scholarly journals Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome

2020 ◽  
Author(s):  
Pingping Li ◽  
Jimin Zheng ◽  
Yun Bai ◽  
Dingxin Wang ◽  
Zijin Cui ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mood Disorders ◽  
High Performance ◽  
Depression Scale ◽  
Kynurenine Pathway ◽  
Self Rating ◽  
Symptom Severity Scale ◽  
Liquid Chromatography Tandem Mass ◽  
Intestinal Symptoms ◽  
Irritable Bowel

Our objectives are to demonstrate whether the kynurenine pathway is activated in diarrhea-type irritable bowel syndrome (IBS-D) patients, and whether the neurotoxic metabolite quinolinic acid (QUIN) is out of balance with the neuroprotective metabolite kynurenic acid (KYNA), and further explore whether this can lead to increase of N-methyl D-aspartate receptor 2B (NMDAR2B) expression in the enteric nervous system and in turn leads to intestinal symptoms and mood disorders. All enrolled healthy controls and patients accepted IBS symptom severity scale (IBS-SSS) score, Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) anxiety and depression scores, and also underwent colonoscopy to collect ileum and colonic mucosa specimens. The expression of NMDAR2B in intestinal mucosa was detected by immunofluorescence, and fasting serum was collected to detect the tryptophan (Trp), kynurenine (KYN), KYNA and QUIN by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Our results showed that the kynurenine pathway of IBS-D patients was activated. The production of QUIN and KYNA was imbalanced and resulting in an increased NMDAR2B for patients with IBS-D, which may be involved in intestinal symptoms and mood disorders of IBS-D.

scholarly journals Efficacy of acupuncture in refractory irritable bowel syndrome: study protocol for a randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e045655
Author(s):  
Jun Zhao ◽  
Min Chen ◽  
Xin Wang ◽  
Kun Ye ◽  
Suhua Shi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Chinese Medicine ◽  
Social Adjustment ◽  
Depression Scale ◽  
Categorical Variables ◽  
Self Rating ◽  
Symptom Profile ◽  
Wilcoxon Rank Sum Test ◽  
Number Of Patients ◽  
Irritable Bowel

IntroductionIrritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder that presents with abdominal pain/discomfort and altered bowel patterns. IBS has multiple potential causes for which conventional medicines have had limited success, resulting in a significant number of patients who do not sensitively respond to pharmacotherapy for a period of 12 months and who develop a continuing symptom profile (described as refractory IBS) and seek help through (non)pharmacological treatments. The aim of this study is to investigate the efficacy and safety of acupuncture therapy for refractory IBS on the basis of conventional treatments.Methods and analysisA total of 170 eligible patients who meet the Rome IV criteria for refractory IBS will be randomly allocated to receive acupuncture or sham acupuncture. Each patient will receive 12 sessions of acupuncture over 4 weeks and a 4-week follow-up. The primary outcome will be the IBS Symptom Severity Score. Secondary outcomes will include the proportion of participants experiencing adequate relief of global IBS symptoms, the weekly frequency of defecation, the stool properties assessed by the Bristol Grading Scale, the Work and Social Adjustment Scale, the IBS-Quality of Life score, and the Self-Rating Depression Scale and Self-Rating Anxiety Scale anxiety and depression scores. Outcome measures will be collected at baseline, 2 and 4 weeks of the intervention, and 6 and 8 weeks after the intervention. Categorical variables will be compared with Fisher’s exact test or the Wilcoxon rank-sum test, and continuous variables will be compared using Student’s t-test or the Wilcoxon rank-sum test.Ethics and disseminationThe entire project has been approved by the ethics committees of Beijing University of Chinese Medicine (2020BZYLL0507) and Sichuan Province Regional Institution for Conducting Research on Traditional Chinese Medicine (2020KL-025). The outcomes of the trial will be disseminated through peer-reviewed publications.Trial registration numberNCT04276961.

scholarly journals The difference of disrupted rhythms of life, work and entertainment between patients with FGIDs and healthy people and their associations with psychological disorders under COVID-19 pandemic

2021 ◽  
pp. 002076402199283
Author(s):  
Jing Wang ◽  
Ping He ◽  
Tianwei Deng ◽  
Xiaoming Xu ◽  
Duowu Zou ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Functional Gastrointestinal Disorders ◽  
Depression Scale ◽  
Healthy People ◽  
Gastrointestinal Disorders ◽  
Related Factors ◽  
Healthy Group ◽  
Self Rating ◽  
The Difference ◽  
Life Work

Aims: To investigate the differences in disrupted rhythms between healthy people and patients with functional gastrointestinal disorders (FGIDs) and their associations with mood disorders during the coronavirus disease 2019 (COVID-19) pandemic. Methods: The rhythm scales were composed of subscales 1 and 2 for the assessment of life-work and entertainment rhythms, respectively; Zung’s Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to assess mood disorders. Results: A total of 671 patients with FGIDs and 4373 healthy people successfully participated. The scores of subscales 1 and 2 for patients with FGIDs were significantly higher than those for healthy people ( p < .005). The SAS and SDS scores, their prevalence rates were significantly higher than those for the healthy group (all p < .001). Health status, current occupation, life-work rhythm, SDS, and SAS were independent related factors of FGIDs. The score of life-work-entertainment rhythm was significantly positively correlated with SDS and SAS (both p < .001). Conclusion: Disrupted rhythms in patients with FGIDs under the COVID-19 pandemic were more frequently and significantly positively associated with mood disorders.

scholarly journals Correlation between lifestyle and social factors in functional dyspepsia among college freshmen

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093970
Author(s):  
Zhen-peng Huang ◽  
Ke Wang ◽  
Yu-hang Duan ◽  
Guang Yang
Keyword(s):  
Mood Disorders ◽  
Functional Dyspepsia ◽  
Social Factors ◽  
Social Life ◽  
Social Stress ◽  
Dietary Habits ◽  
Depression Scale ◽  
Lifestyle Habits ◽  
Psychosocial Disorders ◽  
Self Rating

Objective We aimed to examine the relationship between the prevalence of functional dyspepsia (FD) and lifestyle habits, to identify social factors that may contribute to psychosocial disorders. Methods We enrolled 759 university freshmen in this study, who were categorized into the FD group and healthy group. All participants completed the validated Self-Rating Depression Scale and Self-Rating Anxiety Scale questionnaires, to assess lifestyle and social factors among participants. Results The proportion of participants with FD was 16.86%, and 67.97% were women. Diet irregularities and sleep impairment may have an effect on FD. Tea consumption may play a role in preventing FD. Participants with FD were more likely to have mood disorders than healthy participants. Most participants with FD who had mood disorders experienced mild anxiety or depression. Participants’ main sources of stress arose from daily life, development, social life, life events, and participants’ daily schedule. Conclusion Sex and lifestyle habits, including sleeping patterns and dietary habits, can have an impact on FD. Social stress and mood disorders also have an effect on FD. FD may be prevented by adjusting lifestyle habits and psychological counseling.

Su1325 The Prevalence and Impact of Mood Disorders and Irritable Bowel Syndrome in a Nationwide Military Crohn's Disease Population

2015 ◽  
Vol 148 (4) ◽  
pp. S-475
Author(s):  
Scott E. Cunningham ◽  
Corinne Maydonovitch ◽  
Ganesh R. Veerappan ◽  
John D. Betteridge
Keyword(s):  
Irritable Bowel Syndrome ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mood Disorders ◽  
Irritable Bowel

Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster

2019 ◽  
Vol 10 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Z.F. Ma ◽  
N. Yusof ◽  
N. Hamid ◽  
R.M. Lawenko ◽  
W.M.Z. Wan Mohammad ◽  
...  
Keyword(s):  
Mental Health ◽  
Irritable Bowel Syndrome ◽  
Bodily Pain ◽  
Depression Scale ◽  
Bacterial Overgrowth ◽  
Well Being ◽  
Bifidobacterium Infantis ◽  
Before And After ◽  
Irritable Bowel ◽  
Lower Ratio

Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Of 53 participants, 20 with IBS were given B. infantis M-63 (1×109 cfu/sachet/day) for three months and 33 were controls. IBS symptom severity scale, hospital anxiety and depression scale, SF-36 Questionnaire, hydrogen breath testing for small intestinal bacterial overgrowth and stools for 16S rRNA metagenomic analysis were performed before and after intervention. 11 of 20 who were given probiotics (M-63) and 20 of 33 controls completed study as per-protocol. Mental well-being was improved with M-63 vs controls for full analysis (P=0.03) and per-protocol (P=0.01) populations. Within-group differences were observed for anxiety and bodily pain (both P=0.04) in the M-63 per-protocol population. Lower ratio of Firmicutes/Bacteroidetes was observed with M-63 vs controls (P=0.01) and the lower ratio was correlated with higher post-intervention mental score (P=0.04). B. infantis M-63 is probably effective in improving mental health of victims who developed IBS after floods and this is maybe due to restoration of microbial balance and the gut-brain axis. However, our conclusion must be interpreted within the context of limited sample size. The study was retrospectively registered on 12 October 2017 and the Trial Registration Number (TRN) was NCT03318614.

Psychiatric Disorder, Irritable Bowel Syndrome and Extra-Intestinal Symptoms in a Population-Based Sample of Twins

2009 ◽  
Vol 104 (3) ◽  
pp. 686-694 ◽  
Author(s):  
Anthony J Lembo ◽  
Mohammed Zaman ◽  
Robert F Krueger ◽  
Barbara M Tomenson ◽  
Francis H Creed
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychiatric Disorder ◽  
Population Based ◽  
Intestinal Symptoms ◽  
Irritable Bowel

scholarly journals CHRONIC PELVIC PAIN

2018 ◽  
Vol 25 (02) ◽  
pp. 173-179
Author(s):  
Syeda Rabia ◽  
Naeem Akhtar Qureshi ◽  
Afsha Shahid ◽  
Hira Afreen
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
P Value ◽  
Standard Tool ◽  
The Mean ◽  
Irritable Bowel ◽  
Associated Risk Factors

Objectives: To determine the frequency and associated risk factors of chronicpelvic pain (CPP) in educated women under 30 years of age. Study Design: A cross sectionalstudy. Setting: North Naziabad and Gulshan e Iqbal towns of Karachi. Period: January to July2017. Method: Data was collected through convenient sampling. Informed verbal consentwas taken before data collection. A questioner was used to collect demographic and obstetricdata. Screening of Anxiety and depression was done using standard tool Hospital basedanxiety and depression scale (HADS).Result were analyzed on SPSS. Result: The mean ageof women were 25 years, SD = 4.31. The frequency of chronic pelvic pain was 29% (116).Gynecological cause was found in 68.9% (80). Irritable bowel syndrome was seen in 9% (36)women. Significant association of CPP was noted with Dysmenorrhoea (p-value=000,OR=.207), Dyspareunia (p-value = .000, OR = .166), Heavy menstrual flow (p-value = .033, OR= .333), married (p-value = .000, OR = .414), Vaginal discharge (p-value = .000, OR = .260),Anxiety (p-value = .000, OR = .300), depression (p-value = .002, OR = .452), Normal mentalstatus (p-value = .000, OR = 2.488), Irritable bowel syndrome (p-value = .000, OR = .169)and PMS (p-value = .000, OR = .438). Conclusion: Frequency of chronic pelvic pain is high inyoung educated women. Gynecological causes, irritable bowel syndrome and psychologicaldisorder are significantly associated with CPP. 

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