scholarly journals The Therapeutic Effect of Nigella Sativa Extract on Female Wistar Rats Vaginal Candidiasis Model

2020 ◽  
Author(s):  
Muhammad Rusda ◽  
M. Fidel Siregar ◽  
Aznan Lelo ◽  
Syafruddin Ilyas ◽  
Ratna Ganie ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Vaginal Candidiasis ◽  
Female Wistar Rats

scholarly journals ANTIFUNGAL EFFECT OF NIGELLA SATIVA EXTRACT ON FEMALE WISTAR RATS VULVOVAGINAL CANDIDIASIS MODEL

2020 ◽  
pp. 66-68
Author(s):  
MUHAMMAD RUSDA
Keyword(s):  
Candida Albicans ◽  
Therapeutic Effect ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Vulvovaginal Candidiasis ◽  
Analytic Study ◽  
Control Group ◽  
Antifungal Effect ◽  
Female Wistar Rats

Objective: To assess the antifungal effect of Nigella sativa extract on female Wistar rats vulvovaginal candidiasis. Methods: This was an analytic study that assess the therapeutic effect of Nigella sativa in rats’ vulvovaginal candidiasis model. The subjects were 28 rats that had been inoculated with Candida albicans and divided into 4 groups: control group (G1), fluconazole group (G2), Nigella sativa group (G3) and combination of Nigella sativa with fluconazole group (G4). Candida albicans colony was measured to assess the therapeutic effect of the treatment. Results: There were no difference number of Candida albicans colony between all group before inoculation (p = 0,274) and after inoculation (p = 0,323). There were a significant decreased number of Candida albicans colony on the 72 h after the treatment between the three types of treatment with the control group (Nigella sativa group p = 0,002; Fluconazole group p = 0,001; Nigella sativa+fluconazole p = 0,001) Conclusion: Nigella sativa has a potential antifungal effect by reducing the number of Candida albicans colonies.

scholarly journals Therapeutic Effect of 48 h after Nigella sativa Extract Administration on Female Wistar Rats Vaginal Candidiasis Model: An Experimental Study

2021 ◽  
Vol 9 (T3) ◽  
pp. 6-8
Author(s):  
Muhammad Rusda ◽  
Ichwanul Adenin ◽  
M. Fidel Ganis Siregar ◽  
Andrina Y. M. Rambe ◽  
Yudha Sudewo
Keyword(s):  
Therapeutic Effect ◽  
Group Treatment ◽  
Nigella Sativa ◽  
Vaginal Candidiasis ◽  
Control Group ◽  
Therapeutic Effects ◽  
Post Inoculation ◽  
Common Causes ◽  
Female Wistar Rats

BACKGROUND: Candida albicans was the common causes of vulvovaginalis candidiasis (VVC) in human. To avoid complications, prompt and proper treatment of VVC must be performed. The pharmacological effects of Nigella sativa include antimicrobial, anti-inflammatory, immune stimulation, and anti-cancer properties. AIM: N. sativa has been shown to have an in vivo antifungal effect and the purpose of this study was to determine the antifungal and potential in vivo therapeutic effects. METHODS: This research was an empirical study which evaluated the therapeutic effect of the vaginal candidiasis model of N. sativa in rats. The subjects were 28 rats inoculated with C. albicans and were divided into four groups: Control group (G1), fluconazole group (G2), N. sativa group (G3), and N. sativa and fluconazole group combinations (G4). The colony of C. albicans was assessed to determine the treatment’s therapeutic effect. RESULTS: There was no difference in the number of colonies of C. albicans between all the pre-inoculation (p = 0.274) and post-inoculation (p = 0.323) classes. A substantial decrease in the number of C. albicans colonies within 48 h of treatment was observed between the three control group treatment forms (N. sativa group p = 0.046; fluconazole group p = 0.002; and N. sativa + fluconazole group p = 0.002). CONCLUSIONS: The therapeutic effect of N. sativa has been achieved by reducing the number of colonies of C. albicans.

NEW DATA CONCERNING THE ROLE PLAYED BY PROGESTERONE IN THE CONTROL OF FOLLICULAR GROWTH IN THE RAT

1974 ◽  
Vol 75 (3) ◽  
pp. 569-578 ◽  
Author(s):  
G. Buffler ◽  
S. Roser
Keyword(s):  
Wistar Rats ◽  
Venous Blood ◽  
Oestrous Cycle ◽  
Female Rats ◽  
Cycle Duration ◽  
Follicular Growth ◽  
The Third ◽  
Female Wistar Rats

ABSTRACT The mechanisms involved in the prolongation of the oestrous cycle following LH administration were studied in 4-day cyclic female Wistar rats. In females injected with LH on the morning of dioestrus I there was an increase in ovarian venous blood progesterone as compared with non-injected animals. In both LH-treated females, and those injected with progesterone on the morning of dioestrus I, a slowing up in follicular growth was observed from the afternoon of dioestrus I. The size of follicles greater than 400 urn present in LH or progesterone injected animals on the third day of cycle was similar to the size reached by the same range of follicles in non-injected animals on the second day of the cycle. Hence, the increase in endogenous ovarian progesterone elicited by LH was considered as the cause of the slowing up of follicular growth and therefore of the lengthening of the oestrous cycle duration in female rats injected with LH at the beginning of 4-day cycle.

Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Female Wistar Rats

2010 ◽  
Vol 58 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Roland Pálffy ◽  
Michal Behuliak ◽  
Roman Gardlík ◽  
Peter Jáni ◽  
L'udevít Kádaši ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Female Wistar Rats

scholarly journals The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Izuchukwu Azuka Okafor ◽  
Uchenna Somtochukwu Nnamah ◽  
Jude Nnaka
Keyword(s):  
Estrous Cycle ◽  
Adult Female ◽  
Wistar Rats ◽  
Major Effect ◽  
Reproductive Hormones ◽  
Portulaca Oleracea ◽  
High Dose ◽  
Methanolic Extracts ◽  
Cycle Arrest ◽  
Female Wistar Rats

Abstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts. This study investigated the reproductive effect of methanolic extracts of Portulaca oleracea (MEPO) in adult female Wistar rats. Results Group C showed a significant decrease both in relative ovarian weight (p = 0.000), and relative uterine weight (p = 0.037), when compared with the control. There were no significant (p ˃ 0.05) changes in the levels of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol. When compared to the control, groups B and C showed abnormal estrous cycle and cycle arrest especially at the metestrus phase with mild congestion of a few blood vessels in the ovary and uterus. Conclusions MEPO may possess some anti-fertility effect, as it disrupts the estrous cycle of adult female Wistar rats; although it has no major effect on the reproductive hormones, uterus, and ovarian histology of adult female Wistar rats. However, high dose consumption should be taken with precaution.

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