The clinical utility of red blood cells and reticulocyte-related indices for early detection of latent Iron deficiency

2020 ◽  
Vol 5 (2) ◽  
pp. 62
Author(s):  
HusainY Alkhaldy
Keyword(s):  
Iron Deficiency ◽  
Early Detection ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Clinical Utility ◽  
Latent Iron Deficiency

scholarly journals Implementation of a red blood cell-optical (RBO) channel for detection of latent iron deficiency anaemia by automated measurement of autofluorescence-emitting red blood cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Takahiro Tougan ◽  
Sawako Itagaki ◽  
Yuji Toya ◽  
Kinya Uchihashi ◽  
Toshihiro Horii
Keyword(s):  
Iron Deficiency ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Iron Deficiency Anaemia ◽  
Aminolevulinic Acid ◽  
Nutritional Disorder ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Latent Iron Deficiency

Abstract Iron deficiency is the most common and widespread nutritional disorder worldwide. The automated haematology analyser XN-30 (Sysmex, Kobe, Japan) was developed to detect malaria-infected red blood cells (RBCs) in human blood samples using flow cytometry. The optical system of the analyser detects autofluorescence (AF)-emitting RBCs containing iron-deficient haem groups and would aid in the diagnosis of anaemia resulting from iron deficiency. Here, an RBC-optical (RBO) channel was devised and implemented on the analyser. In vitro analyses showed that the analyser detected AF-emitting RBCs treated with 5-aminolevulinic acid. Furthermore, the analyser detected AF-emitting RBCs in mice fed a low iron diet and infected with a rodent malaria parasite; it could also be effectively used in humans. This study demonstrates that the analyser can quantitatively and reproducibly detect AF-emitting RBCs and measure other haematological parameters, suggesting its usefulness for the initial evaluation of latent iron deficiency anaemia in conjunction with the diagnosis of malaria.

scholarly journals Spectroscopic Evaluation of Red Blood Cells of Thalassemia Patients with Confocal Microscopy: A Pilot Study

Sensors ◽  
2020 ◽  
Vol 20 (14) ◽  
pp. 4039
Author(s):  
Laura Rey-Barroso ◽  
Mónica Roldán ◽  
Francisco J. Burgos-Fernández ◽  
Susanna Gassiot ◽  
Anna Ruiz Llobet ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Confocal Microscopy ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Pediatric Patients ◽  
Single Gene ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Globin Genes ◽  
Molecular Tests

Hemoglobinopathies represent the most common single-gene defects in the world and pose a major public health problem, particularly in tropical countries, where they occur with high frequency. Diagnosing hemoglobinopathies can sometimes be difficult due to the coexistence of different causes of anemia, such as thalassemia and iron deficiency, and blood transfusions, among other factors, and requires expensive and complex molecular tests. This work explores the possibility of using spectral confocal microscopy as a diagnostic tool for thalassemia in pediatric patients, a disease caused by mutations in the globin genes that result in changes of the globin chains that form hemoglobin—in pediatric patients. Red blood cells (RBCs) from patients with different syndromes of alpha-thalassemia and iron deficiency (including anemia) as well as healthy (control) subjects were analyzed under a Leica TCS SP8 confocal microscope following different image acquisition protocols. We found that diseased RBCs exhibited autofluorescence when excited at 405 nm and their emission was collected in the spectral range from 425 nm to 790 nm. Three experimental descriptors calculated from the mean emission intensities at 502 nm, 579 nm, 628 nm, and 649 nm allowed us to discriminate between diseased and healthy cells. According to the results obtained, spectral confocal microscopy could serve as a tool in the diagnosis of thalassemia.

scholarly journals Occurrence of anemia among the people of Gurugram, Haryana: a cross sectional study

2019 ◽  
Vol 9 (1) ◽  
pp. 202-206
Author(s):  
Ashok Kumar Sah ◽  
Rajesh Prasad Jayaswal
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Peripheral Blood Smear ◽  
Nutritional Deficiencies ◽  
P Value ◽  
Inherited Disorders ◽  
Cross Sectional

Anemia is considered a condition, not a disease in which numbers of red blood cells (RBCs) are insufficient to meet the body’s metabolical and physiological needs for oxygen. Anemia may also develop due to nutritional deficiencies such as iron, vitamin B12, folic acid, and vitamin A; moderate and severe inflammation; parasitic infestation; and acquired or inherited disorders that affect hemoglobin synthesis, red blood cell development or red blood cell endurance. This proposed work depicts the distribution of different morphological types of anemia on people of Gurugram, Haryana. All the samples were analyzed for CBC and peripheral blood smear by using Sysmax (three parts) hematology analyzer and microscopy.  In the present study, 300 patients in 6 months study period were included to diagnose anemia. Only 166 cases were positive. Out of 166 cases, 85 (51.2%) were female and 81 (48.8%) were male. The highest number of participants showed RBCs count in the range of 4.5-5.5 million/mm3, 24 (14.5%) with P value 0.000. Most of the cases that we revealed were having hypochromic red cells along with morphological variation in RBCs which may be due to iron deficiency. The further confirmatory analysis may be required in order to know the detail classification of anemia. Keywords: Anemia, Hemoglobin, Iron Deficiency, Hypochromic, Red Blood Cells

CHARACTERISTIC OF ANEMIC SYNDROME IN ONCOLOGIC PATIENTS WITH SEPSIS IN THE EARLY POST-OPERATIVE PERIOD

2020 ◽  
Vol 65 (3) ◽  
pp. 169-173
Author(s):  
Valentina Nikolaevna Blindar ◽  
M. M. Dobrovolskaya ◽  
G. N. Zubrikhina ◽  
T. V. Davydova ◽  
A. V. Sytov ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Iron Deficiency ◽  
Red Blood Cells ◽  
Cancer Patients ◽  
Blood Cells ◽  
The Other ◽  
Normal Range ◽  
Post Operative Period ◽  
Oncologic Patients

A study of the main indicators of red blood (RBC, HGB, HCT, MCV, MCH) and the concentration of EPO, sTfR in 9 cancer patients with anemic syndrome (AS) against sepsis was carried out. Among them, patients with chronic disease anemia (ACh), with normocytic, normochromic characteristics of red blood cells and low hematocrit predominated. In 2 patients, microcytosis and erythrocyte hypochromia were noted, the concentration of sTfR was significantly higher than normal (0.9 ± 0.07 μg / ml), amounted to 2.7 μg / ml in one of them and 1.9 μg / ml in the other, which testified to t iron deficiency erythropoiesis (IDE) on the background of the ACh,. In 7 patients with ACh without IDE, sTfR values were within the normal range (0.1-1.2) μg / ml, the median was 0.5 μg/ml. In all patients with sepsis, the production of EPO was inadequate for the severity of the AS, to a lesser extent in patients with IDE. The average EPO production in the group was 19.4 ± 5.1 (7.7-52.8) mU / ml, median = 12.1 mE / ml. Further studies of EPO, sTfR are planned in order to determine their role in therapeutic tactics in the correction of AS in cancer patients with sepsis.

scholarly journals AYUVEDIYA APPROCH TOWARD IRON DEFICIENCY ANAEMIA - A CASE STUDY

2021 ◽  
Vol 9 (5) ◽  
pp. 983-986
Author(s):  
Vd. Ruksar Piparvadiya ◽  
Keyword(s):  
Iron Deficiency ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Iron Deficiency Anaemia ◽  
Common Type ◽  
Shortness Of Breath ◽  
Deficiency Anaemia

Iron deficiency anaemia is a common type of anaemia – a condition in which blood lacks adequate healthy red blood cells. Anaemia symptoms like leave tired and shortness of breath. In Ayurveda, this can considered under the heading Pandu roga. A case of Iron deficiency anaemia with Ayurveda treatment was discussed here.

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