Low plasma antioxidant status in patients with epilepsy and the role of antiepileptic drugs on oxidative stress

AbstractBackgroundVitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.MethodsHerein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.ResultsThere was significant difference in the parameters viz., SOD (p<0.001) and CAT (p<0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.ConclusionsThe results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.

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The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise

European Journal of Nutrition ◽

10.1007/s00394-011-0193-4 ◽

2011 ◽

Vol 51 (1) ◽

pp. 69-79 ◽

Cited By ~ 42

Author(s):

Glen Davison ◽

Robin Callister ◽

Gary Williamson ◽

Karen A. Cooper ◽

Michael Gleeson

Keyword(s):

Oxidative Stress ◽

Antioxidant Status ◽

Prolonged Exercise ◽

Dark Chocolate ◽

Plasma Antioxidant

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Physical Fitness and Plasma Non-Enzymatic Antioxidant Status at Rest and After a Wingate Test

Canadian Journal of Applied Physiology ◽

10.1139/h03-007 ◽

2003 ◽

Vol 28 (1) ◽

pp. 79-92 ◽

Cited By ~ 21

Author(s):

Carole Groussard ◽

Guillaume Machefer ◽

Françoise Rannou ◽

Henri Faure ◽

Hassane Zouhal ◽

...

Keyword(s):

Oxidative Stress ◽

Ascorbic Acid ◽

Uric Acid ◽

Antioxidant Status ◽

Wingate Test ◽

Anaerobic Exercise ◽

Enzymatic Antioxidant ◽

Plasma Antioxidant ◽

Β Carotene ◽

Lipid Radical

We tested seven physical education students whether 30-s sprint anaerobic exercise (Wingate test) would result in oxidative stress (evaluated by lipid radical levels) sufficient to alter plasma non-enzymatic antioxidant status (plasma uric acid, ascorbic acid, α-tocopherol, β-carotene). This study demonstrates that 1) Wingate test increases plasma uric and ascorbic acid concentrations (p < .05), and decreases plasma α-tocopherol and β-carotene levels (p < .05); 2) lipid radical levels at rest and sprint performance are negatively correlated with resting plasma uric acid and α-tocopherol concentrations (p < .05). In conclusion, this study 1) demonstrates that a 30-s sprint anaerobic exercise is associated with acute changes in plasma non-enzymatic antioxidant status, 2) indicates that the subjects with largest leg peak power are those who exhibit the lowest plasma antioxidant status at rest (uric acid and α-tocopherol), 3) and suggests that antioxidant intake by maintaining plasma antioxidant concentration at rest in the normal range might protect athletes against oxidative stress induced by exercise. Key words: ascorbic acid, α-tocopherol, β-carotene, uric acid, oxidative stress

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Oxidative stress in patients with epilepsy is independent of antiepileptic drugs

Seizure ◽

10.1016/j.seizure.2012.09.003 ◽

2012 ◽

Vol 21 (10) ◽

pp. 780-784 ◽

Cited By ~ 39

Author(s):

Bindu Menon ◽

Krishnan Ramalingam ◽

Rajendiran Vinoth Kumar

Keyword(s):

Oxidative Stress ◽

Antiepileptic Drugs ◽

Patients With Epilepsy

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The role of vitamin and mineral complexes in the elimination of oxidative stress and its consequences

Terapevt (General Physician) ◽

10.33920/med-12-2009-06 ◽

2020 ◽

pp. 58-66

Author(s):

O. A. Gizinger

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Antioxidant Status ◽

Multiple Organ ◽

Adaptive Potential ◽

Effective Prevention ◽

Therapeutic Practice ◽

Important Approach ◽

Coronavirus Infection

A prolonged phase of self-isolation and hypodynamia caused by the coronavirus infection negatively affect most homeostatic reactions in the human body and antioxidant status. The use of vitamin and mineral complexes which contain substances with antioxidant activity are part of a comprehensive correction of antioxidant status and medication-based antioxidant therapy. This direction of general therapeutic practice marks an important approach to overcoming the combined multiple organ pathology, provides effective prevention of morbidity, and contributes to improving the adaptive potential of a person.

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Yolk testosterone reduces oxidative damages during postnatal development

Biology Letters ◽

10.1098/rsbl.2010.0421 ◽

2010 ◽

Vol 7 (1) ◽

pp. 93-95 ◽

Cited By ~ 25

Author(s):

José Carlos Noguera ◽

Carlos Alonso-Alvarez ◽

Sin-Yeon Kim ◽

Judith Morales ◽

Alberto Velando

Keyword(s):

Oxidative Stress ◽

Oxidative Damage ◽

Postnatal Development ◽

Early Development ◽

Early Life ◽

Antioxidant Defences ◽

Oxidative Damages ◽

Plasma Antioxidant ◽

Yolk Testosterone

Conditions experienced during early life can influence the development of an organism and several physiological traits, even in adulthood. An important factor is the level of oxidative stress experienced during early life. In birds, extra-genomic egg substances, such as the testosterone hormone, may exert a widespread influence over the offspring phenotype. Interestingly, testosterone can also upregulate the bioavailability of certain antioxidants but simultaneously increases the susceptibility to oxidative stress in adulthood. However, little is known about the effects of maternally derived yolk testosterone on oxidative stress in developing birds. Here, we investigated the role of yolk testosterone on oxidative stress of yellow-legged gull chicks during their early development by experimentally increasing yolk testosterone levels. Levels of antioxidants, reactive oxygen species and lipid oxidative damage were determined in plasma during nestlings' growth. Our results revealed that, contrary to control chicks, birds hatched from testosterone-treated eggs did not show an increase in the levels of oxidative damage during postnatal development. Moreover, the same birds showed a transient increase in plasma antioxidant levels. Our results suggest that yolk testosterone may shape the oxidative stress-resistance phenotype of the chicks during early development owing to an increase in antioxidant defences and repair processes.

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Soccer players under regular training show oxidative stress but an improved plasma antioxidant status

Clinical Science ◽

10.1042/cs19980269 ◽

1999 ◽

Vol 96 (4) ◽

pp. 381 ◽

Cited By ~ 40

Author(s):

Fernando D. BRITES ◽

Pablo A. EVELSON ◽

Marina Garc~ía CHRISTIANSEN ◽

Mar~ía F. NICOL ◽

Mar~ía José BASÍLICO ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Status ◽

Soccer Players ◽

Plasma Antioxidant ◽

Regular Training

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The role of vitamin and mineral complexes in the elimination of oxidative stress and its consequences

Terapevt (General Physician) ◽

10.33920/10.33920/med-12-2009-06 ◽

2020 ◽

pp. 58-66

Author(s):

O. A. Gizinger

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Antioxidant Status ◽

Multiple Organ ◽

Adaptive Potential ◽

Effective Prevention ◽

Therapeutic Practice ◽

Important Approach ◽

Coronavirus Infection

A prolonged phase of self-isolation and hypodynamia caused by the coronavirus infection negatively affect most homeostatic reactions in the human body and antioxidant status. The use of vitamin and mineral complexes which contain substances with antioxidant activity are part of a comprehensive correction of antioxidant status and medication-based antioxidant therapy. This direction of general therapeutic practice marks an important approach to overcoming the combined multiple organ pathology, provides effective prevention of morbidity, and contributes to improving the adaptive potential of a person.

Download Full-text