The role of vitamin and mineral complexes in the elimination of oxidative stress and its consequences

2020 ◽  
pp. 58-66
Author(s):  
O. A. Gizinger
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Status ◽  
Multiple Organ ◽  
Adaptive Potential ◽  
Effective Prevention ◽  
Therapeutic Practice ◽  
Important Approach ◽  
Coronavirus Infection

A prolonged phase of self-isolation and hypodynamia caused by the coronavirus infection negatively affect most homeostatic reactions in the human body and antioxidant status. The use of vitamin and mineral complexes which contain substances with antioxidant activity are part of a comprehensive correction of antioxidant status and medication-based antioxidant therapy. This direction of general therapeutic practice marks an important approach to overcoming the combined multiple organ pathology, provides effective prevention of morbidity, and contributes to improving the adaptive potential of a person.

The role of vitamin and mineral complexes in the elimination of oxidative stress and its consequences

2020 ◽  
pp. 58-66
Author(s):  
O. A. Gizinger
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Status ◽  
Multiple Organ ◽  
Adaptive Potential ◽  
Effective Prevention ◽  
Therapeutic Practice ◽  
Important Approach ◽  
Coronavirus Infection

A prolonged phase of self-isolation and hypodynamia caused by the coronavirus infection negatively affect most homeostatic reactions in the human body and antioxidant status. The use of vitamin and mineral complexes which contain substances with antioxidant activity are part of a comprehensive correction of antioxidant status and medication-based antioxidant therapy. This direction of general therapeutic practice marks an important approach to overcoming the combined multiple organ pathology, provides effective prevention of morbidity, and contributes to improving the adaptive potential of a person.

scholarly journals The Role Of Dietary Zinc Restriction On Antioxidant Status And Oxidative Stress

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Richard S Bruno ◽  
Yang Song ◽  
Scott W Leonard ◽  
Alan W Taylor ◽  
Maret G Traber ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Dietary Zinc ◽  
And Oxidative Stress

In Vitro Study of Antioxidant Activity of Serum and Plasma Samples As Well As Glutathione Exposed to Various Exogenous Stress Factors

2021 ◽  
Author(s):  
Małgorzata Olszowy-Tomczyk ◽  
Łukasz Paprotny ◽  
Agnieszka Celejewska ◽  
Dorota Szewczak ◽  
Dorota Wianowska
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
In Vitro Study ◽  
Stress Factors ◽  
Plasma Samples ◽  
Serum Samples ◽  
Exogenous Stress

Abstract The imbalance between the production of Reactive Oxygen Species (ROS) and their sequestration promotes the formation of so-called oxidative stress conditions which are considered crucial in the aging process and development of many human diseases. Glutathione plays an essential role in the antioxidative barricade against ROS. Its role in the detoxification process of xenobiotics and carcinogen is also known. However, there are no comparative studies on the antioxidant properties of both biological samples and glutathione as well as the change in these properties as a result of exposure to various stress factors. This paper fills this gap comparing the antioxidant activity of serum and plasma samples of the known glutathione content with the activity of glutathione itself assessed by the different methods. In addition, it reveals a significant role of environmental xenobiotics in oxidative stress and differentiates the stress induced by different groups of drugs, among which the greatest one has been demonstrated for antiarrhythmic drugs and cytostatics. More importantly, it proves that human plasma is more resistant to stress factors and N-acetylcysteine clearly promotes the extension of antioxidant properties of both the plasma and serum samples. The latter conclusion is consistent with the implied preventive and/or supportive action of this drug against SARS-CoV-2.

Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation – hospital-based study

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Towseef Amin Rafeeqi ◽  
Farhat Jabeen ◽  
M A Waheed ◽  
Gulam Mohammed Husain ◽  
Alokananda Chakraborthy
Keyword(s):  
Oxidative Stress ◽  
Healthy Subjects ◽  
Skin Disorder ◽  
Antioxidant Status ◽  
The Body ◽  
Oxygen Species ◽  
Statistical Significant Difference ◽  
Significant Difference ◽  
Gpx Activity

AbstractBackgroundVitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.MethodsHerein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.ResultsThere was significant difference in the parameters viz., SOD (p<0.001) and CAT (p<0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.ConclusionsThe results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.

Investigation of the role of α-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats

2017 ◽  
Vol 28 (4) ◽  
Author(s):  
Zafer Sahin ◽  
Ahmet Ozkaya ◽  
Okkes Yilmaz ◽  
Abdurrauf Yuce ◽  
Mehmet Gunes
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Antioxidant Activity ◽  
Lipoic Acid ◽  
Wistar Rats ◽  
Male Rats ◽  
Fatty Acids Profile ◽  
Male Wistar Rats ◽  
Aluminum Accumulation

AbstractBackground:We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlClMethods:Twenty-eight male Wistar rats were divided into four groups as control, LA, AlClResults:AlClConclusions:These results indicate that AlCl

scholarly journals Competing Role of Bioactive Constituents inMoringa oleiferaExtract and Conventional Nutrition Feed on the Performance of Cobb 500 Broilers

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Govindarajan Karthivashan ◽  
Palanisamy Arulselvan ◽  
Abd. Razak Alimon ◽  
Intan Safinar Ismail ◽  
Sharida Fakurazi
Keyword(s):  
Antioxidant Activity ◽  
Meat Quality ◽  
Antioxidant Status ◽  
Cost Effective ◽  
Bioactive Constituents ◽  
Broiler Meat ◽  
Antioxidant Parameters ◽  
Antioxidant Effects

The influence ofMoringa oleifera(MO) leaf extract as a dietary supplement on the growth performance and antioxidant parameters was evaluated on broiler meat and the compounds responsible for the corresponding antioxidant activity were identified. 0.5%, 1.0%, and 1.5% w/v of MO leaf aqueous extracts (MOLE) were prepared, and nutritional feed supplemented with 0%, 0.5%, 1.0%, and 1.5% w/w of MO leaf meal (MOLM) extracts were also prepared and analysed for theirin vitroantioxidant potential. Furthermore, the treated broiler groups (control (T1) and treatment (T2, T3, and T4)) were evaluated for performance, meat quality, and antioxidant status. The results of this study revealed that, among the broilers fed MOLM, the broilers fed 0.5% w/w MOLM (T2) exhibited enhanced meat quality and antioxidant status (P<0.05). However, the antioxidant activity of the MOLE is greater than that of the MOLM. The LC-MS/MS analysis of MOLM showed high expression of isoflavones and fatty acids from soy and corn source, which antagonistically inhibit the expression of the flavonoids/phenols in the MO leaves thereby masking its antioxidant effects. Thus, altering the soy and corn gradients in conventional nutrition feed with 0.5% w/w MO leaves supplement would provide an efficient and cost-effective feed supplement.

scholarly journals Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

2020 ◽  
Vol 8 (12) ◽  
pp. 4343
Author(s):  
Vineetha K. R. ◽  
Santha K. ◽  
Inmozhi R. ◽  
Periyasamy S. ◽  
Kanakasabai G. ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Fibroblast Growth Factor 21 ◽  
Diabetic Patients ◽  
Fibroblast Growth ◽  
Total Antioxidant

Background: Cardiovascular disease is the most prevalent cause of morbidity and mortality in diabetic patients. Fibroblast growth factor 21 (FBG 21) is an endocrine factor that regulates glucose and lipid metabolism, insulin resistance, and obesity. Blood levels of FGF21 are elevated in patients with atherosclerosis, macrovascular, and microvascular complications of diabetes, possibly due to a compensatory up regulation. Studies reported that FGF21 is an important regulator of mitochondrial and oxidative stress. The role of FGF21 in chronic diseases and the diminished oxidative stress observed with anti-diabetic therapy has been the target of new studies. Current study aimed to evaluate serum FGF21 levels and its association with oxidative stress and lipid profile levels in type 2 diabetic patients.Methods: 100 controls and 100 diabetic patients on oral hypoglycemic drugs between 35-55 years of age without any cardiac, renal, liver, and thyroid dysfunction were selected for this study. Oxidative stress (MDA), total antioxidant status (FRAP), and FGF21 were measured. FGF21 was analyzed by ELISA methods. Serum MDA was assessed by the method of Yagi  serum total antioxidant status was measured by the method of Benzie et al.Results: FGF21 level was increased in diabetic patients compared with controls. There was a significant positive correlation of FGF21 with MDA (r=0.875, p<0.01) and negative correlation with FRAP observed (r= -0.867 p<0.01). There was also positive correlation of FGF21 with total cholesterol (r=0.499, p<0.01), triglycerides (r=0.648, p<0.01), LDL-cholesterol (r=0.337, p<0.01) and negative correlation with HDL-cholesterol (r= -0.172, p<0.05) were observed.Conclusions: Increased oxidative stress and decreased antioxidant status were observed in diabetics. This could be due to dyslipidemia and increased generation of free radicals. High levels of FGF21 observed in our study might represent its resistant state and the compensatory response to maintain metabolic homeostasis. Further studies are needed to explore the role of FGF21 as a novel marker in predicting cardiovascular risk in diabetic patients.

scholarly journals Impaired oxidative-antioxidative balance during migraine attack

2019 ◽  
Vol 6 (2) ◽  
pp. 2996-3002 ◽  
Author(s):  
Alireza Khosravi ◽  
Alireza Nakhaee ◽  
Abdoreza Ghoreishi ◽  
Zahra Arefpoor ◽  
Masoud Sadeghi
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Serum Levels ◽  
Protein Carbonyl ◽  
Stress Index ◽  
Healthy Controls ◽  
Antioxidative Status ◽  
Total Antioxidant ◽  
Migraine Group

Background: Recent evidence has suggested that oxidative stress may play a role in the pathophysiology of migraine. In this study, we aimed to evaluate the oxidative-antioxidative status in sera of migraine patients from an Iranian population during migraine attacks. Methods: This study recruited 46 migraine patients with or without aura and 45 sex- and age-matched healthy controls. The levels of protein carbonyl (PC), malondialdehyde (MDA) and total oxidants status (TOS) were measured as the indicators of oxidative stress. The levels of total thiols (T-SH), reduced glutathione (GSH) and total antioxidant capacity (TAC) were determined as markers of antioxidant status. Oxidative stress index (OSI) was calculated by dividing TOS to TAC. Results: The serum levels of MDA (4.10 +/- 0.70 vs. 3.20 +/- 0.62, P = 0.003), TOS (18.46 +/- 4.06 vs. 16.21 +/- 3.67, P = 0.007) and OSI (1.54 +/- 0.60 vs. 1.22 +/- 0.46, P = 0.006) were significantly higher in migraine group compared to controls, however, no statistically significant differences of PC levels were found between migraine patients and controls (0.615 +/- 0.161 vs. 0.517 +/- 0.126, P = 0.1). In contrast, the levels of T-SH (273 +/- 51.71 vs. 310.88 +/- 53.32, P = 0.001), GSH (28.08 +/- 6.20 vs. 32.13 +/- 5.8, P = 0.002) and TAC (1.27 +/- 0.226 vs. 1.41 +/- 0.26, P = 0.01) were significantly lower in migraine patients compared to healthy controls. Conclusion: Our study showed higher levels of oxidative stress and lower levels of antioxidant status in migraine group compared to controls, which indicates the possible role of oxidative stress in triggering migraine attacks.  

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