scholarly journals The difference of disrupted rhythms of life, work and entertainment between patients with FGIDs and healthy people and their associations with psychological disorders under COVID-19 pandemic

2021 ◽  
pp. 002076402199283
Author(s):  
Jing Wang ◽  
Ping He ◽  
Tianwei Deng ◽  
Xiaoming Xu ◽  
Duowu Zou ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Functional Gastrointestinal Disorders ◽  
Depression Scale ◽  
Healthy People ◽  
Gastrointestinal Disorders ◽  
Related Factors ◽  
Healthy Group ◽  
Self Rating ◽  
The Difference ◽  
Life Work

Aims: To investigate the differences in disrupted rhythms between healthy people and patients with functional gastrointestinal disorders (FGIDs) and their associations with mood disorders during the coronavirus disease 2019 (COVID-19) pandemic. Methods: The rhythm scales were composed of subscales 1 and 2 for the assessment of life-work and entertainment rhythms, respectively; Zung’s Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to assess mood disorders. Results: A total of 671 patients with FGIDs and 4373 healthy people successfully participated. The scores of subscales 1 and 2 for patients with FGIDs were significantly higher than those for healthy people ( p < .005). The SAS and SDS scores, their prevalence rates were significantly higher than those for the healthy group (all p < .001). Health status, current occupation, life-work rhythm, SDS, and SAS were independent related factors of FGIDs. The score of life-work-entertainment rhythm was significantly positively correlated with SDS and SAS (both p < .001). Conclusion: Disrupted rhythms in patients with FGIDs under the COVID-19 pandemic were more frequently and significantly positively associated with mood disorders.

scholarly journals Correlation between lifestyle and social factors in functional dyspepsia among college freshmen

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093970
Author(s):  
Zhen-peng Huang ◽  
Ke Wang ◽  
Yu-hang Duan ◽  
Guang Yang
Keyword(s):  
Mood Disorders ◽  
Functional Dyspepsia ◽  
Social Factors ◽  
Social Life ◽  
Social Stress ◽  
Dietary Habits ◽  
Depression Scale ◽  
Lifestyle Habits ◽  
Psychosocial Disorders ◽  
Self Rating

Objective We aimed to examine the relationship between the prevalence of functional dyspepsia (FD) and lifestyle habits, to identify social factors that may contribute to psychosocial disorders. Methods We enrolled 759 university freshmen in this study, who were categorized into the FD group and healthy group. All participants completed the validated Self-Rating Depression Scale and Self-Rating Anxiety Scale questionnaires, to assess lifestyle and social factors among participants. Results The proportion of participants with FD was 16.86%, and 67.97% were women. Diet irregularities and sleep impairment may have an effect on FD. Tea consumption may play a role in preventing FD. Participants with FD were more likely to have mood disorders than healthy participants. Most participants with FD who had mood disorders experienced mild anxiety or depression. Participants’ main sources of stress arose from daily life, development, social life, life events, and participants’ daily schedule. Conclusion Sex and lifestyle habits, including sleeping patterns and dietary habits, can have an impact on FD. Social stress and mood disorders also have an effect on FD. FD may be prevented by adjusting lifestyle habits and psychological counseling.

scholarly journals The Epidemiology of Functional Gastrointestinal Disorders in Mexico: A Population-Based Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Aurelio López-Colombo ◽  
Douglas Morgan ◽  
Dalia Bravo-González ◽  
Alvaro Montiel-Jarquín ◽  
Socorro Méndez-Martínez ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Utilization ◽  
Functional Gastrointestinal Disorders ◽  
Depression Scale ◽  
Sampling Strategy ◽  
Functional Constipation ◽  
Population Based ◽  
Care Utilization ◽  
Gastrointestinal Disorders ◽  
Population Based Study

Aims.The frequency of functional gastrointestinal disorders (FGIDs) in the general population of Mexico is unknown.Methods.To determine the prevalence of FGIDs, associated depression, and health care utilization, a population-based sampling strategy was used to select 500 households in the State of Tlaxcala, in central Mexico. Household interviews were conducted by two trained physicians using the Rome II Modular Questionnaire, a health-care and medication used questionnaire and the CES-D depression scale.Results.The most common FGIDs were IBS: 16.0% (95% CI: 12.9–19.5); functional bloating: 10.8% (8.2–13.9); unspecified functional bowel disorder: 10.6% (8.0–13.6); and functional constipation (FC): 7.4% (5.3–10.1). Uninvestigated heartburn was common: 19.6% (16.2–23.4). All FGIDs were equally prevalent among both genders, except for IBS (P=0.001), IBS-C (P<0.001), IBS-A/M (P=0.049), and FC (P=0.039) which were more frequent in women. Subjects with FGIDs reported higher frequencies of medical visits: 34.6 versus 16.8%; use of medications: 40.7 versus 21.6%; (bothP<0.001); and reported depression: 26.7 versus 6.7%, (P<0.001).Conclusion.In this first population-based study of FGIDs in Mexico, heartburn, IBS, functional distension, and FC were common. Only IBS, IBS-C, IBS-A/M, and FC were more frequent in women. Finally, FGIDs in Mexico had an increased burden of health care utilization and depression.

scholarly journals Ultrasonic System for Diagnosis of Functional Gastrointestinal Disorders: Development, Verification and Clinical Trials

2007 ◽  
Author(s):  
Q. J. Lee ◽  
W. P. Park ◽  
D. Lim ◽  
D. G. Woo ◽  
C. Y. Ko ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Gastrointestinal Tract ◽  
Research Group ◽  
Functional Gastrointestinal Disorders ◽  
Diagnostic Methods ◽  
Healthy People ◽  
Gastrointestinal Disorders ◽  
Ultrasonic Technique ◽  
Functional Disorders

The number of people who are suffering from Functional gastrointestinal disorders is increasing. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes [1, 2]. Recently our research group identified that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders is more rigid than healthy people. we noticed it with palpating the abdominal regions overlaying the gastrointestinal tract. Therefore we developed a system to detect the rigid organs with ultrasonic technique, which can quantify the characteristic above related to the rigidity of the gastrointestinal tract well.

scholarly journals Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome

2020 ◽  
Author(s):  
Pingping Li ◽  
Jimin Zheng ◽  
Yun Bai ◽  
Dingxin Wang ◽  
Zijin Cui ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mood Disorders ◽  
High Performance ◽  
Depression Scale ◽  
Kynurenine Pathway ◽  
Self Rating ◽  
Symptom Severity Scale ◽  
Liquid Chromatography Tandem Mass ◽  
Intestinal Symptoms ◽  
Irritable Bowel

Our objectives are to demonstrate whether the kynurenine pathway is activated in diarrhea-type irritable bowel syndrome (IBS-D) patients, and whether the neurotoxic metabolite quinolinic acid (QUIN) is out of balance with the neuroprotective metabolite kynurenic acid (KYNA), and further explore whether this can lead to increase of N-methyl D-aspartate receptor 2B (NMDAR2B) expression in the enteric nervous system and in turn leads to intestinal symptoms and mood disorders. All enrolled healthy controls and patients accepted IBS symptom severity scale (IBS-SSS) score, Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) anxiety and depression scores, and also underwent colonoscopy to collect ileum and colonic mucosa specimens. The expression of NMDAR2B in intestinal mucosa was detected by immunofluorescence, and fasting serum was collected to detect the tryptophan (Trp), kynurenine (KYN), KYNA and QUIN by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Our results showed that the kynurenine pathway of IBS-D patients was activated. The production of QUIN and KYNA was imbalanced and resulting in an increased NMDAR2B for patients with IBS-D, which may be involved in intestinal symptoms and mood disorders of IBS-D.

scholarly journals Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

2017 ◽  
Vol 35 (Suppl. 1) ◽  
pp. 5-13 ◽  
Author(s):  
Gerald Holtmann ◽  
Ayesha Shah ◽  
Mark Morrison
Keyword(s):  
Mood Disorders ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Symptoms ◽  
Mucosal Inflammation ◽  
Gastrointestinal Disorders ◽  
Low Grade ◽  
Chronic Infections ◽  
Gi Symptoms ◽  
Specific Symptoms ◽  
Biochemical Abnormalities

Background and Summary: Traditionally, functional gastrointestinal disorders (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by more or less specific symptoms and the absence of structural or biochemical abnormalities that cause these symptoms. This concept is now considered to be outdated; if appropriate tests are applied, structural or biochemical abnormalities that explain or cause the symptoms may be found in many patients. Another feature of FGID are the highly prevalent psychiatric comorbidities, such as depression and anxiety. It is implied that mood disorders “cause” gastrointestinal symptoms. In fact, epidemiological data now provide strong evidence that in subsets of cases, gastrointestinal (GI) symptoms arise first and mood disorders occur later, while in other patients the reverse appears to happen. Possible mechanisms for gut-brain dysfunction have been identified, with systemic minimal inflammation as a causal factor in at least some subjects. Other mechanisms that play a role in FGID include chronic infections, intestinal microbiota, low-grade mucosal inflammation including the increase of eosinophils, systemic immune activation, altered intestinal permeability, in diarrhea predominant IBS altered bile salt metabolism, abnormalities in the serotonin metabolism and genetic factors. All these factors might be modulated by environmental factors such as diet. Key Messages: While a number of factors can be linked to specific symptoms (e.g., pain or diarrhea), it is evident that the symptom-based categorization of patients will not allow targeted treatments that specifically address the underlying pathophysiology.

Investigation of affective temperaments and chronobiology in patients with obsessive-compulsive disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S203-S204
Author(s):  
A. Sakalli Kani ◽  
C. Aksoy Poyraz ◽  
B.C. Poyraz ◽  
M.R. Bayar
Keyword(s):  
Mood Disorders ◽  
Obsessive Compulsive Disorder ◽  
Rating Scale ◽  
Clinical Effects ◽  
Obsessive Compulsive ◽  
Healthy Group ◽  
Compulsive Disorder ◽  
Affective Temperaments ◽  
The Difference ◽  
Subsyndromal Symptoms

IntroductionComorbid mood disorders affect negatively the prognosis of obsessive-compulsive disorder (OCD). Affective temperaments are assumed to be subsyndromal symptoms and precursors of mood disorders but its effects on OCD outcome remain unclear. There is a body of evidence, which supports the association between circadian rhythm disturbances and mood disorders in literature. In contrast, there is limited data concerning the effects of chronobiological preference among the patients with OCD and OCD comorbid mood disorders.ObjectiveThe aim of this study is to assess the clinical effects of affective temperaments and chronotype differences in patients with OCD.MethodsThe research was performed in patients with OCD which have been under treatment at least for 12 weeks (n = 76) and healthy controls (n = 55). Yale Brown Obsession Compulsion Scale, TEMPS-A, Morningness and Eveningness Questionnaire, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale were used in the study.ResultsThere were higher scores in depressive, cyclothymic, irritable and anxious temperaments in patients with OCD compared to the healthy group. There were significant differences between patients with remission and not remission in depressive, cyclothymic, irritable and anxious temperaments. Compared to healthy group eveningness chronotype was more frequent in patients; however the difference was not statistically significant. The OCD patients did not differ from comorbid anxiety, depression and remission levels according to the chronotype.ConclusionUnderstanding the effects of affective temperaments and chronotype differences on the outcome of patients with OCD, may provide developing new treatment approaches in especially treatment resistant OCD patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Depression during Pregnancy and Postpartum Period among Women

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Ms. Puja Kumari ◽  
Dr. Gayatri Raina
Keyword(s):  
Postpartum Period ◽  
Depression Scale ◽  
Himachal Pradesh ◽  
T Test ◽  
Third Trimester ◽  
Self Rating ◽  
Pregnancy And Postpartum ◽  
The Difference ◽  
Level Of Significance

Depression during pregnancy and postpartum period affect women drastically. The present work evaluated depression during pregnancy and postpartum period among women of Shimla town, Himachal Pradesh. Eighty women were contacted during their third trimester of pregnancy and again during their one month postpartum period. Depression was assessed with Zung Self- Rating Depression Scale. t-Test was applied to see the difference between the level of depression during third trimester of pregnancy and postpartum period. The result revealed that depression was higher during third trimester of pregnancy as compared to postpartum period among women although the difference failed to reach the level of significance.

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