scholarly journals Novel extraction and application of okra gum as a film coating agent using theophylline as a model drug

2014 ◽  
Vol 5 (2) ◽  
pp. 70 ◽  
Author(s):  
IkoniJ. Ogaji ◽  
StephenW. Hoag
Keyword(s):  
Film Coating ◽  
Coating Agent ◽  
Okra Gum ◽  
Model Drug

Formulation and Evaluation of Pellets of natural Okra gum prepared by Extrusion and Spheronization

2021 ◽  
pp. 3290-3294
Author(s):  
Hemant K S Yadav ◽  
Shahnaz Usman ◽  
KVRNS Ramesh ◽  
Quamrul Islam
Keyword(s):  
Drug Release ◽  
Mechanical Strength ◽  
Flow Characteristics ◽  
Okra Gum ◽  
Model Drug

The aim of the current study was to explore the possibility of preparing pellets of okra gum using extrusion and spheronization technique. Different formulations were prepared by altering the concentration of okra gum. Metronidazole was chosen as a model drug. The pellets were smooth and spherical in shape. FTIR and DSC spectra’s confirmed that there was no interaction between drug and polymer. The pellets were free-flowing and exhibited satisfactory flow characteristics along with good mechanical strength. Okra gum was able to control the drug release and around 90% drug was released in 8hrs. Pellets showed increase in swelling as the concentration of gum was increased. Mucoadhesion study exhibited that the prepared pellets had good mucoadhesive strength.

scholarly journals The Use ofHibiscus esculentus(Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Nurul Dhania Zaharuddin ◽  
Mohamed Ibrahim Noordin ◽  
Ali Kadivar
Keyword(s):  
Sodium Alginate ◽  
Release Kinetics ◽  
Oral Dosage ◽  
Propranolol Hydrochloride ◽  
Infrared Study ◽  
Crushing Strength ◽  
Solid Oral Dosage Form ◽  
Okra Gum ◽  
Model Drug ◽  
Physical And Chemical

The effectiveness of Okra gum in sustaining the release of propranolol hydrochloride in a tablet was studied. Okra gum was extracted from the pods ofHibiscus esculentususing acetone as a drying agent. Dried Okra gum was made into powder form and its physical and chemical characteristics such as solubility, pH, moisture content, viscosity, morphology study using SEM, infrared study using FTIR, crystallinity study using XRD, and thermal study using DSC and TGA were carried out. The powder was used in the preparation of tablet using granulation and compression methods. Propranolol hydrochloride was used as a model drug and the activity of Okra gum as a binder was compared by preparing tablets using a synthetic and a semisynthetic binder which are hydroxylmethylpropyl cellulose (HPMC) and sodium alginate, respectively. Evaluation of drug release kinetics that was attained from dissolution studies showed that Okra gum retarded the release up to 24 hours and exhibited the longest release as compared to HPMC and sodium alginate. The tensile and crushing strength of tablets was also evaluated by conducting hardness and friability tests. Okra gum was observed to produce tablets with the highest hardness value and lowest friability. Hence, Okra gum was testified as an effective adjuvant to produce favourable sustained release tablets with strong tensile and crushing strength.

scholarly journals THE EFFECT OF BANGGAI YAM (DIOSCOREA ALATA L.) MODIFICATION ON FILM CHARACTERISTICS AS A FILM COATING MATERIAL FOR MODIFIED RELEASE DOSAGE FORMS

2021 ◽  
pp. 106-110
Author(s):  
YUSRIADI ◽  
EVI SULASTRI ◽  
ATHIYAH ◽  
NUUR AANISAH
Keyword(s):  
Film Thickness ◽  
Mechanical Strength ◽  
Film Coating ◽  
Dosage Forms ◽  
Dioscorea Alata ◽  
Modified Release ◽  
Coating Agent ◽  
Release Drug ◽  
Film Characteristics ◽  
Tapped Density

Objective: This study aims to determine the effect of modification of Banggai yam (Dioscorea alata L.) as a coating agent in modified release drug based on the film characteristics. Methods: Banggai yam starch was physically modified to produce pregelatinized Banggai yam starch (PGBYS) powder as well as chemically to produce pregelatinized Banggai yam starch phthalate (PGBYSP). Powder obtained was each physically and chemically characterized including organoleptics, morphology, tapped density, water content content and degree of substitution. Furthermore, the formulation was made to produce film-coated drug with the same coating agent concentration in 2 formulas: F1 (PGBYSP 6 %) and F2 (PGBYS 6 %). Results: The results were then evaluated including organoleptics, film thickness, morphology, mechanical strength, and film solubility. Results of evaluation showed that film thickness values for both formulas, ​​F1 and F2 respectively, were 0.13±0.020 mm and 0.18±0.005 mm. Mechanical strength included tensile strength consecutively at values of F1= 0.08±0.005 MPa and F2= 0.27±0.05 MPa; % elongation of F1= 114.16±11.8 % and F2= 164.06±57.94%; Young's modulus of F1= 7.3×104±9.8×10-5 MPa and F2= 1.8×103±7.9×10-4 MPa. The solubility of the film-coating in HCl pH 1.2 medium for F1 was 7.9±1.92% and F2 was 25.8±2.42%. In pH 6.8 medium, F1 was 8.6±2.27% and F2 was 11.6±1.44%, while in pH 7.4 medium, F1 was 19.1±5.46% and F2 was 13.1±1.78%. Both film-coated formulas were soluble in alkaline medium, but F2 could not maintain its conditions in acid medium. This proves that the chemical modification product by esterification to form a film can withstand acidic medium. Conclusion: Therefore, PGBYSP has potential to be used as a coating agent in controlled release drug.

In-Vitro Evaluation of Gum Extracted from Abelmoschus Aesculentes of Colon Targeted Matrix Forming Material, in Tablet Form, using Lovastatin as Model Drug

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Anupama Poulose
Keyword(s):  
Phosphate Buffer ◽  
Guar Gum ◽  
In Vitro Release ◽  
Physical Characteristics ◽  
Matrix Tablets ◽  
Tablet Form ◽  
Weight Variation ◽  
Okra Gum ◽  
Model Drug

Matrix tablets of Lovastatin were fabricated using Ae (okra) gum and guar gum, alone or on combination with other excipients. The tablets were evaluated for physical characteristics like hardness, weight variation, friability, swelling index and drug content. In this study Ae(okra ) gum was extracted and purified by the researcher. In vitro release of drug was performed in 0.1NHCl (pH 1.2) (without enzymes) for up to 2 h and the rest of dissolution in citric acid-phosphate buffer (pH 6.0) and phosphate buffer (pH 7.4) up to 3 h. All the physical characteristics of the fabricated tablets were within accepted limit. The tablets with Ae gum gave better release properties. The level of matrix affects drug release. The Ae gum showed better sustained release properties compared to guar gum. Okra gum also served as colon targeted matrix forming material in tablet form using Lovastatin as model drug. Chemical compounds studied In this article: Lovastatin [PubChem CID: 53232]

High-Viscosity HPMC as a Film-Coating Agent

1993 ◽  
Vol 19 (16) ◽  
pp. 2043-2053 ◽  
Author(s):  
G. Maffione ◽  
P. Iamartino ◽  
G. Guglielmini ◽  
A. Gazzaniga
Keyword(s):  
Film Coating ◽  
High Viscosity ◽  
Coating Agent

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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