Effects of Dietary Vitamin C and E Supplementation on Exercise-Induced Muscle Damage among Young Kelantan Weightlifters

We investigated the effects of a 40 min bout of bicycle exercise, and the effects of vitamin C administration 12 h before exercise, on the serum markers of oxidative stress in young untrained subjects. Increased levels of malondialdehyde, the marker of the lipid peroxidation, and a decrease in specific activity of the antioxidant enzyme glutathione peroxidase that were observed as a result of exercise, pointed to the presence of exercise-induced oxidative stress. These markers were reduced by pre-administration of vitamin C. The results suggest that physically active subjects could increase their daily dietary vitamin C intake in order to reinforce their antioxidant defenses prior to exercise training.

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Nutritional Antioxidants as Therapeutic and Preventive Modalities in Exercise-Induced Muscle Damage

Canadian Journal of Applied Physiology ◽

10.1139/h99-021 ◽

1999 ◽

Vol 24 (3) ◽

pp. 249-266 ◽

Cited By ~ 66

Author(s):

Allan H. Goldfarb

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Free Radical ◽

Vitamin E ◽

Vitamin C ◽

Muscle Damage ◽

Antioxidant Properties ◽

Beta Carotene ◽

Free Radical Damage ◽

Exercise Induced

Several mechanisms have been forwarded to explain the etiology of exercise-induced muscle damage. Free-radical mediated processes appear to be an important component of the inflammatory mediated response. Free radicals have also been demonstrated to be a contributing factor in the loss of calcium homeostasis within the cell. Therefore, one of the proposed treatments for preventing or reducing the extent of this damage is the intervention of free-radical mediated processes. Antioxidants are agents that typically work to prevent free-radical mediated alterations within cells by quenching free radicals. The traditional dietary antioxidants most commonly investigated to inhibit free-radical damage are vitamin E, vitamin C, and beta carotene. Other nutritional agents have also been noted to posses antioxidant properties. Isoflavonoids and some phytochemicals have been proposed to contain antioxidant properties. This paper briefly reviews some aspects of these agents and their role, either proven or proposed, in the prevention of oxidative stress and muscle damage. Key words: vitamin E, vitamin C, beta carotene, genistein, oxidative stress

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Protective Role of Vitamin C Intake on Muscle Damage in Male Adolescents Performing Strenuous Physical Activity

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.337 ◽

2018 ◽

Vol 6 (9) ◽

pp. 1594-1598 ◽

Cited By ~ 1

Author(s):

Shreef G. N. Gabrial ◽

Marie-Christine R. Shakib ◽

Gamal N. Gabrial

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Muscle Damage ◽

Inflammatory Markers ◽

Inflammatory Responses ◽

Plasma Concentrations ◽

Male Adolescents ◽

Strenuous Physical Activity ◽

Exercise Induced

BACKGROUND: Strenuous non-regular exercise increases reactive oxygen species ROS level leading to an impaired balance between the endogenous antioxidant defence system and the free radicals production. Antioxidants intake can detoxify the peroxides produced during exercise, attenuating the inflammatory responses and therefore may prevent exercise-induced muscle damage. AIM: The purpose of this study was to determine the role of vitamin C intake in attenuating markers of muscle damage, oxidative stress and inflammatory responses in male adolescents performing the non-regular strenuous exercise. MATERIAL AND METHODS: Twenty recreationally active male adolescents were assigned to participate in the study. Eligible subjects performed strenuous recreational exercise (2-3 times per week) were randomly divided into two groups: The vitamin C (VC) group that consumed 500 mg of capsulated vitamin C after breakfast for a period of 90 days and the placebo (PL) group that consumed identical capsules in form and aspect that contained 500 mg of maltodextrin for the same period. Aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH) were assessed for muscle damage. Malondialdehyde (MDA) was evaluated as a marker of lipid peroxidation. Plasma creatinine, uric acid and urea were determined to monitor kidney function. C-reactive protein, a marker of systemic inflammation was also measured. RESULTS: In comparison between PL and VC groups, the plasma concentrations of muscle damage markers, oxidative stress markers, kidney function and inflammatory markers showed no significant difference in their baseline values (P > 0.05). The plasma concentrations of CK, LDH, MDA, urea, uric acid and CRP were significantly decreased in the VC group (P < 0.05) as compared to their values before the intake of vitamin C. CONCLUSION: The present results support the intake of vitamin C as an antioxidant for attenuating exercise-induced muscle damage, oxidative stress and inflammatory markers in male adolescents performing the strenuous physical activity.

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Vitamin C: Effects of Exercise and Requirements with Training

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.13.2.125 ◽

2003 ◽

Vol 13 (2) ◽

pp. 125-151 ◽

Cited By ~ 46

Author(s):

Jonathan M. Peake

Keyword(s):

Ascorbic Acid ◽

Vitamin C ◽

Acute Exercise ◽

Dietary Vitamin ◽

Regular Exercise ◽

Dietary Intakes ◽

The Hours ◽

High Doses ◽

Review Reports ◽

Exercise Induced

Ascorbic acid or vitamin C is involved in a number of biochemical pathways that are important to exercise metabolism and the health of exercising individuals. This review reports the results of studies investigating the requirement for vitamin C with exercise on the basis of dietary vitamin C intakes, the response to supplementation and alterations in plasma, serum, and leukocyte ascorbic acid concentration following both acute exercise and regular training. The possible physiological significance of changes in ascorbic acid with exercise is also addressed. Exercise generally causes a transient increase in circulating ascorbic acid in the hours following exercise, but a decline below pre-exercise levels occurs in the days after prolonged exercise. These changes could be associated with increased exercise-induced oxidative stress. On the basis of alterations in the concentration of ascorbic acid within the blood, it remains unclear if regular exercise increases the metabolism of vitamin C. However, the similar dietary intakes and responses to supplementation between athletes and nonathletes suggest that regular exercise does not increase the requirement for vitamin C in athletes. Two novel hypotheses are put forward to explain recent findings of attenuated levels of cortisol postexercise following supplementation with high doses of vitamin C.

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LEVELS OF VITAMIN C IN CHAIN SMOKERS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i7.1436 ◽

2020 ◽

Vol 4 (7) ◽

Author(s):

Simerpreet Kukreja

Keyword(s):

Cigarette Smoking ◽

Vitamin C ◽

Dietary Intake ◽

Serum Vitamin ◽

Inverse Correlation ◽

Serum Levels ◽

Negative Association ◽

Alcoholic Beverages ◽

Vitamin Supplementation ◽

Dietary Vitamin

Introduction: Cigarette smoking induces many chronic illnesses, but in developed countries it is a preventable risk factor. However, by increasing the protective protection mechanism, it may be possible to alleviate the smoke-induced damage. As smoking risk is minimised by vitamin C intake, it is recommended that smokers should take more vitamin C. This inverse correlation between both vitamin C intake and serum levels and smoking was independent of age, sex, body weight, ethnicity, and consumption of alcoholic beverages. The negative association between cigarette smoking and serum vitamin C levels continued, following further adjustment for dietary vitamin C intake. The risk of severe hypovitaminosis C, especially when not accompanied by vitamin supplementation, has been increased in smokers. These data indicate that the inverse relationship between smoking and serum vitamin C levels exists independently of dietary intake, while smoking adversely affects preferences for vitamin C rich foods. Methods: A survey method was performed, with 50 smokers (S) receiving either 500 mg of vitamin C or placebo (P) daily for 4 weeks, and 50 non-smokers receiving vitamin C without supplementation. All finished the hearing. Both groups were equal and C: 14.2 + /- 1.8 pack-years was the amount of cigarettes smoked. Concentrations of plasma vitamin C increased significantly (p < 0.005) only in the vitamin C supplement community. Results: At SMHRC Hospital Nagpur, we examined the relationship between smoking and vitamin C status, dietary and serum vitamin C levels of 100 participants. Smokers of 20 cigarettes a day had the lowest dietary intake of vitamin C and serum levels, whereas smokers of 1-19 cigarettes a day had lower intake of vitamin C and serum levels (compared to respondents who had never smoked. This inverse correlation between vitamin C and smoking intake and serum levels was independent of age, sex, body weight, race, and consumption of alcoholic beverages. The negative association between cigarette smoking and serum vitamin C levels continued, following further adjustment for dietary vitamin C intake. In smokers, the risk of severe hypo-vitaminosis C, particularly when not accompanied by vitamin supplementation, has increased. Conclusion: These data indicate that the inverse relationship between smoking and serum vitamin C levels exists independently of dietary intake, while smoking adversely affects preferences for vitamin C rich foods. A balanced diet for smokers will obtain a hearty recommendation at this time, but guidelines should remain cautious about high-dose nutrition supplements. Keywords: Chain Smoker, Vitamin C, hypo-vitaminosis C and cigarette.

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