Diagnostic accuracy of the mean platelet volume in oral lichen planus

2019 ◽  
Vol 14 (1) ◽  
pp. 52
Author(s):  
Mai Zakaria ◽  
Ola Khashaba
Keyword(s):  
Diagnostic Accuracy ◽  
Lichen Planus ◽  
Mean Platelet Volume ◽  
Oral Lichen Planus ◽  
Platelet Volume ◽  
The Mean ◽  
Oral Lichen

scholarly journals Elevated mean platelet volume in oral lichen planus and increased blood urea nitrogen level in its red-form: an observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Yao ◽  
Yiwen Deng ◽  
Guanhuan Du ◽  
Yufeng Wang ◽  
Guoyao Tang
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Kidney Function ◽  
Lichen Planus ◽  
Mean Platelet Volume ◽  
Oral Lichen Planus ◽  
Platelet Volume ◽  
Biochemical Tests ◽  
Oral Lichen ◽  
Red Form

Abstract Background This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients. Methods Eighty pathologically confirmed OLP patients and 51 healthy controls were enrolled. Data on full blood count and biochemical tests were obtained from the electronic medical record system of the hospital. Results MPV was elevated in OLP patients compared to controls (10.68 ± 0.97 fL versus 10.33 ± 0.89 fL, P = 0.042) while platelet count showed no difference between them. Red-form OLP group had increased blood urea nitrogen (BUN, 5.24 ± 1.15 mmol/L versus 4.69 ± 0.98 mmol/L, P = 0.036) than white-form OLP group. By contrast, there were no differences between those two groups in the other variables including MPV, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine. In terms of C-reactive protein (CRP), 92.5% of the OLP patients had a value of less than 3.48 mg/L. Besides, 75% of the OLP patients were overweight with body mass index (BMI) more than 25 kg/m2. Conclusions These findings indicate MPV might play roles in inflammation in OLP. The red-form OLP might be associated with damage or reduction of kidney function.

scholarly journals p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus

2013 ◽  
Vol 14 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Iraj Mirzaii-Dizgah ◽  
Farzaneh Agha-Hosseini
Keyword(s):  
Clinical Significance ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Whole Saliva ◽  
The Mean ◽  
Unstimulated Whole Saliva ◽  
Oral Lichen ◽  
Mean Concentration

ABSTRACT Aim Unstimulated whole salivary p53 was assessed in patients suffering from erosive and plaque-like form of oral lichen planus (OLP). Materials and methods Eighteen patients with erosive form, 17 patients suffering from plaque-like form and 38 noninvolvement subjects were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA. Results The mean concentration of salivary p53 was significantly higher in patients with plaque-like form compared to both patients with erosive form and the control group. Conclusion We conclude that plaque like form of OLP is important in view of the potential for malignancy and is not safety form. Clinical significance It seems that all forms of OLP must be considered accurately, should be followed up with biannual examinations, and if possible, assessment of salivary p53 every year. How to cite this article Agha-Hosseini F, Mirzaii-Dizgah I. p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus. J Contemp Dent Pract 2013;14(1):1-3.

Association of Oral Lichen Planus with Dyslipidemia in Patients Of Rahim Yar Khan

2021 ◽  
Vol 15 (11) ◽  
pp. 3136-3137
Author(s):  
Nazia Hanif ◽  
Tahir Hassan ◽  
Muhammad Khurram Shahzad ◽  
Raheel Tahir ◽  
Madiha Anwar ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Chronic Inflammatory Condition ◽  
The Mean ◽  
Oral Lichen

Introduction: Oral lichen planus (LP) is a chronic inflammatory condition and this inflammation leads to alteration in lipid metabolism and increase the cardiovascular risk factors. Objective: To determine the prevalance of dyslipidemias in patient with oral lichen planus coming in dermatology outdoor of Sheikh Zayed Hoapital Rahim Yar Khan. Methods: It was a case control study that was conducted at Department of Dermatology, Sheikh Zayed Hospital Rahim Yar Khan during October 2016 to April 2017. In this study there were total 50 cases of oral LP and 50 controls of both genders with age range of 15 to 60 years. The cases of both the groups underwent fasting lipid profile in terms to look for serum total cholesterol, triglyceride, LDL cholesterol and HDL cholesterol. Results: In this study there were total 100 cases out of which 50 were cases of oral LP and 50 were controls. In cases groups there were 27 (54%) males and 23 (46%) females while in control group there were same number of males and females were taken with p= 0.85. The mean age in case group was 37.22±8.15 years while in control group was 35.66± 7.78 years while the mean BMI was 24.42±2.21 and 25.11±3.01 respectively. The mean difference in cases and controls in terms of serum total cholesterol, TG, HDL Cholesterol and LDL cholesterol was found statistically significant. Conclusion: Dyslipidemias are common in cases with oral lichen planus and all its parameters have significant association with it especially TG. Keywords; LP, Dyslipidemia, LDL, HDL, TG

scholarly journals The Assessment of Angiogenesis by Microvessel Density in Patients With Atrophic/Erosive or Reticular Oral Lichen Planus

2021 ◽  
Author(s):  
Maryam Mardani ◽  
Azadeh Andisheh-Tadbir ◽  
Mahya Haghparast
Keyword(s):  
Lichen Planus ◽  
Microvessel Density ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Disease ◽  
Staining Procedure ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
Oral Lichen

The role of angiogenesis in the development of chronic inflammatory diseases, including oral lichen planus (OLP), is of great concern. The most representative method for the assessment of angiogenesis is the semi-quantification of microvessel density (MVD) using specific markers such as CD105. We aimed to assess the MVD in patients with OLP and find its clinical significance to differentiate the atrophic/erosive forms from reticular ones. This cross-sectional study was conducted on 82 patients with clinically and histopathologically proven cases of OLP, including reticular (n=52) or atrophic/erosive (n=30) lesions. The control group comprised 82 age- and sex-matched subjects without any oral disease. To assess the MVD using CD105, tissue blocks were sliced, and the immunoexpression of CD105 was measured by the standard immunohistochemical staining procedure. The mean value of MVD in OLP patients was significantly higher than that in the controls (14.61±12.48 vs. 8.67±1.76, P<0.0001). Furthermore, there was a significant difference in the mean MVD value between reticular and atrophic/erosive lesions (8.19±7.13 vs. 25.73±12.06, P=0.001). However, no significant difference was observed between the reticular lesions and normal tissues (P=0.58). An increased level of CD105 in OLP patients can improve our knowledge about the causes and mechanisms of the disease. The CD105-MVD assessment might be a useful method for semiquantitative measurement of angiogenesis in OLP patients as well as differentiating its clinical forms; therefore, it can open new vistas for formulating strategies based on antiangiogenic treatments for the management of OLP and other precancerous lesions.

scholarly journals Matrix Metalloproteinases Neutralizing Agents: A Possible Treatment Modality for Oral Lichen Planus (Preliminary Study)

2021 ◽  
Author(s):  
Hossam Elsabagh ◽  
Yasmine Gaweesh ◽  
Jaylane Ghonima
Keyword(s):  
Matrix Metalloproteinases ◽  
Disease Severity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Test Group ◽  
Control Group ◽  
Oral Diseases ◽  
The Mean ◽  
Oral Lichen

Abstract Background: Oral lichen planus is one of the most prevalent oral diseases. Matrix metalloproteinases have been implicated in its pathogenesis thus this study was executed to evaluate the effectiveness of matrix metalloproteinases neutralizing agents in the treatment of oral lichen planus. Methods: Patients were assigned to either control group who received topical corticosteroids and antifungal treatment, or test group who received matrix metalloproteinases neutralizing spray. All patients were evaluated for disease severity and pain at baseline, 1 week, and 4 weeks after treatment. Results: The mean pain score in test and control groups was 9.00 (0.89), and 9.33 (0.82), respectively, at baseline while it was 2.33 (1.75) and 2.83 (1.72) at 4th week follow up. The mean disease severity score was 4.33 (0.52) for test group and 4.50 (0.55) for control group at baseline and decreased to 1.83 (0.75) and 2.17 (0.98) at 4th week follow up. Despite the better results seen in test group on the expense of control group, no statistically significant differences could be detected between groups at any timepoint. Conclusion: The use of matrix metalloproteinases neutralizing agents might be an equally effective sole treatment for erosive oral lichen planus compared to the conventional treatment, without the risk of secondary candidiasis. Trial registration: The study was registered retrospectively at ClinicalTrials.gov (NCT04336488), date (07/04/2020)

scholarly journals Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

2020 ◽  
Author(s):  
Alberto Deganello ◽  
Alberto Paderno ◽  
Riccardo Morello ◽  
Milena Fior ◽  
Giulia Berretti ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Prospective Study ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
A Prospective Study ◽  
Oral Lichen

scholarly journals Quantitative Analysis of Salivary TNF-αin Oral Lichen Planus Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
T. Malarkodi ◽  
S. Sathasivasubramanian
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Necrosis Factor Alpha ◽  
Mean Values ◽  
Binomial Proportion ◽  
Whole Saliva ◽  
Factor Alpha ◽  
The Mean ◽  
Group B ◽  
Oral Lichen

Objective. The aim of this study was to quantitatively evaluate the salivary tumor necrosis factor-alpha (TNF-α) level in oral lichen planus patients and to compare the levels of TNF-αbetween saliva and serum of OLP and controls.Methods. Serum and whole saliva from 30 patients with active lesions of oral lichen planus (OLP) and 30 healthy persons were investigated for the presence of TNF-αby enzyme immunoassay. Student’s independentt-test and two-sample binomial proportion test were used to calculate significance of the mean values of TNF-alpha in serum and saliva and to determine the proportions of the detected and nondetected samples in both groups.Results. Proportion of detection and the mean of detectability between saliva and serum of Group B show an almost equal value, which suggests that saliva can be a good alternate to serum to analyze TNF-αin oral lichen planus patients.

scholarly journals Cost of illness of oral lichen planus: a multicenter university hospital–based outpatient observational study

2022 ◽  
Author(s):  
Lajolo C ◽  
Rupe C ◽  
Gioco G ◽  
Giuliani M ◽  
Contaldo M ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Lichen Planus ◽  
Cost Of Illness ◽  
Annual Cost ◽  
Oral Lichen Planus ◽  
Therapy Group ◽  
University Hospital ◽  
The Mean ◽  
Oral Lichen ◽  
Italian Cohort

Abstract Objectives To estimate the economic costs of oral lichen planus (OLP) through a multicenter university hospital–based outpatient study conducted in Italy and Finland. Materials and methods A multicenter retrospective study was conducted on patients affected by OLP to evaluate the economic cost of managing the disease. Direct costs concerning diagnostic procedures, therapeutic management, and follow-up visits were obtained from clinical records. Statistics was performed with IBM SPSS Statistics. Results One hundred and eight patients with a confirmed diagnosis of OLP (81 women and 27 men), 58 Italians and 50 Finnish, were enrolled in this study. The mean annual cost was 1087.2 euros per patient. The mean annual cost was higher in Finnish than in Italian cohort (1558.7 euros vs. 680.7 euros—p < 0.05). Within the Italian cohort, the local immunosuppressive therapy group and atrophic and erosive OLP type had a higher cost (p < 0.05). Within the Finnish cohort, the local immunosuppressive therapy group had a higher cost (p < 0.05). Conclusions OLP-related costs are very similar to other chronic oral disorders (i.e., periodontitis) with differences between investigated countries. Moreover, patients with more severe clinical features, who need immunosuppressive therapy, are facing more expensive costs. Clinical relevance. In this multicenter cost of illness study, we estimated the direct health care costs of OLP and we found that patients with more severe clinical features, who therefore need symptomatic therapy, are facing more expensive costs.

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