Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction

Key Points When activated and in platelet storage bags, platelets release respiratory-competent mitochondria, a recognized damage-associated molecular pattern. Mitochondria, descendant of Rickettsia prowazekii, serve as substrate for bactericidal sPLA2-IIA to promote inflammation.

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Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2010.03676.x ◽

2011 ◽

Vol 41 (6) ◽

pp. 801-810 ◽

Cited By ~ 43

Author(s):

T. S. Hallstrand ◽

Y. Lai ◽

Z. Ni ◽

R. C. Oslund ◽

W. R. Henderson ◽

...

Keyword(s):

Phospholipase A2 ◽

Asthma Severity ◽

Secreted Phospholipase A2

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Inhaled Terbutaline Administered via a Spacer Fully Prevents Exercise-Induced Asthma in Young Asthmatic Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

Journal of International Medical Research ◽

10.1177/030006058901700602 ◽

1989 ◽

Vol 17 (6) ◽

pp. 506-513 ◽

Cited By ~ 3

Author(s):

A.T. Dinh Xuan ◽

C. Lebeau ◽

R. Roche ◽

A. Ferriere ◽

M. Chaussain

Keyword(s):

Room Temperature ◽

Work Load ◽

Cycle Ergometer ◽

Forced Expiratory Volume ◽

Controlled Study ◽

Adrenergic Agonist ◽

Double Blind ◽

Asthmatic Children ◽

Exercise Induced ◽

Age Range

The effects of inhaled terbutaline, a β2-adrenergic agonist, administered via a 750-ml spacer device were studied in young asthmatic subjects with exercise-induced asthma. A double-blind, randomized, placebo-controlled study of the effects of inhaled 0.5 mg terbutaline and placebo was conducted in 10 asthmatic children (age range 6–16 years) with documented exercise-induced asthma. Forced expiratory volume in 1 s (FEV1) was measured at baseline, 15 min after inhaling terbutaline or placebo, and at intervals up to 60 min after exercising. Subjects exercised using a cycle ergometer for 5 min at a submaximal, constant work-load while breathing dry air at room temperature. Terbutaline induced bronchodilation at rest in all subject and fully prevented exercise-induced asthma in nine out of the 10 subjects; the exercise-induced fall in FEV1 was markedly reduced in the remaining subject. It is concluded that exercise-induced asthma can be inhibited by pretreatment with inhaled terbutaline, administered via a spacer, in a majority of young asthmatics.

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Distance Running Improves Fitness in Asthmatic Children Without Pulmonary Complications or Changes in Exercise-Induced Bronchospasm

PEDIATRICS ◽

10.1542/peds.71.2.147 ◽

1983 ◽

Vol 71 (2) ◽

pp. 147-152

Author(s):

Bruce G. Nickerson ◽

Daisy B. Bautista ◽

Marla A. Namey ◽

Warren Richards ◽

Thomas G. Keens

Keyword(s):

Stress Test ◽

Clinical Status ◽

Control Period ◽

Bicycle Ergometer ◽

Pulmonary Complications ◽

Inspiratory Pressure ◽

Distance Running ◽

Asthmatic Children ◽

Need For Treatment ◽

Exercise Induced

The effect of a distance running program was studied in 15 children with severe chronic asthma. Following a 6-week control period, the subjects ran four days a week for 6 weeks. The distance was increased gradually to 3.2km. Clinical status and need for treatment did not change. Episodes of exercise-induced bronchospasm were readily reversed. Fitness improved as measured by the distance run in 12 minutes (P <.005). Resting pulmonary function did not change. Exercise-induced bronchospasm following a bicycle ergometer stress test under comparable conditions did not change. Ventilatory muscle strength, measured as the maximal inspiratory pressure, and endurance, measured as the sustainable inspiratory pressure, were at a high level initially and did not change. It is concluded that distance running is safe and can increase the fitness of asthmatic children who are receiving adequate therapy.

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Grading, Time Course, and Incidence of Exercise-Induced nduced Airway Obstruction and Hyperinflation in Asthmatic Children

PEDIATRICS ◽

10.1542/peds.56.5s.868 ◽

1975 ◽

Vol 56 (5s) ◽

pp. 868-879

Author(s):

Gerd J. A. Cropp ◽

I. J. Schmultzler

Keyword(s):

Pulmonary Function ◽

Airway Obstruction ◽

Clinical Status ◽

Small Airway ◽

Strenuous Exercise ◽

Normal Children ◽

Asthmatic Children ◽

Ergometer Exercise ◽

Exercise Induced ◽

Small Airway Obstruction

We evaluated clinical status and pulmonary function in 60 perennially asthmatic and 11 normal children before and repeatedly after incrementally increasing bicycle ergometer exercise. The changes in clinical status and pulmonary function which were elicited by strenuous exercise were graded by an air exchange and a physiological grading system respectively. Normal children showed no significant clinical or physiological changes after exercise. Strenuous exercise elicited significant deteriorations in clinical and physiological measurements in 36% to 77% of asthmatic girls and 46% to 90% of asthmatic boys, the frequency depending on the test used to determine exercise-induced abnormalities. The incidence of exercise-induced asthma (EIA) was statistically significantly higher in asthmatic boys than girls. The higher incidence of EIA in boys was primarily due to a larger number of very severe attacks in boys than girls; mild and moderate EIA was about equally common in the two sexes. Most patients with EIA developed large and small airway obstruction, although large airway obstruction tended to be the predominant and the more severe abnormality. Clinical and physiological abnormalities, regardless of severity, were usually most marked during the first ten minutes after exercise and lessened thereafter. Mild EIA usually lasted for only 15 minutes or less; severe EIA improved, but usually did not resolve within 35 minutes of exercise. There were three patients in whom the severity of EIA got worse after exercise and an additional seven in whom the improvement was minimal. In these ten patients isoproterenol aerosol terminated EIA, indicating that exercise-induced large and small airway obstruction in asthmatic children is primarily. if not solely. due to bronchospasm.

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Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A2 from Snake Venom

PLoS ONE ◽

10.1371/journal.pone.0093741 ◽

2014 ◽

Vol 9 (4) ◽

pp. e93741 ◽

Cited By ~ 14

Author(s):

Elbio Leiguez ◽

Karina Cristina Giannotti ◽

Vanessa Moreira ◽

Márcio Hideki Matsubara ◽

José María Gutiérrez ◽

...

Keyword(s):

Phospholipase A2 ◽

Functional Response ◽

Snake Venom ◽

Critical Role ◽

Secreted Phospholipase A2

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The Effects of Climate Therapy on Cardiorespiratory Fitness and Exercise-Induced Bronchoconstriction in Children with Asthma

Atmosphere ◽

10.3390/atmos12111486 ◽

2021 ◽

Vol 12 (11) ◽

pp. 1486

Author(s):

Carlo De Pieri ◽

Michele Arigliani ◽

Maria Pia Francescato ◽

Maurizio Droli ◽

Michael Vidoni ◽

...

Keyword(s):

Urban Area ◽

Positive Impact ◽

Asthmatic Children ◽

Children With Asthma ◽

Z Scores ◽

Exercise Induced ◽

Run Test ◽

Age Range ◽

Cardiorespiratory Endurance ◽

Shuttle Run

We investigated whether a 1-week stay in the mountains may have a positive impact on Exercise-Induced Bronchoconstriction (EIB) and cardiorespiratory endurance in asthmatic children from an urban area. Spirometry was performed before and 10 min after a 20 m shuttle run test (20mSRT) on the first and seventh day of a summer asthma camp in the Italian Alps at 900 m of altitude. Spirometry z-scores were derived from the Global Lung Initiative 2012 prediction equations, and percentiles of the 20mSRT performance were assigned according to De Miguel-Etayo’s and Tomkinson’s predictive equations. A FEV1 decrease ≥10% after the exercise was defined as EIB. Particulate matter pollution was monitored during the camp and in the urban area of provenience. Twenty-four subjects (age range 7–16 years) were included. Frequency of EIB decreased from 58% (14/24) at day-1 to 33% (8/24) at the end of the camp (p = 0.08). Most subjects with a 20mSRT in the lowest quartile at day 1 had EIB (9/11). The proportion of children with a 20mSRT <25° percentile decreased from 45% (11/24) at day-1 to 16% (4/24) at day-7 (p = 0.02). Conclusion: One-week climate therapy in the mountains improved both bronchial hyperreactivity and cardiorespiratory endurance in our cohort of asthmatic children.

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