Correlation between Iron Status Parameters and Hormone Levels in Women with Polycystic Ovary Syndrome

Much research has shown that iron store parameters are increased in women with polycystic ovary syndrome (PCOS), but an exact explanation for this phenomenon remains unavailable. The objective of this study was to investigate the correlation between iron status parameters and hormonal disturbances in women with PCOS that accounts for their increased iron store levels. Iron status parameters and hormones were measured using colorimetric and enzyme-linked immunosorbent assays, respectively. The results demonstrated a mild iron overload in the patients with PCOS. Good positive correlations between iron status parameters and serum testosterone, prolactin, and insulin were detected in the patient group, whereas iron status parameters and BMI were not significantly correlated. The data also suggest that the increase in serum ferritin and body iron store levels in patients with PCOS are associated with hyperandrogenemia, hyperprolactinemia, and hyperinsulinemia. The findings of this study expand current knowledge on the factors affecting iron stores and suggest a different mechanism of interaction between iron stores and the endocrine system through the harmful deposition of iron in endocrine glands and through hormonal effects on iron absorption and metabolism.

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[PP.03.22] BODY IRON STORE IN POLYCYSTIC OVARY SYNDROME ASSOCIATED TO WEIGHT EXCESS

Journal of Hypertension ◽

10.1097/01.hjh.0000491689.48468.10 ◽

2016 ◽

Vol 34 ◽

pp. e131-e132

Author(s):

K. Chaabouni ◽

A. Lahiani ◽

M. Messedi ◽

M. Turki ◽

M. Naifar ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Iron Store ◽

Ovary Syndrome ◽

Body Iron ◽

Body Iron Store ◽

Weight Excess

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Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome: Unraveling the Conundrum in Skeletal Muscle?

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2019-00167 ◽

2019 ◽

Vol 104 (11) ◽

pp. 5372-5381 ◽

Cited By ~ 12

Author(s):

Nigel K Stepto ◽

Alba Moreno-Asso ◽

Luke C McIlvenna ◽

Kirsty A Walters ◽

Raymond J Rodgers

Keyword(s):

Insulin Resistance ◽

Skeletal Muscle ◽

Polycystic Ovary Syndrome ◽

Molecular Mechanisms ◽

Current Knowledge ◽

Polycystic Ovary ◽

Evidence Synthesis ◽

Basic Research ◽

Future Research ◽

Ovary Syndrome

Abstract Context Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting 8% to 13% of women across the lifespan. PCOS affects reproductive, metabolic, and mental health, generating a considerable health burden. Advances in treatment of women with PCOS has been hampered by evolving diagnostic criteria and poor recognition by clinicians. This has resulted in limited clinical and basic research. In this study, we provide insights into the current and future research on the metabolic features of PCOS, specifically as they relate to PCOS-specific insulin resistance (IR), that may affect the most metabolically active tissue, skeletal muscle. Current Knowledge PCOS is a highly heritable condition, yet it is phenotypically heterogeneous in both reproductive and metabolic features. Human studies thus far have not identified molecular mechanisms of PCOS-specific IR in skeletal muscle. However, recent research has provided new insights that implicate energy-sensing pathways regulated via epigenomic and resultant transcriptomic changes. Animal models, while in existence, have been underused in exploring molecular mechanisms of IR in PCOS and specifically in skeletal muscle. Future Directions Based on the latest evidence synthesis and technologies, researchers exploring molecular mechanisms of IR in PCOS, specifically in muscle, will likely need to generate new hypothesis to be tested in human and animal studies. Conclusion Investigations to elucidate the molecular mechanisms driving IR in PCOS are in their early stages, yet remarkable advances have been made in skeletal muscle. Overall, investigations have thus far created more questions than answers, which provide new opportunities to study complex endocrine conditions.

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The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome

Acta Endocrinologica ◽

10.1530/eje.0.1370670 ◽

1997 ◽

pp. 670-674 ◽

Cited By ~ 31

Author(s):

Y Sahin ◽

F Kelestimur

Keyword(s):

Polycystic Ovary Syndrome ◽

Late Onset ◽

Polycystic Ovary ◽

Serum Testosterone ◽

Free Testosterone ◽

Sex Hormone Binding Globulin ◽

Acth Stimulation ◽

Hydroxylase Deficiency ◽

Ovary Syndrome ◽

Biochemical Features

OBJECTIVE: To determine the frequency of late-onset adrenal hyperplasia (LOCAH) due to 21-hydroxylase (21-OH) and 11 beta-hydroxylase (11 beta-OH) deficiency in women with clinical and biochemical features of polycystic ovary syndrome (PCOS). DESIGN: Eighty-three consecutively selected women with PCOS and eighteen normal women were included in the study. METHODS: Ultrasound, clinical and hormonal parameters were used to define PCOS. Basal FSH, LH, testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG) and cortisol levels were measured. Serum 17-hydroxyprogesterone (17-OHP) and 11-deoxycortisol (11-DOC) levels were also measured before, 30 and 60 min after a single bolus injection of 0.25 mg ACTH (1-24) at 0900 h during the mid-follicular phase of the cycle. ACTH-stimulated 17-OHP levels > 30 nmol/l were considered as the criteria of 21-OH deficiency. The diagnosis 11 beta-OH deficiency was made if the adrenal 11-DOC response to ACTH stimulation exceeded threefold the 95th percentile of controls. RESULTS: Basal serum testosterone, free testosterone, androstenedione, DHEA-S, cortisol and 11-DOC levels were significantly higher in PCOS than in control subjects. ACTH-stimulated 17-OHP (P < 0.05) and 11-DOC (P < 0.0005) levels were found to be significantly higher in patients with PCOS than in controls. Seven (8.4%) patients had an 11-DOC response to ACTH higher than threefold the 95th percentile of controls, while no patients showed evidence of 21-OH deficiency. CONCLUSIONS: We have found that 8.4% of the women with clinical and biochemical features of PCOS could be presumed to have 11 beta-OH deficiency. No patients among the women with PCOS showed evidence of 21-OH deficiency. 11 beta-OH deficiency is unexpectedly more common than 21-OH deficiency in women with PCOS.

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Effect of Low-Frequency Electro-Acupuncture on Serum Testosterone and Menstrual Pattern in Women with Polycystic Ovary Syndrome Compared to Physical Exercise: Randomised Controlled Trial.

10.1210/endo-meetings.2010.part2.p9.p2-410 ◽

2010 ◽

pp. P2-410-P2-410

Author(s):

E Jedel ◽

G Holm ◽

F Labrie ◽

A Oden ◽

L Nilsson ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Physical Exercise ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Controlled Trial ◽

Low Frequency ◽

Serum Testosterone ◽

Ovary Syndrome ◽

Menstrual Pattern ◽

Randomised Controlled

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Correlation of serum androgen and gonadotropin with anti-mullerian hormone in polycystic ovarian syndrome in Eastern Indian population

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195918 ◽

2019 ◽

Vol 8 (1) ◽

pp. 256

Author(s):

Somnath Singh Raghuvanshi ◽

Anirban Sinha ◽

Animesh Maiti ◽

Partha Pratim Chakraborty ◽

Asish Kumar Basu ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovarian Syndrome ◽

Pulse Generator ◽

Polycystic Ovary ◽

Serum Testosterone ◽

Pulse Frequency ◽

Strong Positive Correlation ◽

Ovary Syndrome ◽

Cross Sectional ◽

Ovarian Syndrome

Background: Ovarian steroidogenesis requires gonadotropin stimulation, Luteinizing Hormone (LH) is a key factor in the hyperandrogenaemia of the polycystic ovary syndrome. Progesterone is the primary regulator of Gonadotropin-Releasing Hormone (GnRH) pulse frequency; however, in the polycystic ovary syndrome, the GnRH pulse generator is relatively resistant to the negative feedback effects of progesterone. Study aims to evaluate the association of Anti-mullerian hormone with serum androgen and gonadotropin level in adolescents and young women of Polycystic Ovary Syndrome (PCOS).Methods: This was a single centre observational Cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from March 2017 to January 2019. Total number of study subjects were 207 out of which 138 were cases.Results: The AMH had strong positive correlation with serum testosterone in both case and control groups (r 0.542, p<0.001 and r 0.57, p<0.001) respectively .After the adjustment of age and BMI , the AMH moderately positive but extremely significant correlation with serum testosterone as compare to control.Conclusions: Hyperandrogenaemia and higher ratio of LH and FSH associated with higher serum AMH level is associated with the higher serum AMH in polycystic ovarian syndrome.

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