Review: Application of Platelet-Rich Plasma in Hard Tissue Defects

2011 ◽  
Vol 01 (S2) ◽  
Author(s):  
P Gentile ◽  
MG Scioli
Keyword(s):  
Platelet Rich Plasma ◽  
Hard Tissue ◽  
Tissue Defects

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

Clinical Application of Platelet-Rich Plasma Gel (PRP) in Trauma Wounds of Extremities

2021 ◽  
Author(s):  
Jie Zhang ◽  
Xiaolin Feng ◽  
Yuxia Wang ◽  
Dakang Chen ◽  
Bo Zhang
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Platelet Rich Plasma ◽  
Healing Time ◽  
Second Stage ◽  
Autologous Platelet Rich Plasma ◽  
Wound Healing Time ◽  
Autologous Platelet ◽  
Tissue Defects ◽  
Wound Healing Rate

Research purposes: Autologous platelet-rich plasma gel (Platelet-Rich Plasma, PRP) was prepared and used for transplantation for the treatment of traumatic trauma wounds of extremities. Explore platelet-rich plasma gel (PRP) to promote the healing of exposed bone and tendon wounds. Methods: Fifteen patients with extremity bone and tendon exposed wounds were treated with autologous platelet-rich plasma gel (PRP) transplantation to observe the wound healing rate and wound healing time. Results: Among the 15 patients, 8 cases healed directly, 7 cases had active granulation growth, and second-stage skin graft wound healing; the wound healing rate was 100%, and the average wound healing time was 36 days. Conclusion: Autologous platelet-rich plasma gel (PRP) transplantation for the treatment of traumatic trauma hard wounds of the extremities, can inhibit the bacterial growth of the wounds, effectively promote the repair of soft tissue defects and accelerate the healing of bone and tendon wounds of the extremities.

scholarly journals The method of diagnosis and classification of the gingival line defects of the teeth hard tissues

2017 ◽  
Vol 24 (2) ◽  
Author(s):  
Olena Bulbuk ◽  
Mykola Rozhko ◽  
Oleksandr Bulbuk
Keyword(s):  
Dental Treatment ◽  
Therapeutic Approaches ◽  
Hard Tissue ◽  
Dental Hard Tissues ◽  
Hard Tissues ◽  
Diagnosis And Classification ◽  
Clinical Variants ◽  
Line Defects ◽  
Tissue Defects

For solving the problem of diagnosis and treatment of hard tissue defects the significant role belongs to the choice of tactics for dental treatment of hard tissue defects located in the gingival line of any tooth.This work aims to study the problems of diagnosis and classification of gingival line defects of the teeth hard tissues. That will contribute to the objectification of differentiated diagnostic and therapeutic approaches in the dental treatment of various clinical variants of these defects localization.The objective of the study – is to develop the anatomical-functional classification for differentiated estimation of hard tissue defects in the gingival part, as the basis for the application of differential diagnostic-therapeutic approaches to the dental treatment of hard tissue defects disposed in the gingival part of any tooth.Materials and methods of investigation: There was conducted the examination of 48 patients with hard tissue defects located in the gingival part of any tooth. To assess the magnitude of gingival line destruction the periodontal probe and X-ray examination were used.Results. The result of the performed research the classification of the gingival line defects of the hard tissues was offered using exponent power. The value of this indicator is equal to an integer number expressed in millimeters of distance from the epithelial attachment to the cavity’s bottom of defect.Conclusions. The proposed classification fills an obvious gap in academic representations about hard tissue defects located in the gingival part of any tooth. Also it offers the prospects of consensus on differentiated diagnostic-therapeutic approaches in different clinical variants of location.  This classification builds methodological “bridge of continuity” between therapeutic and prosthetic dentistry in the field of treatment of the gingival line defects of dental hard tissues.

scholarly journals Role of Platelet-Rich Fibrin (PRF) and Platelet-Rich Plasma (PRP) in Oro-Facial Tissue Regeneration: A Narrative Review

2020 ◽  
Vol 11 (1) ◽  
pp. 5-11
Author(s):  
Modhi Al Deeb
Keyword(s):  
Platelet Rich Plasma ◽  
Cost Effective ◽  
Full Potential ◽  
Hard Tissue ◽  
Therapeutic Tool ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Cost Effective Technique

Background and Aim: Regeneration potential of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in oral tissues regeneration has revolutionized the clinical dentistry in recent years. The in vivo and in vitro research on PRP and PRF has opened a new avenue in the dentistry and medicinal care. It is a minimally invasive and cost-effective technique that will raise the bar of clinical dentistry. The results presently documented are overwhelming; the potential to use PRF and PRP in the clinical dentistry have improved dental quality, satisfaction, and clinical outcome. The aim of the review was to recapitulate the regenerative and healing potential of platelet extracts in different disciplines of clinical dentistry. Materials and Methods: The attempt was to answer the following question: what are the various clinical oral health applications for PRF and PRP available in the published literature? The dual functions (tissue sealants and drug delivery systems to carry biomolecules and chemotactic growth factors) have helped the practitioners to treat the complicated oral conditions and tissues regeneration. The PRF and plasma has emerged as a powerful therapeutic tool for management of soft and hard tissue healing and regenerative procedures, including implant osseointegration. More research is mandatory to use these platelets concentrate to their full potential in various clinical applications. Conclusion: PRF is an emerging therapeutic tool in the management of oral soft and hard tissue healing and regenerative procedures.

Flow Chart for Reconstructive Head and Neck Surgery in Composite Soft and Hard Tissue Defects

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Bernd Lethaus ◽  
Mohammad Kamal ◽  
Franziska Kettner ◽  
Anita Kloss-Brandstätter ◽  
Dirk Halama ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Flow Chart ◽  
Hard Tissue ◽  
Tissue Defects

Research and Development of Calcium Phosphate Cement

2007 ◽  
Vol 353-358 ◽  
pp. 2267-2270
Author(s):  
Chang Sheng Liu
Keyword(s):  
Calcium Phosphate ◽  
Research And Development ◽  
Calcium Phosphate Cement ◽  
Ambient Conditions ◽  
Hard Tissue ◽  
Shape Characteristic ◽  
Different Types ◽  
Tissue Defects

Hydroxyapatite (HAP)-forming calcium phosphate cement (CPC), due to the high biocompatibility, easy-to-shape characteristic, and the capacity to self-setting under ambient conditions, has been widely used for the repair of hard tissue defects. To satisfy the different clinical need, some modified CPC, including porous CPC, fast-biodegradable CPC, injectable CPC, water-resistant CPC, and rhBMP-2/CPC, have been designed and fabricated in recent years. This paper attempts to give an overview of different types of CPC that have being developed at the present time. Meanwhile, the application perspective of these modified CPC is also explored.

scholarly journals Transforming Growth Factor-β3/Chitosan Sponge (TGF-β3/CS) Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells

2019 ◽  
Vol 20 (20) ◽  
pp. 4982 ◽  
Author(s):  
Yangfan Li ◽  
Zhifen Qiao ◽  
Fenglin Yu ◽  
Huiting Hu ◽  
Yadong Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Periodontal Disease ◽  
Osteogenic Differentiation ◽  
Periodontal Ligament ◽  
Transforming Growth Factor ◽  
Calcium Content ◽  
Hard Tissue ◽  
Periodontal Ligament Stem Cells ◽  
Tissue Defects

Periodontal disease is the main reason for tooth loss in adults. Tissue engineering and regenerative medicine are advanced technologies used to manage soft and hard tissue defects caused by periodontal disease. We developed a transforming growth factor-β3/chitosan sponge (TGF-β3/CS) to repair periodontal soft and hard tissue defects. We investigated the proliferation and osteogenic differentiation behaviors of primary human periodontal ligament stem cells (hPDLSCs) to determine the bioactivity and potential application of TGF-β3 in periodontal disease. We employed calcein-AM/propidium iodide (PI) double labeling or cell membranes (CM)-Dil labeling coupled with fluorescence microscopy to trace the survival and function of cells after implantation in vitro and in vivo. The mineralization of osteogenically differentiated hPDLSCs was confirmed by measuring alkaline phosphatase (ALP) activity and calcium content. The levels of COL I, ALP, TGF-βRI, TGF-βRII, and Pp38/t-p38 were assessed by western blotting to explore the mechanism of bone repair prompted by TGF-β3. When hPDLSCs were implanted with various concentrations of TGF-β3/CS (62.5–500 ng/mL), ALP activity was the highest in the TGF-β3 (250 ng/mL) group after 7 d (p < 0.05 vs. control). The calcium content in each group was increased significantly after 21 and 28 d (p < 0.001 vs. control). The optimal result was achieved by the TGF-β3 (500 ng/mL) group. These results showed that TGF-β3/CS promotes osteogenic differentiation of hPDLSCs, which may involve the p38 mitogen-activated protein kinase (MAPK) signaling pathway. TGF-β3/CS has the potential for application in the repair of incomplete alveolar bone defects.

Sign in / Sign up

Export Citation Format

Share Document