LEVELS OF VITAMIN C IN CHAIN SMOKERS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Simerpreet Kukreja
Keyword(s):  
Cigarette Smoking ◽  
Vitamin C ◽  
Dietary Intake ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Negative Association ◽  
Alcoholic Beverages ◽  
Vitamin Supplementation ◽  
Dietary Vitamin

Introduction: Cigarette smoking induces many chronic illnesses, but in developed countries it is a preventable risk factor. However, by increasing the protective protection mechanism, it may be possible to alleviate the smoke-induced damage. As smoking risk is minimised by vitamin C intake, it is recommended that smokers should take more vitamin C. This inverse correlation between both vitamin C intake and serum levels and smoking was independent of age, sex, body weight, ethnicity, and consumption of alcoholic beverages. The negative association between cigarette smoking and serum vitamin C levels continued, following further adjustment for dietary vitamin C intake. The risk of severe hypovitaminosis C, especially when not accompanied by vitamin supplementation, has been increased in smokers. These data indicate that the inverse relationship between smoking and serum vitamin C levels exists independently of dietary intake, while smoking adversely affects preferences for vitamin C rich foods. Methods: A survey method was performed, with 50 smokers (S) receiving either 500 mg of vitamin C or placebo (P) daily for 4 weeks, and 50 non-smokers receiving vitamin C without supplementation. All finished the hearing. Both groups were equal and C: 14.2 + /- 1.8 pack-years was the amount of cigarettes smoked. Concentrations of plasma vitamin C increased significantly (p < 0.005) only in the vitamin C supplement community.  Results: At SMHRC Hospital Nagpur, we examined the relationship between smoking and vitamin C status, dietary and serum vitamin C levels of 100 participants. Smokers of 20 cigarettes a day had the lowest dietary intake of vitamin C and serum levels, whereas smokers of 1-19 cigarettes a day had lower intake of vitamin C and serum levels (compared to respondents who had never smoked. This inverse correlation between vitamin C and smoking intake and serum levels was independent of age, sex, body weight, race, and consumption of alcoholic beverages. The negative association between cigarette smoking and serum vitamin C levels continued, following further adjustment for dietary vitamin C intake. In smokers, the risk of severe hypo-vitaminosis C, particularly when not accompanied by vitamin supplementation, has increased. Conclusion: These data indicate that the inverse relationship between smoking and serum vitamin C levels exists independently of dietary intake, while smoking adversely affects preferences for vitamin C rich foods. A balanced diet for smokers will obtain a hearty recommendation at this time, but guidelines should remain cautious about high-dose nutrition supplements. Keywords: Chain Smoker, Vitamin C, hypo-vitaminosis C and cigarette.

scholarly journals Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Li Ran ◽  
Wenli Zhao ◽  
Xiaodong Tan ◽  
Hongwu Wang ◽  
Kaito Mizuno ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin C ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
English Articles

Background. Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure. Aim. Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength. Method. Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases. A total of 18 eligible studies were analyzed in the Reviewer Manager 5.3 software, including 14 English articles and 4 Chinese articles. Results. In the evaluation of serum vitamin C levels, the concentration in hypertensive subjects is 15.13 μmol/L lower than the normotensive ones (mean difference=−15.13, 95% CI [-24.19, -6.06], and P=0.001). Serum vitamin C has a significant inverse relation with both systolic blood pressure (Fisher’s Z=−0.17, 95% CI [-0.20, -0.15], P<0.00001) and diastolic blood pressure (Fisher’s Z=−0.15, 95% CI [-0.20, -0.10], P<0.00001). Conclusions. People with hypertension have a relatively low serum vitamin C, and vitamin C is inversely associated with both systolic blood pressure and diastolic blood pressure.

scholarly journals P547 Inadequate vitamin C status and association with inflammatory biomarkers in adults with active Crohn’s disease

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S465-S466
Author(s):  
C Wall ◽  
K MacFarlane ◽  
A Carr ◽  
A Day ◽  
R Gearry
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin C ◽  
High Performance ◽  
Serum Vitamin ◽  
Water Soluble ◽  
Dietary Vitamin ◽  
Micronutrient Deficiencies ◽  
Faecal Calprotectin ◽  
Exclusive Enteral Nutrition

Abstract Background Micronutrient deficiencies are common in inflammatory bowel disease (IBD) due to the inflammatory burden and changes in dietary intake. Vitamin C, an essential water-soluble antioxidant required for tissue repair and immune function, is found primarily in fresh fruit and vegetables however, this food group is more often avoided by people with IBD compared with the general population. This research aimed to determine serum vitamin C status in subjects with active Crohn’s disease, measure urinary vitamin C excretion in healthy controls (HC) and Crohn’s disease patients before and after exclusive enteral nutrition (EEN) and assess associations between inflammatory markers and vitamin C. Methods Stored serum and random urine samples prospectively collected from adults with mild to moderately active Crohn’s disease and adult HC were analysed. Both HC and Crohn’s disease groups received EEN with a known vitamin C content for two weeks. Serum and urinary vitamin C were measured using high-performance liquid chromatography with electrochemical detection. Urinary vitamin C was standardised to urinary creatinine. Non-parametric t-tests and correlations were performed. Results EEN was initiated in 38 patients (aged 16 to 39 years old). Inadequate serum vitamin C (&lt;50 µmol/l) was present in 36/38 patients with active Crohn’s disease and 45% had hypovitaminosis C. Baseline C-reactive protein (CRP) was 12 mg/l (range, 3 to 158 mg/l) and faecal calprotectin was 1065 µg/g (range, 60 to 3838 µg/g). Serum vitamin C correlated weakly with CRP (r = −0.30 95% CI: −0.58 to 0.03, p = 0.06) but not with faecal calprotectin. Two weeks of EEN was completed by 30 (79%) patients and 17 (81%) HC. The average vitamin C intake was 168mg/day (range, 108–252 mg/day). Baseline urinary excretion of vitamin C was low in both Crohn’s disease and HC. Following EEN urinary vitamin C excretion increased significantly in both groups (Figure 1). Conclusion Patients with active Crohn’s disease had inadequate vitamin C status. EEN increased urinary vitamin C excretion in both Crohn’s disease and HC, suggesting low baseline dietary vitamin C intake and potentially enhanced utilisation. Further research with a larger patient cohort would provide a greater understanding of vitamin C metabolism in active Crohn’s disease.

Deliberate Vitamin C S elf-Administration by the Public

1983 ◽  
Vol 2 (3-4) ◽  
pp. 211-216
Author(s):  
Cedric W. M Wilson ◽  
Gillian C. Coffey
Keyword(s):  
Ascorbic Acid ◽  
Side Effects ◽  
Vitamin C ◽  
Dietary Intake ◽  
Medical Advice ◽  
Recommended Dose ◽  
Dietary Vitamin ◽  
The Public ◽  
Abdominal Symptoms ◽  
Daily Dose

A questionnaire was distributed to 38 organisations in Dublin to obtain information about the extent to which Vitamin C is deliberately taken by the public in the form of fruit, or tablets containing ascorbic acid, the reasons for its consumption and the side-effects attributed to it, in relation to the basic dietary intake of Vitamin C. Of the 950 subjects in the sample, 60% significantly more of whom were female, deliberately took supplementary Vitamin C. Of the Vitamin C takers, 70% took a daily dose of 50 mg, 7% took 1000 mg or more; 28% took the supplementary dose all the time, 12% took it only when ill, in the form of tablets. Subjects with a dialy dietary intake of more than 75 mg were more likely to take supplementary Vitamin C. 36% of takers took Vitamin C for control of cold symptoms. Only 5% took it on medical advice. 8% of the subjects attributed side-effects to Vitamin C, sleepiness, soreness of the tongue and constipation being the most common, and equally common after fruit or tablets. Only 4% experienced abdominal symptoms. The results indicate that females who normally have higher tissue ascorbic acid levels, and those individuals who have higher basic dietary Vitamin C intakes, tend to supplement themselves to a greater degree with extra Vitamin C in the form of fruit or tablets. It appears that a proportion of the population has a higher physiological requirement of Vitamin C than other individuals who exist on the recommended dose.

scholarly journals The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

2020 ◽  
Author(s):  
Aida Torkzaban ◽  
Seyed Amir Mansour Alavi Naeini ◽  
Akbar Hassanzadeh ◽  
Mehrdad Namdari
Keyword(s):  
Uric Acid ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Case Control Study ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Case Control ◽  
Significant Difference ◽  
Control Study

Abstract Background: Coronary Heart Disease (CHD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. The aim of this study is to measure the serum level of UA and vitamin C as well as the antioxidant status of CHD patients to evaluate their relationship and compare them with the healthy individual.Materials and methods: The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. Food frequency questionnaire (FFQ) and international physical activity questionnaire were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid (UA), vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results: A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C intake (P<0.047). A significant relationship was also observed between the systolic blood pressure and CHD (P<0.028).Conclusion: Our results suggest that increasing of serum uric acid and a decrease in serum vitamin C level can be considered as risk factors for CHD patients. Due to the lack of significant correlation between TAC and CHD in this study, it seems that different results will be obtained with increasing sample size.

scholarly journals Dietary vitamin C intake and cigarette smoking.

1990 ◽  
Vol 80 (12) ◽  
pp. 1526-1526 ◽  
Author(s):  
G Gridley ◽  
J K McLaughlin ◽  
W J Blot
Keyword(s):  
Cigarette Smoking ◽  
Vitamin C ◽  
Dietary Vitamin

scholarly journals Current Estimates of Serum Vitamin C and Vitamin C Deficiency in the United States

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1067-1067
Author(s):  
Srivats Narayanan ◽  
Sharan Satish Kumar ◽  
Angellar Manguvo ◽  
Elizabeth Friedman
Keyword(s):  
United States ◽  
Logistic Regression ◽  
Vitamin C ◽  
Weight Status ◽  
Smoking Status ◽  
Serum Vitamin ◽  
The United States ◽  
Vitamin Supplementation ◽  
Multivariable Logistic Regression Analysis ◽  
Vitamin C Deficiency

Abstract Objectives This study aimed to assess current mean serum vitamin C level and prevalence of vitamin C deficiency (serum level &lt;11.4 μmol/L) in the United States using nationally representative data, as well as compare to the previous decade's distributions. The study also explored the predictive effects of demographic variables on prevalence of vitamin C deficiency. Methods The study population included 6740 non-institutionalized civilians aged 6 years and older in the National Health and Nutrition Examination Survey (NHANES) 2017–2018 who represented 274,157,096 individuals in the United States. Multivariable linear and logistic regression analyses were used to test the predictive effects of covariates. Serum vitamin C levels and deficiency prevalence were compared with NHANES 2005–2006 data using Student's t-tests. Results The mean serum vitamin C level was 53.4 μmol/L (95% CI: 50.9, 55.8) and the prevalence of vitamin C deficiency was 5.9% (95% CI: 4.3, 7.6). In multivariable logistic regression analysis accounting for gender, age, race, smoking status, and obesity classification, only current smoking status was associated with deficiency (OR = 3.78 [95% CI: 2.70, 5.29], P = 0.02). Multivariable linear regression of the same factors found that underweight status (P = 0.04) and women (P = 0.02) were associated with higher vitamin C, while smoking status (P = 0.01) and obesity (P = 0.01) were associated with lower level. Although mean serum vitamin C declined from NHANES 2005–2006 to NHANES 2017–2018 (P &lt; 0.05), there was no significant change in deficiency prevalence (P = 0.27). Conclusions In NHANES 2017–2018, mean serum vitamin C level declined, but the prevalence of vitamin C deficiency did not significantly change from that during NHANES 2005–2006. Although gender, smoking status, and weight status were predictive of serum vitamin C level, deficiency was significantly more common only among smokers. These findings suggest that clinicians should continue to be wary of signs and symptoms of vitamin C deficiency and encourage vitamin supplementation when appropriate, particularly with patients who smoke. Funding Sources No funding was required/used for the research.

scholarly journals The Effects Of Cigarette Smoking On The Serum Levels Of Some Antioxidants (Vitamin C And E ) Amongst Male Smokers In Levels In College Of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Okwara John Ekenedilichukwu ◽  
Ibe Chukwuemeka Solomon ◽  
Ogbodo Emmanue Chukwuemeka ◽  
Analike Rosemary Adamma ◽  
Onyegbule Onyema Athanatius ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Vitamin C ◽  
Biochemical Parameters ◽  
Serum Levels ◽  
Health Sciences ◽  
Anthropometric Data ◽  
Cigarette Smokers ◽  
Anambra State ◽  
The Mean ◽  
Structured Questionnaire

Smoking has been identified as one of the major risk factors in human diseases such as atherosclerosis and several cancers. This study investigated the effect of smoking on vitamin C and E levels in male cigarette smokers in College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State. A total of 100 subjects comprising of (50 smokers and controls) each were recruited for the study. A well structured questionnaire was used in obtaining the demographic and anthropometric data as well as dietary pattern of subjects. Thereafter, 5mls of blood sample was collected from subjects and used for the evaluation biochemical parameters. Biochemical parameters (vitamin C and E levels) were estimated using standard methods and results subjected to statistical analysis using student t-test and Pearson r correlation. The results show a significant decrease in the mean serum levels of Vitamins C (0.82±0.33 vs 1.49±0.25; p=0.000) and E (12.36±1.61 vs15.61±1.91; p=0.000) in smokers compared with non smokers respectively. More so, there was a significant positive correlation between BMI and serum level of Vitamin C (r=0.345; P=0.014) and E (r=0.187; P=0.024) in cigarette smokers. In conclusion, the study revealed the deleterious effects of cigarette smoking on serum levels of vitamins C and E in smokers. Hence, there is need for proper dietary management in patients.

scholarly journals Influence of dietary supplementation on serum vitamin A and D concentrations and their seasonal variation in horses

1992 ◽  
Vol 1 (5) ◽  
pp. 477-482 ◽  
Author(s):  
Markku Saastamoinen ◽  
Johanna Juusela
Keyword(s):  
Seasonal Variation ◽  
Vitamin A ◽  
Serum Vitamin ◽  
Vitamin Supplementation ◽  
Dietary Vitamin ◽  
Serum Retinol ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Grazing Period ◽  
One Year

An experiment involving 40 adult trotters and saddle horses was conducted during a period of one year in order to investigate the influence of vitamin A (retinol) and D (25-(OH)D) supplementation on serum vitamin concentrations and the seasonal variation of the serum concentrations of these vitamins. Vitamin supplementation was started either at the beginning or in the middle of the indoor (winter) feeding period. Supplementation lasted from the beginning of September or January to the end of May. According to the results, neither the dietary vitamin supplementation nor the length of the grazing period had any consistent effect on the serum vitamin concentrations. Neither was there any systematic seasonal variation in the serum retinol and 25-hydroxyvitamin D levels.

SOME OBSERVATIONS ON THE RELATIONSHIP BETWEEN VITAMIN B12 AND REPRODUCTION IN SWINE

1961 ◽  
Vol 41 (2) ◽  
pp. 212-219 ◽  
Author(s):  
G. L. Frederick ◽  
G. J. Brisson
Keyword(s):  
Dietary Intake ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Milk Diet ◽  
Feed Conversion ◽  
Deficient Diet ◽  
Adult Females ◽  
The Relationship

Six female swine were maintained during one or more gestations on a vitamin B12-deficient diet. Two that had been fed the deficient diet for more than 2 years prior to their first gestation aborted. Four that received the deficient diet for 7 months prior to their first gestation farrowed a total of 8 litters containing 68 live piglets; 27 died within 3 days. All piglets fed a synthetic milk diet, deficient in vitamin B12, died within 14 days.Five adult females fed the deficient diet supplemented with 400 μg. of vitamin B12 per animal per day farrowed a total of 8 litters containing 83 live piglets; none died within 3 days. Of 14 piglets fed a vitamin B12-deficient synthetic milk diet, 2 died within 14 days.The different dietary vitamin B12 intakes of the adults influenced the serum vitamin B12 levels of the adults and of their offspring.Piglets fed vitamin B12 gained more, but feed conversion was not influenced by the vitamin B12 dietary intake of the piglets or by the intake of their dams during gestation.It is concluded that vitamin B12 influences swine reproduction and neonatal survival.

scholarly journals Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients

2020 ◽  
Vol 12 ◽  
pp. 251584142095168
Author(s):  
Ramazan Kürşad Zor ◽  
Serpil Erşan ◽  
Erkut Küçük ◽  
Gamze Yıldırım ◽  
İsmail Sarı
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Age Related

Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants ( n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group ( p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group ( p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.

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