Association of cord blood zinc level and birth weight in a sample of Iranian neonates

Background: Women are at increased risk of zinc deficiency during pregnancy because of high fetal requirements for zinc. Severe maternal zinc deficiency has been associated with poor fetal growth, spontaneous abortion and congenital malformations (i.e., anencephaly), whereas milder forms of zinc deficiency have been associated with low birth weight (LBW), intrauterine growth retardation, and preterm delivery. However, the research relating maternal zinc status and birth weight has not produced consistent results. This study has been undertaken to confirm the association between maternal serum zinc concentration and birth weight and period of gestation in setting like India.Methods: A total of 100 new-borns were included and divided into two groups, the ‘study group’ had babies with birth weight <2.5 kg and control group’ with babies >2.5 kg birth weight. Cord blood from the new-borns and serum samples of mothers were collected and the zinc levels were measured.Results: The correlation of cord blood and the maternal serum zinc levels were assessed in relation to birth weight and the gestational age. The results were compared between the two groups. The difference in values between the two groups was statistically significant, maternal serum zinc levels and birth weight (84.78±21.62 vs 66.04±18.66) (‘P’ value 0.04), cord blood zinc levels and birth weight (98.44±22.59 vs 79.78±19.54) (‘P’ value <0.001). The maternal serum and cord blood zinc was compared between the preterm and term; the results were statistically significant.Conclusions: The maternal and cord blood levels of zinc are correlated well with the birth weight and the gestational age at delivery. Supplementation of zinc during gestation might help reduce the incidence of IUGR and the risk of prematurity.

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Study of cord blood zinc level in term AGA & term SGA newborns

International Journal of Paediatrics and Geriatrics ◽

10.33545/26643685.2019.v2.i2b.39 ◽

2019 ◽

Vol 2 (2) ◽

pp. 90-91

Author(s):

Dr. Thumjaa Annamalai ◽

Dr. Ramya ◽

Dr. Shafath Ahmed

Keyword(s):

Cord Blood ◽

Zinc Level ◽

Blood Zinc

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Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v25i1.166 ◽

1970 ◽

Vol 25 (1) ◽

pp. 9-13

Author(s):

S Jahan ◽

TR Das ◽

KB Biswas

Keyword(s):

Body Mass Index ◽

Birth Weight ◽

Cord Blood ◽

Body Mass ◽

Anthropometric Measurements ◽

Anthropometric Parameters ◽

Serum Leptin ◽

C Peptide ◽

Cord Serum ◽

The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

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Impact of Maternal Metabolic Parameters on Birth Weight and Cord Blood Insulin Concentration—Findings from the Born in Guangzhou Study

Diabetes ◽

10.2337/db18-1442-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 1442-P

Author(s):

JINGYA WANG ◽

YASHU KUANG ◽

MALCOLM J. PRICE ◽

JINHUA LU ◽

JIANRONG HE ◽

...

Keyword(s):

Birth Weight ◽

Cord Blood ◽

Metabolic Parameters ◽

Insulin Concentration ◽

Blood Insulin

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Antioxidant Levels in Cord Blood of Term Low Birth Weight Neonates Requiring Delivery Room Resuscitation

Journal of Neonatology ◽

10.1177/0973217921991402 ◽

2021 ◽

pp. 097321792199140

Author(s):

Rimjhim Sonowal ◽

Anamika Jain ◽

V. Bhargava ◽

H.D. Khanna ◽

Ashok Kumar

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Vitamin A ◽

Cord Blood ◽

Serum Levels ◽

Study Groups ◽

Delivery Room ◽

Normal Birth Weight ◽

Normal Birth ◽

Major Congenital Malformations

Objective: The objective of this study was to evaluate the serum levels of various antioxidants, namely, vitamin A and E, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) in the cord blood of term low birth weight (LBW) neonates who required delivery room resuscitation (DRR). Materials and Methods: This case control study included 37 term LBW neonates who needed DRR as cases and 44 term neonates as controls (15 term LBW and 29 term normal birth weight) who did not require resuscitation at birth. Neonates suffering from major congenital malformations, infection, or hemolytic disease were excluded. Standard methods were used to measure the levels of vitamin A, vitamin E, SOD, catalase, and GPx levels in the cord blood. Results: Vitamin A and E levels were significantly low in cases compared to term LBW controls as well as term normal birth weight controls. Levels of SOD, GPx, and catalase were comparable in different study groups. Conclusion: Our study shows that term LBW neonates requiring DRR had significantly low levels of vitamin A and E in their cord blood. This might compromise their ability to tolerate oxidative stress during DRR.

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Effect of Maternal Nutritional Status and Mode of Delivery on Zinc and Iron Stores at Birth

Nutrients ◽

10.3390/nu13030860 ◽

2021 ◽

Vol 13 (3) ◽

pp. 860

Author(s):

Oraporn Dumrongwongsiri ◽

Pattanee Winichagoon ◽

Nalinee Chongviriyaphan ◽

Umaporn Suthutvoravut ◽

Veit Grote ◽

...

Keyword(s):

Nutritional Status ◽

Cord Blood ◽

Mode Of Delivery ◽

Serum Zinc ◽

Maternal Blood ◽

Second Trimester ◽

Food Frequency ◽

Iron Stores ◽

Maternal Nutritional Status ◽

Blood Zinc

Zinc and iron deficiencies among infants aged under 6 months may be related with nutrient store at birth. This study aimed to investigate the association between zinc and iron stores at birth with maternal nutritional status and intakes during pregnancy. 117 pregnant women were enrolled at the end of second trimester and followed until delivery. Clinical data during pregnancy, including pre-pregnancy body mass index (BMI) and at parturition were collected from medical record. Zinc and iron intakes were estimated from a food frequency questionnaire. Serum zinc and ferritin were determined in maternal blood at enrollment and cord blood. Mean cord blood zinc and ferritin were 10.8 ± 2.6 µmol/L and 176 ± 75.6 µg/L, respectively. Cord blood zinc was associated with pre-pregnancy BMI (adj. ß 0.150; p = 0.023) and serum zinc (adj. ß 0.115; p = 0.023). Cord blood ferritin was associated with pre-pregnancy BMI (adj. ß −5.231; p = 0.009). Cord blood zinc and ferritin were significantly higher among those having vaginal delivery compared to cesarean delivery (adj. ß 1.376; p = 0.007 and 32.959; p = 0.028, respectively). Maternal nutritional status and mode of delivery were significantly associated with zinc and iron stores at birth. Nutrition during preconception and pregnancy should be ensured to build adequate stores of nutrients for infants.

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Maternal and cord blood metal concentrations and low birth weight—a case-control study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/31.7.1181 ◽

1978 ◽

Vol 31 (7) ◽

pp. 1181-1187 ◽

Cited By ~ 24

Author(s):

J D Bogden ◽

I S Thind ◽

D B Louria ◽

H Caterini

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Cord Blood ◽

Case Control Study ◽

Case Control ◽

Metal Concentrations ◽

Control Study

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Serum Zinc Level at Term Pregnancy and Newborn Anthropometry

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v3i4.53 ◽

2016 ◽

Cited By ~ 1

Author(s):

Irma Seriana ◽

Yusrawati Yusrawati ◽

Gustina Lubis

Keyword(s):

Birth Weight ◽

Head Circumference ◽

Serum Zinc ◽

Zinc Level ◽

Birth Length ◽

Anthropometric Measurement ◽

Term Pregnancy ◽

Serum Zinc Level ◽

Average Birth Weight ◽

Newborn Anthropometry

Objective: To determine the relationship between serum zinc level at term pregnancy and newborn anthropometry. Methods: This study is an observational study with cross-sectional design. Serum zinc level at term pregnancy was measured and then anthropometric measurement was done to the newborn, including birth weight, birth length and head circumference at birth. The data were statistically analyzed using regression correlation test. Results: Mean serum zinc level at term pregnancy is 36.01 μg/dl (SD=18.34 μg/dl), the average birth weight is 3158 gr (SD=480.4 gr), the average birth length is 48.42 cm (SD=1.75 cm) and the average head circumference at birth is 33.13 cm (SD=1.14 cm). There was no statistically significant relationship between serum zinc levels at term pregnancy and birth weight (p-value=0.152). Meanwhile, there are statistically significant relationships between serum zinc level at term pregnancy with birth length and head circumference with pvalue 0.026 and 0.012, respectively. Conclusion: Serum zinc level at term pregnancy is correlated with birth length and head circumference, but is not correlated with birth weight. [Indones J Obstet Gynecol 2015; 3-4: 190-195] Keywords: birth length, birth weight, head circumference at birth, serum zinc level, term pregnancy

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Determinant of Maternal and Hair Zinc Level on Stunting and Developmental Disorders in Under Five Aged Children: A Path Analysis

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.03.34 ◽

2020 ◽

Author(s):

Nunik Ike Yunia Sari ◽

◽

Estin Gita Maringga ◽

Keyword(s):

Birth Weight ◽

Developmental Disorders ◽

Zinc Level ◽

Birth Length ◽

Hair Zinc ◽

Upper Arm ◽

Under Five ◽

Arm Circumference ◽

Zinc Levels ◽

Mid Upper Arm Circumference

ABSTRACT Background: Stunting can cause various developmental problems in children under five. Stunting can reduce a person productivity at a young age and increase the risks of developing non-communicable diseases when older. This study aimed to determine of maternal and hair zinc level on stunting and developmental disorders in under five aged children. Subjects and Method: This was a case study conducted at Gurah Public Health Center, Kediri Regency, East java, August 4-29, 2020. approach with a fixed disease sampling technique. A sample size of 100 subjects was selected by simple random sampling. The dependent variable was stunting and developmental disorders. The independent variables were pregnant women Mid-Upper Arm Circumference, exclusive breastfeeding, LBW, birth length, hair zinc level. The data were collected by questionnaire, measuring height and weight and checking hair zinc levels in the laboratory. The data were analyzed by path analysis. Results: Child development was influenced by Mid-Upper Arm Circumference (b= 0.12; SE= 0.36; p< 0.001), birth weight (b= 0.29; SE= 0.15; p= 0.042); birth length (b= 0.37; SE= 0.15; p= 0.011), breastfeeding (b= 0.08; SE= 0.04; p= 0.033), stunting (b= 0.39; SE= 0.10; p <0.001), hair zinc levels (b= 0.58; SE= 0.67; p <0.001). Hair zinc levels were affected by birth weight (b= 0.92; SE= 0.04; p <0.001). Stunting was affected by breastfeeding (b= 0.12; SE= 0.04; p <0.001); birth length (b= 0.73; SE= 0.06; p <0.001), zinc levels (b= 0.16; SE= 0.06; p= 0.006) Conclusion: Child development was influenced by Mid-Upper Arm Circumference, birth weight, birth length, breastfeeding, stunting, hair zinc levels. Hair zinc levels were affected by birth weight. Stunting was affected by breastfeeding, birth length, zinc levels. Keywords: maternal determinant factor, hair zinc level, predictor of stunting, developmental disorder Correspondence: Nunik Ike Yunia Sari. School of Health Sciences Karya Husada Kediri. Email: [email protected]. Mobile: +6282257969278. DOI: https://doi.org/10.26911/the7thicph.03.34

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