scholarly journals The Association between Serum Vitamin D Concentration and Colon Polyp: A Cross-Sectional Study Using Health Care Screening Database in a Tertiary Hospital in Korea

2021 ◽  
Vol 42 (4) ◽  
pp. 303-309
Author(s):  
Mun Young Yoo ◽  
Jungkwon Lee ◽  
Ji In Chung ◽  
Yohwan Yeo ◽  
In Young Cho
Keyword(s):  
Vitamin D ◽  
Precancerous Lesions ◽  
Medical Center ◽  
Serum Vitamin ◽  
Colorectal Polyps ◽  
Colon Polyps ◽  
Hyperplastic Polyps ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: As indoor activity increases with modern lifestyles changes, reduced exposure to sunlight may lead to reduced vitamin D synthesis. Previous studies demonstrated that increased vitamin D level is associated with decreased risk of colon cancer; therefore, this study attempted to determine the association between vitamin D and colon polyps, which may be precancerous lesions, in participants who underwent colonoscopy exams.Methods: A total of 31,004 participants who underwent routine health checkups, including vitamin D level and colonoscopy, at Samsung Medical Center in South Korea from 2010 to 2018 were included in the study. Colorectal polyps were diagnosed through biopsy after performing colonoscopy exams. Participants were categorized into three groups according to level of vitamin D (deficient: <20 ng/mL), insufficient: 20≤ vitamin D <30 ng/mL, and sufficient: ≥30 ng/mL). We analyzed the presence of colorectal polyps according to vitamin D level, and performed multiple logistic regression analyses for the association between vitamin D level and colorectal polyps.Results: About 50% of participants had colorectal polyps (hyperplastic polyp, n=4,864; adenomatous polyp, n=10,470; adenocarcinoma, n=24). There were no significant associations between vitamin D categories and colorectal polyp and colorectal cancer. However, when further analyzing by type of polyp, the risk of hyperplastic polyps significantly decreased with increasing vitamin D levels (P for trend=0.006).Conclusion: We did not find evidence for an association between vitamin D and overall colorectal polyps; however, we observed a trend for decreased odds of hyperplastic polyps with increased vitamin D levels in comparison to vitamin D deficient subjects.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

scholarly journals Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome

2021 ◽  
Vol 4 (1) ◽  
pp. 64-71
Author(s):  
Shasya Aniza Santoso ◽  
◽  
Tita Husnitawati Madjid ◽  
Anita Rachmawati
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Fasting Blood Glucose ◽  
Serum Vitamin ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method. Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant. Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

scholarly journals Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes

2017 ◽  
Vol 87 (6) ◽  
pp. 385-395 ◽  
Author(s):  
Debika Nandi-Munshi ◽  
Maryam Afkarian ◽  
Kathryn B. Whitlock ◽  
Jamie L. Crandell ◽  
Ronny A. Bell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Serum Vitamin ◽  
Nutrition Survey ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Urine Albumin ◽  
Health And Nutrition ◽  
Vitamin D Levels

Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6–19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.

Association of statin use and risk for severe headache or migraine by serum vitamin D status: A cross-sectional population-based study

Cephalalgia ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. 757-766 ◽  
Author(s):  
Catherine Buettner ◽  
Rami Burstein
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Serum Vitamin ◽  
Severe Headache ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Adjusted Logistic Regression ◽  
Statin Use

Objective The objective of this article is to evaluate whether statin use and vitamin D status is associated with severe headache or migraine in a nationally representative sample. Methods We conducted a cross-sectional study of US individuals aged ≥40 years for whom information on statin use, serum 25-hydroxy vitamin D (25(OH)D), and self-reported severe headache or migraine had been collected. We calculated prevalence estimates of headache according to statin and 25(OH)D, and conducted adjusted logistic regression analyses stratified by the median 25(OH)D (≤57 and >57 nmol/l). Results Among 5938 participants, multivariable-adjusted logistic regression showed that statin use was significantly associated with a lower prevalence of severe headache or migraine (OR 0.67; 95% CI 0.46, 0.98, p = 0.04). We found a significant interaction between statin use and 25(OH)D with the prevalence of severe headache or migraine ( p for interaction = 0.005). Among participants who had serum 25(OH)D > 57 nmol/l, statin use was associated with a multivariable-adjusted odds ratio of 0.48 (95% CI 0.32, 0.71, p = 0.001) for having severe headache or migraine. Among those with 25(OH)D ≤ 57 nmol/l, no significant association was observed between statin use and severe headache or migraine. Conclusion Statin use in those with higher serum vitamin D levels is significantly associated with lower odds of having severe headache or migraine.

scholarly journals VITAMIN D DEFICIENCY;

2012 ◽  
Vol 19 (02) ◽  
pp. 208-213
Author(s):  
MUHAMMAD ASLAM ◽  
ZAHID MASOOD ◽  
Abdul SATTAR ◽  
Maria Qudsia
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Vitamin D 3

Objective: To study the Prevalence of Vitamin D deficiency in pregnant women. Study Design: A Cross-sectional analyticalstudy through convenient sampling technique. Setting and duration: At a private Clinic located at East Canal Road Faisalabad, from March2011 to June 2011. Material and method: The study included consecutive 61 pregnant women of reproductive age and non-pregnant womenwere excluded. Blood samples were taken in morning i.e. overnight fasting samples, by venepuncture by disposable syringes sample weretaken and samples were stored at -20 degree centigrade till they were analyzed. Our interest was in age and serum Vitamin D 3 levels. Results:Out of 61 pregnant women results showed that 87.0% pregnant women were having Vitamin D deficiency, 10.0% were having Vitamin Dinsufficiency, 3.0% had Vitamin D sufficiency and none shows Vitamin D intoxication. Vitamin D deficiency was more prevalent in pregnantwomen of younger age group. Furthermore prevalence was higher among the pregnant mothers with high parity. Moreover, 65% women werenot exposed to sunlight properly, 60% women had muscle cramps and bony aches. 90% women never were tested for tested Vitamin D levelsbefore. Conclusions: Prevalence of Vitamin D deficiency is significant in pregnant women. It is also important for its effects on various organsand systems of body as well as on pregnancy and neonate. The different aspects of study led to conclusion to emphasize that Health educationbe imparted to pregnant women and their families in terms of diet, proper sunlight exposure and taking Vitamin D supplements in pregnancy. It isthus recommended to perform Vitamin D levels in every pregnant woman.

scholarly journals Does Vitamin D Have a Role in the Inception of Childhood Asthma? - A Comparative Cross-Sectional Study

2021 ◽  
Vol 8 (17) ◽  
pp. 1157-1162
Author(s):  
Mohan Jayabal ◽  
Rashmi Ramanathan ◽  
Arun Kumar ◽  
Pavithra Vyshnavi Yogisparan ◽  
Manishankar Subramaniyam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Function ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BACKGROUND Global prevalence of paediatric asthma has shown a sharp increase in last three decades. Recently vitamin D has been linked with lung function and vitamin D supplementation can lessen the acute exacerbations in asthmatic children. The purpose of the study was to compare lung parameters and vitamin D levels in asthmatic and non-asthmatic children and assess the correlation between vitamin D levels and pulmonary function parameters in children. METHODS A cross-sectional study was conducted among 40 asthmatic children and 42 healthy volunteers between the age group of 5 and 18 years attending the paediatric outpatient department (OPD) in a tertiary care centre in Coimbatore. Pulmonary functions were assessed using computerized spirometer and the serum 25-hydroxy vitamin D levels were estimated by Diazyme EZ vitamin D assay latex enhanced immunoturbidimetric method. The results were compared between asthmatics and non-asthmatics to find out the association. RESULTS The average age of the study participants was 10.5 ± 2.5 years. Lung parameters and mean vitamin D levels are reduced in asthmatics. There is a positive significant correlation between serum vitamin D levels and forced expiratory volume FEV1 / forced vital capacity (FVC) (P < 0.05, r = 0.781), and also between vitamin D and FEV1 (P < 0.05, r = 0.28). Lung parameters like FEV1, FEV1 / FVC ratio and peak expiratory flow rate (PEFR) are significantly decreased in asthmatic children. CONCLUSIONS Majority of the asthmatics have insufficient vitamin D levels than the normal peers with no asthma. Our study confirms the positive association between vitamin D and FEV1 and FEV1 / FVC ratio. KEYWORDS Vitamin D, Asthma, Pulmonary Function, Lung Parameters

scholarly journals association of Serum Vitamin D levels with Hypertension

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Maryam Rao ◽  
◽  
Tabinda Kazmi ◽  
Muhammad Imran ◽  
Aamir Mahmood ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Key Words Hypertension ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Cardiology Department ◽  
Potential Association ◽  
Vitamin D Levels

Objectives: The objective of our study was to identify the effect of low serum vitamin D levels on hypertension & to make a comparison of levels of vitamin D in hypertensives and healthy individuals. Materials and Method: A cross-sectional comparative study carried out in Cardiology Department of Shaikh Zayed Hospital and Punjab Institute of Cardiology, which involved measurement and comparison of serum Vitamin D levels in 64 subjects, categorized in two groups; hypertensives and normotensives, in order to establish a potential association between vitamin D levels and hypertension. Results: Our study showed that Serum Vitamin D was equally sub-optimal in all participants of study, including both hypertensive group and the healthy controls. As a result of this finding, a clear pattern of association of vitamin D deficiency with hypertension could not be seen. Mean ±SD Vitamin D levels was 19.5±10.0 ng/L in hypertensives and 19.5±13.6 in healthy individuals. This study did not lead to establishment of an association between hypertension and vitamin D levels. Conclusion: Because of deficiency of Vitamin D in general population in this region, our study failed to show an association between Vitamin D and hypertension. Further exploration is needed in this regard. Key words: Hypertension, serum Vitamin D levels

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