scholarly journals Phytochemical Composition, Anti-Inflammatory and Cytotoxic Activities of Chloroform Extract of <i>Senna crotalarioides</i> Kunth

2021 ◽  
Vol 12 (06) ◽  
pp. 887-900
Author(s):  
Roberto Serrano-Vega ◽  
Salud Pérez-Gutiérrez ◽  
Francisco Alarcón-Aguilar ◽  
Julio Almanza-Pérez ◽  
Cuauhtémoc Pérez-González ◽  
...  
Keyword(s):  
Chloroform Extract ◽  
Cytotoxic Activities ◽  
Phytochemical Composition ◽  
Anti Inflammatory

scholarly journals Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities ofLaennecia confusa

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
María G. Martínez Ruiz ◽  
Melissa Richard-Greenblatt ◽  
Zaida N. Juárez ◽  
Yossef Av-Gay ◽  
Horacio Bach ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Leishmania Donovani ◽  
Sesquiterpene Lactones ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Cytotoxic Activities ◽  
Chemical Analyses ◽  
Antiparasitic Activity ◽  
Anti Inflammatory ◽  
Chloroform Methanol

The current paper investigated the potential benefit of the traditional Mexican medicinal plantLaennecia confusa(Cronquist) G. L. Nesom (Asteraceae). Fractions from the hexane, chloroform, methanol, and aqueous extracts were analyzed for antibacterial, antifungal, anti-inflammatory, and antiparasitic activities. The antimicrobial activity of the extracts and fractions was assessed on bacterial and fungal strains, in addition to the protozoaLeishmania donovani, using a microdilution assay. The propensity of the plant's compounds to produce adverse effects on human health was also evaluated using propidium iodine to identify damage to human macrophages. The anti-inflammatory activity of the extracts and fractions was investigated by measuring the secretion of interleukin-6. Chemical analyses demonstrated the presence of flavonoids, cyanogenic and cardiotonic glycosides, saponins, sesquiterpene lactones, and triterpenes in the chloroform extract. A number of extracts and fractions show antibacterial activity. Of particular interest is antibacterial activity againstStaphylococcus aureusand its relative methicillin-resistant strain, MRSA. Hexanic and chloroformic fractions also exhibit antifungal activity and two extracts and the fraction CE 2 antiparasitic activity againstLeishmania donovani. All bioactive extracts and fractions assayed were also found to be cytotoxic to macrophages. In addition, the hexane and methane extracts show anti-inflammatory activity by suppressing the secretion of interleukine-6.

Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of white truffles (Tuber magnatum Pico)

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
I Beara ◽  
M Marija ◽  
D Četojević-Simin ◽  
Ž Marjanović ◽  
J Ristić ◽  
...  
Keyword(s):  
Cytotoxic Activities ◽  
Phenolic Profile ◽  
Tuber Magnatum ◽  
Anti Inflammatory

scholarly journals Evaluation of anti-inflammatory, antibacterial and cytotoxic activities of Cordia africana leaf and stem bark extracts

2016 ◽  
Vol 9 (1) ◽  
pp. 228 ◽  
Author(s):  
Adamu Imam Isa ◽  
Malajiya Ibrahim Alhaji Saleh ◽  
Ahmad Abubakar ◽  
Jean Paul Dzoyem ◽  
Salman Adeniyi Adebayo ◽  
...  
Keyword(s):  
Stem Bark ◽  
Cytotoxic Activities ◽  
Cordia Africana ◽  
Anti Inflammatory

scholarly journals Anti-Cancer and Anti-Inflammatory Potential of the Green Synthesized Silver Nanoparticles of the Red Sea Sponge Phyllospongia lamellosa Supported by Metabolomics Analysis and Docking Study

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1155
Author(s):  
Areej A. Al-Khalaf ◽  
Hossam M. Hassan ◽  
Aisha M Alrajhi ◽  
Rania Ali El Hadi Mohamed ◽  
Wael N. Hozzein
Keyword(s):  
Silver Nanoparticles ◽  
Molecular Docking ◽  
Red Sea ◽  
Docking Study ◽  
Chloroform Extract ◽  
Docking Studies ◽  
Silver Nanostructure ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Metabolomics Analysis

Background: The Red Sea sponges have been endorsed as a plentiful source of bioactive compounds with promising anti-cancer and anti-inflammatory activities; therefore, exploring their potential as a source of anti-cancer metabolites has stimulated a growing research interest. Purpose: To investigate the anti-cancer and anti-inflammatory potential of the Red Sea sponges, in their bulk and silver nanostructure. Metabolomics analysis of the selected sponge followed by molecular docking studies, will be conducted to explore and predict the secondary metabolites that might provide its capability of inhibiting cancer. Materials and Methods: We prepared a chloroform extract (CE) and ethyl acetate extract (EE) of the Red Sea sponge Phyllospongia lamellosa synthesized silver nanoparticles. The prepared silver nanoparticles were characterized through UV–vis spectrophotometric, transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for their anti-cancer activities was performed against MCF-7, MDB-231, and MCF-10A cells. Anti-inflammatory activity against COX-1 and 2 was assessed. Furthermore, liquid chromatography–mass spectrometry (LC–MS)-based metabolomics analysis and molecular docking were also applied.

scholarly journals Anti-Inflammatory Effect of Chloroform Extract from Potentilla chinensis

KSBB Journal ◽  
2013 ◽  
Vol 28 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Chang-Ho Kang ◽  
Sang-Hyun Han ◽  
Jae-Seong So
Keyword(s):  
Chloroform Extract ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Activity and Composition ofSenecio salignusKunth

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Cuauhtemoc Pérez González ◽  
Roberto Serrano Vega ◽  
Marco González-Chávez ◽  
Miguel Angel Zavala Sánchez ◽  
Salud Pérez Gutiérrez
Keyword(s):  
Medicinal Plant ◽  
Methanol Extract ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Active Fraction ◽  
Ear Edema ◽  
Methanol Extracts ◽  
Anti Inflammatory ◽  
Inflammatory Effect

We investigated the anti-inflammatory activity ofSenecio salignus. This medicinal plant is often used in Mexico for the treatment of fever and rheumatism. Chloroform and methanol extracts of the plant were tested on 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced edema in mice ears. The methanol extract of the plant inhibited edema by36±4.4% compared with the control, while the chloroform extract exhibited an even greater level of inhibition (64.1%). The chloroform extract was then fractionated, and the composition of the active fraction was determined by GC-MS. The anti-inflammatory activity of this fraction was then tested on TPA-induced ear edema in mice, and we found that the active fraction could inhibit edema by 46.9%. The anti-inflammatory effect of the fraction was also tested on carrageenan-induced paw edema in rats at doses of 100 mg/kg; a58.9±2.8% reduction of the edema was observed 4 h after administration of carrageenan, and the effect was maintained for 5 h.

Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Jasminum multiflorum (Burm. F.) Andrews Leaves towards MCF-7 Breast Cancer and HCT 116 Colorectal Cell Lines and Identification of Bioactive Metabolites

2021 ◽  
Vol 21 ◽  
Author(s):  
Seham Salah El-Hawary ◽  
Hala M. EL-Hefnawy ◽  
Samir Mohamed Osman ◽  
Mohamed A. El-Raey ◽  
Fatma Alzahraa Mokhtar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Mass Spectroscopy ◽  
Cytotoxic Activities ◽  
Isolation And Identification ◽  
Antioxidant Power ◽  
Hct 116 ◽  
Anti Inflammatory ◽  
Β Carotene ◽  
Mcf 7

Background: The plants of high phenolic contents are perfect antioxidant and anti-inflammatory candidates and participate in biological studies as effective agents towards different cancer cell lines. Objective: To investigate the antioxidant, anti-inflammatory, and cytotoxic activities of the hydromethanolic leaf extract of Jasminum multiflorum (Burm. f.) Andrews. (J. multiflorum), and phenolic profiling of the extract. Methods: The antioxidant activity for the extract was estimated using β-Carotene-linoleic and ferric reducing antioxidant power (FRAP) assays. The anti-inflammatory activity was evaluated by histamine release assay. Cytotoxicity of J. multiflorum was performed using a neutral red uptake assay towards breast cancer (MCF-7) and colorectal cancer (HCT 116) cell lines. Phenolic profiling of the leaves was characterized using high performance liquid chromatography coupled to photodiode array detector-mass spectroscopy-mass spectroscopy (HPLC-PDA-MS/MS), and chromatographic isolation and identification of the isolated compounds were performed using spectroscopic and NMR data, and virtual docking was performed to the isolated compounds against HSP90 (HEAT SHOCK PROTEIN 90). Results : At a concentration of 75 µg mL-1, J. multiflorum extract showed high antioxidant power; 68.23±0.35 % inhibition and 60.30±0.60 a TEAC (µmol Trolox g-1) for β-Carotene-linoleic assay and FRAP assay; respectively, and possessed anti-inflammatory activity with IC50 67.2 µg/ml. J. multiflorum showed high cytotoxic activity with IC50 of 24.81 µg/ml and 11.38 µg/ml for MCF-7 and HCT 116 cell lines, respectively. HPLC-PDA-MS/MS analysis tentatively identified 39 compounds; major compounds are secoiridoid glycosides, kaempferol, and quercetin glycosides, in addition to simple phenylethanoid compounds. Isolation of active metabolites was performed and led to the isolation and identification of four compounds. On the basis of docking study using HSP90 legend, kaempferol neohesperidoside showed a high cytotoxic potential supported by a high affinity score towards HSP90 legend protein. Conclusion: Jasminum multiflorum is a good candidate to isolate cytotoxic agents.

Antinociceptive and Anti-inflammatory Properties of Melastoma malabathricum Leaves Chloroform Extract in Experimental Animals

2006 ◽  
Vol 1 (4) ◽  
pp. 337-345 ◽  
Author(s):  
Z.A. Zakaria ◽  
R.N.S. Raden Mohd Nor ◽  
M.R. Sulaiman ◽  
Z.D.F. Abdul Ghani ◽  
G. Hanan Kumar ◽  
...  
Keyword(s):  
Chloroform Extract ◽  
Experimental Animals ◽  
Melastoma Malabathricum ◽  
Anti Inflammatory

scholarly journals Antibacterial and Cytotoxic Activities of the Sesquiterpene Lactones Cnicin and Onopordopicrin

2011 ◽  
Vol 6 (2) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Sandra M. Bach ◽  
Mario A. Fortuna ◽  
Rodgoun Attarian ◽  
Juliana T. de Trimarco ◽  
César A. N. Catalán ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Sesquiterpene Lactones ◽  
Antibacterial Activities ◽  
Chloroform Extract ◽  
Cytotoxic Activities ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
High Cytotoxicity

The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens.

Antioxidant, Anti‐inflammatory and Cytotoxic Activities of Polyphenols Extracted from Chroogomphus rutilus

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Ye Zhang ◽  
Meng Lan ◽  
Jin‐Peng Lü ◽  
Jing‐Feng Li ◽  
Kai‐Yue Zhang ◽  
...  
Keyword(s):  
Cytotoxic Activities ◽  
Anti Inflammatory
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