Solitary intraosseous neurofibroma of the mandible: Report of an extremely rare histopathologic feature

Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion(reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidativestress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the celldeath. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion.This study was an experimental laboratory research with post-test-only control group design including 20male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutesischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) andtreatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathologicalcharacteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.

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P16INK4A Expression on Retinoblastoma at Mohammad Hoesin Hospital Palembang

Sriwijaya Journal of Ophthalmology ◽

10.37275/sjo.v1i1.37 ◽

2018 ◽

Vol 1 (1) ◽

pp. 1-17

Author(s):

Sri Tanty Fuji A Harahap ◽

Ika Kartika ◽

Rusdianto

Keyword(s):

Optic Nerve ◽

Descriptive Study ◽

Cdk Inhibitor ◽

Cyclin D ◽

Rb1 Gene ◽

Histopathological Feature ◽

P16ink4a Expression ◽

Degree Of Differentiation ◽

Histopathologic Feature ◽

Hematoxylin Eosin

ABSTRACT Background: Retinoblastoma is a malignant tumor with an average incidence of one case per 15,000-20,000 births. Retinoblastoma is associated with the presence of the Rb1 gene mutation which has role in preventing DNA replication. Various studies have linked the existence of p16INK4A as a CDK inhibitor that inhibits Cyclin D and CDK4 so that the activity of the Rb1 gene is inhibited. Objective: This study was conducted to identify p16INK4A expression on Retinoblastoma at Mohammad Hoesin Hospital. Methodology: A descriptive study used on the paraffin blocks of 14 cases Retinoblastoma in Mohammad Hoesin Hospital Palembang from January 2014- July2018. Histopathologic feature were examined with Hematoxylin- Eosin staining and immunohistochemical were examined with p16INK4A antibody. Data were analyzed using SPSS version23 to identify histopathological feature of p16INK4A expression in Retinoblastoma Results: Most retinoblastoma samples in this study were expressed in p16INK4A (92.86%). The degree of differentiation of retinoblastoma with the largest number at Mohammad Hoesin Hospital is moderately differentiated (57.14%). Retinoblastoma invasion of the optic nerve and sclera in the study at Mohammad Hoesin Hospital, respectively at 57.14% and 42.86%. Conclusion: Most retinoblastoma samples in this study were expressed in p16INK4A.

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THE MORPHOLOGICAL FEATURES OF VARIANTS OF GIANT CELL TUMOR STRUCTURE

Traumatology and Orthopedics of Russia ◽

10.21823/2311-2905-2010-0-1-139-145 ◽

2010 ◽

Vol 16 (1) ◽

pp. 139-145

Author(s):

M. Yu. Zaytseva ◽

Ph. Yu. Zasulsky

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Treatment Approach ◽

Cell Tumor ◽

Long Term Results ◽

Results Of Treatment ◽

Morphological Criteria ◽

Histopathologic Feature

The morphological criteria of giant cell tumor and the different ways of the run of the disease were designated as the result of collation between the histopathologic feature with the clinicoradiographic dates and the long-term results of treatment of 101 of patients. These findings promote a better collaboration of pathologist and surgeons. In future these results could be used for creating an algorithm of determination of the surgery extent and treatment approach.

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