scholarly journals Severe canine distemper outbreak in unvaccinated dogs in Mozambique

2016 ◽  
Vol 87 (1) ◽  
Author(s):  
Julieta Zacarias ◽  
Alberto Dimande ◽  
Sara Achá ◽  
Paula T. Dias ◽  
Elisa M. Leonel ◽  
...  
Keyword(s):  
Developing Countries ◽  
Animal Welfare ◽  
Low Income ◽  
Immunohistochemical Staining ◽  
Canine Distemper Virus ◽  
Large Scale ◽  
Clinical Signs ◽  
Canine Distemper ◽  
Animal Suffering ◽  
Low Income Families

Although significant animal suffering caused by preventable diseases is frequently seen in developing countries, reports of this are scarce. This report describes avoidable animal suffering owing to a suspected canine distemper (CD) outbreak in unvaccinated dogs owned by low-income families in Mozambique that killed approximately 200 animals. Affected dogs exhibited clinical signs, and gross and microscopic lesions compatible with CD. Immunohistochemical staining confirmed the presence of canine distemper virus (CDV) in the kidney of one dog from the cohort. This brief communication again illustrates that large outbreaks of CDV in unvaccinated dogs occur and that large-scale avoidable suffering and threats to the health of dogs and wild canines continue. Mass vaccination supported by government and non-government organisations is recommended.Keywords: Canine distemper; dogs; outbreak; animal welfare; Mozambique

scholarly journals Vaccination against Canine Distemper Virus Infection in Infant Ferrets with and without Maternal Antibody Protection, Using Recombinant Attenuated Poxvirus Vaccines

2000 ◽  
Vol 74 (14) ◽  
pp. 6358-6367 ◽  
Author(s):  
Janet Welter ◽  
Jill Taylor ◽  
James Tartaglia ◽  
Enzo Paoletti ◽  
Charles B. Stephensen
Keyword(s):  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Neutralizing Antibody ◽  
Maternal Antibody ◽  
Canine Distemper ◽  
Parenteral Immunization ◽  
Multiple Routes ◽  
Antibody Titers ◽  
Group 3 ◽  
Rabies Glycoprotein

ABSTRACT Canine distemper virus (CDV) infection of ferrets is clinically and immunologically similar to measles, making this a useful model for the human disease. The model was used to determine if parenteral or mucosal immunization of infant ferrets at 3 and 6 weeks of age with attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) would induce serum neutralizing antibody and protect against challenge infection at 12 weeks of age. Ferrets without maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 5) or ALVAC-HF (n = 4) developed significant neutralizing titers (log10 inverse mean titer ± standard deviation of 2.30 ± 0.12 and 2.20 ± 0.34, respectively) by the day of challenge, and all survived with no clinical or virologic evidence of infection. Ferrets without maternal antibody that were vaccinated intranasally (i.n.) developed lower neutralizing titers, with NYVAC-HF producing higher titers at challenge (1.11 ± 0.57 versus 0.40 ± 0.37, P = 0.02) and a better survival rate (6/7 versus 0/5, P = 0.008) than ALVAC-HF. Ferrets with maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 7) and ALVAC-HF (n = 7) developed significantly higher antibody titers (1.64 ± 0.54 and 1.28 ± 0.40, respectively) than did ferrets immunized with an attenuated CDV vaccine (0.46 ± 0.59;n = 7) or the recombinant vectors expressing rabies glycoprotein (RG) (0.19 ± 0.32; n = 8,P = 7 × 10−6). The NYVAC vaccine also protected against weight loss, and both the NYVAC and attenuated CDV vaccines protected against the development of some clinical signs of infection, although survival in each of the three vaccine groups was low (one of seven) and not significantly different from the RG controls (none of eight). Combined i.n.-parenteral immunization of ferrets with maternal antibody using NYVAC-HF (n = 9) produced higher titers (1.63 ± 0.25) than did i.n. immunization with NYVAC-HF (0.88 ± 0.36; n = 9) and ALVAC-HF (0.61 ± 0.43; n = 9, P = 3 × 10−7), and survival was also significantly better in the i.n.-parenteral group (3 of 9) than in the other HF-vaccinated animals (none of 18) or in controls immunized with RG (none of 5) (P = 0.0374). Multiple routes were not tested with the ALVAC vaccine. The results suggest that infant ferrets are less responsive to i.n. vaccination than are older ferrets and raises questions about the appropriateness of this route of immunization in infant ferrets or infants of other species.

New Trends in Interaction of Developed and Developing Countries in Innovation Sphere

2012 ◽  
pp. 3-14
Author(s):  
A. Eroshkin ◽  
M. Petrov
Keyword(s):  
Developing Countries ◽  
International Relations ◽  
Low Income ◽  
Large Scale ◽  
Research Capacity ◽  
Transnational Corporations ◽  
Income Groups ◽  
Global Innovation ◽  
Low Income Groups ◽  
Adaptive Nature

The economic and innovative rise of the developing states stimulated a deep restructuring of the existing system of international relations in science and technology sphere. As the article points, one of the main manifestations of this trend can be seen in the transformation of global innovation strategies of transnational corporations. The world’s largest TNCs, mostly based in the industrial nations, have begun to transfer growing segments and parts of their R&D programs to the developing countries in order to take advantage of their increased research capacity. As a result, the nature of the projects being implemented there by the TNCs is changing. Historically, the TNCs’ local R&D activities were of adaptive nature. Namely, the stress was made on modification of the products and services offered by the TNCS globally to the specifics of local markets. Currently, a growing number of transnational corporations are implementing the large-scale programs in the developing countries aimed at designing new types of products, including those targeted at the low-income groups of consumers that make up the bulk of the population in developing countries.

scholarly journals Natural Canine Distemper Virus Infection in Linnaeus’s 2-Toed Sloths (Choloepus didactylus)

2020 ◽  
Vol 57 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Allison M. Watson ◽  
Andrew C. Cushing ◽  
Julie D. Sheldon ◽  
Eman Anis ◽  
Rebecca P. Wilkes ◽  
...  
Keyword(s):  
Virus Infection ◽  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Hepatic Necrosis ◽  
Nasal Discharge ◽  
The Novel ◽  
Canine Distemper ◽  
The Central Nervous System ◽  
Lymphoid Depletion ◽  
Viral Sequencing

An outbreak of canine distemper virus in a private zoo in eastern Tennessee in July 2016 led to fatal clinical disease in 5 adult, wild-caught Linnaeus’s 2-toed sloths ( Choloepus didactylus). Clinical signs included hyporexia, lethargy, mucopurulent nasal discharge, and oral and facial ulcers. At necropsy, affected animals had crusts and ulcers on the lips, nose, tongue, and oral cavity. Microscopically, all sloths had widespread, random, hepatic necrosis; lymphoid depletion; and bronchointerstitial pneumonia. The central nervous system did not contain gross or histopathologic lesions in any of the 5 sloths, although immunoreactivity for viral antigen was present within vessel walls. Epithelial cells and histiocytes within numerous organs contained intranuclear and intracytoplasmic inclusions and occasional syncytial cells. Canine distemper virus was confirmed with immunohistochemistry and virus isolation. Viral sequencing identified the novel American-4 strain prevalent in eastern Tennessee wildlife. This is the first pathologic characterization of canine distemper virus infection in sloths (family Choloepodidae, order Pilosa) and emphasizes the significant morbidity and mortality in this species.

scholarly journals Canine Distemper Virus Antigen Detection in External Epithelia of Recently Vaccinated, Sick Dogs by Fluorescence Microscopy Is a Valuable Prognostic Indicator: TABLE 1

2014 ◽  
Vol 53 (2) ◽  
pp. 687-691 ◽  
Author(s):  
Sanjay Kapil ◽  
Tina Neel
Keyword(s):  
Clinical Outcomes ◽  
Respiratory Disease ◽  
Canine Distemper Virus ◽  
Fluorescent Antibody ◽  
Clinical Signs ◽  
Antibody Test ◽  
Prognostic Indicator ◽  
Symptomatic Therapy ◽  
Canine Distemper ◽  
Clinical Recovery

Currently, there are no reliable predictors of the clinical outcomes of domesticated dogs that have been recently vaccinated against canine distemper virus (CDV) and develop respiratory disease. In this study, vaccinated dogs from Oklahoma City that were showing clinical signs of respiratory disease were evaluated for CDV antigen using a direct fluorescent antibody test (FAT). Clinical outcomes after standard symptomatic therapy for respiratory disease were recorded, and a statistical analysis of the results was performed. We present our study showing that CDV FAT results were predictive of clinical recovery (prognostic indicator, prospects of clinical recovery) among vaccinated dogs showing clinical signs of respiratory disease. Negative CDV FAT results equated to 80% chances of recovery after symptomatic therapy, compared to 55% chances of recovery when the CDV FAT results were positive. Based on the results of this study, we show that veterinarians can make better informed decisions about the clinical outcomes of suspected CDV cases, with 2-h turnaround times, by using the CDV FAT. Thus, antemortem examination with the CDV FAT on external epithelia of recently vaccinated, sick dogs is a clinically useful diagnostic test and valuable prognostic indicator for veterinarians. Application of the CDV FAT to these samples avoids unnecessary euthanasia of dogs with suspected CDV.

scholarly journals Opinion of low-income families on public support of the population of the Sakhalin Oblast (on the materials of surveys and interviews)

2020 ◽  
pp. 43-52
Author(s):  
Ol'ga Vladimirovna Chudnova
Keyword(s):  
Low Income ◽  
Large Scale ◽  
Public Assistance ◽  
Public Support ◽  
Vulnerable Groups ◽  
Sociological Research ◽  
Key Issues ◽  
Low Income Families ◽  
Socially Vulnerable Groups ◽  
Sakhalin Oblast

The object of this research is the low-income incomplete households of the Sakhalin Oblast. The subject is the current state of trends and peculiarities of the measures of public assistance for the low-income incomplete households of the Sakhalin Oblast. The author gives detailed overview to the main vectors of public assistance of households in the region, and describes the key issues faced by the recipients of public assistance. Special attention is given to the questions of assessment of efficiency of public assistance measures, signifying the prioritized vectors for optimization of this process in the Sakhalin Oblast. The conclusions are based on results of specific sociological research, conducted by the author using surveys and interviews. The research demonstrates that the region is undergoing large-scale efforts on meeting the vital needs of the socially vulnerable groups of the population, but not all measures correspond to the volume, quality and accessibility requirements of low-income incomplete households, and are in need of serious correction and establishing constant monitoring of the efficiency of measures based on feedback from the recipients.

scholarly journals Clinical, pathological, and immunohistochemistry characterization of toxoplasmosis in dogs with distemper in the semiarid region of Paraíba, Brazil

2015 ◽  
Vol 36 (6Supl2) ◽  
pp. 4251
Author(s):  
Maria Talita Soares Frade ◽  
Lisanka Ângelo Maia ◽  
Rachel Livingstone Felizola Soares Andrade ◽  
Rodrigo Cruz Alves ◽  
Elise Miyuki Yamasaki ◽  
...  
Keyword(s):  
Canine Distemper Virus ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
Neurological Involvement ◽  
Semiarid Region ◽  
Histopathological Analysis ◽  
Thin Wall ◽  
Canine Distemper ◽  
Eosinophilic Inclusion ◽  
The Brain

The objective of this study was to describe the clinical, pathological, and immunohistochemistry characteristics of five cases of toxoplasmosis, an infection often associated with distemper in dogs. From January 2000 to December 2012, a retrospective study was performed analyzed dogs with distemper in the semiarid region of Paraíba. We evaluated this sample to focus on individuals who presented with concomitant structures in protozoa characteristics, and performed immunohistochemistry (IHC) tests using polyclonal anti-Toxoplasma gondii antibody. In all cases, the clinical signs were similar including digestive changes, as well as respiratory, neurological, and ocular lesions, suggesting an infection of canine distemper virus. The diagnosis of distemper was confirmed on histopathological analysis depending on the presence of intranuclear and intracytoplasmic eosinophilic inclusion bodies in different tissues. Histopathological examination also revealed the characteristic presence of parasitic cysts T. gondii in the brain in four cases, and in the lung in one case. The brain cysts were associated with multifocal areas of malacia and lung there was alveolar septa thickening due to infiltration of macrophages, lymphocytes, and plasma cells, with moderate proliferation of type II pneumocytes and coalescing multifocal areas of necrosis. These cysts are characterized by round and strongly basophilic structures, measuring approximately 5 to 70 ?m, delimited by thin wall, stained by hematoxylin and eosin, and immunomarked as brown by immunohistochemistry (IHC) using the chromogen DAB. The diagnosis of toxoplasmosis associated with infection by canine distemper virus in the five case studied was based on microscopic findings and confirmed by immunohistochemistry. Toxoplasmosis should be included in the differential diagnosis of dogs with severe progressive systemic signs, especially when respiratory and neurological involvement is suspected.

Central nervous system lesions caused by canine distemper virus in 4 vaccinated dogs

2021 ◽  
pp. 104063872110092
Author(s):  
Gimena Feijóo ◽  
Kanji Yamasaki ◽  
Luis Delucchi ◽  
José Manuel Verdes
Keyword(s):  
Choroid Plexus ◽  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Ependymal Cells ◽  
South American ◽  
Canine Distemper ◽  
Pia Mater ◽  
Naturally Occurring ◽  
Type Strains

We examined the cerebellum and cerebrum of 4 vaccinated dogs, 3–60-mo-old, that displayed clinical signs of canine distemper virus (CDV) infection, and died 7–40 d after developing neurologic signs. The main histologic lesions were demyelination, gliosis, meningitis, perivascular lymphocytic cuffing, and inclusion bodies. These lesions were similar in all 4 cases regardless of the time since vaccination, except that meningoencephalitis and gliosis were subacute in 3 dogs and chronic in 1 dog. However, these differences did not appear to be related to their vaccination status. Immunohistologically, a CDV-positive immunoreaction was seen mainly in astrocytes, neurons and their axons, lymphocytes around and in the blood vessels of the pia mater and choroid plexus, ependymal cells of each ventricle, and the cells of the choroid plexus. The histologic and immunohistologic changes were similar in the cerebellum and cerebrum. The genetic characterization of the virus strains in 2 of these naturally occurring canine distemper cases confirmed that they were South American wild-type strains (Kiki and Uy251) belonging to the EU1/SA1 lineage. These strains are not included in the commercial CDV vaccines available in Uruguay.

scholarly journals Evolution and Interspecies Transmission of Canine Distemper Virus—An Outlook of the Diverse Evolutionary Landscapes of a Multi-Host Virus

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 582 ◽  
Author(s):  
July Duque-Valencia ◽  
Nicolás Sarute ◽  
Ximena A. Olarte-Castillo ◽  
Julián Ruíz-Sáenz
Keyword(s):  
Wild Species ◽  
Complete Genome ◽  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Interspecies Transmission ◽  
Conservation Strategies ◽  
Broad Host Range ◽  
High Morbidity ◽  
Canine Distemper ◽  
Animal Populations

Canine distemper virus (CDV) is a worldwide distributed virus which belongs to the genus Morbillivirus within the Paramyxoviridae family. CDV spreads through the lymphatic, epithelial, and nervous systems of domestic dogs and wildlife, in at least six orders and over 20 families of mammals. Due to the high morbidity and mortality rates and broad host range, understanding the epidemiology of CDV is not only important for its control in domestic animals, but also for the development of reliable wildlife conservation strategies. The present review aims to give an outlook of the multiple evolutionary landscapes and factors involved in the transmission of CDV by including epidemiological data from multiple species in urban, wild and peri-urban settings, not only in domestic animal populations but at the wildlife interface. It is clear that different epidemiological scenarios can lead to the presence of CDV in wildlife even in the absence of infection in domestic populations, highlighting the role of CDV in different domestic or wild species without clinical signs of disease mainly acting as reservoirs (peridomestic and mesocarnivores) that are often found in peridomestic habits triggering CDV epidemics. Another scenario is driven by mutations, which generate genetic variation on which random drift and natural selection can act, shaping the genetic structure of CDV populations leading to some fitness compensations between hosts and driving the evolution of specialist and generalist traits in CDV populations. In this scenario, the highly variable protein hemagglutinin (H) determines the cellular and host tropism by binding to signaling lymphocytic activation molecule (SLAM) and nectin-4 receptors of the host; however, the multiple evolutionary events that may have facilitated CDV adaptation to different hosts must be evaluated by complete genome sequencing. This review is focused on the study of CDV interspecies transmission by examining molecular and epidemiological reports based on sequences of the hemagglutinin gene and the growing body of studies of the complete genome; emphasizing the importance of long-term multidisciplinary research that tracks CDV in the presence or absence of clinical signs in wild species, and helping to implement strategies to mitigate the infection. Integrated research incorporating the experience of wildlife managers, behavioral and conservation biologists, veterinarians, virologists, and immunologists (among other scientific areas) and the inclusion of several wild and domestic species is essential for understanding the intricate epidemiological dynamics of CDV in its multiple host infections.

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