

Incurable Disease ◽

Distinct Disease ◽

Disease Entities

The original description of erythromelalgia of Mitchell has been separated into three distinct disease entities of aspirin responsive erythromelalgia in thrombocythemia, incurable congenital dominant primary erythermalgia (PE), and aspirin resistant secondary erthermalgia. Aspirin responsive platelet-mediated erythromelalgic and thrombotic processes in the end-arterial circulation of toes or fingers has been discovered as a distinct arterial thrombophilic disease entity (Sticky Platelet Syndrome) in acquired and congenital thrombocythemia due to gain of function mutations in the JAK2, TPO, MPL and CALR genes. PE is a congenital dominant incurable disease with symmetric bilateral localization of red congestion and burning pain in legs with relative sparing of the toes, which spontaneously arises in childhood or adolecence and persists life long in adults. Incurable PE has been discovered as a dominant neuropathic pain disorder caused by hyperexcitibility of the sodium channel alpha subunit Nav1.7 protein located in dorsal root ganglions and nocireceptive peripheral neurons due to gain of function mutations in the SCN9A gene on chromosome 2q coding for the Nav1.7 sodium channel. Recessive chronic insensitivity for pain (CIP) is caused by homozygous or double heterozygous loss of function mutations of the SCN9A gene and loss of Nav1.7 sodium channel excitibility

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