Effect of aqueous/methanolic extract of Ocimum sanctum (OciBest) on the Male and Female reproductive performance of wistar rats

2018 ◽  
Vol 14 (55) ◽  
pp. 256
Author(s):  
R Kaul-Ghanekar ◽  
P Raina ◽  
B Bharathi ◽  
A Senthilkumar ◽  
S Sagar ◽  
...  
Keyword(s):  
Reproductive Performance ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Ocimum Sanctum ◽  
Male And Female

Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

2018 ◽  
Vol 8 (4) ◽  
pp. 061-065
Author(s):  
F.N OGUWIKE ◽  
◽  
I.C IFEDI ◽  
C.N DIM ◽  
C.P IGWEDIBIA ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Male And Female

scholarly journals Serum pharmacokinetics and coagulation aberration induced by sodium dehydroacetate in male and female Wistar rats

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yumei Zhang ◽  
Donglai Ying ◽  
Hao Liu ◽  
Zengrong Yu ◽  
Lingling Han ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Male And Female ◽  
Female Wistar Rats

Coumarins and a Naphthyl Labdanoate Diarabinoside from the Fruits of Peucedanum grande C. B. Clarke

2012 ◽  
Vol 67 (11-12) ◽  
pp. 580-586 ◽  
Author(s):  
Mohammad Aslam ◽  
Mohammed Ali ◽  
Rameshwar Dayal ◽  
Kalim Javed
Keyword(s):  
Data Analysis ◽  
Spectral Data ◽  
Chemical Reactions ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Nephroprotective Activity ◽  
Coumarin 1 ◽  
Spectral Data Analysis

Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3α-ol-18-(3’’’-methoxy-2’’’- naphthyl-oate)-3α-L-arabinofuranosyl-(2’→1’’)-α-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicininduced nephrotoxicity in Wistar rats.

Fixed-consecutive-number performance in male and female Wistar rats

1990 ◽  
Vol 37 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Frans van Haaren ◽  
Annemieke van Hest
Keyword(s):  
Wistar Rats ◽  
Male And Female ◽  
Female Wistar Rats ◽  
Consecutive Number

scholarly journals GENDER SPECIFIC VARIATION OF TWO PHENOLIC GLYCOSIDES (POPULIN AND SALICIN) IN POPULUS CILIATA AND IDENTIFICATION OF A NEW COMPOUND (CINNAMOYL-SALICIN)

2016 ◽  
Vol 8 (12) ◽  
pp. 156
Author(s):  
Amita Kumari ◽  
Navneet K. Upadhyay ◽  
Prem K. Khosla
Keyword(s):  
Methanolic Extract ◽  
Standard Procedure ◽  
Phenolic Glycosides ◽  
Male And Female ◽  
H Nmr ◽  
Flowering Season ◽  
Crude Plant Extract ◽  
Populus Ciliata ◽  
Specific Variation ◽  
Gender Specific

<p><strong>Objective: </strong>To observe gender specific seasonal variation of two phenolic glycosides (PG’s) (populin and salicin) in <em>Populus ciliata</em> male and female trees.</p><p><strong>Methods: </strong>Plant material (bark) was collected from male and female trees throughout the year. The content of salicin and populin was measured using HPLC. Because of the lack of populin in the market, the standard compound was synthesized in the laboratory from salicin following standard procedure. Confirmation and characterization of synthesized populin were done using <sup>1</sup>H NMR and <sup>13</sup>C NMR. TLC and LC-MS of methanolic extract were performed to observe the presence of populin and salicin in the plant bark.</p><p><strong>Results: </strong>TLC showed the presence of populin and salicin in crude plant extract at Rf value 0.84 and 0.52, respectively. The results of monthly variation showed a consistent pattern of two PG’s for both the sexes. However, salicin content was observed highest compared to populin content. Whereas female trees were observed with low content of PG’s compared to male trees. The maximum content of salicin and populin was observed in the flowering season. LC-MS of bark methanolic extract confirmed the presence of a significantly larger peak, which was identified as a cinnamoyl-salicin peak at 463.</p><p><strong>Conclusion: </strong>The study confirms the highest content of PG’s in the flowering season. Additionally, LC-MS study concluded a new compound cinnamoyl-salicin (M<sup>+</sup>at 463) which is reported first time to the best of author’s knowledge. It seems that it could be the denaturation product of 2'-O-cinnamoyl salicortin and can be further explored for biological applications.</p>

scholarly journals The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

2012 ◽  
Vol 03 (02) ◽  
pp. 162-173 ◽  
Author(s):  
El Mrabet Fatima Zahra ◽  
Lagbouri Ibtissam ◽  
Mesfioui Abdelhalim ◽  
El Hessni Aboubakr ◽  
Ouichou Ali
Keyword(s):  
Sex Hormones ◽  
Wistar Rats ◽  
Male And Female ◽  
Antidepressant Effects ◽  
Female Wistar Rats

scholarly journals Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

2021 ◽  
Vol 11 (1-s) ◽  
pp. 113-116
Author(s):  
Dhaval M Patel ◽  
Advaita B Patel ◽  
Bhumi R Patel ◽  
Deepa R Patel ◽  
Nishith K Patel
Keyword(s):  
Oral Administration ◽  
Calcium Oxalate ◽  
Analysis Of Variance ◽  
Cucumis Melo ◽  
Wistar Rats ◽  
Renal Excretion ◽  
Methanolic Extract ◽  
Urinary Oxalate ◽  
Calcium Oxalate Urolithiasis ◽  
Oxalate Synthesis

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

scholarly journals Histopathological Studies on the Effects of Chloroform and Methanolic Extracts of Ilex kudingcha in Trypanosoma brucei Infected Albino Wistar Rats

2018 ◽  
Vol 04 ◽  
pp. 50
Author(s):  
Olajoju. T. Soniran ◽  
Kalu. K. Ngele ◽  
Christopher. O. Alisa ◽  
Damilola. A. Omoboyowa ◽  
Nnabude. H. Agu ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Phytochemical Analysis ◽  
Diminazene Aceturate ◽  
Leaf Extracts ◽  
Standard Drug ◽  
Phytochemical Study ◽  
Reference Drug ◽  
Histopathological Studies

Histopathological studies of the effects of chloroform and methanolic leaf extracts of Ilex kudingcha in Trypanosoma brucei infected albino wistar rats were investigated. The toxicity and phytochemical study were also carried out using standard protocol. T. brucei infected animals were administered orally with 200 and 400 mg/kg b.w. of the extracts and 3.5 mg/kg b.w. of the standard drug (diminazene aceturate). Results on acute toxicity studies (LD50) revealed no sign of lethality up to the dose of 5,000 mg/kg body weight but the liver and kidney histology of infected animals treated with 5,000 mg/kg b.w. of I. kudingcha extracts were observed to be hepatotoxic and nephrotoxic. The methanol extracts showed appreciably high in vivo anti-trypanosomal activities compared to the reference drug. Histological examination of the organs revealed serious pathological lesions in the liver of the infected animals without treatment (negative control). In the positive control animals (infected animals administered standard drug), mild multifocal aggregate of inflammatory leucocytes was observed. In the other experimental animals, no pathological lesion was observed in the liver, kidney, brain, and heart of infected animals treated with the methanolic extract and combined methanol and chloroform extracts. The effectiveness of the methanolic extract at reducing the lesions caused by the parasite is the same compared with the standard drug. Phytochemical analysis of the plant extracts showed that methanol extract contained appreciable high levels of alkaloids, saponin, tannins, phenol, and glycoside while flavonoid was not detected. Hence, the curative properties of methanolic extract of I. kudingcha as observed in the organs indicate its anti-trypanosomal properties but it should be consumed at minimal doses.

scholarly journals Effects of Maternal Deprivation on Anxiety, Depression, and Empathy in Male and Female Offspring of Wistar Rats in the Face of Novel Objects

2019 ◽  
Vol 8 ◽  
pp. 1093
Author(s):  
Solmaz Khalifeh ◽  
Fariba Khodagholi ◽  
Mehrad Moghtadaei ◽  
Ali Behvarmanesh ◽  
Afshin Kheradmand ◽  
...  
Keyword(s):  
Life Stress ◽  
Wistar Rats ◽  
Female Offspring ◽  
Maternal Deprivation ◽  
Female Rats ◽  
Control Group ◽  
Male And Female ◽  
Male And Female Rats ◽  
Novel Objects ◽  
Anxiety Depression

Background: Early life stress (ELS) models such as maternal deprivation (MD) are used to in¬vestigate behavioral changes in rodents under stressful situations. MD is a situation in which rat pups are separated from the dam; MD has different paradigms. The purpose of this research is to evaluate the effects of maternal deprivation on anxiety, depression, and empathy in adult Wistar rats. Materials and Methods: MD was applied to pups as per specifically designed protocol to compare rats of the control group with maternal deprivation rats and also the group, which faced novel objects. Each group consisted of eight rats. In this study, separation started from postnatal day (PND) 14 for various periods up to PND 60. EPM test was undertaken to measure anxiety; moreover, FST was used to indicate levels of depression. Also, changes in the empathy ratio were also demonstrated. One-way analysis of variance (ANOVA), Tukey’s post hoc analysis, and t-test were applied to analyze the results. Results: MD-treated rats showed a significant decrease in anxiety and empathy indexes compared with those in the control group (P<0.05). However, MD significantly increased depression in both male and female rats (P<0.05). Final¬ly, exposure to novel objects decreased depression but did not have any effect on anxiety and empathy levels in MD rats (P<0.05). Conclusion: ELS may lead to various states of mood and behavior in adulthood. According to the findings of this study, depression increases due to MD, though both anxiety and empathy decrease in both male and female Wistar rats. Moreover, ex¬posure to novel objects decreases depression, while anxiety and empathy do not change signifi¬cantly with exposure to novel objects. [GMJ.2019;8:e1093]

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