Morbidity and mortality in dengue fever: Does it too change periodically?

The incidence of dengue fever increase annually and can increase morbidity and mortality. Dengue fever is mosquito-borne disease and caused by one of four serotype dengue viruses. Severe dengue is characterized either by plasma leakage, fluid accumulation, respiratory distress, severe bleeding, or organ impairment. Mortality and serious morbidity of dengue were caused by several factors including the late recognition of the disease and the changing of clinical signs and symptoms. Understanding the prognostic factors in severe dengue will give early warning to physician thus decreasing the morbidity and mortality, and also improving the treatment and disease management. The aim of this study was to analyze the prognostic factors of severe dengue infection in children. This study was observational cohort study in children (2 months-18 years) with dengue infection according to WHO 2009 criteria which admitted in Soetomo and Soewandhie Hospital Surabaya. Analysis with univariate, bivariate and multivariate with IBM SPSS Statistic 17. All patients were confirmed by serologic marker (NS-1 or IgM/IgG Dengue). Clinical and laboratory examination such as complete blood count, aspartate aminotrasnferase (AST), alanine aminotrasferase (ALT), albumin, and both partial trombocite time and activated partial trombosit time (PTT and aPPT) were analyzed comparing nonsevere dengue and severe dengue patients. There were 40 subjects innonsevere and 27 subjects with severe dengue infection. On bivariate analysis, there were significant differences of nutritional status, abdominal pain, petechiae, pleural effusion, leukopenia, thrombocytopenia, hypoalbuminemia, history of transfusion, increasing AST>3x, prolonged PPT and APTT between severe and nonsevere dengue group. After multivariate analyzed, the prognostic factors of severe dengue were overweight/obesity (p=0.003, RR 94), vomiting (p=0.02, RR 13.3), hepatomegaly (p=0.01, RR=69.4), and prolonged APTT (p=0.005, RR=43.25). In conclusion, overweight/obesity, vomiting, hepatomegaly, and prolonged APTT were prognostic factors in severe dengue infection in children.Those factors should be monitored closely in order to reduce the mortality and serious morbidity.

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Laboratory and clinical profile of dengue: a study from coaching city, Kota, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200785 ◽

2020 ◽

Vol 8 (3) ◽

pp. 1081

Author(s):

Pankaj Jain ◽

Om Prakash Meena ◽

Shivcharan Jelia

Keyword(s):

Dengue Fever ◽

Cross Sectional Study ◽

Clinical Profile ◽

Morbidity And Mortality ◽

Common Symptom ◽

Care Hospital ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Study Laboratory

Background: Dengue, an endemic disease in most subtropical and tropical regions of the world and it causes severe epidemics in India. Dengue is one of the most common acute viral illness associated with considerable morbidity and mortality. The objective of this study was to study laboratory findings and clinical profile of patients with dengue fever at a tertiary care hospital of coaching city Kota.Methods: This study was cross sectional study. The patients were examined at one point of time and later they were never followed which is similar to the cross-sectional study design. A total of 100 patients of dengue fever who were NS1 Antigen or IgM dengue positive, admitted to department of medicine of government medical college, Kota included in the study. Through clinical examination and relevant laboratory investigations performed in all patients.Results: In the present study, there were 74 males and 26 females. The sex ratio was 2.8:1. Maximum number of males (50%) was in the age group of 15-25 Years. Among females the maximum (42.3%) were in the age group of 15-25 years. The most common presenting symptom was fever in all cases followed by headache in 96%. Among bleeding manifestation, Epistaxis, gum bleeding and melena (24%) were the common symptom. 47% patients showed hepatomegaly and 38% showed splenomegaly. 12% patients were anemic and 51% showed leucopenia while 93% showed thrombocytopenia.Conclusions: Males were commonly affected. Young age group of 15-25 was more commonly affected. Fever and headache were the most common presenting symptom. As dengue causes increased morbidity and mortality and requires prompt diagnosis and treatment for the proper management of these cases, this study helps physicians in early diagnosis of dengue by suspecting the features as of dengue and can prevent morbidity and mortality associated with dengue.

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DENGUE FEVER

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.02.1972 ◽

2018 ◽

Vol 21 (02) ◽

pp. 243-246

Author(s):

Muhammad Naeem ◽

Aneela Shaheen ◽

Saima Batool ◽

Sara Rubab ◽

Tehmina Saba ◽

...

Keyword(s):

Dengue Fever ◽

Early Identification ◽

Febrile Illness ◽

Dengue Shock Syndrome ◽

Hemorrhagic Fever ◽

Morbidity And Mortality ◽

Female Ratio ◽

Viral Illness ◽

Male To Female

Background: Dengue is the most prevalent mosquito-born viral illness in theworld. Clinically dengue ranges from asymptomatic, non-febrile illness, classic dengue todengue hemorrhagic fever/dengue shock syndrome. Objective: Subjects & Methods: Thisstudy was included 79 patients conducted at Nawaz Sharif Social Sevurity Hospital, Lahoreduring the epidemic of dengue in Lahore from September 2011 to Dec 2011. Results: Twenty outof 79 patients suspected of dengue fever were dengue IgM positive. Male to female ratio was1.19: 1. Our study included 79 patients suspected of having dengue fever. Fever was the mostcommon symptom in these patients. Conclusions: Early identification of dengue with risk ofdeveloping hemorrhage is an important clinical objective. The morbidity and mortality can bereduced by appropriate and judicious treatment of dengue patients.

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