Spontaneous regression of breast carcinoma: review of English publications from 1753 to 1897

Regression is an important phenomenon in oncology. Two reviews in 2011 dealt at length with what in modern parlance may be called its permutations and combinations. Specifically, in both 1982 and 1987, when its occurrence in breast cancer was presented from two centers, the oldest accounts of it were dated back to 1900. Therefore, a search for much older English literature was undertaken in order to widen current knowledge of this important problem. Consequently, a published long case dating back to 1897 is abridged and a short 1846 case is also noted. Furthermore, general etiological concepts are exemplified as far back as 1753. It is concluded that the history of cancer regression is like fishing in an ocean of this illness. However, the findings are deemed to complement what modern historical accounts lack.

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Oral Metastasis of Metaplastic Breast Carcinoma in a Patient with Neurofibromatosis 1

Case Reports in Oncological Medicine ◽

10.1155/2014/719061 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Ana Paula Molina Vivas ◽

Luana Eschholz Bomfin ◽

Clovis Antonio Lopes Pinto ◽

Ulisses Ribaldo Nicolau ◽

Fabio Abreu Alves

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

English Literature ◽

Neurofibromatosis Type ◽

Nerve Sheath Tumors ◽

Peripheral Nerve Sheath Tumors ◽

Increased Risk ◽

Multiple Metastases ◽

Metaplastic Breast Carcinoma ◽

Oral Metastasis

Neurofibromatosis type 1 (NF1) has been associated with an increased risk for development of malignancy, especially malignant peripheral nerve sheath tumors. In addition, recently, literature has demonstrated an increased risk of breast cancer in women with NF1. The present paper shows a 53-year-old woman with NF1 who presented with metaplastic breast carcinoma and developed multiple metastases, including mandible. Furthermore, we reviewed the English literature, found 63 cases showing the association between NF1 and breast cancer, and added one more case. The present study demonstrated an important association between NF1 and breast cancer. Until the present time, there has been only one case of metaplastic breast carcinoma associated with NF1. Curiously, in our case the oral metastasis corresponded to sarcomatous component of metaplastic breast carcinoma.

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Insulin-like growth factor 1 and musculoskeletal pain among breast cancer patients on aromatase inhibitor therapy and women without a history of cancer

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-013-1391-7 ◽

2013 ◽

Vol 139 (5) ◽

pp. 837-843 ◽

Cited By ~ 7

Author(s):

Lisa Gallicchio ◽

Ryan MacDonald ◽

Kathy J. Helzlsouer

Keyword(s):

Breast Cancer ◽

Growth Factor ◽

Aromatase Inhibitor ◽

Cancer Patients ◽

Musculoskeletal Pain ◽

Insulin Like Growth Factor ◽

Breast Cancer Patients ◽

Aromatase Inhibitor Therapy ◽

History Of ◽

History Of Cancer

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Accuracy of self-reported family history of cancer, mutation status and tumor characteristics in patients with early onset breast cancer

Acta Oncologica ◽

10.1080/0284186x.2017.1404635 ◽

2017 ◽

Vol 57 (5) ◽

pp. 595-603 ◽

Cited By ~ 8

Author(s):

Annelie Augustinsson ◽

Carolina Ellberg ◽

Ulf Kristoffersson ◽

Åke Borg ◽

Håkan Olsson

Keyword(s):

Breast Cancer ◽

Family History ◽

Early Onset ◽

Tumor Characteristics ◽

Early Onset Breast Cancer ◽

Mutation Status ◽

Family History Of Cancer ◽

Cancer Mutation ◽

History Of ◽

History Of Cancer

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COGNITIVE FUNCTIONING AMONG BREAST CANCER SURVIVORS AND NON-CANCER PARTICIPANTS: EVIDENCE FOR SIMILARITIES

Innovation in Aging ◽

10.1093/geroni/igz038.2411 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S649-S650

Author(s):

Giancarlo Pasquini ◽

Brent J Small ◽

Jacqueline Mogle ◽

Martin Sliwinski ◽

Stacey B Scott

Keyword(s):

Breast Cancer ◽

Working Memory ◽

Executive Functioning ◽

Cancer Survivors ◽

Cognitive Functioning ◽

Processing Speed ◽

Breast Cancer Survivors ◽

Cancer History ◽

History Of ◽

History Of Cancer

Abstract Breast cancer survivors may experience accelerated decline in cognitive functioning compared to same-aged peers with no cancer history (Small et al., 2015). Survivors may show important differences in mean-level performance or variability in cognitive functioning compared to those without a history of cancer (Yao et al., 2016). This study compared ambulatory cognitive functioning in a sample of breast cancer survivors and an age-matched community sample without a history of cancer (n_cancer=47, n_non-cancer=105, age range: 40-64 years, M=52.13 years). Participants completed three cognitive tasks measuring working memory, executive functioning, and processing speed up to five times per day for 14 days. Results indicated no mean-level differences in cognitive performance on the three tasks between cancer survivors and those without cancer history (p’s>.05). Unexpectedly, women without cancer history showed more variability than survivors on working memory but not on the other two tasks. Across both groups, those without a college education performed worse on executive functioning (B=-0.05, SE=0.03, p<.05) and working memory (B=0.94, SE=0.36, p<.05) compared to those that completed college. Additionally, older age was associated with slower processing speed (B=31.67, SE=7.44, p<.001). In sum, this study did not find mean-level group differences in cognitive functioning between cancer survivors and age-matched women without a history of cancer. Contrary to hypotheses, those without a history of cancer were more variable on working memory. Results suggested similarities in cognitive functioning in the two samples and that education and age are important predictors of cognitive functioning independent of cancer history.

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Quality of life and mental health in breast cancer survivors compared with non-cancer controls: a study of patient-reported outcomes in the United Kingdom

Journal of Cancer Survivorship ◽

10.1007/s11764-020-00950-3 ◽

2020 ◽

Author(s):

Helena Carreira ◽

Rachael Williams ◽

Harley Dempsey ◽

Susannah Stanway ◽

Liam Smeeth ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Primary Care ◽

Cancer Survivors ◽

Patient Reported Outcomes ◽

Breast Cancer Survivors ◽

Patient Reported ◽

History Of ◽

History Of Cancer

Abstract Purpose There is limited high-quality evidence on quality of life, anxiety, and depressive symptoms in breast cancer survivors and women with no history of cancer. We aimed to address this by comparing patient-reported outcomes between breast cancer survivors and women with no history of breast cancer. Methods Breast cancer survivors and women with no prior cancer were selected from the UK Clinical Practice Research Datalink GOLD primary care database, which includes population-based primary care electronic health record data. Breast cancer survivors and controls were frequency matched by age and primary care practice. Outcomes were assessed with validated instruments via postal questionnaire. Linear and logistic regression models were fitted to estimate adjusted associations between breast cancer survivorship and outcomes. Results A total of 356 breast cancer survivors (8.1 years post diagnosis) and 252 women with no prior cancer participated in the study. Compared with non-cancer controls, breast cancer survivors had poorer QoL in the domains of cognitive problems (adjusted β (aβ) = 1.4, p = 0.01), sexual function (aβ = 1.7, p = 0.02) and fatigue (aβ = 1.3, p = 0.01), but no difference in negative feelings, positive feelings, pain, or social avoidance. Breast cancer survivors had higher odds of borderline-probable anxiety (score ≥ 8) (adjusted OR = 1.47, 95%CI:1.15–1.87), but no differences in depression. Advanced stage at diagnosis and chemotherapy treatment were associated with poorer QoL. Conclusions Compared with women with no history of cancer, breast cancer survivors report more problems with cognition, sexual function, fatigue, and anxiety, particularly where their cancer was advanced and/or treated with chemotherapy. Implications for Cancer Survivors Breast cancer survivors with more advanced disease and/or treated with chemotherapy should be closely monitored and, when possible, offered evidence-based intervention for fatigue, cognitive dysfunction, and sexual problems.

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Mortality and Risk of Cancer After Prophylactic Bilateral Oophorectomy in Women With a Family History of Cancer

JNCI Cancer Spectrum ◽

10.1093/jncics/pky034 ◽

2018 ◽

Vol 2 (3) ◽

Cited By ~ 1

Author(s):

Julie Abildgaard ◽

Magnus Glindvad Ahlström ◽

Gedske Daugaard ◽

Dorte Lisbet Nielsen ◽

Anette Tønnes Pedersen ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Rate Ratio ◽

Bilateral Oophorectomy ◽

Family History Of Cancer ◽

Increased Risk ◽

History Of ◽

Risk Of Cancer ◽

The Impact ◽

History Of Cancer

Abstract Background Current international guidelines recommend systemic hormone therapy (HT) to oophorectomized women until the age of natural menopause. Despite an inherited predisposition to estrogen-dependent malignancies, the guidelines also apply to women oophorectomized because of a family history of cancer. The objective of this study was to investigate the impact of HT on mortality and risk of cancer in women oophorectomized because of a family history of cancer. Methods A nationwide, population-based cohort was used to study women oophorectomized because of a family history of cancer (n = 2002). Comparison cohorts included women from the background population individually matched on age (n = 18 018). Oophorectomized women were subdivided into three groups: oophorectomized at 1) age 45 years or younger not using HT, 2) age 45 years or younger using HT, 3) older than age 45 years, and their respective population comparison cohorts. Results Women oophorectomized at age 45 years or younger using HT had increased overall mortality (mortality rate ratio [MRR] = 3.45, 95% confidence interval [CI] = 1.53 to 7.79), mortality because of cancer (MRR = 5.67, 95% CI = 1.86 to 17.34), and risk of overall cancer (incidence rate ratio [IRR] = 3.68, 95% CI = 1.93 − 6.98), primarily reflected in an increased risk of breast cancer (IRR = 4.88, 95% CI = 2.19 − 10.68). Women oophorectomized at age 45 years or younger not using HT and women oophorectomized at older than age 45 years did not have increased mortality, mortality because of cancer, or risk of overall cancer, but they had increased risk of breast cancer (IRR = 2.64, 95% CI = 1.14 to 6.13, and IRR = 1.72, 95% CI = 1.14 to 2.59, respectively). Conclusions Use of HT in women oophorectomized at age 45 years or younger with a family history of cancer is associated with increased mortality and risk of overall cancer and breast cancer. Our study warrants further investigation to establish the impact of HT on mortality and cancer risk in oophorectomized women with a family history of cancer.

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Hospital visitors as controls in case-control studies

Revista de Saúde Pública ◽

10.1590/s0034-89102001000500005 ◽

2001 ◽

Vol 35 (5) ◽

pp. 436-442 ◽

Cited By ~ 5

Author(s):

Gulnar Azevedo S Mendonça ◽

José Eluf-Neto

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Family History ◽

Case Control ◽

Breast Size ◽

Case Control Studies ◽

Family History Of Cancer ◽

History Of ◽

Incident Cases ◽

History Of Cancer

OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute) in Rio de Janeiro (Brazil). METHODS: The study included 177 incident cases and 377 controls recruited among female visitors. Three different models of control group composition were compared: Model 1, with all selected visitors; Model 2, excluding women visiting relatives with breast cancer; and Model 3, excluding all women visiting relatives with any type of cancer. Odds ratios (OR) and 95% confidence intervals were calculated to test the associations. RESULTS: Age-adjusted OR for breast cancer associated with risk factors other than family history of cancer, except smoking and breast size, were similar in the three models. Regarding family history of all cancers, except for breast cancer, there was a decreased risk in Models 1 and 2, while in Model 3 there was an increased risk, but not statistically significant. Family history of breast cancer was a risk factor in Models 2 and 3, but no association was found in Model 1. In multivariate analysis a significant risk of breast cancer was found when there was a family history of breast cancer in Models 2 and 3 but not in Model 1. CONCLUSIONS: These results indicate that while investigating risk factors unrelated to family history of cancer, the use of hospital visitors as controls may be a valid and feasible alternative.

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Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa272 ◽

2020 ◽

Vol 2020 (8) ◽

Author(s):

Saifullah Mohamed ◽

Khurum Mazhar ◽

Ahmed Osman ◽

Akshay Patel ◽

Lakshmi Srinivasan ◽

...

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Previous History ◽

Metastatic Breast ◽

Extent Of Resection ◽

Left Breast ◽

Term Survival ◽

Metastatic Breast Carcinoma ◽

History Of ◽

Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

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Intermittent attendance at breast cancer screening

Journal of Public Health Research ◽

10.4081/jphr.2013.e14 ◽

2013 ◽

Vol 2 (2) ◽

pp. 14 ◽

Cited By ~ 10

Author(s):

Padraic Fleming ◽

Sinead O'Neill ◽

Miriam Owens ◽

Therese Mooney ◽

Patricia Fitzpatrick

Keyword(s):

Breast Cancer ◽

Word Of Mouth ◽

Private Insurance ◽

Good Health ◽

History Of ◽

Fear And Anxiety ◽

Demographic Patterns ◽

Design And Methods ◽

History Of Cancer ◽

Structured Questionnaire

Background. To determine why women skip rounds and factors influencing return of previous non attenders (PNAs) to breast screening. Design and methods. Retrospective, quantitative, structured questionnaire posted to 2500 women. First PNAs did not attend their first screening appointment in 2007/2008 but then attended in 2010; First Controls first attended in 2010 without missed previous appointments. Women who attended screening in 2006 or earlier then skipped a round but returned in 2010 were Subsequent PNAs; Subsequent Controls attended all appointments. Results. More First Controls than First PNAs had family history of cancer (72.7% vs 63.2%; P=0.003); breast cancer (31.3% vs 24.8%; P=0.04). More PNAs lived rurally; more First PNAs had 3rd level education (33.2% vs 23.6%; P=0.002) and fewer had private insurance than First Controls (57.7% vs 64.8%; P=0.04). Excellent/good health was reported in First PNAs and First Controls (82.9% vs 83.2%), but fewer Subsequent PNAs than Subsequent Controls (72.7% vs 84.9%; P=0.000). Common considerations at time of missed appointment were had mammogram elsewhere (33% First PNA) and postponed to next round (16% First PNA, 18.8% Subsequent PNA). Considerations when returning to screening were similar for First PNAs and Subsequent PNAs: I am older (35.4%, 29.6%), I made sure I remembered (29%, 23.6%), could reschedule (17.6%, 20.6%), illness of more concern (16.5%, 19%). More First PNAs stated my family/friends advised (22.3% vs 15.2%) or my GP (12.6% vs 4.6%) advised me to attend, heard good things about BreastCheck (28.8% vs 13.6%). Conclusions. Intermittent attenders do not fit socio-demographic patterns of non-attenders; GP recommendation and word of mouth were important in women’s return to screening. Fear and anxiety seem to act as a screening facilitator rather than an inhibitor.

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