scholarly journals Hepatocellular carcinoma and cancer-related mortality after kidney transplantation with rituximab treatment

2022 ◽  
Vol 102 (1) ◽  
pp. 55
Author(s):  
Hayoung Lee ◽  
Young Hoon Kim ◽  
Seong Jun Lim ◽  
Youngmin Ko ◽  
Sung Shin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Kidney Transplantation ◽  
Related Mortality

scholarly journals Screening for Hepatocellular Carcinoma to Improve Cancer-Related Mortality: Looking Behind When We Should Be Looking Ahead

2019 ◽  
Vol 156 (4) ◽  
pp. 1215-1217 ◽  
Author(s):  
Neil Mehta ◽  
Alexander Monto ◽  
Francis Y. Yao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Related Mortality

One- year mortality in patients with advanced hepatocellular carcinoma on immunotherapy: Prediction using machine learning models (Preprint)

2021 ◽  
Author(s):  
Thomas Ka-Luen Lui ◽  
Ka Shing, Michael Cheung ◽  
Wai Keung Leung
Keyword(s):  
Machine Learning ◽  
Hepatocellular Carcinoma ◽  
Characteristic Curve ◽  
False Negative ◽  
False Negative Rate ◽  
Absolute Error ◽  
Advanced Hepatocellular Carcinoma ◽  
Data Set ◽  
One Year ◽  
Related Mortality

BACKGROUND Immunotherapy is a new promising treatment for patients with advanced hepatocellular carcinoma (HCC), but is costly and potentially associated with considerable side effects. OBJECTIVE This study aimed to evaluate the role of machine learning (ML) models in predicting the one-year cancer-related mortality in advanced HCC patients treated with immunotherapy METHODS 395 HCC patients who had received immunotherapy (including nivolumab, pembrolizumab or ipilimumab) in 2014 - 2019 in Hong Kong were included. The whole data set were randomly divided into training (n=316) and validation (n=79) set. The data set, including 45 clinical variables, was used to construct six different ML models in predicting the risk of one-year mortality. The performances of ML models were measured by the area under receiver operating characteristic curve (AUC) and the mean absolute error (MAE) using calibration analysis. RESULTS The overall one-year cancer-related mortality was 51.1%. Of the six ML models, the random forest (RF) has the highest AUC of 0.93 (95%CI: 0.86-0.98), which was better than logistic regression (0.82, p=0.01) and XGBoost (0.86, p=0.04). RF also had the lowest false positive (6.7%) and false negative rate (2.8%). High baseline AFP, bilirubin and alkaline phosphatase were three common risk factors identified by all ML models. CONCLUSIONS ML models could predict one-year cancer-related mortality of HCC patients treated with immunotherapy, which may help to select patients who would most benefit from this new treatment option.

scholarly journals From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Yaojie Fu ◽  
Shanshan Liu ◽  
Shan Zeng ◽  
Hong Shen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Small Cell Lung ◽  
Immune Microenvironment ◽  
Liver Malignancy ◽  
The Third ◽  
Clinical Investigations ◽  
Tumor Immune Microenvironment ◽  
Novel Strategy ◽  
Immunosuppressive Microenvironment ◽  
Related Mortality

Abstract Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% of HCC patients are eligible for potentially curative therapies. Recently, cancer immunotherapy has emerged as one of the most promising approaches for cancer treatment. It has been proven therapeutically effective in many types of solid tumors, such as non-small cell lung cancer and melanoma. As an inflammation-associated tumor, it’s well-evidenced that the immunosuppressive microenvironment of HCC can promote immune tolerance and evasion by various mechanisms. Triggering more vigorous HCC-specific immune response represents a novel strategy for its management. Pre-clinical and clinical investigations have revealed that various immunotherapies might extend current options for needed HCC treatment. In this review, we provide the recent progress on HCC immunology from both basic and clinical perspectives, and discuss potential advances and challenges of immunotherapy in HCC.

scholarly journals Nucleos(t)ide analogues and Hepatitis B virus-related hepatocellular carcinoma: A literature review

2020 ◽  
Vol 28 ◽  
pp. 204020662092133 ◽  
Author(s):  
Mohamed A Abd El Aziz ◽  
Rodolfo Sacco ◽  
Antonio Facciorusso
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Literature Review ◽  
Nucleoside Analogues ◽  
B Virus ◽  
Effect Of Treatment ◽  
Related Mortality

Hepatitis B virus is mainly considered to cause hepatocellular carcinoma which is the fourth leading cause of cancer-related mortality worldwide. Treatment of Hepatitis B virus with nucleos(t)ide analogues can decrease the progression of the disease and subsequently decreases the incidence of hepatocellular carcinoma. In this review, we have discussed the different classes of nucleos(t)ide analogues used in the treatment of Hepatitis B virus and their relationship with the development of hepatocellular carcinoma. Furthermore, we discussed the effect of treatment of Hepatitis B virus with Nucleoside analogues (NAs) before, during and after surgery, chemoembolization, radiofrequency ablation, and chemotherapy for the treatment of hepatocellular carcinoma.

Outcomes of Simultaneous Liver Kidney Transplantation in Patients With Hepatocellular Carcinoma

2017 ◽  
Vol 101 (1) ◽  
pp. e12-e19 ◽  
Author(s):  
Nicole Rich ◽  
Bekir Tanriover ◽  
Amit G. Singal ◽  
Jorge A. Marrero
Keyword(s):  
Hepatocellular Carcinoma ◽  
Kidney Transplantation

scholarly journals The risk factors associated with treatment-related mortality in 16,073 kidney transplantation—A nationwide cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236274 ◽  
Author(s):  
Hyunji Choi ◽  
Woonhyoung Lee ◽  
Ho Sup Lee ◽  
Seom Gim Kong ◽  
Da Jung Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Kidney Transplantation ◽  
Factors Associated ◽  
Treatment Related Mortality ◽  
Related Mortality

HEPATOCELLULAR CARCINOMA ASSOCIATED WITH CHRONIC HEPATITIS B VIRUS INFECTION AFTER KIDNEY TRANSPLANTATION

The Lancet ◽  
1982 ◽  
Vol 320 (8294) ◽  
pp. 381-382 ◽  
Author(s):  
GerhardP.J Schröter ◽  
Richard Weil ◽  
Israel Penn ◽  
WendellC Speers ◽  
WilliamR Waddell
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Kidney Transplantation ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus

P687 PROGRESSION TO CIRRHOSIS, HEPATOCELLULAR CARCINOMA AND LIVER RELATED MORTALITY IN ITALIAN PATIENTS WITH CHRONIC HEPATITIS B

2014 ◽  
Vol 60 (1) ◽  
pp. S298
Author(s):  
D. Ieluzzi ◽  
L. Covolo ◽  
N. Passigato ◽  
A. Tonon ◽  
F. Donato ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Related Mortality
Sign in / Sign up

Export Citation Format

Share Document