scholarly journals Trends in the Annual Incidence of Carbapenem Resistant among Gram Negative Bacilli in a Large Teaching Hospital in Makah City, Saudi Arabia

2017 ◽  
Vol 05 (04) ◽  
pp. 229-236 ◽  
Author(s):  
Hani S. Faidah ◽  
Aiman M. Momenah ◽  
Hamdi M. El-Said ◽  
Abeer A. A. Barhameen ◽  
Sami S. Ashgar ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Teaching Hospital ◽  
Annual Incidence ◽  
Gram Negative ◽  
Carbapenem Resistant ◽  
Large Teaching Hospital

scholarly journals BACTERIAL EPIDEMIOLOGY AND ANTIMICROBIAL RESISTANCE IN THE SURGERY WARDS OF A LARGE TEACHING HOSPITAL IN SOUTHERN ITALY

2015 ◽  
Vol 7 ◽  
pp. e2015040 ◽  
Author(s):  
Silvano Esposito ◽  
Renato Gioia ◽  
Giuseppe De Simone ◽  
Silvana Noviello ◽  
Sebastiano Leone
Keyword(s):  
Antimicrobial Resistance ◽  
Teaching Hospital ◽  
Antimicrobial Susceptibility ◽  
Southern Italy ◽  
National Health System ◽  
Gram Positive ◽  
Chi Square ◽  
Gram Negative ◽  
Exact Test ◽  
Large Teaching Hospital

Objectives: Surgical infections represent an increasingly important problem for the National Health System. In this study we retrospectively evaluated the bacterial epidemiology and antimicrobial susceptibility of the microorganisms concerned as well as the utilization of antibiotics in the General and Emergency Surgery wards of a large teaching hospital in southern Italy in the period 2011-2013.Methods: Data concerning bacterial isolates and antimicrobial susceptibility were retrieved from the Vitek II database. The pharmacy provided data about the consumption of antibiotics in the above reported wards. Chi-square or Fisher’s exact test were used to analyze categorical variables.Results: In all, 94 Gram-negative were isolated in 2011, 77 in 2012, and 125 in 2013, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa always being the most frequently isolated microorganisms. In the same years, there were respectively 105, 93, and 165 Gram-positive isolated, Enterococcus faecalis, Staphylococcus epidermidis and Staphylococcus aureus being the most commonly found. No significant variation in the antibiotic susceptibility pattern was observed, either among Gram-negative or among Gram-positive pathogens; carbapenems (especially meropenem) consumption remained stable over time.Conclusions: Our results show no significant increase in antimicrobial resistance over the period in question, and a higher rate of both MRSA isolates and resistance to carbapenems in A. baumannii compared with other European data.

scholarly journals High Burden of Resistant Gram-Negative Pathogens Causing Device-Associated Healthcare Infections in Saudi Arabia, 2008–2016

2020 ◽  
Vol 41 (S1) ◽  
pp. s249-s250
Author(s):  
Hanan Balkhy ◽  
Aiman Ramadan ◽  
Majid Alshamrani ◽  
Asim Alsaedi ◽  
Wafa Al Nasser ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Saudi Arabia ◽  
Bacterial Resistance ◽  
National Guard ◽  
Gram Negative ◽  
Carbapenem Resistant ◽  
The Us ◽  
Vancomycin Resistant ◽  
Healthcare Associated ◽  
Resistance Rates

Objectives: There is local and regional deficiency in the data examining the contribution of resistant pathogens to device-associated healthcare-associated infections (DA-HAIs). We examined such data in a multihospital system in Saudi Arabia in comparison with the US NHSN reports. Methods: Surveillance of DA-HAIs was prospectively conducted between 2008 and 2016 in 4 hospitals of Ministry of National Guard Health Affairs. Consecutive NHSN reports were used for comparison. Definitions and methodology of DA-HAIs and bacterial resistance were based on the NHSN reports. Results: In total, 1,260 pathogens causing 1,141 DA-HAI events were included. Gram-negative pathogens (GNPs) were responsible for 62.5% of DA-HAIs, with significantly higher Klebsiella, Pseudomonas, Acinetobacter, and Enterobacter than NHSN hospitals. Approximately 28.3% of GNPs and 23.5% of gram-positive pathogens (GPPs) exhibited some type of resistance. Nearly 34.3% of Klebsiella were cephalosporin-resistant; 4.8% of Enterobacteriaceae were carbapenem-resistant (CRE); 24.4% of Staphylococcus aureus were methicillin-resistant (MRSA; and 21.9% of Enterococci were Vancomycin-resistant (VRE). The multidrug resistance (MDR) rates were 65.0% for Acinetobacter, 26.4% for Escherichia coli, 23.0% for Klebsiella, and 14.9% for Pseudomonas. Resistant GNPs including cephalosporin-resistant Klebsiella, MDR Klebsiella, and MDR Escherichia coli were significantly more frequent than in NHSN hospitals, whereas resistant GPPs including MRSA and VRE were significantly less frequent than in NHSN hospitals. Conclusion: Compared with American hospitals, GNPs that contribute to DA-HAIs in Saudi hospitals show more resistance. The higher resistance rates in Klebsiella and Escherichia coli are alarming and call for effective antimicrobial stewardship programs.Funding: NoneDisclosures: None

scholarly journals Draft Genome Sequence of a Multidrug-Resistant Klebsiella pneumoniae Strain Isolated from King Abdullah Medical City, Makkah, Saudi Arabia

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Rayd Algowaihi ◽  
Sami Ashgar ◽  
Bashir Sirag ◽  
Sheerin Shalam ◽  
Anmar Nassir ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Klebsiella Pneumoniae ◽  
Genome Sequence ◽  
Draft Genome ◽  
Multidrug Resistant ◽  
Draft Genome Sequence ◽  
Gram Negative ◽  
Carbapenem Resistant ◽  
Medical City ◽  
Global Threat

Multidrug-resistant (MDR) Gram-negative infections represent a growing problem and a serious global threat. Carbapenem-resistant Klebsiella pneumoniae is perhaps cause the most difficult infection to treat and is associated with increased morbidity and mortality. Here, we report the draft genome sequence of an MDR K. pneumoniae strain isolated from Makkah, Saudi Arabia.

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